Tag: M.W=200-250

Shen, Li published the artcileNovel hybrids from lamellarin D and combretastatin A4 as cytotoxic agents, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Medicinal Chemistry (2010), 45(1), 11-18, database is CAplus and MEDLINE.

A new series of hybrids of lamellarin D and combretastatin A4, 1,2-diphenyl-5,6-dihydropyrrolo[2,1-a]isoquinolines, was designed as cytotoxic agents based on principles of combination in medicinal chem. and taking the parent compounds’ different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids, e.g. I, were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC₅₀ ranges.

European Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H14BNO4S, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cui, De-Yun published the artcileSystematic research of H₂dedpa derivatives as potent inhibitors of New Delhi Metallo-¦Â-lactamase-1, Quality Control of 140-28-3, the publication is Bioorganic Chemistry (2020), 103965, database is CAplus and MEDLINE.

New Delhi Metallo-¦Â-lactamase-1 (NDM-1), a Zn (II)-dependent enzyme, can catalyze the hydrolysis of almost all ¦Â-lactam antibiotics including carbapenems, resulting in bacterial antibiotic resistance, which threatens public health globally. Based on our finding that H2dedpa is as an efficient NDM-1 inhibitor, a series of H2dedpa derivatives was systematically prepared These compounds exhibited significant activity against NDM-1, with IC50 values 0.06-0.94 ¦ÌM. In vitro, compounds 6k and 6n could restore the activity of meropenem against Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis possessing either NDM or IMP. In particular, the activity of meropenem against E. coli producing NDM-4 could be improved up to 5333 times when these two compounds were used. Time-kill cell-based assays showed that 99.9% of P. mirabilis were killed when treated with meropenem in combination with compound 6k or 6n. Furthermore, compounds 6k and 6n were nonhemolytic (HC50 > 1280 ¦Ìg/mL) and showed low toxicity toward mammalian (HeLa) cells. Mechanistic studies indicated that compounds 6k and 6n inhibit NDM-1 by chelating the Zn2+ ion of the enzyme.

Bioorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Kuo published the artcileCatalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer, Safety of 2,4,6-Triisopropylbenzenethiol, the publication is Journal of the American Chemical Society (2019), 141(22), 8752-8757, database is CAplus and MEDLINE.

In the presence of an iridium photocatalyst and tetraphenylphosphonium trifluoroacetate or di-Ph phosphate or collidine, alkenyl-substituted cyclic and heterocyclic alcs. such as I (R = H, Ph, 4-t-BuC₆H₄, 4-MeO₂CC₆H₄) underwent regioselective photochem. one- and two-carbon ring expansion reactions under blue LED irradiation via proton-coupled electron transfer to yield cyclic ketones such as II and III (R = Ph, 4-t-BuC₆H₄, 4-MeO₂CC₆H₄). When an aryl substituent was present at the terminal position of the alkenyl moiety, one-carbon ring expansion was observed, while when an alkyl substituent or a proton was present, two-carbon ring expansion occurred exclusively.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C22H18O2, Safety of 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Fuchao published the artcileThree-component solvent-free synthesis of highly substituted tetrahydroimidazo[1,2-a]pyridines, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is RSC Advances (2011), 1(4), 596-601, database is CAplus.

An efficient and green method was developed for the synthesis of tetrahydroimidazo[1,2-a]pyridines by three-component reactions of heterocyclic ketene aminals, triethoxymethane, and nitro alkenes in one-pot in the absence of catalyst and solvent. This protocol has advantages of environmental friendliness, high yields (73-93%), short reaction time and convenient operation.

RSC Advances published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C7H5ClN2S, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Ling published the artcileCatalyst-free one-pot three-component rapid synthesis of polysubstituted pyrroles by liquid-assisted grinding, HPLC of Formula: 4230-93-7, the publication is Journal of Heterocyclic Chemistry, database is CAplus.

A series of polysubstituted pyrroles were rapidly synthesized in moderate to good yields via catalyst-free one-pot three-component reaction of 1,3-dicarbonyl compounds with primary amines and nitrostyrenes by using liquid-assisted grinding. This protocol provided several advantages over the conventional chem. synthesis, such as simple work-up procedure, wide substrate scope, short reaction time and environmental friendliness. Structures of polysubstituted pyrroles were confirmed by ¹H NMR, ¹³C NMR and ESI-MS studies.

Journal of Heterocyclic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, HPLC of Formula: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fujiwara, Masazumi published the artcileSecond order nonlinear optical properties of the single crystal of N-benzyl 2-methyl-4-nitroaniline: anomalous enhancement of the d₃₃₃ component and its possible origin, Quality Control of 201157-13-3, the publication is Japanese Journal of Applied Physics, Part 1: Regular Papers, Brief Communications & Review Papers (2006), 45(11), 8676-8685, database is CAplus.

A single crystal of N-benzyl 2-methyl-4-nitroaniline (BNA) whose dimensions were 8 ¡Á 10 mm (diameter ¡Á length) was grown using a vertical Bridgman method with sufficient optical transparency for spectroscopic use. Polarized reflection spectra of the crystal were measured in order to determine its linear optical parameters (refractive indexes and extinction coefficients). The relative magnitudes of the d-tensor components of the crystal were determined to be d₃₃₃ = (17 ¡À 9) ¡Á d₃₂₂, d₃₂₂ > d₃₁₁, d₃₁₁ ? 0 from polarization dependencies of the second harmonic generation. These results are in disagreement with previously reported theor. studies, in which the effects of intermol. interactions were completely neglected. Here, we have included these intermol. interactions in the calculations assuming the presence of supra-mol. clusters. We conclude that the anomalous enhancement of d₃₃₃ is due to the interactions along the direction of the hydrogen bonds in the crystal and the resonance effect.

Japanese Journal of Applied Physics, Part 1: Regular Papers, Brief Communications & Review Papers published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Quality Control of 201157-13-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sugita, Atsushi published the artcilePhoto-excited state of N-benzyl MNA studied by femtosecond time-resolved absorption spectroscopy, Related Products of catalysis-chemistry, the publication is Chemical Physics Letters (2003), 382(5,6), 693-698, database is CAplus.

Ultrafast photoexcitation dynamics of N-benzyl-2-Me-4-nitroaniline was studied with femtosecond time-resolved absorption spectroscopy. The photo-induced absorption spectrum was found to consist of 3 transient components with different decay times. A 260 fs-decay time stimulated emission appeared during a geometrical relaxation from a charge-transfer excited state to a geometrically relaxed excited state. A following energy relaxation of the geometrically relaxed excited state was completed within 680 fs. Third 2.6 ps decay time reflected a cooling process of hot electrons in a ground state potential.

Chemical Physics Letters published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C9H9BrO2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jiang-Sheng published the artcilet-BuONa-Mediated Transition-Metal-Free Autoxidation of Diarylmethanes to Ketones, Safety of Bis(4-fluorophenyl)methane, the publication is Synlett (2017), 28(8), 994-998, database is CAplus.

Autoxidative sp³ C-H transformation of diarylmethanes ArCH₂Ar¹ (Ar = Ph, 2-chlorophenyl, 3,4-dimethylphenyl, etc.; Ar¹ = 2-methoxyphenyl, 4-nitrophenyl, 3,4-dichlorophenyl, etc.) has been demonstrated using O₂-mediation by t-BuONa. This protocol enables an alternative route for the access to diaryl ketones ArC(O)₂Ar¹ from benzyl derivatives in good to excellent yields under mild reaction conditions, without transition metal catalysts or addnl. chem. oxidants.

Synlett published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lin, Qing-Yu published the artcileVisible-Light-Induced Hydrodifluoromethylation of Alkenes with Bromodifluoromethylphosphonium Bromide, Formula: C15H15OP, the publication is Angewandte Chemie, International Edition (2016), 55(4), 1479-1483, database is CAplus and MEDLINE.

Bromodifluoromethylphosphonium bromide was solely used as the precursor of difluorocarbene. Herein, an unprecedented visible-light-induced hydrodifluoromethylation of alkenes with bromodifluoromethylphosphonium bromide using H₂O and THF as hydrogen sources for the synthesis of difluoromethylated alkanes is described. This difluoromethylation is characterized by mild reaction conditions, ready availability of reagents, and excellent functional-group tolerance.

Angewandte Chemie, International Edition published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Formula: C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lin, Qing-Yu published the artcileVisible light-induced selective hydrobromodifluoromethylation of alkenes with dibromodifluoromethane, Application of Allyldiphenylphosphine oxide, the publication is Organic & Biomolecular Chemistry (2015), 13(32), 8740-8749, database is CAplus and MEDLINE.

A visible light-induced selective hydrobromodifluoromethylation of alkenes using CF₂Br₂ was developed. This transformation proceeded smoothly in the presence of catalytic Eosin Y at room temperature to give various hydrobromodifluoromethylated compounds with broad functional group tolerance.

Organic & Biomolecular Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Application of Allyldiphenylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia