Tag: M.W=200-250

Rocha, Ana Fatima Braga published the artcileTreatment administered to newborns with congenital syphilis during a penicillin shortage in 2015, Fortaleza, Brazil, Computed Properties of 140-28-3, the publication is BMC Pediatrics (2021), 21(1), 166, database is CAplus and MEDLINE.

Between 2014 and 2016, Brazil experienced a severe shortage in penicillin supply, resulting in a lack of treatment among some pregnant women and newborns with syphilis and the use of non-evidence-based regimens. This study evaluated all live births in Fortaleza reported with CS in 2015 in order to identify the different therapeutic regimens used in newborns during this period of penicillin shortage. A retrospective cross-sectional study design was conducted using manually extracted data from medical chart review of maternal and infant cases delivered in 2015 from all public maternity hospitals in the city of Fortaleza. Data collection occurred from June 2017 to July 2018. A total of 575 congenital syphilis cases were reported to the municipality of Fortaleza during 2015 and 469 (81.5%) were analyzed. Of these, only 210 (44.8%) were treated with a nationally-recommended treatment. As alternative therapeutic options, ceftriaxone was used in 65 (13.8%), Cefazolin in 15 (3.2%) and the combination of more than one drug in 179 (38.2%). Newborns with serum VDRL titers �:16 (p = 0.021), who had some clin. manifestation at birth (p = 0.003), who were born premature (p < 0.001), with low birth weight (p = 0.010), with jaundice indicative of the need for phototherapy (p = 0.019) and with hepatomegaly (p = 0.045) were more likely to be treated with penicillin according to national treatment guidelines compared to newborns treated with other regimens. During the period of shortage of penicillin in Fortaleza, less than half of the infants reported with CS were treated with a nationally-recommended regimen, the remaining received treatment with medications available in the hospital of birth including drugs that are not part of nationally or internationally-recommended treatment recommendations.

BMC Pediatrics published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Computed Properties of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gonzalez-Perez, Jose A. published the artcileMolecular features of organic matter in diagnostic horizons from andosols as seen by analytical pyrolysis, Application of 2,4,6-Trimethoxybenzenethiol, the publication is Journal of Analytical and Applied Pyrolysis (2007), 80(2), 369-382, database is CAplus.

Andosols are usually formed from volcanic substrates, with thick A horizons high in organic carbon mainly in the form of stabilized humic fractions. The peculiar properties of these soils are, to large extent, affected by poorly crystalline materials like allophanes, imogolite and other Fe and Al oxyhydroxides that induce intense organo-mineral interactions which are considered to play a relevant role in OM protection against biodegradation as regards other soils developed under similar climatic conditions. Little is known about the mol. composition of this stabilized OM in a soil scenario often considered as an efficient C-sink in terms of C sequestration processes. Whole soil samples in addition to isolated humic and fulvic acids from organic A horizons of three soils with andic properties and one non-andic soil (Sodic Cambisol) from the island of Tenerife (Canary Islands, Spain) were analyzed by double shot pyrolysis-gas chromatog.-mass spectrometry (Py-GC/MS) in order to get some insight on the mol. composition of different structural domains of progressive structural stability. Clear differences were found between soils, both in thermal desorption and pyrolysis behavior of humic substances. In general the results suggest large yields of aliphatic (both alkyl and carbohydrate-derived pyrolysis compounds) pointing to high-performance processes of incorporation of aliphatic humic constituents in andosols probably favored by interactions with amorphous minerals, whereas in non-andic soils the latter are comparatively less stabilized and are removed in early pyrolysis stages as if they occurred as loosely joined, thermoevaporation-released products. In fact, compared to Cambisol, humic and fulvic acids from andic soils led to comparatively richer pyrograms and compound assemblages. The lack of similar amounts of these loosely joined, mainly aliphatic structures after thermal desorption of the whole andic soils indicate an origin for humic substances based on rapid sequestration of C-forms of recent (litter or microbial) origin.

Journal of Analytical and Applied Pyrolysis published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Application of 2,4,6-Trimethoxybenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levens, Alison published the artcileEnantioselective (4+2) Annulation of Donor-Acceptor Cyclobutanes by N-Heterocyclic Carbene Catalysis, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Angewandte Chemie, International Edition (2016), 55(52), 16136-16140, database is CAplus and MEDLINE.

Herein we report the enantioselective (4+2) annulation of donor-acceptor cyclobutanes and unsaturated acyl fluorides using N-heterocyclic carbene catalysis. The reaction allows a 3-step synthesis of cyclohexyl β-lactones (25 examples) in excellent chem. yield (most â‰?0 %) and stereochem. integrity (all >20:1 d.r., most â‰?7:3 e.r.). Mechanistic studies support ester enolate Claisen rearrangement, while derivatizations provide functionalized cyclohexenes and dihydroquinolinones.

Angewandte Chemie, International Edition published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Tianguo published the artcileMineralogical and iron recovery from CCS flotation tails by physico-interfacial separation: separation of magnetite and iron silicates, Synthetic Route of 2016-56-0, the publication is Oxidation Communications (2016), 39(1), 25-40, database is CAplus.

Copper converter slag (CCS) discharge causes significant environmental problems. In this work, on the basis of a study of mineralogical characteristics, the recovery of iron from CCS flotation tails using a combined process of magnetic separation and reverse flotation was investigated. The study revealed that CCS flotation tails are primarily composed of magnetite (21.49%) and iron silicates (72.52%). The iron content of CCS flotation tails is as high as 49.60%, while only 30.31% of the iron distributed in the magnetite and ferroalloy shows significant magnetic properties. Zeta-potential studies of magnetite, quartz and fayalite samples have shown that amines are well adsorbed, both on the surfaces of the magnetite and also on the surfaces of the iron silicates, within a pH range of 5-10. The iron content of CCS flotation tails can be effectively upgraded to 59.61% using magnetic separation Amines with different mol. structures performed different selectivity for iron silicates when reverse flotation was used to remove iron silicates from the magnetic concentrate The use of mixtures of cationic and anionic collectors provided a formation of a stable hydrophobic adsorption layer on the surface of the iron silicates and magnetite-silicate aggregates; this improved the flotation of these mineral particles, even in the presence of a starch, which acted as a depressant of Fe oxides. The scheme of combining magnetic separation and reverse flotation is a promising method to use to (a) recover iron and (b) produce iron concentrates with Si02 content of 6.59% and Fe content of up to 63.35% from CCS flotation tails with Si02 content as high as 36.40%.

Oxidation Communications published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Synthetic Route of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sekar, K. G. published the artcileKinetics of oxidation of phenoxyacetic acids by nicotinium dichromate, Synthetic Route of 1798-04-5, the publication is Oxidation Communications (2011), 34(2), 314-319, database is CAplus.

The kinetics of oxidation of phenoxyacetic acid and several para- and meta-substituted phenoxyacetic acids by nicotinium dichromate (NDC) in the presence of perchloric acid was studied in 60% (volume/volume) aqueous acetic acid. The reaction shows unit order dependence each with respect to oxidant and substrate. The order with respect to hydrogen ion concentration is two. The rate of oxidation increases with increase in the percentage of acetic acid and increase in ionic strength has negligible effect on the rate. The reaction does not induce the polymerization of acrylonitrile. The addition of Mn²⁺ ion had a noticeable catalytic effect on the reaction rate. In general, electron-releasing substituents accelerate the rate while electron attracting substituents retard the rate and the rate data obey the Hammett relation.

Oxidation Communications published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C15H21BO2, Synthetic Route of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takayama, Toshio published the artcileSilicon-29 NMR chemical shifts of organosilicons as studied by the finite-perturbation theory CNDO/2 method, COA of Formula: C12H10F2Si, the publication is Bulletin of the Chemical Society of Japan (1987), 60(9), 3125-9, database is CAplus.

The ²⁹Si chem. shifts of silicon hydrides and fluorosilanes were calculated by means of the finite-perturbation theory method within the CNDO/2 framework. By a small revision of the formula for the off-diagonal elements of the core Hamiltonian matrix in the CNDO/2 method, the calculated results agree well with the gross trend of the exptl. values of the ²⁹Si chem. shifts in the literature. The relationship between the ²⁹Si chem. shift and the electronic structure was discussed.

Bulletin of the Chemical Society of Japan published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C14H10N2O, COA of Formula: C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

De Simone, Filippo published the artcileCatalytic formal homo-Nazarov cyclization, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Organic Letters (2009), 11(4), 1023-1026, database is CAplus and MEDLINE.

The first catalytic method for the cyclization of vinyl-cyclopropyl ketones (formal homo-Nazarov reaction) is reported. Starting from activated cyclopropanes, heterocyclic, and carbocyclic compounds were obtained under mild conditions using Bronsted acid catalysts. Preliminary investigation of the reaction mechanism indicated a stepwise process.

Organic Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Swain, Baijayantimala published the artcileNew coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation, COA of Formula: C11H12O4, the publication is Bioorganic & Medicinal Chemistry (2020), 28(15), 115586, database is CAplus and MEDLINE.

Two novel series of phenylacrylamide linked coumarins I [R = H, Me; Ar = Ph, 4-FC₆H₄, 4-MeOC₆H₄, etc.] and sulfocoumarins II [Ar¹ = 4-FC₆H₄, 3-F₃CC₆H₄, 4-NCC₆H₄, etc.] were synthesized and evaluated against four physiol. relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, hCA II, hCA IX and hCA XII for their inhibitory action. Compounds I and II when screened for carbonic anhydrase inhibitory activity, they showned selective inhibition toward the tumor associated isoforms hCA IX and XII over CA I and II, with inhibition constants in the submicromolar to low nanomolar range. Compound I [R = H; Ar = 4-FC₆H₄] and II [Ar¹ = 4-NCC₆H₄] exhibited significant inhibition with low nanomolar potency against hCA IX, whereas I [R = H; Ar = 3,4-(OMe)₂C₆H₃] was effective against hCA XII. Compounds I [R = H; Ar = 4-FC₆H₄, 3,4-(OMe)₂C₆H₃] and II [Ar¹ = 4-NCC₆H₄] might be considered as lead mols. for future development of cancer therapeutics based on a novel mechanism of action.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C18H14BrNO3, COA of Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Voronkov, M. G. published the artcileReaction of phenyltrifluorosilane and phenyl(hydrocarbyl)difluorosilanes with bis(2-hydroxyethyl)-and tris(2-hydroxyethyl)amine and their N-methyl and O-trimethylsilyl derivatives. A novel route to quasisilatranes, Application In Synthesis of 312-40-3, the publication is Russian Journal of General Chemistry (2006), 76(12), 1854-1859, database is CAplus.

Reaction of phenyltrifluorosilane, diphenyldifluorosilane, and methylphenyldifluorosilane with bis(2-hydroxyethyl)amine, Me-bis(2-hydroxyethyl)amine, Me-bis(2-trimethylsiloxyethyl)amine, leads to 1,3-dioxa-6-aza-2-silacyclooctane derivatives, (N→Si) quasisilatranes: 1,1-difluoroquasisilatrane, 1-phenyl-1-fluoro-5-methylquasisilatrane, or 1-methyl-1-fluoroquasisilatrane, containing the donor-acceptor bond N→Si and pentacoordinate Si atom. 1-Phenylsilatrane is the product of the reaction of phenyltrifluorosilane with tris(2-trimethylsiloxyethyl)amine, whereas with tris(2-hydroxyethyl)amine 1-phenylsilatrane and 1-fluorosilatrane were formed in the molar ratio of 3:1. The structure of the synthesized compounds was proved by ¹H, ¹³C, ¹⁵N, ¹⁹F, ²⁹Si NMR and IR spectroscopy.

Russian Journal of General Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C20H19NO4, Application In Synthesis of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Postma, Tobias M. published the artcileN-Chlorosuccinimide, an Efficient Reagent for On-Resin Disulfide Formation in Solid-Phase Peptide Synthesis, Category: catalysis-chemistry, the publication is Organic Letters (2013), 15(3), 616-619, database is CAplus and MEDLINE.

N-Chlorosuccinimide is described as a widely applicable on-resin disulfide-forming reagent. Disulfide bond formation was completed within 15 min in DMF. This strategy was successfully used in the synthesis of oxytocin and a regioselective synthesis of an α-conotoxin. Moreover, disulfide formation with N-chlorosuccinimide was found to be compatible with oxidation-prone methionine and tryptophan.

Organic Letters published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia