Catalysis-chemistry

Thomson, Jaclyn published the artcile1,3,5-Triazaadamantan-7-amine, Formula: C7H14N4, the publication is Acta Crystallographica, Section E: Structure Reports Online (2010), 66(10), o2637, database is CAplus and MEDLINE.

7-Amino-1,3,5-triazaadamantane, C₇H₁₄N₄, represents the 1st structurally characterized, isolated triazaadamantane. In the crystal structure, weak intermol. N-H¡¤¡¤¡¤N H bonds link the mols. into columns about the crystallog. 4-fold axis. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C14H12O2, Formula: C7H14N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nechifor, Marioara published the artcileSodium tetraborate/benzyltriethylammonium chloride-mediated synthesis of substituted cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids, Safety of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Revue Roumaine de Chimie (2013), 58(2-3), 161-164, database is CAplus.

A simple, efficient, cost-effective synthesis of some cinnamic acid derivatives was carried out by one-pot condensation reaction of benzaldehydes and aliphatic carboxylic acids in presence of sodium tetraborate and benzyltriethylammonium chloride and N-methyl-pyrrolidinone as solvent. This reaction proved to be faster and efficient alternative route to the Perkin reaction but requires high temperatures (reflux at 180-190¡ãC) and strong basic conditions.

Revue Roumaine de Chimie published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Safety of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fleming, Matthew C. published the artcileDiscovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4, Related Products of catalysis-chemistry, the publication is Journal of Medicinal Chemistry (2022), 65(10), 7231-7245, database is CAplus and MEDLINE.

MAGE proteins are cancer testis antigens (CTAs) that are characterized by highly conserved MAGE homol. domains (MHDs) and are increasingly being found to play pivotal roles in promoting aggressive cancer types. MAGE-A4, in particular, increases DNA damage tolerance and chemoresistance in a variety of cancers by stabilizing the E3-ligase RAD18 and promoting trans-lesion synthesis (TLS). Inhibition of the MAGE-A4:RAD18 axis could sensitize cancer cells to chemotherapeutics like platinating agents. We use an mRNA display of thioether cyclized peptides to identify a series of potent and highly selective macrocyclic inhibitors of the MAGE-A4:RAD18 interaction. Co-crystal structure indicates that these inhibitors bind in a pocket that is conserved across MHDs but take advantage of A4-specific residues to achieve high isoform selectivity. Cumulatively, our data represent the first reported inhibitor of the MAGE-A4:RAD18 interaction and establish biochem. tools and structural insights for the future development of MAGE-A4-targeted cellular probes.

Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Malbari, Khushboo D. published the artcileStructure-aided drug development of potential neuraminidase inhibitors against pandemic H1N1 exploring alternate binding mechanism, SDS of cas: 1772-76-5, the publication is Molecular Diversity (2019), 23(4), 927-951, database is CAplus and MEDLINE.

The rate of mutability of pathogenic H1N1 influenza virus is a threat. The emergence of drug resistance to the current competitive inhibitors of neuraminidase, such as oseltamivir and zanamivir, attributes to a need for an alternative approach. The design and synthesis of new analogs with alternate approach are particularly important to identify the potential neuraminidase inhibitors which may not only have better anti-influenza activity but also can withstand challenge of resistance. Five series of scaffolds, namely aurones (1a-1e), pyrimidine analogs (2a-2b), cinnamic acid analogs (3a-3k), chalcones (4a-4h) and cinnamic acid linkages (5a-5c), were designed based on virtual screening against pandemic H1N1 virus. Mol. modeling studies revealed that the designed analogs occupied 430-loop cavity of neuraminidase. Docking of sialic acid in the active site preoccupied with the docked analogs, i.e. in 430-loop cavity, resulted in displacement of sialic acid from its native pose in the catalytic cavity. The favorable analogs were synthesized and evaluated for the cytotoxicity and cytopathic effect inhibition by pandemic H1N1 virus. All the designed analogs resulting in displacement of sialic acid suggested alternate binding mechanism. Overall results indicated that aurones can be measured best among all as potential neuraminidase inhibitor against pandemic H1N1 virus.

Molecular Diversity published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, SDS of cas: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Joseph, Roymon published the artcileBenzothiazole appended lower rim 1,3-di-amido-derivative of calix[4]arene: Synthesis, structure, receptor properties towards Cu²⁺, iodide recognition and computational modeling, Computed Properties of 1798-04-5, the publication is Inorganica Chimica Acta (2010), 363(12), 2833-2839, database is CAplus.

A new mol. fluorescent sensor (L) for Cu²⁺ was synthesized by derivatizing the lower rim of calix[4]arene with benzothiazole moiety, through amide linkage to result in 1,3-di-derivative The receptor mol., L exhibited fluorescence quenching towards Cu²⁺ among eleven divalent ions, viz., Mn²⁺, Fe²⁺, Co²⁺, Ni²⁺, Cu²⁺, Zn²⁺, Cd²⁺, Hg²⁺, Ca²⁺, Mg²⁺ and Pb²⁺, studied. The 1:1 stoichiometry of the complex formed between L and Cu²⁺ was demonstrated by electronic absorption and ESI-MS. The role of calix[4]arene for the selective sensing of Cu²⁺ was established by comparing the data with that obtained for an appropriate control mol. The min. concentration at which L can detect Cu²⁺ is 403 ppb. The computations carried out at DFT level provided the coordination and structural features of the Cu²⁺ complex of L as species of recognition. The Cu²⁺ complex thus formed recognizes iodide by bringing change in the color, among the 14 anions studied.

Inorganica Chimica Acta published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Asha Bhanu, P. published the artcileFacile synthesis and docking studies of 7-hydroxyflavanone isoxazoles and acrylates as potential anti-microbial agents, Related Products of catalysis-chemistry, the publication is Medicinal Chemistry Research (2020), 29(2), 217-228, database is CAplus.

Two series of compounds, 2-phenyl-7-((3-phenylisoxazol-5-yl)methoxy)chroman-4-ones I [R¹ = Ph, 4-MeC₆H₄, 2,3-(MeO)C₆H₃, 3,4,5-(MeO)₃C₆H₂, etc.] and 4-oxo-2-phenylchroman-7-yl acrylates II (R² = Ph, 4-FC₆H₄, 2-Cl-6-FC₆H₃, 3-O₂NC₆H₄. etc.), were synthesized starting from 7-hydroxyflavanone. All the compounds were subjected to antibacterial, antifungal activity and mol. docking studies. The results showed that majority of the compounds exhibited potent antibacterial and antifungal activities when compared with the standard drugs. Further, the docking studies revealed that the compounds I (R¹ = Ph) and II (R² = 4-BrC₆H₄) have the highest binding affinity score of sterol 14-¦Á demethylase and DNA gyrase B, resp.

Medicinal Chemistry Research published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Forte, Gianpiero published the artcileSustainable Carboxylation of Diamines with Hydrogen Carbonate, Quality Control of 17351-61-0, the publication is Organic Process Research & Development (2018), 22(9), 1323-1327, database is CAplus.

A protocol for the carboxylation of diamines employing quaternary ammonium hydrogen carbonates as C1 source is presented. The approach is used to obtain industrially relevant bis-O-alkyl carbamates with diverse structural features in very high yield, even on gram scale. The quaternary ammonium salts, formally acting as “transporters” of the carboxylating agent, can be recovered after the reaction, and recycled with high efficiency. Regeneration of the hydrogen carbonates on ion-exchange resin grants excellent atom economy in the process.

Organic Process Research & Development published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Quality Control of 17351-61-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Roubinet, Benoit published the artcileA Synthetic Route to 3-(Heteroaryl)-7-hydroxycoumarins Designed for Biosensing Applications, Category: catalysis-chemistry, the publication is European Journal of Organic Chemistry (2015), 2015(1), 166-182, database is CAplus.

A straightforward method to synthesize 3-(2-benzimidazolyl)-7-hydroxycoumarins, based on a condensation reaction of 7-acetoxy-3-(formyl)coumarin with various C- and/or N-substituted ortho-phenylenediamine derivatives is presented. This unusual approach proved particularly effective for introducing different hydrophilic groups (carboxylic or sulfonic acids or trimethylalkylammonium moieties) onto the heteroaryl scaffold, leading to cyan-green emitting coumarins that were both water-soluble and strongly fluorescent under physiol. conditions. The further extension of this condensation reaction to bis(2-aminophenyl)diselenide enabled the first synthesis of 3-(2-benzoselenazolyl)-7-hydroxycoumarin. The potential utility of these new 7-hydroxycoumarins was demonstrated through the synthesis and spectroscopic and analyte-responsive behavior of fluorogenic probes suitable for sensing biol. relevant thiols and urokinase, a protease that plays a key role in cancer invasion and metastasis. A fluorescence probe for urokinase-type plasminogen activator (uPA, peptidolytic urokinase which is a biomarker for breast cancer, mammary gland neoplasm) was developed and the synthesis of the target compound was achieved by attaching N-acetyl-3-[(1,1-dimethylethyl)dithio]-L-alanyl-L-serylglycyl-L-arginyl-L-seryl-L-alanyl-L-asparaginyl-L-alanyl-L-lysinamide (heptapeptide) [(hydroxy)(oxo)(sulfo)benzopyranyl]benzimidazolecarboxylic acid. The title compounds thus formed included 2-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-benzimidazole-6-carboxylic acid and related substances.

European Journal of Organic Chemistry published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Benmalek, M. published the artcileExtraction of halides with organometallics. I. Comparative study of extraction with phenyl derivatives of Group IV and VA elements, Recommanded Product: Difluorodiphenylsilane, the publication is Journal of Inorganic and Nuclear Chemistry (1974), 36(6), 1359-63, database is CAplus.

The extraction of F- from aqueous solutions was studied using Ph derivatives of Group IVA and VA elements. At pH < 2, Ph2SiCl2 is the most suitable extractant, but Ph3SbCl2 and Ph3BiCl2, although less soluble, allow F- separation at pH 1-7.

Journal of Inorganic and Nuclear Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jha, Salil K. published the artcileChiral Optical Properties of a Helical Polymer Synthesized from Nearly Racemic Chiral Monomers Highly Diluted with Achiral Monomers, SDS of cas: 3115-28-4, the publication is Journal of the American Chemical Society (1999), 121(8), 1665-1673, database is CAplus.

In polyisocyanates composed only of randomly distributed (R) and (S) units, the chiral optical properties of the polymer are far out of proportion to the enantiomeric excess of the monomers. This highly disproportionate relationship, which arises from a majority-rule effect among these enantiomeric units on the helical sense of the backbone, is unaffected, within certain limits, by the overwhelming presence of achiral units randomly distributed along the chain. This exptl. result can be explained quant. by an anal. based on the one-dimensional random-field Ising model, which shows that dilution of the chiral units with achiral units increases the helical domain size in a manner that compensates for the dilution In qual. terms, since the random-field domain size is limited by the objection of the minority units to the helical sense dictated by the majority units, dilution of this objection acts to increase the domain size. As long as this domain size is not limited by the chain length or by thermal fluctuations, the achiral dilution will not reduce the optical activity of the polymer.

Journal of the American Chemical Society published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, SDS of cas: 3115-28-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia