Tag: M.W=200-250

Xie, Rui published the artcileDesign, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents, Application of 4-(Phenoxymethyl)benzoic acid, the publication is European Journal of Medicinal Chemistry (2017), 1-12, database is CAplus and MEDLINE.

Many studies have indicated that histone deacetylase (HDAC) inhibitors are promising agents for the treatment of cancer. With the aim to search for novel potent HDAC inhibitors, two series of hydroxamates and 2-aminobenzamides 4-R¹CH₂C₆H₄CONHR² [R¹ = PhO, 4-HON:CMeC₆H₄O, R² = OH; R¹ = PhO, 4-MeOC₆H₄O, 5-bromo-2,3-dihydro-1H-indol-1-yl, etc., R² = 2-H₂NC₆H₄, 2-H₂N-4-FC₆H₃] and (E)-4-R¹CH₂C₆H₄CH:CHCONHR² [R¹ = PhO, 2,3-dihydro-1H-indol-1-yl, 1,2,3,4-tetrahydroisoquinolin-2-yl; R² = OH, 2-H₂NC₆H₄, 3-aminopyridin-4-yl] were designed and synthesized as HDAC inhibitors and antitumor agents. Those compounds were investigated for their HDAC enzymic inhibitory activities and in vitro anti-proliferation activities against diverse cancer cell line (A549, HepG2, MGC80-3 and HCT116). Most of the synthesized compounds displayed potent HDAC inhibitory activity and antiproliferative activity. In particular, the compound 4-R¹CH₂C₆H₄CONHR² (R¹ = 4-FC₆H₄O; R² = 2-H₂NC₆H₄) (I) was shown to have the most HDAC inhibitory activity (70.6% inhibition at 5 ¦ÌM) and antitumor activity with IC₅₀ value of as low as 3.84 ¦ÌM against HepG2 human liver hepatocellular carcinoma cell line, more than 4.8-fold lower than CS055 and 5.9-fold lower than CI994. HDAC isoform selectivity assay indicated the compound I is a potent HDAC2 inhibitor. Docking study of I suggested that it bound tightly to the binding pocket of HDAC2. Further investigation showed that the compound I could inhibit the migration and colony formation of A549 cancer cells. Furthermore, this compound remarkably induced apoptosis and G2/M phase cell cycle arrest in A549 cancer cells. Those results indicated that the compound I could be a promising candidate for treatment of cancer.

European Journal of Medicinal Chemistry published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C40H35N7O8, Application of 4-(Phenoxymethyl)benzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, He published the artcileVisible-light-driven anti-Markovnikov hydrocarboxylation of acrylates and styrenes with CO₂, Safety of 2,4,6-Triisopropylbenzenethiol, the publication is CCS Chemistry (2021), 3(6), 1746-1756, database is CAplus.

Herein, the first visible-light-driven photocatalyst-free hydrocarboxylation of alkenes with CO₂ is reported. Diverse acrylates and styrenes, including challenging tri- and tetrasubstituted ones, underwent anti-Markovnikov hydrocarboxylation with high selectivities to generate valuable succinic acid derivatives and 3-arylpropanoic acids. In addition to the use of stoichiometric aryl thiols, the thiol catalysis has also been developed, representing the first visible light-driven organocatalytic hydrocarboxylation of alkenes with CO₂. The UV-vis measurements, NMR analyses, and computational investigations support the formation of a novel charge-transfer complex (CTC) between thiolate and acrylate/styrene. Further mechanistic studies and d. functional theory (DFT) calculations indicate that both alkene and CO₂ radical anions might be generated, illustrating the unusual selectivities and providing a novel strategy for CO₂ utilization.

CCS Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Safety of 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Jie published the artcileVisible-Light-Promoted Cross-Coupling of O-Aryl Oximes and Nitrostyrenes to Access Cyanoalkylated Alkenes, Synthetic Route of 4230-93-7, the publication is Organic Letters (2022), 24(25), 4640-4644, database is CAplus and MEDLINE.

A photoinduced, photocatalyst-free cyanoalkylation of nitrostyrenes was explored, affording a series of cyanoalkylated alkenes in moderate to good yields. Mechanistic studies reveal that an electron donor-acceptor complex formed between O-aryl oximes and DIPEA was presumably involved in this process. The excellent functional group compatibility of this newly designed synthetic protocol allows for cyanoalkylation of structurally varied substrates, which offered an eco-friendly pathway for the assembly of cyanoalkylated alkenes.

Organic Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chang, Sheng published the artcileDesign and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Molecules (2009), 14(10), 4166-4179, database is CAplus and MEDLINE.

A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl]acrylamide(12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571.

Molecules published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Qing-qing published the artcilePreparation and properties of ammonium-based ionic liquids and polyether demulsifier complexes, Synthetic Route of 2016-56-0, the publication is Jingxi Huagong (2013), 30(1), 99-103, 107, database is CAplus.

Two kinds of ammonium-based ionic liquids, i. e. n-butylamine nitrate and dodecylamine acetate were synthesized. The effects of ammonium-based ionic liquid and crosslinking polyether demulsifier NJ-20 complexes on the dehydration of simulated crude oil emulsion were studied. The results showed that, when the dosage of the demulsifier complexes was 200 mg/L and the temperature was 50 degree, the dehydration rate reached 75% and 91%, resp., in 2 h. With sep. polyether demulsifier NJ-20, the dehydration rate was only 65% under the same conditions. When the dosage was 200 mg/L and the temperature was 40degree, the dehydration rate reached 59% in 2 h, which was much higher than that of polyether demulsifier NJ-20, displaying strong low-temperature demulsification effect.

Jingxi Huagong published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Synthetic Route of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ohta, Shun published the artcileOxido-Bridged Di-, Tri-, and Tetra-Nuclear Iron Complexes Bearing Bis(trimethylsilyl)amide and Thiolate Ligands, Computed Properties of 22693-41-0, the publication is Inorganic Chemistry (2012), 51(4), 2645-2651, database is CAplus and MEDLINE.

Di-, tri-, and tetra-nuclear iron-oxido clusters with bis(trimethylsilyl)amide and thiolate ligands were synthesized from the reactions of Fe{N(SiMe₃)₂}₂ (1) with one equiv of thiol HSR (R = C₆H₅ (Ph), 4-^tBuC₆H₄, 2,6-Ph₂C₆H₃ (Dpp), 2,4,6-ⁱPr₃C₆H₂ (Tip)) and subsequent treatment with O₂. The trinuclear clusters [{(Me₃Si)₂N}Fe]₃(¦Ì₃-O){¦Ì-S(4-RC₆H₄)}₃ (R = H (3a), ^tBu (3b)) were obtained from the reactions of 1 with HSPh or HS(4-^tBuC₆H₄) and O₂, while the authors isolated a tetranuclear cluster [{(Me₃Si)₂N}₂Fe₂(¦Ì-SDpp)]₂(¦Ì₃-O)₂ (4) as crystals from an analogous reaction with HSDpp. Treatment of a tertrahydrofuran (THF) solution of 1 with HSTip and O₂ gave dinuclear [{(Me₃Si)₂N}(TipS)(THF)Fe]₂(¦Ì-O) (5). The mol. structures of these complexes were determined by x-ray crystallog. anal. Cyclic voltammograms of the mixed valent Fe(II)Fe(III)₂ complexes 3a and 3b are also presented which show a single one-electron oxidation and a single one-electron reduction for each of the two complexes.

Inorganic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Computed Properties of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Xiao-Ming published the artcileAllylic Arylation of 1,3-Dienes via Hydroboration/Migrative Suzuki-Miyaura Cross-Coupling Reactions, Application In Synthesis of 4141-48-4, the publication is ACS Catalysis (2018), 8(7), 6094-6099, database is CAplus.

The hydroboration/Pd-catalyzed migrative Suzuki-Miyaura cross-coupling of 1,3-dienes with electron-deficient aryl halides has been developed, which enables the synthesis of branched allylarenes directly from primary homoallylic alkyl boranes. A ligand-tuned linear- or branch-selective coupling for these aryl halides has also been achieved.

ACS Catalysis published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C16H12O, Application In Synthesis of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhou, Binghua published the artcileGluconic acid aqueous solution as a sustainable and recyclable promoting medium for organic reactions, Product Details of C10H11NO4, the publication is Green Chemistry (2011), 13(8), 2204-2211, database is CAplus.

For the first time, gluconic acid aqueous solution (GAAS), a biobased weakly acidic liquid, was used as an effective promoting medium for organic reactions, such as the Michael addition of indoles to ¦Á,¦Â-unsaturated ketones, the electrophilic ring-opening reaction of 3,4-dihydropyran with indoles and Friedel-Crafts alkylation of electron-rich aromatics with benzyl alcs. The concept of using GAAS as a solvent for organic reactions not only offers a sustainable candidate for progress in solvent innovation, but also opens up a new avenue for the utilization of this biobased polyhydroxylated acid. Among the features that render GAAS as a solvent so interesting is the ability to act as both the reaction medium and catalyst. Moreover, this methodol. offers significant improvements with regard to the yield of products, simplicity in operation, cost efficiency and green aspects, in terms of avoiding toxic catalysts and minimizing the generation of waste.

Green Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C12H23N3S, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Xiang published the artcileOrganocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold, SDS of cas: 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(77), 8692-8694, database is CAplus and MEDLINE.

A novel multicatalytic MBH-Michael tandem reaction has been developed for the asym. assembly of ninhydrin, nitroolefins and aldehydes into a structurally complex oxa-spirocyclic indanone backbone, e.g., I. Successive iodocyclization allowed us to convert these multifunctional allylic products into fused chiral natural product mimics,e.g.,II.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, SDS of cas: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Jing published the artcileNew tetraphenylethene-based efficient blue luminophors: aggregation induced emission and partially controllable emitting color, Recommanded Product: Bis(4-fluorophenyl)methane, the publication is Journal of Materials Chemistry (2012), 22(6), 2478-2484, database is CAplus.

Two new TPE-based conjugated mols., constructed using tetraphenylethene (TPE) and carbazole or spirofluorene moieties, were successfully prepared They exhibited aggregation induced emission (AIE) properties, high thermal and morphol. stabilities, and low oxidation potential, making them promising properties for optoelec. materials. The fabricated nondoped multilayer OLEDs demonstrate that devices using these luminophors as the emitting layer show relatively good performance, and the device of SFTPE gives a maximum luminance and efficiency of 8196 cd m^-2 and 3.33 cd A^-1, resp., with the maximum emission wavelength at ?466 nm, thanks to the adjusted mol. structure and AIE characteristic of TPE.

Journal of Materials Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Recommanded Product: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia