Catalysis-chemistry

Pei, Xue-Chen published the artcileEffects of different antioxidants and their combinations on the oxidative stability of DHA algae oil and walnut oil, Application In Synthesis of 6217-54-5, the publication is Food Science & Nutrition (Hoboken, NJ, United States) (2022), 10(8), 2804-2812, database is CAplus and MEDLINE.

Through monitoring Rancimat induction time (RIT), peroxide value (POV), and thiobarbituric acid-reactive substances (TBARS) of docosahexaenoic acid (DHA) algae oil and walnut oil during accelerated storage, the effects of the single and the combinations of seven kinds of antioxidants involving ascorbyl palmitate (AP), phytic acid (PA), vitamin E (VE), antioxidant of bamboo leaves (AOB), rosemary extract, tea polyphenols (TP), and tea polyphenol palmitate (TPP) against lipid oxidation were evaluated. RIT, POV, and TBARS results showed that the DHA algae oil sample containing 600 mg/kg TPP revealed the strongest stability and the walnut oil sample containing 450 mg/kg TPP and 100 mg/kg TP revealed the strongest stability. Then, the shelf lives of two oils were predicted from the extrapolation of the linear regression model between Log RIT and temperature Our results indicated that the optimal antioxidant could prolong the shelf lives of DHA algae oil and walnut oil by 2.31- and 7.74-fold, resp.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Application In Synthesis of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chang, Kah Haw published the artcileOptimization of Headspace Solid-Phase Microextraction Technique for Extraction of Volatile Smokeless Powder Compounds in Forensic Applications, Synthetic Route of 1821-27-8, the publication is Journal of Forensic Sciences (2014), 59(4), 1100-1108, database is CAplus and MEDLINE.

Smokeless powders are low explosives and are potentially found in cases involving firearms and improvised explosive devices. Apart from inorganic compound anal., forensic determination of organic components of these materials appears as a promising alternative, especially the chromatog. techniques. This work describes the optimization of a solid-phase microextraction technique using an 85 ¦Ìm polyacrylate fiber followed by gas chromatog.-flame ionization detection for smokeless powder. A multivariate exptl. design was performed to optimize extraction-influencing parameters. A 2⁴ factorial first-order design revealed that sample temperature and extraction time were the major influencing parameters. Doehlert matrix design has subsequently selected 66¡ãC and 21 min as the compromised conditions for the two predetermined parameters. This extraction technique has successfully detected the headspace compounds of smokeless powders from different ammunition types and allowed for their differentiation. The novel technique allows more rapid sample preparation for chromatog. detection of smokeless powders.

Journal of Forensic Sciences published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Synthetic Route of 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Caumo, Sofia published the artcileParticulate matter-bound organic compounds: levels, mutagenicity, and health risks, SDS of cas: 191-07-1, the publication is Environmental Science and Pollution Research (2022), 29(21), 31293-31310, database is CAplus and MEDLINE.

Increased industrialization and consumption of fossil fuels in the Metropolitan Region of SaoPaulo (MRSP), Brazil, have caused a growth of the particulate matter emissions to the atm. and an increase in population health problems. Particulate and gaseous phase samples were collected in different short campaigns (2015, 2016, and 2017) near an urban-industrial area. Organic carbon (OC), elemental carbon (EC), polycyclic aromatic hydrocarbons (PAH), and its derivatives (nitro and oxy-PAH), n-alkanes, hopanes, and pesticides were determined The Salmonella/microsome test confirmed the mutagenic activity of these samples. Among PAH, benzo(a)pyrene was detected as one of the most abundant compounds Benzo(a)pyrene equivalent concentrations for PAH and nitro-PAH, and the associated risk of lung cancer, showed values above those recommended in the literature. The profile of n-alkanes confirmed the predominance of anthropogenic sources. Pesticide concentrations and estimated risks, such as the daily inhalation exposure and hazard quotient, suggest that exposure to these compounds in this area may be dangerous to human health.

Environmental Science and Pollution Research published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, SDS of cas: 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Jie published the artcileVisible-Light-Promoted Cross-Coupling of O-Aryl Oximes and Nitrostyrenes to Access Cyanoalkylated Alkenes, Synthetic Route of 4230-93-7, the publication is Organic Letters (2022), 24(25), 4640-4644, database is CAplus and MEDLINE.

A photoinduced, photocatalyst-free cyanoalkylation of nitrostyrenes was explored, affording a series of cyanoalkylated alkenes in moderate to good yields. Mechanistic studies reveal that an electron donor-acceptor complex formed between O-aryl oximes and DIPEA was presumably involved in this process. The excellent functional group compatibility of this newly designed synthetic protocol allows for cyanoalkylation of structurally varied substrates, which offered an eco-friendly pathway for the assembly of cyanoalkylated alkenes.

Organic Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, He published the artcileVisible-light-driven anti-Markovnikov hydrocarboxylation of acrylates and styrenes with CO₂, Safety of 2,4,6-Triisopropylbenzenethiol, the publication is CCS Chemistry (2021), 3(6), 1746-1756, database is CAplus.

Herein, the first visible-light-driven photocatalyst-free hydrocarboxylation of alkenes with CO₂ is reported. Diverse acrylates and styrenes, including challenging tri- and tetrasubstituted ones, underwent anti-Markovnikov hydrocarboxylation with high selectivities to generate valuable succinic acid derivatives and 3-arylpropanoic acids. In addition to the use of stoichiometric aryl thiols, the thiol catalysis has also been developed, representing the first visible light-driven organocatalytic hydrocarboxylation of alkenes with CO₂. The UV-vis measurements, NMR analyses, and computational investigations support the formation of a novel charge-transfer complex (CTC) between thiolate and acrylate/styrene. Further mechanistic studies and d. functional theory (DFT) calculations indicate that both alkene and CO₂ radical anions might be generated, illustrating the unusual selectivities and providing a novel strategy for CO₂ utilization.

CCS Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Safety of 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gul, Iram published the artcilePermeability of boron- and nitrogen-doped graphene nanoflakes for protium/deuterium ions, Safety of Coronene, the publication is RSC Advances (2022), 12(7), 3883-3891, database is CAplus and MEDLINE.

Two-dimensional (2D) monolayer nanomaterials are the thinnest possible membranes with interesting selective permeation characteristics. Among two-dimensional materials, graphenes and hexagonal boron nitride (h-BN) are the most promising membrane materials, which can even allow the separation of proton isotopes. The current work aims at understanding the higher reported permeability of h-BN by sequential doping of B and N atoms in graphene nanoflakes. The kinetic barriers were calculated with two different models of graphenes; coronene and dodecabenzocoronene via zero-point energy calculations at the transition state for proton permeability. The lower barriers for h-BN are mainly due to boron atoms. The trends of kinetic barriers are B < BN < N-doped graphenes. The permeation selectivity of graphene models increases with doping. Our studies suggest that boron-doped graphene models show an energy barrier of 0.04 eV for the permeation of proton, much lower than that of the model graphene and h-BN sheet, while nitrogen-doped graphenes have a very high energy barrier up to 7.44 eV for permeation. Therefore, boron-doped graphene models are suitable candidates for proton permeation. Moreover, the presence of carbon atoms in the periphery of BN sheets has significant neg. effects on the permeation of proton isotopes, an unexplored dimension of the remote neighboring effect in 2-D materials. This study illustrates the need for permeation study through other hetero-2D surfaces, where interesting hidden chem. is still unexplored.

RSC Advances published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Safety of Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Rui published the artcileDesign, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents, Application of 4-(Phenoxymethyl)benzoic acid, the publication is European Journal of Medicinal Chemistry (2017), 1-12, database is CAplus and MEDLINE.

Many studies have indicated that histone deacetylase (HDAC) inhibitors are promising agents for the treatment of cancer. With the aim to search for novel potent HDAC inhibitors, two series of hydroxamates and 2-aminobenzamides 4-R¹CH₂C₆H₄CONHR² [R¹ = PhO, 4-HON:CMeC₆H₄O, R² = OH; R¹ = PhO, 4-MeOC₆H₄O, 5-bromo-2,3-dihydro-1H-indol-1-yl, etc., R² = 2-H₂NC₆H₄, 2-H₂N-4-FC₆H₃] and (E)-4-R¹CH₂C₆H₄CH:CHCONHR² [R¹ = PhO, 2,3-dihydro-1H-indol-1-yl, 1,2,3,4-tetrahydroisoquinolin-2-yl; R² = OH, 2-H₂NC₆H₄, 3-aminopyridin-4-yl] were designed and synthesized as HDAC inhibitors and antitumor agents. Those compounds were investigated for their HDAC enzymic inhibitory activities and in vitro anti-proliferation activities against diverse cancer cell line (A549, HepG2, MGC80-3 and HCT116). Most of the synthesized compounds displayed potent HDAC inhibitory activity and antiproliferative activity. In particular, the compound 4-R¹CH₂C₆H₄CONHR² (R¹ = 4-FC₆H₄O; R² = 2-H₂NC₆H₄) (I) was shown to have the most HDAC inhibitory activity (70.6% inhibition at 5 ¦ÌM) and antitumor activity with IC₅₀ value of as low as 3.84 ¦ÌM against HepG2 human liver hepatocellular carcinoma cell line, more than 4.8-fold lower than CS055 and 5.9-fold lower than CI994. HDAC isoform selectivity assay indicated the compound I is a potent HDAC2 inhibitor. Docking study of I suggested that it bound tightly to the binding pocket of HDAC2. Further investigation showed that the compound I could inhibit the migration and colony formation of A549 cancer cells. Furthermore, this compound remarkably induced apoptosis and G2/M phase cell cycle arrest in A549 cancer cells. Those results indicated that the compound I could be a promising candidate for treatment of cancer.

European Journal of Medicinal Chemistry published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C40H35N7O8, Application of 4-(Phenoxymethyl)benzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Ming-Jun published the artcileDual Anti-cancer and Anti-Itch Activity of PD176252 Analogues: Design, Synthesis and Biological Evaluation, SDS of cas: 104-03-0, the publication is Anti-Cancer Agents in Medicinal Chemistry (2020), 19(8), 992-1001, database is CAplus and MEDLINE.

Cancer patients treated with targeted anti-cancer drug suffer from itch or pruritus. Itch or pruritus is an unpleasant sensation that brings about a neg. impact on quality of life, and serious itch may lead to dose reduction and even discontinuation. Gastrin releasing peptide receptor (GRPR) plays a critical role in itch, inflammation and cancer, and GRPR antagonist has obvious effect on cancer, inflammation and itch. The aim of this paper is to develop a new agent with anti-cancer and anti-itch activity. A series of GRPR antagonist PD176252 analogs (3a-3l) were designed and synthesized. Both anticancer and anti-itch activities were evaluated. Anti-cancer activity was evaluated in three human cancer cell lines in vitro, the anti-itch activity in evaluated with Kunming mice by intrathecal injection of chloroquine phosphate as a modeling medium. And the cytotoxicity on normal cells was evaluated. Of the tested compounds, compound 3i showed potently anti-cancer activity to all cancer cell lines tested with IC50 values of 10.5¦ÌM (lung), 11.6¦ÌM (breast) and 12.8¦ÌM (liver) resp. and it also showed significant inhibition of the scratching behavior. Comparing with PD17625, compound 3i and 3g gave better inhibition activities against all cancer cell lines, compound 3b, 3c and 3i showed better anti-itch activity. The compound 3i is safe for normal breast and liver normal cells, but it has high cytotoxicity on normal lung cell. The synthesized compounds have dual anti-cancer and anti-itch activity, so the development of drug with dual anti-tumor and anti-itch property is possible.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C18H10, SDS of cas: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moore, Whylder published the artcileSpin-spin interaction and relaxation in two trityl-nitroxide diradicals, Product Details of C10H25NO2Si, the publication is Journal of Magnetic Resonance (2021), 107078, database is CAplus and MEDLINE.

Trityl-nitroxides show substantial promise as polarizing agents in solid state dynamic nuclear polarization. To optimize performance it is important to understand the impact of spin-spin interactions on relaxation times of the diradicals. CW spectra and electron spin relaxation were measured for two trityl-nitroxides that differ in the substituents on the amide linker and have different strengths of the exchange interaction J. Anal. of the EPR spectra in terms of overlapping AB spin-spin splitting patterns explains the impact of J on various regions of the spectra. Even modest values of J are large relative to the separation between trityl and nitroxide resonances for some nitrogen nuclear spin state. Two conformations for each diradical were observed in CW spectra in fluid solution at X-band and Q-band. For one diradical J = 15 G (83%) and 5 G (17%) at 293 K, and J = 27 G (67%) and 3 G (33%) with interspin distances of 16 ? and 12 ?, resp., at 80 K. For the second diradical the exchange interaction is stronger: the two conformations in fluid solution at 293 K had J = 113 G (67%) and 59 G (33%) and at 80 K the value of J was 43 G and there were two conformations with interspin distances of 13 and 11.5 ?. The observation of two conformations for each diradical, with different values of J, demonstrates the dependence of their exchange interactions on through-bond orbital interactions. X-band values of spin relaxation rates 1/T1 and 1/Tm at 80 to 120 K for the trityl-nitroxides are similar to values for nitroxide mono-radicals, and faster than for trityl radicals. These observations show that even for a relatively small value of J, the nitroxide is very effective in enhancing the relaxation of the more slowly relaxing trityl.

Journal of Magnetic Resonance published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Product Details of C10H25NO2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Dong published the artcileThallium(I and III) exposure leads to liver damage and disorders of fatty acid metabolism in mice, Formula: C22H32O2, the publication is Chemosphere (2022), 307(Part_1), 135618, database is CAplus and MEDLINE.

Thallium (Tl), a highly toxic and priority pollutant heavy metal, exposure can damage mitochondria and disrupt their function. The liver is the central organ that controls lipid homeostasis and contains a large number of mitochondria. So far, there is no study investigating the effects of Tl exposure on hepatic fatty acid metabolism Here, we showed that 10 ppm of Tl(I) and Tl(III) exposures for two weeks did not significantly affect the body weight and water/food intake in mice. However, it decreased the ratio of liver/weight and induced hepatic sinus congestion and hepatocyte necrosis. Inductively coupled plasma-mass spectrometry (ICP-MS) anal. revealed Tl accumulation in the liver. Gas chromatog.-mass spectrometry (GC-MS) results showed that Tl(I) exposure significantly increased hepatic C18:0 concentration, while significantly decreased the concentrations of C16:1n-7, C20:1n-9, C18:3n-6, and C20:2n-9. Tl(III) exposure significantly reduced hepatic concentrations of C20:0, C22:0, C20:1n-9, C18:3n-6, and C20:3n-6. In addition, Tl(I) exposure upregulated the genes related to antioxidation (HO-1, GPX1, and GPX4), fatty acid synthesis (FADS2 and Elovl2), and fatty acid oxidation pathway (PPAR¦Á, ACADM, ACADVL, ACAA2, and CPT1A) in the liver. Tl(III) exposure did not significantly affect the transcript levels of liver antioxidative/metabolic enzymes and fatty acid synthesis-related genes, but upregulated fatty acid oxidation pathway-related genes (CYP4A10 and CPT1A). These results suggest that Tl(I) and Tl(III) exposures can cause liver damage and disrupt hepatic fatty acid metabolism, which provide new insights into Tl exposure-induced energy depletion from the perspective of fatty acid metabolism

Chemosphere published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Formula: C22H32O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia