Tag: M.W=100-150

Dreyer, R. published the artcileSynthesis and characterization of cationic astatine compounds with sulfur-containing ligands stable in aqueous solutions, Synthetic Route of 6972-05-0, the publication is Journal of Radioanalytical and Nuclear Chemistry (1985), 96(3), 333-41, database is CAplus.

The formation of cationic At compounds with thiourea, thiourea derivatives and some N-acylthioureas was studied in aqueous solutions The ion mobilities in free electrolytes were determined for the detection of carrier-free At compounds and their characterization. Information about the stability of this group of compounds could be given after studies in the presence of halide and pseudohalide ions (Cl^–, Br^–, I^–, SCN^–).

Journal of Radioanalytical and Nuclear Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Synthetic Route of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Culbertson, Townley P. published the artcileNew 7-substituted quinolone antibacterial agents. The synthesis of 1-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl and 4-thiazolyl)-3-quinolinecarboxylic acids, Category: catalysis-chemistry, the publication is Journal of Heterocyclic Chemistry (1987), 24(6), 1509-20, database is CAplus.

A series of 1-ethyl-1,4-dihydro-4-oxo-7-(4-thiazolyl)-3-quinolinecarboxylic acids e.g. I (R = NH₂, MeNH, AcNCH₂, Me₂N, 3-pyridyl, morpholino, etc.; R¹,R² = H, F), and 1-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl)-3-quinolinecarboxylic acids were prepared Also prepared was 10-[2-(aminomethyl)-4-thiazolyl]-9-fluoro-2,3-dihydro-3-methyl-7–oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (II). Analogs with basic amine substituents on the thiazole moiety were found to have antibacterial activity.

Journal of Heterocyclic Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Xing Xing published the artcileDiscovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis, Name: 2-Methylbenzoic acid, the publication is European Journal of Medicinal Chemistry (2022), 114357, database is CAplus and MEDLINE.

A series of pterostilbene derivatives I [R¹ = tert-Bu, Ph, 2-furyl, etc] were designed and synthesized based on previous SAR, leading to discovery of new effective NLRP3 inflammasome inhibitors with metabolic stability. Among them, the most effective compound I [R¹ = 2-furyl] showed high inhibitory efficacy (against IL-1 ¦Â: IC₅₀ = 1.23¦ÌM) and almost no toxicity (against IL-1 b: IC₅₀ > 100¦ÌM). Further mechanism studies have showed that compound I [R¹ = 2-furyl] directly targets the NLRP3 and affects the assembly of inflammasomes to inhibit the activation of NLRP3 inflammasomes. More importantly, in vitro experiments show that compound I [R¹ = 2-furyl] has a significant therapeutic effect on DSS-induced colitis in mice with good metabolic stability to liver microsomes (t_1/2 = 138.6 min). This research encourages the further development of more effective NLRP3 inflammasome inhibitors based on this chem. scaffold.

European Journal of Medicinal Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C21H37BO, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abbs Fen Reji, T. F. published the artcileSynthesis and cytotoxicity studies of thiazole analogs of the anticancer marine alkaloid dendrodoine, Category: catalysis-chemistry, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2008), 47B(7), 1145-1150, database is CAplus.

The synthesis and cytotoxicity evaluation of 2-N,N-dimethylamino-5-indol-3-oylthiazole as the first member of a new portfolio of the thiazole analogs of the cytotoxic marine alkaloid dendrodoine (3-N,N-dimethylamino-5-indol-3-oyl-1,2,4-thiadiazole) is described. Exploiting the opportunity arising from the replacement of the thiadiazole ring of dendrodoine by a thiazole ring which allowed further substitution on the five-membered ring, 2-N,N-dimethylamino-5-indol-3-oyl-4-phenylthiazole has also been synthesized. Structural diversity is further extended by synthesizing 5-fur-2-oyl- and 5-coumarin-3-oyl-2-N,N-dimethylaminothiazoles, as well as 5-fur-2-oyl, 5-thiophen-2-oyl, 5-(1-methylbenzimidazol-2-oyl) and 5-benzothiazol-2-oyl derivatives of 2-N,N-dimethylamino-4-phenylthiazoles. Among these new N,N-dimethylaminothiazoles, 2-N,N-dimethylamino-5-indol-3-oyl-4-phenylthiazole shows significant in vitro cytotoxicity against a panel of human cancer cell lines.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Setti, Eduardo L. published the artcile3,4-Disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity, Application In Synthesis of 6972-05-0, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(5), 1529-1534, database is CAplus and MEDLINE.

The synthesis of a series of highly potent and selective inhibitors of cathepsin K based on the 3,4-disubstituted azetidin-2-one warhead is reported. A high degree of potency and selectivity was achieved by introducing a basic nitrogen into the distal part of the P3 element of the mol. Data from kinetic and mass spectrometry experiments are consistent with the interpretation that compounds of this series transiently acylate the sulfhydrile of cathepsin K.

Bioorganic & Medicinal Chemistry Letters published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C14H26O2, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lokeshkumar, Venugopal published the artcileNutritive evaluations of laboratory-reared edible field cricket Coiblemmus compactus Chopard, 1928 (Orthoptera: Gryllidae), for utilising them as an alternate protein source, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Journal of Basic & Applied Zoology (2022), 83(1), 26, database is CAplus.

The increasing world population has made researchers to explore and validate alternate food sources for the future; in that regard, due to the attractive nutritive profile, edible insects ensure the food and feed security in some developing countries. Crickets are orthopteran edible insects widely eaten around the world not as an emergency food but as a delicacy. This present study aims to stabilize a mass rearing technique of field cricket Coiblemmus compactus using cost-effective rearing medium and feed materials. The reared adult crickets were processed and analyzed for its proximate, mineral, amino acid, fatty acid and energy contents. The cost-effective rearing methods were standardised for the cricket species, and the obtained nutritive values were comparatively higher than other edible meat sources. The cricket Coiblemmus compactus had 50.2 ¡À 0.37, 26.50 ¡À 0.80, 8.20 ¡À 1.61, 5.50 ¡À 0.48, 10.93 ¡À 0.19 and 5.40 ¡À 0.16 g/100 g of crude protein, crude fat, carbohydrate, crude fiber, moisture and ash contents, resp. The cricket also possessed higher amounts of potassium (897.83 ¡À 1.55 mg/100 g) and phosphorous elements (604.66 ¡À 4.11 mg/100 g) with 458.30 ¡À 0.29 kcal/100 g of energy content. The chromatog. studies showed the abundance of amino acid and fatty acid contents in the reared edible cricket. The attractive and high-protein nutritive profile of edible cricket Coiblemmus compcatus makes itself an alternate food and feed material to elevate food crisis in developing countries.

Journal of Basic & Applied Zoology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tadros, Joseph published the artcileA Comparison of Immobilised Triphenylphosphine and 1-Hydroxybenzotriazole as Mediators of Catch-and-Release Acylation Under Flow Conditions, Safety of 2-Methylbenzoic acid, the publication is Chemistry – An Asian Journal (2022), 17(5), e202101308, database is CAplus and MEDLINE.

Herein, a comparative study of immobilized triphenylphosphine (PS-PPh₃) and 1-hydroxybenzotriazole (PS-HOBt) to mediate amide couplings under continuous flow was described. Compared to Appel-type amidations (PS-PPh₃), the developed ‘catch-and-release’ approach (PS-HOBt) afforded near-quant. amide conversions. Utilizing this strategy, sulfonyl chloride amenability enabled facile access to an expanded library of sulfonate and sulfonamides. Post-constructional peptide modification was also demonstrated, affording two N¦Â-functionalized pentapeptides in high yields and purities. In contrast to frequently utilized coupling agents, the PS-HOBt resin could be recycled six times without a reduction in efficacy or regeneration requirements.

Chemistry – An Asian Journal published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C15H21BO3, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hofmann, Andreas published the artcileCyclometalated Analogues of Platinum Terpyridine Complexes: Kinetic Study of the Strong ¦Ò-Donor Cis and Trans Effects of Carbon in the Presence of a ¦Ð-Acceptor Ligand Backbone, Recommanded Product: 1,1-Dimethylthiourea, the publication is Inorganic Chemistry (2003), 42(20), 6528-6538, database is CAplus and MEDLINE.

The substitution kinetics of the complexes [Pt(N-N-C)Cl] (N-N-CH = 6-phenyl-2,2′-bipyridine), [Pt(N-C-N)Cl] (N-CH-N = 1,3-di(2-pyridyl)benzene), and [Pt(N-N-N)Cl]Cl (N-N-N = 2,2′:6′,2”-terpyridine) with the nucleophiles Br^–, I^–, and, for the first two complexes, also thiourea, N,N-dimethylthiourea, and N,N,N’,N’-tetramethylthiourea, have been studied in methanol as solvent. In case of the thioureas, the activation parameters ¦¤H^?, ¦¤S^?, and ¦¤V^? were also determined from the temperature and pressure dependence of the reactions. Two crystal structures of [Pt(N-N-C)Cl] were determined (yellow and red polymorphs); the intense red color of the latter polymorph results from Pt-Pt interactions (Pt-Pt distance = 3.366 ?). The data enable an anal. of the cis and trans effects and the influence of the strong ¦Ò-donor carbon in the presence of an electron withdrawing ¦Ð-acceptor ligand backbone. The results indicate that the intrinsic reactivity is enhanced greatly by the labilizing effect of the trans carbon donor, but the nucleophilic discrimination is dramatically reduced due to the decrease in electrophilicity on the metal center. However, although the electron withdrawing ¦Ð-acceptor effect is partly counteracted by the ¦Ò-donor effect, the complex still benefits from a higher nucleophilic discrimination than in the comparable Pt(II) trans carbon donor complexes, where no or fewer ¦Ð-acceptors are present. In the case of the cis carbon donor complex, the intrinsic reactivity remains unchanged, but the nucleophilic discrimination is reduced and leads to a reduced reactivity of the [Pt(N-N-C)Cl] complex in comparison to [Pt(N-N-N)Cl]Cl. On the basis of these results, a more detailed treatment of the nature of the cis effect is offered.

Inorganic Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wargny, Matthieu published the artcileNutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort, Related Products of catalysis-chemistry, the publication is Cardiovascular Diabetology (2022), 21(1), 101, database is CAplus and MEDLINE.

Heart failure (HF) is a growing complication and one of the leading causes of mortality in people living with type 2 diabetes (T2D). Among the possible causes, the excess of red meat and the insufficiency of vegetables consumption are suspected. Such an alimentation is associated with nutritional biomarkers, including trimethylamine N-oxide (TMAO) and its precursors. Here, we aimed to study these biomarkers as potential prognostic factors for HF in patients with T2D. We used the SURDIAGENE (SURvival DIAbetes and GENEtics) study, a large, prospective, monocentric cohort study including 1468 patients with T2D between 2001 and 2012. TMAO and its precursors (trimethylamine [TMA], betaine, choline, and carnitine) as well as thio-amino-acids (cysteine, homocysteine and methionine) were measured by liquid chromatog.-tandem mass spectrometry. The main outcome was HF requiring Hospitalization (HFrH) defined as the first occurrence of acute HF leading to hospitalization and/or death, established by an adjudication committee, based on hospital records until 31st Dec. 2015. The secondary outcomes were the composite event HFrH and/or cardiovascular death and all-cause death. The association between the biomarkers and the outcomes was studied using cause-specific hazard-models, adjusted for age, sex, history of coronary artery disease, NT-proBNP, CKD-EPI-derived eGFR and the urine albumin/creatinine ratio. Hazard-ratios (HR) are expressed for one standard deviation. The data of interest were available for 1349/1468 of SURDIAGENE participants (91.9%), including 569 (42.2%) women, with a mean age of 64.3 ¡À 10.7 years and a median follow-up of 7.3 years [25th-75th percentile, 4.7-10.8]. HFrH was reported in 209 patients (15.5%), HFrH and/or cardiovascular death in 341 (25.3%) and all-cause death in 447 (33.1%). In unadjusted hazard-models, carnitine (HR = 1.20, 95% CI [1.05; 1.37]), betaine (HR = 1.34, [1.20; 1.50]), choline (HR = 1.35, [1.20; 1.52]), TMAO (HR = 1.32, [1.16; 1.50]), cysteine (HR = 1.38, [1.21; 1.58]) and homocysteine (HR = 1.28, [1.17; 1.39]) were associated with HFrH, but not TMA and methionine. In the fully adjusted models, none of these associations was significant, neither for HFrH nor for HFrH and/or CV death, when homocysteine only was pos. associated with all-cause death (HR = 1.16, [1.06; 1.27]). TMAO and its precursors do not appear to be substantial prognosis factors for HFrH, beyond usual cardiac- and kidney-related risk factors, whereas homocysteine is an independent risk factor for all-cause death in patients with T2D.

Cardiovascular Diabetology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C6H8O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Lei published the artcileNIS-Mediated Intramolecular sp³ C-H Oxidation of 2-Alkyl-Substituted Benzamides, HPLC of Formula: 118-90-1, the publication is European Journal of Organic Chemistry, database is CAplus.

The N-iodosuccinimide-mediated benzyl sp³ C-H oxidation of 2-alkyl-substituted benzamide derivatives was described. This Hofmann-Loffler-Freytag (HLF) type reaction involving intramol. sp³ C-O bond formation differs from the construction of the C-N bond in the classic and modified HLF reactions. This reaction proceeded smoothly via 1,5-hydrogen atom transfer of N-centered radicals directly afforded by in-situ N-I bond generation, provided iminoisobenzofuran derivatives in moderate to excellent yields with exclusive chemoselectivity.

European Journal of Organic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C6H5NO, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia