Tag: M.W=200-250

Schulz, Michael D. published the artcileCopper(I) halides inhibit olefin isomerized by-products from phosphine-based Grubbs’ metathesis catalysts in polar protic solvents, Synthetic Route of 4141-48-4, the publication is Transition Metal Chemistry (Dordrecht, Netherlands) (2014), 39(7), 763-767, database is CAplus.

Copper(I) halides were employed as ‘phosphine sponges’ to sequester phosphor-ylides when using phosphine-based Grubb’s metathesis catalysis in polar protic solvents and under heat. These cuprous halides were hypothesized to significantly slow the formation of the ruthenium hydride olefin isomerization catalyst. Their use was demonstrated in both cross metathesis and ring-closing metathesis.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C38H24F4O4P2, Synthetic Route of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rakowitz, Dietmar published the artcileSynthesis and aldose reductase inhibitory activities of novel O-substituted hydroxyphenylacetic acid derivatives, Quality Control of 1860-58-8, the publication is Archiv der Pharmazie (Weinheim, Germany) (2006), 339(10), 547-558, database is CAplus and MEDLINE.

In continuation of our work aimed towards the preparation of novel aldose reductase inhibitors, several O-substituted hydroxyphenylacetic acid derivatives were investigated. The highest inhibitory activity was found for compounds 7b (3-(cyclohexylmethoxy)benzeneacetic acid) and 7c (4-(cyclohexylmethoxy)benzeneacetic acid). This result demonstrates that within these series, this moiety is a useful surrogate for the 4-bromo-2-fluorobenzyl residue which can be often found in potent aldose reductase inhibitors.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shaimol, T. published the artcileWilson disease-an overview, COA of Formula: C6H20Cl2N4, the publication is World Journal of Pharmaceutical Research (2017), 6(1), 154-175, database is CAplus.

A review. Wilson disease is a rare inherited disorder that prevents the body from getting rid of extra copper. Our body needs a small amount of copper from food to stay healthy. Too much copper is poisonous. The condition is due to mutations in the Wilson disease protein (ATP7B) gene. Normally liver releases extra copper into bile. With Wilson disease, the copper builds up in liver and it releases the copper directly into bloodstream. This can cause damage to brain, kidneys and eyes. Wilson disease is present at birth, but symptoms usually start between ages 5 and 35. It first attacks the liver, the central nervous system or both. The most characteristic sign is a rusty brown ring around the cornea of the eye. A phys. exam and laboratory tests can diagnose it. Treatment is with drugs to remove the extra copper from body. It needs to take medicine and follow a low-copper diet for the rest of life. WD is treated with medication that reduces copper absorption or removes the excess copper from the body, but occasionally a liver transplant is required. A single abnormal copy of the gene is present in 1 in 100 people, who do not develop any symptoms (they are carriers). If a child inherits the gene from both parents, the child may develop Wilson’s disease. Wilson’s disease occurs in 1 to 4 per 100,000 people.

World Journal of Pharmaceutical Research published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C7H8BNO5, COA of Formula: C6H20Cl2N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rao, K. Hanumantha published the artcileFlotation of mica minerals and selectivity between muscovite and biotite while using mixed anionic/cationic collectors, Quality Control of 2016-56-0, the publication is Transactions of Society for Mining, Metallurgy, and Exploration, Inc. (1991), 127-32, database is CAplus.

Selective flotation of muscovite from a material containing muscovite (15.4%), biotite (13%), and siliceous gangue (quartz and feldspar), using a mixed collector system of Na oleate and dodecylamine acetate, is described. Muscovite floats in preference to biotite when the pulp is initially conditioned with oleate followed by amine at basic pH values. The results indicate that a product containing 63% muscovite with a recovery of 93% can be obtained while using 75-150 g oleate and 96 g amine per ton. The biotite grade and recovery are �0 and 20%, resp. A good selectivity between muscovite and siliceous gangue is obtained. A final product containing 95% muscovite with an overall recovery of 75% is obtained when the flotation concentrate is subjected to magnetic separation Thus, muscovite can be separated from biotite by using a mixture of collectors.

Transactions of Society for Mining, Metallurgy, and Exploration, Inc. published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Quality Control of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rao, K. Hanumantha published the artcileFlotation of mica minerals and selectivity between muscovite and biotite while using mixed anionic/cationic collectors, Computed Properties of 2016-56-0, the publication is Minerals & Metallurgical Processing (1990), 7(3), 127-32, database is CAplus.

Selective flotation of muscovite from a material containing muscovite 15.4, biotite 13%, and quartz and feldspar gangue by using a mixed collector system of Na oleate and dodecylamine acetate is described. Muscovite floats in preference to biotite, when the pulp is initially conditioned with oleate followed by amine at basic pH values. A product containing 63% muscovite with a recovery of 93% was obtained, while using 75-150 oleate and 96 g/ton amine. The biotite grade and recovery are �0 and 20%, resp. High selectivity between muscovite and siliceous gangue is obtained. A final product containing 95% muscovite with an overall recovery of 75% is obtained when the flotation concentrate is subjected to magnetic separation The possibility of separating muscovite from biotite by using a mixture of collectors is discussed.

Minerals & Metallurgical Processing published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Computed Properties of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Luo, Na published the artcileπ-Face Promoted Catalysis in Water: From Electron-deficient Molecular Cages to Single Aromatic Slides, COA of Formula: C16H20N2, the publication is Chemistry – An Asian Journal (2021), 16(22), 3599-3603, database is CAplus and MEDLINE.

Exploiting noncovalent π-interactions particularly emerging anion-π interactions to drive efficient catalysis is fascinating. Even with exciting progresses, can anion-π activation operate in water remains elusive. Herein, design, synthesis and catalytic studies of a class of water-soluble electron-deficient mol. cages and relevant aromatic slide compounds is reported. The prism-like cages contain three divided, long, cationic aromatic walls which constitute three highly electron-deficient V-shape cavities. They were efficiently synthesized in two steps from a parent triformyl cage in gram-scale. Crystal structure showed the π-walls bind to the counter bromide through strong anion-π interactions. Just 5 mol% of cages were effective in catalyzing decarboxylative Aldol reactions of aldehydes and malonic acid half thioesters in water but not in organic solvents, showing a pronounced hydrophobic amplification effect. Meantime, a series of single π-slides resembling the π-wall of the cage performed equally well, while those lacking an extended π-surface were ineffective, highlighting the essential role of electron-deficient π-face on promoting the conversion.

Chemistry – An Asian Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bardin, V. V. published the artcileReactions of (triethylgermyl)pentafluorobenzene and perfluorotetraphenylgermane with nucleophiles, COA of Formula: C9H9F5Si, the publication is Zhurnal Obshchei Khimii (1990), 60(8), 1820-6, database is CAplus.

Oxygen- or nitrogen-containing nucleophiles attack the Ge atom in Et₃GeC₆F₅, while sulfur-, carbon-, and hydrogen-containing nucleophiles attack the C-4 atom of the C₆F₅ group. (C₆F₅)₄Ge undergoes C_aryl-Ge bond cleavage in reactions with O– and S-nucleophiles, while reactions with C-nucleophiles give complex mixtures of products from cleavage and defluorination. Piperidine reacts with (C₆F₅)₄Ge by substitution of an F atom, apparently due to steric screening of Ge.

Zhurnal Obshchei Khimii published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, COA of Formula: C9H9F5Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bardin, V. V. published the artcilePolyfluorophenylation of halosilanes, -germanes and -stannanes, Quality Control of 1206-46-8, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1989), 2153-4, database is CAplus.

Reaction of R₃MX (R = Me, Et; M = Si, Ge, Sn; X = Cl, Br) with 4-R¹C₆F₄Br (R¹ = F, PrO, CF₃) in pentane containing P(NEt₂)₃ gave 4-R¹C₆F₄MR₃. Thus, reaction of C₆F₅Br with Me₃MCl (M = Si, Ge, Sn) gave 50-66% C₆F₅MMe₃.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Quality Control of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takahashi, Eiki published the artcileThe discovery of potent glycine transporter type-2 inhibitors: Design and synthesis of phenoxymethylbenzamide derivatives, HPLC of Formula: 31719-76-3, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(18), 4603-4606, database is CAplus and MEDLINE.

The authors describe the discovery of phenoxymethylbenzamide derivatives as a novel class of glycine transporter type-2 (GlyT-2) inhibitors. The authors found a hit compound (human GlyT-2, IC₅₀ = 4040 nM) in their library and converted its 1-[[(2-naphthalenyl)methyl]-4-piperidinyl]-3-pyrrolidine group to an 1-(N,N-dimethylaminopropyl)piperidine group and its tert-Bu group to a trifluoromethyl group to obtain N-[1-[3-(dimethylamino)propyl]-4-piperidinyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide. This compound showed good inhibitory activity against human GlyT-2 (IC₅₀ = 15.3 nM) and exhibited antiallodynia effects in a mouse neuropathic pain model. The title compounds thus formed included N-(1′-methyl[1,4′-bipiperidin]-4-yl)-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide, N-[1-[3-(dimethylamino)propyl]-4-piperidinyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide. The synthesis of the target compounds was achieved by a reaction of 4-(phenoxymethyl)benzoic acid derivatives with amines, such as 1-[1-(phenylmethyl)-4-piperidinyl]-3-pyrrolidinamine, 1′-methyl-[1,4′-bipiperidin]-4-amine, 4-amino-N,N-dimethyl-1-piperidinepropanamine, 4-amino-1-piperidineethanol and similar compounds

Bioorganic & Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H31NO2, HPLC of Formula: 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ohki, Yasuhiro published the artcileSynthesis and Characterization of Bioinspired [Mo₂Fe₂]-Hydride Cluster Complexes and Their Application in the Catalytic Silylation of N₂, Product Details of C15H24S, the publication is Chemistry – A European Journal (2017), 23(53), 13240-13248, database is CAplus and MEDLINE.

The hydride-supported [Mo₂Fe₂] cluster complex {Cp*Mo(PMe₃)}₂{FeN(SiMe₃)₂}₂(H)₈ (2a; Cp*=η⁵-C₅Me₅) and its [Mo₂Mn₂] congener 2b were synthesized from the reactions of Cp*Mo(PMe₃)(H)₅ (1) with M{N(SiMe₃)₂}₂ (M=Fe, Mn). The amide-to-thiolate ligand-exchange reactions of complex 2a with bulky thiol reagents (HSR; R=2,4,6-iPr₃C₆H₂ (Tip), 2,6-(SiMe₃)₂C₆H₃ (Btp)) furnished the corresponding hydride-supported [Mo₂Fe₂](SR)₂ cluster complexes. The [Mo₂Fe₂] clusters served as catalyst precursors for the reductive silylation of N₂ and yielded â‰?5-69 equiv of N(SiMe₃)₃ relative to the [Mo₂Fe₂] clusters. Treatment of complexes 2a and b with an excess of CNtBu resulted in the formation of dinuclear Mo-Fe and Mo-Mn complexes, which indicated that the [Mo₂M₂] cores (M=Fe, Mn) split into two dinuclear species upon accommodation of substrates.

Chemistry – A European Journal published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Product Details of C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia