Catalysis-chemistry

Hawkins, Paige M. E. published the artcilePotent bactericidal antimycobacterials targeting the chaperone ClpC1 based on the depsipeptide natural products Ecumicin and Ohmyungsamycin A, Application of Fmoc-Pro-OH, the publication is Journal of Medicinal Chemistry (2022), 65(6), 4893-4908, database is CAplus and MEDLINE.

Ohmyungsamycin A and ecumicin are structurally related cyclic depsipeptide natural products that possess activity against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Herein, we describe the design and synthesis of a library of analogs of these two natural products using an efficient solid-phase synthesis and late-stage macrolactamization strategy. Lead analogs possessed potent activity against Mtb in vitro (min. inhibitory concentration 125-500 nM) and were shown to inhibit protein degradation by the mycobacterial ClpC1-ClpP1P2 protease with an associated enhancement of ClpC1 ATPase activity. The most promising analog from the series exhibited rapid bactericidal killing activity against Mtb, capable of sterilizing cultures after 7 days, and retained bactericidal activity against hypoxic non-replicating Mtb. This natural product analog was also active in an in vivo zebrafish model of infection.

Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Application of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hoffmann, Markus published the artcileCamostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity, Recommanded Product: 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, the publication is EBioMedicine (2021), 103255, database is CAplus and MEDLINE.

Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clin.-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However, antiviral activity of Camostat mesylate metabolites and potential viral resistance have not been analyzed. Moreover, antiviral activity of Camostat mesylate in human lung tissue remains to be demonstrated. We used recombinant TMPRSS2, reporter particles bearing the spike protein of SARS-CoV-2 or authentic SARS-CoV-2 to assess inhibition of TMPRSS2 and viral entry, resp., by Camostat mesylate and its metabolite GBPA. We show that several TMPRSS2-related proteases activate SARS-CoV-2 and that two, TMPRSS11D and TMPRSS13, are robustly expressed in the upper respiratory tract. However, entry mediated by these proteases was blocked by Camostat mesylate. The Camostat metabolite GBPA inhibited recombinant TMPRSS2 with reduced efficiency as compared to Camostat mesylate. In contrast, both inhibitors exhibited similar antiviral activity and this correlated with the rapid conversion of Camostat mesylate into GBPA in the presence of serum. Finally, Camostat mesylate and GBPA blocked SARS-CoV-2 spread in human lung tissue ex vivo and the related protease inhibitor Nafamostat mesylate exerted augmented antiviral activity. Our results suggest that SARS-CoV-2 can use TMPRSS2 and closely related proteases for spread in the upper respiratory tract and that spread in the human lung can be blocked by Camostat mesylate and its metabolite GBPA. NIH, Damon Runyon Foundation, ACS, NYCT, DFG, EU, Berlin Mathematics center MATH+, BMBF, Lower Saxony, Lundbeck Foundation, Novo Nordisk Foundation.

EBioMedicine published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, Recommanded Product: 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kufs, Johann E. published the artcileRational Design of Flavonoid Production Routes Using Combinatorial and Precursor-Directed Biosynthesis, Application In Synthesis of 1772-76-5, the publication is ACS Synthetic Biology (2020), 9(7), 1823-1832, database is CAplus and MEDLINE.

Combinatorial biosynthesis has great potential for designing synthetic circuits and amplifying the production of new active compounds Studies on multienzyme cascades are extremely useful for improving our knowledge on enzymic catalysis. In particular, the elucidation of enzyme substrate promiscuity can be potentially used for bioretrosynthetic approaches, leading to the design of alternative and more convenient routes to produce relevant mols. In this perspective, plant-derived polyketides are extremely adaptable to those synthetic biol. applications. Here, we present a combination of an in vitro CoA ligase activity assay coupled with a bacterial multigene expression system that leads to precursor-directed biosynthesis of 21 flavonoid derivatives When the vast knowledge from protein databases is exploited, the herein presented procedure can be easily repeated with addnl. plant-derived polyketides. Lastly, we report an efficient in vivo expression system that can be further exploited to heterologously express pathways not necessarily related to plant polyketide synthases.

ACS Synthetic Biology published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application In Synthesis of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

De Wet, J. R. published the artcileThe influence of cyanide on the flotation of pyrite from Witwatersrand gold leach residues, Recommanded Product: Dodecylamineacetate, the publication is Minerals Engineering (1995), 8(11), 1333-45, database is CAplus.

A significant portion of the gold in Witwatersrand ores may occur in the pyritic fraction, which seldom comprises >4% of the ore. Consequently, pyrite recovery through flotation offers an opportunity to increase gold recovery through further treatment of the concentrate The traditional processing routes are no longer economically viable due to the high cost of acid treatment to overcome the depressing influence of cyanide on xanthate flotation. Amines were identified as possible alternative collectors for pyrite flotation in the presence of cyanide. The influence of cyanide on pyrite flotation with dodecylamine acetate (I) was investigated by using electrochem. impedance measurements, flotation tests, and in-situ Raman spectroscopy. Cyanide acted as a slight depressant or no depressant at all for the flotation of pyrite with I, a much smaller effect than that which cyanide has on pyrite flotation with xanthate. In pH 11 solutions, pyrite electrodes exhibited a lower interfacial capacitance in the presence of I and reflect the formation of a layer on the electrode surface by adsorption of the cationic amine collector on the pyrite surface. At cyanide concentrations typical of gold leaching, this capacitance decrease is not observed and probably reflects an inhibiting effect of cyanide on amine adsorption. Raman spectroscopy measurements demonstrated a strong pH effect on amine adsorption and little effect of cyanide in broad agreement with flotation tests and electrochem. impedance measurements.

Minerals Engineering published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Recommanded Product: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mertens, Lucas published the artcileFluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines, Recommanded Product: 1,1,1-Trifluoropropan-2-amine, the publication is Chemistry – A European Journal (2016), 22(28), 9542-9545, database is CAplus and MEDLINE.

A novel continuous-flow approach for the synthesis of fluoroalkyl-substituted diazomethanes has been developed. Utilizing a cheap, self-made microreactor fluoroalkyl-substituted amines were transformed into the corresponding diazomethanes using tert-Bu nitrite and acetic acid as catalyst. These diazomethanes were employed in [2+3] cycloaddition reactions with olefins and alkynes, yielding valuable pyrazolines and pyrazoles, e.g. I, in good to excellent yields.

Chemistry – A European Journal published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Recommanded Product: 1,1,1-Trifluoropropan-2-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rosenwald, R. H. published the artcileAlkyl phenols as antioxidants, COA of Formula: C12H16O3, the publication is Industrial and Engineering Chemistry (1950), 162-5, database is CAplus.

A number of Me- and Bu-substituted phenols were tested as stabilizers for cracked gasoline, and the effects on stabilizing potency of number of substituents and their size, position, and configuration were studied. Potency of a phenol as stabilizer was found to increase with increased number of substituents, but size of substituent had little effect. Substituting in the ortho position was most effective, and the tert-Bu group gave best results. The best stabilizer studied was 2,4-dimethyl-6-tert-butylphenol. Phys. properties reported for new compounds are: 2-methyl-6-sec-butylphenol b_2.5 81.5-2¡ã, 229-31¡ã, n_D²⁰ 1.5197; 2,4-dimethyl-6-sec-butylphenol b_2.5 91-2.5¡ã, n_D²⁰ 1.5189; 2-tert-butyl-4-butylphenol b. 270-2¡ã, n_D²⁰ 1.5089; 2-tert-butyl-4-isobutylphenol b. 259-60¡ã, b_2.5 105-106¡ã, n_D²⁰ 1.5070; 2-tert-butyl-sec-butylphenol b. 255-6¡ã, n_D²⁰ 1.5078.

Industrial and Engineering Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Balatoni, Istvan published the artcile¦Â-amino- and alkoxy-substituted disilanides, Related Products of catalysis-chemistry, the publication is Molecules (2019), 24(21), 3823, database is CAplus and MEDLINE.

Our recent study on formal halide adducts of disilenes led to the investigation of the synthesis and properties of ¦Â-fluoro- and chlorodisilanides. The reaction of the functionalized neopentasilanes (Me₃Si)₃SiSiPh₂NEt₂ and (Me₃Si)₃SiSiMe₂OMe with KOtBu in the presence of 18-crown-6 provided access to structurally related ¦Â-alkoxy- and amino-substituted disilanides. The obtained Et₂NPh₂Si(Me₃Si)₂SiK¡¤18-crown-6 was converted to a magnesium silanide and further on to Et₂NPh₂Si(Me₃Si)₂Si-substituted ziroconocene and hafnocene chlorides. In addition, an example of a silanide containing both Et₂NPh₂Si and FPh₂Si groups was prepared with moderate selectivity. Also, the analogous germanide Et₂NPh₂Si(Me₃Si)₂GeK¡¤18-crown-6 could be obtained.

Molecules published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Balatoni, Istvan published the artcileDisilene Fluoride Adducts versus ¦Â-Halooligosilanides, Formula: C12H10F2Si, the publication is Inorganic Chemistry (2019), 58(20), 14185-14192, database is CAplus and MEDLINE.

Extending the chem. of disilene fluoride adducts studied earlier by us, we investigated the formation of 1,1-bis(trimethylsilyl)fluorodiphenylsilylsilanide, which was prepared by reaction of (Me₃Si)₃SiSiPh₂F with KO^tBu. The formed FPh₂SiSi(Me₃Si)₂K displays distinctively different structural and spectroscopic features compared to the earlier reported F(Me₃Si)₂SiSi(SiMe₃)₂K. While the latter eliminates metal fluoride upon reaction with MgBr₂, the resp. magnesium silanide is formed from FPh₂SiSi(Me₃Si)₂K. Reaction of (Me₃Si)₃SiSiPh₂Cl with KO^tBu proceeded similarly, but the formed ClPh₂SiSi(Me₃Si)₂K easily undergoes potassium chloride elimination to the disilene Ph₂Si:Si(SiMe₃)₂. Compared to F(Me₃Si)₂SiSi(SiMe₃)₂K, which can be regarded as a disilene fluoride adduct, structural, spectroscopic, and reactivity properties of FPh₂SiSi(Me₃Si)₂K distinguish it as a ¦Â-fluorodisilanide. Potassium 2-fluoro- and 2-chloro-2,2-diphenyl-1,1-bis(trimethylsilyl)disilanides can be prepared by reaction of fluoro- and chlorodiphenylsilyltris(trimethylsilyl)silanes with KOtBu. Structural and spectroscopic evidence characterizes these compounds as ¦Â-oligosilylsilanides, which is in contrast to the previously observed 2-fluoro-1,1,2,2-tetrakis(trimethylsilyl)disilanides, which can be regarded as disilene fluoride adducts.

Inorganic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Formula: C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gale, Philip A. published the artcileAcyclic indole and carbazole-based sulfate receptors, SDS of cas: 17351-61-0, the publication is Chemical Science (2010), 1(2), 215-220, database is CAplus.

The anion complexation properties of acyclic receptors consisting of diindolylurea groups appended with amide, amidoindole or amidocarbazole groups have been studied. The receptors selectively bind and encapsulate sulfate via either 6 or 8 H bonds. Receptors containing 8 H bond donors perturb the pK_a of bound dihydrogen phosphate and bicarbonate to the extent that they are deprotonated by free anion in solution

Chemical Science published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, SDS of cas: 17351-61-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuroda, Tokuyuki published the artcileSynthesis and biological activity of novel mitomycin C analogs derived from mitomycin A, Related Products of catalysis-chemistry, the publication is Journal of Heterocyclic Chemistry (1994), 31(1), 113-19, database is CAplus.

A variety of mitomycin C analogs were synthesized from mitomycin A and their biol. activities were studied. Mitomycin A (I) underwent nucleophilic displacement reactions involving intramol. hydrogen migrations upon treatment with nitrogen nucleophiles bearing mobile hydrogens, but the mode of hydrogen migration depended on the nature of the nucleophiles. The reaction with alkoxyamines gave oximes II (R = Me, CH₂CHMe₂). However, the reaction with hydroxylamine and benzohydrazine afforded imines III (R¹ = OH, NHBz). These products were converted into various types of mitomycin C derivatives by methylation with Me iodide or di-Me sulfate. The mechanistic features of these reactions are discussed. The in vitro and in vivo biol. activities were tested by using P388 leukemia and Sarcoma 180 tumor cells. Several of the synthesized compounds exhibited better activity than that of mitomycin C.

Journal of Heterocyclic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia