Tag: M.W=200-250

Arienzo, Rosa published the artcileQuinazoline and benzimidazole MCH-1R antagonists, COA of Formula: C9H7F3O3, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(5), 1403-1407, database is CAplus and MEDLINE.

Two novel series of MCH-1R antagonists were obtained by modification of previous reported 2-aminoquinoline derivatives Representative quinazoline compound I and benzimidazole derivative II were shown to be potent and selective, with promising in vitro eADME profiles.

Bioorganic & Medicinal Chemistry Letters published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, COA of Formula: C9H7F3O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bowley, C. C. published the artcileImproved reflective displays based on polymer-dispersed liquid crystals, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline, the publication is Journal of Optical Technology (Translation of Opticheskii Zhurnal) (2000), 67(8), 717-722, database is CAplus.

Layered dispersions of liquid crystals and polymers form a new class of materials for reflective displays, known as holog. polymer-dispersed liquid crystals (H-PDLC). Alternating layers of liquid crystal and polymer having dimensions of about 150 nm possess a variable reflectance, providing a wide reflection spectrum in the absence of a field. When an elec. field is applied, this coefficient takes an intermediate value between the refractive index of the liquid crystal and that of the polymer, smoothing out the difference between them. This article is devoted to research and development of these materials, which are promising for use in reflective displays due to their brightness, saturation, and low control voltage.

Journal of Optical Technology (Translation of Opticheskii Zhurnal) published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levitskaia, Tatiana G. published the artcileEvaluation of Cuprimine and Syprine for Decorporation of ⁶⁰Co and ²¹⁰Po, SDS of cas: 38260-01-4, the publication is Health Physics (2010), 98(3), 471-479, database is CAplus and MEDLINE.

The acknowledged risk of deliberate release of radionuclides into local environments by terrorist activities has prompted a drive to improve novel materials and methods for removing internally deposited radionuclides. These decorporation treatments will also benefit workers in the nuclear industry, should an exposure occur. Cuprimine and Syprine are oral therapeutics based on the active ingredients D-penicillamine and N,N’-bis-(2-aminoethyl)-1,2-ethanediamine dihydrochloride, resp. These therapeutic drugs have been used for several decades to treat Wilson’s disease, a genetic defect leading to copper overload, by chelation and accelerated excretion of internally deposited copper. Studies were undertaken to evaluate these FDA-approved drugs for the in vivo decorporation of radioactive cobalt (⁶⁰Co) and polonium (²¹⁰Po) using male Wistar-Han rats. In these studies, ⁶⁰Co or ²¹⁰Po was administered to animals by IV injection, followed by oral gavage doses of either Cuprimine or Syprine. Control animals received the radionuclide alone. For ⁶⁰Co studies, animals received a single dose of Cuprimine or Syprine, while for ²¹⁰Po studies animals were repeatedly dosed at 24-h intervals for a total of 5 doses. Results show that Syprine significantly increased urinary elimination and skeletal concentrations of ⁶⁰Co compared to controls. While Cuprimine had little effect on total excretion of ⁶⁰Co, the skeletal, kidney, liver, muscle, and stomach tissues had significantly lower radioactivity compared to control animals. The low overall excretion of ²¹⁰Po made it difficult to reliably measure urinary or fecal radioactivity and draw a definitive conclusion on the effect of Cuprimine or Syprine treatment on excretion. However, Cuprimine treatment was effective at reducing spleen levels of ²¹⁰Po compared to controls. Similarly, Syprine treatment produced statistically significant reductions of ²¹⁰Po in the spleen and skeletal tissues compared to control animals. Based on these promising findings, further studies to evaluate the dose-response pharmacokinetic profiles for decorporation are warranted.

Health Physics published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, SDS of cas: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levitskaia, Tatiana G. published the artcileEvaluation of cuprimine and syprine for decorporation of radioisotopes of cesium, cobalt, iridium and strontium, Quality Control of 38260-01-4, the publication is Health Physics (2011), 101(2), 118-127, database is CAplus and MEDLINE.

Cuprimine and Syprine are therapeutics approved by the USFDA to treat copper overload in Wilson Disease (a genetic defect in copper transport) by chelation and accelerated excretion of internally-deposited copper. These oral therapeutics are based on the resp. active ingredients D-penicillamine (DPA) and N,N’-bis (2-aminoethyl) -1,2-ethanediamine dihydrochloride (Trien). Cuprimine is considered the primary treatment, although physicians are increasingly turning to Syprine as a first-line therapy. Both drugs exhibit oral systemic activity and low toxicity; their biol. effects and safety are established. Previous in vivo studies using a rodent animal model established the decorporation potential of Cuprimine and Syprine for Co and Po. Currently these studies are being expanded to evaluate the in vivo decorporation efficacy of these drugs for several addnl. radionuclides. In this report, results of this investigation are discussed using the radionuclides Cs, Co, Ir and Sr. Short-term 48-h pilot studies were undertaken to evaluate DPA and Trien for their in vivo decorporation potential using male Wistar-Han rats. In these studies, a radionuclide solution was administered to the animals by i.v. (IV) injection, followed by a single IV dose of either DPA or Trien. Control animals received the radionuclide alone. Results show effective decorporation of Co by DPA within the time frame evaluated. DPA and Trien were also modestly effective in decorporation of Cs and Sr, resp. The study did not find DPA or Trien effective for decorporation of Ir. Based on these encouraging findings, further studies to evaluate the dose-response profiles and timing of the chelator administration post exposure to radionuclides are warranted.

Health Physics published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Quality Control of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nurchi, Valeria M. published the artcileComplex formation equilibria of Cu^II and Zn^II with triethylenetetramine and its mono- and di-acetyl metabolites, Application In Synthesis of 38260-01-4, the publication is Dalton Transactions (2013), 42(17), 6161-6170, database is CAplus and MEDLINE.

Triethylenetetramine (TETA) dihydrochloride, or trientine, is a therapeutic mol. that has long been used as a copper-chelating agent for the second-line treatment of patients with Wilson’s disease. More recently, it has also been employed as an exptl. therapeutic mol. in diabetes where it improves cardiac structure in patients with diabetic cardiomyopathy and left-ventricular hypertrophy. TETA is metabolized by acetylation, which leads to the formation of two main metabolites in humans and other mammals, monoacetyl-TETA (MAT) and diacetyl-TETA (DAT). These metabolites have been identified in the plasma and urine of healthy and diabetic subjects treated with TETA, and could themselves play a role in TETA-mediated copper chelation and restoration of physiol. copper regulation in diabetes. In this regard, a potentiometric and spectrophotometric study of Cu^II-complex formation equilibrium of TETA, MAT and DAT is presented here, to provide a comprehensive evaluation of the stoichiometries of the complexes formed and of their relative stability constants A potentiometric study has also been conducted on the corresponding Zn^II complexes, to evaluate any possible interference with TETA-mediated Cu^II binding by this second physiol. transition-metal ion, which is present in similar concentrations in human plasma and which also binds to TETA. An ESI-MS study of these systems has both confirmed the complex formation mechanisms established from the potentiometric and spectrophotometric results, and in addition provided direct information on the stoichiometry of the complexes formed in solution These data when taken together show that the 1 : 1 complexes formed with Cu^II and Zn^II have different degrees of protonation. The stability of the Cu^II and Zn^II complexes with the three ligands, evaluated by the parameters pCu and pZn, decreases with the introduction of the acetyl groups. Nevertheless the stability of Cu^II complexes with MAT is sufficiently high to enable its participation in copper scavenging from the patient. A speciation study of the behavior of TETA and MAT with Cu^II in the presence of Zn^II at peri-physiol. plasma concentrations is also presented. While Zn^II did not hinder copper binding, the possibility is raised that prolonged TETA treatment could possibly alter the homeostatic regulation of this essential metal ion. The lack of reliable literature stability constants concerning the Cu^II and Zn^II interaction with the major transport proteins in plasma is also briefly considered.

Dalton Transactions published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cavalla, David published the artcileHorner-Wittig reactions of ¦Â-aminoalkyl- and [¦Â-(acylamino)alkyl]diphenylphosphine oxides: synthesis of N-allylamines and -amides and 5-(diphenylphosphinoyl)-2-phenyl-5,6-dihydro-4H-1,3-oxazines, Formula: C15H15OP, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1987), 1883-98, database is CAplus.

Lithium derivatives of [(¦Â-diphenylphosphinoyl)alkyl]amines and dilithium derivatives of the corresponding amides combine with aldehydes or ketones in the Horner-Wittig reaction. Separation of the diastereoisomeric intermediates leads to single positional and geometric isomers of N-allylamines and amides. Thus, treatment of Ph₂P(O)CH₂CH₂NR₂ [R₂ = (CH₂)₅, CH₂CH₂OCH₂CH₂] with BuLi, followed by Me₂CO, afforded erythro– and threo-Ph₂P(O)CH[CMe₂(OH)]CH₂NR₂, which were separated by fractional crystallization, then treated with NaH in DMF to give elimination products Z– and E-MeCH:CHCH₂NR, resp. Attempted rearrangement of the same intermediates in acid solution gave dihydrooxazines or, in one case, a [¦Ã-(acylamino)allyl]diphenylphosphine oxide. The x-ray crystal structure of syn,anti-[(acylamino)hydroxypentyl]diphenylphosphine oxide I was determined

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Formula: C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gonzalez-Nogal, Ana M. published the artcileEpoxysilanes as substrates in regio- and stereo-specific synthesis of silylated ¦Ã-hydroxyphosphane oxides, precursors of stereodefined allylphosphane oxides, Product Details of C15H15OP, the publication is Tetrahedron (2013), 69(37), 8080-8087, database is CAplus.

Epoxysilanes experienced trans stereospecific ¦Á- or ¦Â-cleavage by the Li derivative of methyldiphenylphosphine oxide leading to different compounds The behavior of the epoxysilanes towards this nucleophilic reagent depends on the nature of the silyl group, the position of the substituents and the configuration of the epoxysilane. Unsubstituted and cis ¦Â-substituted dimethylphenylsilylepoxides underwent ¦Á-nucleophilic attack of Li methyldiphenylphosphine oxide giving stereodefined ¦Ã-phosphino-¦Â-silylalcs. Nevertheless, in the same conditions the intermediate ¦Â-hydroxysilane, formed by ¦Á-opening from trans ¦Â-substituted dimethylphenylsilylepoxides, experienced Peterson elimination to give stereodefined allylphosphine oxides. The steric requirements for the nucleophilic attack determined the regiochem. of the reaction. ¦Á-Substituted phenyldimethylsilyl- and tert-butyldiphenylsilylepoxides were exclusively attacked at the ¦Â-position affording ¦Ã-hydroxy-¦Ã-silylphosphine oxides and ¦Ã-phosphino silyl ether, resulting from Brook rearrangement. However, the allylphosphine oxides resulting from syn- or anti-elimination of ¦Â-dimethylphenylsilyl-¦Ã-hydroxyphosphine oxides, are of interest in the synthesis of phosphorylated and functionalized building blocks.

Tetrahedron published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Product Details of C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gonzalez-Nogal, Ana M. published the artcileSome synthetic applications of vinylphosphane oxides, Application In Synthesis of 4141-48-4, the publication is Tetrahedron (2010), 66(50), 9610-9619, database is CAplus.

Vinylphosphine oxides have been used as Michael acceptors for the diastereoselective synthesis of anti ¦Á-functionalized-¦Â-silylated phosphine oxides and ¦Â-stannyl-, ¦Â-phenylthio- or ¦Â-phosphinyl phosphine oxides. Although the utility of these substrates as dipolarophiles was more limited, authors have obtained a mixture of 3- and 4-phosphinylpyrazoles in which the latter is the major regioisomer, by 1,3-cycloaddition with N-phenylsydnone. Moreover, vinylphosphine oxides reacted with aldehydes in the presence of LDA by a Baylis-Hillman type reaction, leading to (E)-¦Â-hydroxyphosphine oxides, which were readily converted in allenes. It is noteworthy that the application of this methodol. to silylated substrates has permitted us to synthesize an interesting and more versatile silylallene.

Tetrahedron published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Application In Synthesis of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Jing published the artcileRadical Hydrosilylation of Alkynes Catalyzed by Eosin Y and Thiol under Visible Light Irradiation, Related Products of catalysis-chemistry, the publication is Organic Letters (2018), 20(11), 3174-3178, database is CAplus and MEDLINE.

A visible light-promoted hydrosilylation of alkynes was explored and achieved using 1 mol % organic dye Eosin Y as the photocatalyst and a catalytic amount of thiol as the radical quencher. The corresponding alkenylsilanes were provided with high regio- and stereoselectivites in the reactions of various terminal and internal alkynes. The reaction is preferentially initiated by a single electron transfer process, and a photoredox pathway is suggested.

Organic Letters published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C7H5ClN2S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takacs, James M. published the artcileCatalytic Palladium-Mediated Bisdiene Carbocyclizations: Bisdiene to Ene diene Cycloisomerizations, Synthetic Route of 4141-48-4, the publication is Journal of the American Chemical Society (1997), 119(25), 5804-5817, database is CAplus.

The palladium-catalyzed cycloisomerization of acyclic bisdienes to cyclized ene dienes defines a novel strategy for the stereoselective cyclization of certain unsym. bisdiene substrates to form functionalized five- and six-membered rings. The full details of our investigation into this novel cycloisomerization, including our observations on substrate requirements, stereoselectivity, the influence of the catalyst precursor, and some mechanistic insights drawn from deuterium labeling studies, are discussed.

Journal of the American Chemical Society published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C8H7ClO3, Synthetic Route of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia