Tag: M.W=200-250

Corriu, R. J. P. published the artcileUse of antimony(V) fluoride intercalated in graphite as fluorinating reagent in organosilicon and -germanium chemistry, Product Details of C12H10F2Si, the publication is Journal of Organometallic Chemistry (1980), 192(3), 347-52, database is CAplus.

The use of SbF₅ intercalated in graphites as fluorinating reagent of organosilicon and -germanium derivatives is described. Whereas Si-O and Si-Cl bonds are readily cleaved, Si-H and Si-S bonds are only reactive in bifunctional silanes. Ge-X bonds (X = Br, Cl, OR, H) are unreactive. Allyl-silicon and allyl-germanium bonds are broken under mild conditions and in high yields, leading to the corresponding fluorosilane or fluorogermane. With bifunctional silanes, the difluorinated derivatives are always obtained.

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Product Details of C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gaspar, Rafael D. L. published the artcileLuminescent oxygen probes based on Tb^III complexes chemically bonded to polydimethylsiloxane, Safety of Allyldiphenylphosphine oxide, the publication is Sensors and Actuators, B: Chemical (2019), 557-568, database is CAplus.

In this work, the functionalization degree of siloxane crosslinkers by allyldiphenylphosphine oxide (adppo) and its effect on the performance of a lanthanide-based optical oxygen sensor were evaluated. Linear poly(dimethyl-co-hydromethylsiloxane) (PMS) and cyclic tetramethylcyclotetrasiloxane (D4i) crosslinkers were functionalized with different concentrations of adppo to chem. bond the [Tb(dcba)₃]¡¤1/2H₂O (dcba = dichlorobenzoate) complex. Mech. stable luminescent silicone membranes were obtained after the curing of the poly(dimethylsiloxane)-vinyl terminated siloxane backbone with the pre-functionalized crosslinkers. Sensing materials exhibit green emission upon 350 nm excitation, and their luminescent properties are dependent of functionalization degree of the crosslinkers. The luminescent sensor materials show fully reversible response and non-linear Stern-Volmer plots, which are fitted by two quenching parameter model, with highest KSV of 0.08930%^-1 when using functionalized D4i as crosslinker and complex concentration of 0.75%.

Sensors and Actuators, B: Chemical published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Safety of Allyldiphenylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kronenberger, Thales published the artcileDesign, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors, Related Products of catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry (2020), 28(15), 115600, database is CAplus and MEDLINE.

The fragment MB872 I [R¹ = H; R² = 3-C(O)OH; W = O; Y = CH₂] was used as a prototype for analog development by bioisosterism/retro-bioisosterism, which resulted in substituted 3-benzoic acid derivatives I [R¹ = H, OH, OMe, NO₂; R² = 3-C(O)OH, 4-C(O)OH, 3-C(O)OMe, 4-C(O)OMe, 3-NO₂; W = O, S, NH, CH₂; Y = O, CH₂]. Compounds I were active against MtDHFR, with IC₅₀ values ranging from 7 to 40¦ÌM, where compound I [R¹ = H; R² = 3-C(O)OH; W = NH; Y = CH₂] not only had the best inhibitory activity (IC₅₀ = 7¦ÌM), but also was 71-fold more active than the original fragment MB872. The compound I [R¹ = H; R² = 3-C(O)OH; W = NH; Y = CH₂] inhibition kinetics indicated an uncompetitive mechanism, which was supported by mol. modeling which suggested that the compounds I could access an independent backpocket from the substrate and competitive inhibitors. Thus, based on these results, substituted 3-benzoic acid derivatives I had strong potential to be developed as novel MtDHFR inhibitors and also anti-TB agents.

Bioorganic & Medicinal Chemistry published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Macke, Jeffrey D. published the artcileSulfinic acids and related compounds. 19. Synthesis and properties of 1-propane-, 1-butane-, and 1-pentanesulfinates terminally substituted with di- and trisulfide functions, Synthetic Route of 77189-99-2, the publication is Journal of Organic Chemistry (1988), 53(2), 396-402, database is CAplus.

RSS(CH₂)_nSO₂Na (I; R = HO₂CCH₂CH₂, Ph, 4-MeC₆H₄; n = 3-5) were prepared as potential antiradiation agents (no data) in 53-85% yield by reaction of thiosulfonates II with RSNa. Studies of the disproportionation of I suggest that the principal process occurring is homolysis with light but heterolysis with heat. NaO₂S(CH₂)_nSSS(CH₂)_nSO₂Na (III; n = 3-5) were prepared in 73-85% yield by reaction of Na₂S with II. When heated in water, III rearranged to NaO₂S(CH₂)_nSS(CH₂)_nSO₂SNa.

Journal of Organic Chemistry published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Synthetic Route of 77189-99-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Jingjing published the artcileUltrathin mesoporous NiCo₂O₄ nanosheets as an efficient and reusable catalyst for benzylic oxidation, Application In Synthesis of 457-68-1, the publication is RSC Advances (2015), 5(4), 2405-2410, database is CAplus.

Ultrathin mesoporous NiCo₂O₄ nanosheets as a high efficient and reusable catalyst for benzylic oxidation have been prepared The nanosheets are less than 5 nm in thickness, the pore distribution is in the range of 2-5 nm and the sp. surface area of the nanosheets is about 81.0 m²g^-1. The ultrathin and mesoporous features with high sp. surface area not only provide large amount of binary active sites of Co and Ni, but also improve the contacting ability between the substrate and these active sites, therefore accelerating the rate of reaction and providing high catalytic efficiency for benzylic oxidation The NiCo₂O₄ nanosheets are efficient heterogeneous catalyst in the oxidation of 4,4′-difluorodiphenylmethane into 4,4′-difluorobenzophenone with a yield of 99%. Furthermore, the NiCo₂O₄ nanosheets catalyst exhibits general applicability, convenient separability and good stability in the benzylic oxidation

RSC Advances published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C6H13NO2, Application In Synthesis of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shie, Jiun-Jie published the artcileInhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic ¦Á,¦Â-unsaturated esters, Computed Properties of 16909-09-4, the publication is Bioorganic & Medicinal Chemistry (2005), 13(17), 5240-5252, database is CAplus and MEDLINE.

The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide ¦Á,¦Â-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease. Though AG7088 is inactive (IC₅₀ > 100 ¦ÌM), the ketomethylene isosteres and tripeptide ¦Á,¦Â-unsaturated esters containing both P1 and P2 phenylalanine residues show modest inhibitory activity (IC₅₀ = 11-39 ¦ÌM). The Phe-Phe dipeptide inhibitors are designed on the basis of computer modeling of the enzyme-inhibitor complex. The most potent inhibitor (I) with an inhibition constant of 0.52 ¦ÌM is obtained by condensation of the Phe-Phe dipeptide ¦Á,¦Â-unsaturated ester with 4-(dimethylamino)cinnamic acid. The cell-based assays also indicate that I is a nontoxic anti-SARS agent with an EC₅₀ value of 0.18 ¦ÌM.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C8H6ClN, Computed Properties of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yuehui published the artcileA General Catalytic Methylation of Amines Using Carbon Dioxide, Product Details of C14H23N, the publication is Angewandte Chemie, International Edition (2013), 52(36), 9568-9571, database is CAplus and MEDLINE.

In this article authors discuss a single Ru complex that is able to convert carbon dioxide and amines into various kinds of N-methylated products. The initial design was motivated by previous reports on the dehydration of primary amides using silanes and the hydrosilylation of carboxylic acid derivatives by us and other groups. Hence, the reaction of carbon dioxide and N-methylaniline in the presence of silanes as a model system was investigated. To identify active catalysts different metal precursors including Ru, Rh, Cu and Fe complexes and phosphine and nitrogen ligands were tested using phenylsilane as reductant.

Angewandte Chemie, International Edition published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Product Details of C14H23N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fenwick, Andrew E. published the artcileSynthesis, Characterization, and Reduction Chemistry of Mixed-Cyclopentadienyl/Arylsulfide Titanium Dichlorides, Quality Control of 22693-41-0, the publication is Organometallics (2003), 22(3), 535-540, database is CAplus.

A series of titanium derivatives [CpTi(SAr)Cl₂] containing both cyclopentadienyl and various substituted arylsulfide ligands (SAr = SC₆H₄Me-4 (1), SC₆H₂Me₃-2,4,6 (2), SC₆H₂Prⁱ₃-2,4,6 (3), SC₆H₂Ph₃-2,4,6 (4)) has been synthesized from the reaction of [CpTiCl₃] with 1 equivalent of the lithium salt of the corresponding aryl sulfides in benzene. X-ray diffraction studies show that each metal center possesses a pseudo-tetrahedral geometry. The compounds undergo one-electron reduction to produce sulfur-bridged dimers of the type [CpTiCl(¦Ì-SAr)]₂ (SAr = SC₆H₂Me₃-2,4,6 (5), SC₆H₂Prⁱ₃-2,4,6 (6)). The solid-state structures of these dimers show that the cyclopentadienyl rings are arranged in a transoid fashion about the [Ti(¦Ì-SAr)₂Ti] core. The Ti-Ti distances, 3.242(1) and 3.225(1) ?, resp., are similar to those found in previously reported Cp/aryloxide dimers with terminal aryloxides and bridging chlorides.

Organometallics published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Quality Control of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Katz, Michael G. published the artcileMolecular cardiac surgery with recirculating delivery (MCARD): procedure and vector transfer, Quality Control of 140-28-3, the publication is Methods in Molecular Biology (New York, NY, United States) (2017), 271-289, database is CAplus and MEDLINE.

Despite progress in clin. treatment, cardiovascular diseases are still the leading cause of morbidity and mortality worldwide. Therefore, novel therapeutic approaches are needed, targeting the underlying mol. mechanisms of disease with improved outcomes for patients. Gene therapy is one of the most promising fields for the development of new treatments for the advanced stages of cardiovascular diseases. The establishment of clin. relevant methods of gene transfer remains one of the principal limitations on the effectiveness of gene therapy. Recently, there have been significant advances in direct and transvascular gene delivery methods. The ideal gene transfer method should be explored in clin. relevant large animal models of heart disease to evaluate the roles of specific mol. pathways in disease pathogenesis. Characteristics of the optimal technique for gene delivery include low morbidity, an increased myocardial transcapillary gradient, esxtended vector residence time in the myocytes, and the exclusion of residual vector from the systemic circulation after delivery to minimize collateral expression and immune response. Here we describe myocardial gene transfer techniques with mol. cardiac surgery with recirculating delivery in a large animal model of post ischemic heart failure.

Methods in Molecular Biology (New York, NY, United States) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dixon, David A. published the artcileStructural studies of tris(dialkylamino)sulfonium (TAS) fluorosilicates, Quality Control of 312-40-3, the publication is Heteroatom Chemistry (1993), 4(2-3), 287-95, database is CAplus.

The crystal structures of two pentavalent silicon anions are discussed. The structure of [SiMe₃F₂]^–?1 shows a trigonal bipyramidal structure with the fluorines in apical positions. The Si-F bond distances are the longest known of this type. The crystal structure of fluorosilicate 2 (1,1-diphenyl-1-fluoro-3,3-bis[trifluoromethyl]-1,3-dihydro-2,1-benzoxasilole[ion 1-]) is distorted toward a rectangular structure along the Berry pseudorotation coordinate. The lone Si-F bond distance in 2 is much shorter than that in 1. The ab initio calculations on a variety of pentavalent fluorinated silicon anions are reported, and good agreement with the exptl. data are found. Fluoride affinities for the fluorosilanes are reported and are in reasonable agreement with the exptl. values where known. The fluoride affinity of the tetra-coordinated species is related to the length of the Si-F bond in the pentavalent anion.

Heteroatom Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Quality Control of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia