Tag: M.W=200-250

Farooq, Omar published the artcileAlkali metal salts of perfluorinated complex anions. Effective reagents for nucleophilic fluorination, SDS of cas: 312-40-3, the publication is Journal of Organic Chemistry (1994), 59(8), 2122-4, database is CAplus.

Alkali metal salts of perfluorinated complex anions, e.g., NaPF₆, were used to effect halogen-exchange fluorination in organohalosilanes, e.g., Ph₃SiCl, both in the presence and absence of solvent. Using salts of perfluorinated nonnucleophilic anions in a high-boiling multifunctional etheral solvent, organofluorosilanes, e.g., Ph₃SiF, were conveniently prepared in high yields.

Journal of Organic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, SDS of cas: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Calimano, Elisa published the artcileSynthesis and Structure of PNP-Supported Iridium Silyl and Silylene Complexes: Catalytic Hydrosilation of Alkenes, Related Products of catalysis-chemistry, the publication is Journal of the American Chemical Society (2009), 131(31), 11161-11173, database is CAplus and MEDLINE.

Oxidative addition of bulky primary, secondary, and tertiary silanes to PNP (PNP = [N(2-PⁱPr₂-4-Me-C₆H₃)₂]^–) iridium complexes (PNP)IrH₂ and (PNP)Ir(COE) (11) afforded iridium silyl hydride complexes (PNP)Ir(H)(SiRR’R”) (3–8). Addition of 2 equivalent of PhSiH₃ or (3,5-Me₂C₆H₃)SiH₃ to (PNP)IrH₂ or 11 yielded disilyl complexes (PNP)Ir(SiH₂R)₂ (R = Ph (9), 3,5-Me₂C₆H₃ (10)). Hydride abstraction from (PNP)Ir(H)(SiH₂R) (R = Trip (5), Dmp (6)) by [Ph₃C][B(C₆F₅)₄] afforded iridium silylene complexes [(PNP)(H)Ir:SiR(H)][B(C₆F₅)₄] (R = Trip (12), Dmp (13)) exhibiting downfield ²⁹Si NMR resonances (234 ppm (12), 226 ppm (13)) and downfield ¹H NMR resonances for the Si-H group (10.76 ppm (12), 9.76 ppm (13)). Thermally stable disubstituted silylene complexes [(PNP)(H)Ir:SiPh₂][A] (A = ^–B(C₆F₅)₄ (14), ^–CB₁₁H₆Br₆ (16)) were isolated via hydride abstraction from (PNP)Ir(H)(SiHPh₂). The x-ray structure of 16 confirmed sp² hybridization at silicon and revealed a short Ir-Si bond of 2.210(2) ?. Catalytic hydrosilation of alkenes by hydrogen-substituted silylene complexes [(PNP)(H)Ir:SiMes(H)][B(C₆F₅)₄] (1) and 14 exhibited anti-Markovnikov regioselectivity with an array of alkene substrates. Addition of H₃SiMes to complex 1 afforded [(PNP)(SiH(Mes)(Hex))IrH(SiH₂Mes)][B(C₆F₅)₄] (19), featuring a ¦Â-agostic interaction demonstrated by a J_SiH of 102 Hz for the N-SiH hydrogen. Similarly, addition of H₂SiPh₂ to 16 afforded the structurally characterized Ir(V) disilyl complex [(PNP)(SiPh₂)Ir(SiPh₂H)(H)₂][CB₁₁H₆Br₆] (20). Complex 20 was catalytically active for the hydrosilation of alkenes, which is consistent with its intermediacy in the catalytic cycle.

Journal of the American Chemical Society published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pietrasiak, Ewa published the artcileSynthesis and characterization of fluorinated hypervalent tellurium derivatives, Category: catalysis-chemistry, the publication is Organometallics (2017), 36(19), 3750-3757, database is CAplus.

Aryl telluroethers o-substituted with acetal, aldehyde, ketone, carboxylate or aldimine donor atom functions were prepared and examined for hypervalent Te-heteroatom binding by x-ray crystallog. and tellurium-125 NMR spectra. The synthesis of tellurium derivatives bearing fluorinated groups, similar in structure to their hypervalent iodine congeners, is reported. Thus, a series of CF₃, CF₂H, and C₆F₅ aryltellurium(II) species bearing various functional groups interacting with the Te atom was obtained. The installation of the various fluorinated groups relies on the use of the corresponding trimethylsilyl precursors. The hypervalent nature of the products is discussed on the basis of their NMR spectroscopic and X-ray crystallog. characterization.

Organometallics published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kong, Xianqiang published the artcileElectrochemical Oxidative C(sp³)-H/N-H Coupling of Diarylmethanes with Sulfoximines or Benzophenone Imine, Name: Bis(4-fluorophenyl)methane, the publication is Journal of Organic Chemistry (2021), 86(19), 13610-13617, database is CAplus and MEDLINE.

An efficient electrochem. method for the synthesis of N-alkylated sulfoximines I [R = Ph, 2-BrC₆H₄, 4-MeOC₆H₄, etc.; R¹ = Me, Et, n-Bu, Ph, 4-MeC₆H₄; Ar¹ = Ph, 4-FC₆H₄, 4-ClC₆H₄; Ar² = Ph, 4-FC₆H₄] by electrochem. oxidative C(sp³)-H/N-H coupling of sulfoximines and diarylmethanes was developed. In addition, used the same conditions for electrochem. dehydrogenative amination of diarylmethanes with benzophenone imine as an aminating agent to obtain II [Ar³ = Ph, 4-MeC₆H₄, 4-FC₆H₄; Ar⁴ = Ph, 4-MeC₆H₄, 4-FC₆H₄, 4-ClC₆H₄]. The reactions showed good functional group tolerance and afforded the corresponding products in moderate to good yields without the use of a stoichiometric oxidant, a metal catalyst, or an activating agent.

Journal of Organic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Name: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pudovik, M. A. published the artcile2-(2-Hydroxyphenyl)imidazolidines and their O-phosphorylated derivatives, Name: N1,N2-Dibenzylethane-1,2-diamine, the publication is Russian Journal of General Chemistry (2017), 87(1), 60-65, database is CAplus.

2-(2-Hydroxyaryl)imidazolidines were synthesized by reaction of aromatic carbonyl compounds with N,N’-dialkylethylenediamines. The title compounds were also prepared using the corresponding Schiff bases instead of carbonyl compounds Phosphorylation of 2-(2-hydroxyphenyl)imidazolidines with phosphoryl and phosphorothioyl chlorides and phosphorochloridites was accomplished. The reaction of O-phosphorylsalicylaldehyde with N,N’-dialkylethylenediamines also afforded 2-(2-hydroxyphenyl)imidazolidines.

Russian Journal of General Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Name: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Frohn, Hermann-Josef published the artcileC₆F₅XeF, a versatile starting material in xenon-carbon chemistry, Synthetic Route of 1206-46-8, the publication is Journal of Fluorine Chemistry (2004), 125(6), 981-988, database is CAplus.

Arylxenon fluorides undergo substitution reactions to give sym. and asym. diarylxenons. The mols. Ar^FXeF (Ar^F = C₆F₅, 2,4,6-C₆H₂F₃) with a more polar Xe-F bond than XeF₂ are versatile starting materials for substitution reactions. Reaction of C₆F₅XeF (1) with Ar^F₂Cd gave C₆F₅XeAr^F (2, 4), which, in case of Ar^F = 2,4,6-C₆H₂F₃, upon symmetrization gave (2,4,6-C₆H₂F₃)₂Xe (5), the same result was obtained by reaction of 1 with C₆F₅SiF₃. Applying C₆F₅BF₂, with a higher F^–-affinity than the corresponding aryltrifluorosilane, in contrast gave the salt [C₆F₅Xe][Ar^FBF₃]. Using the alkenyl and alkyl compounds CF₂:CFSiMe₃/[F]^–, CF₃SiMe₃/[F]^–, and Cd(CF₃)₂ in reactions with C₆F₅XeF, the perfluoroalkenyl or -alkyl transfer reagents were consumed without formation of corresponding xenon derivatives The formation of Xe(C₆F₅)₂ in these reactions suggests the symmetrization of the corresponding vinylxenon intermediate; the unstable aryl-trifluoromethyl xenon afforded octafluorotoluene as coupling product.

Journal of Fluorine Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Synthetic Route of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Weiss, Karl Heinz published the artcileComparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is European Journal of Drug Metabolism and Pharmacokinetics (2021), 46(5), 665-675, database is CAplus and MEDLINE.

Wilson disease (WD) is an autosomal recessive inherited disorder of copper metabolism Chelation of excessive copper is recommended but data on the pharmacokinetics of trientine are limited. The aim of this study was to compare the pharmacokinetics of a new trientine tetrahydrochloride formulation (TETA 4HCl) with those of an established trientine dihydrochloride (TETA 2HCl) salt. A randomised single-center crossover study to evaluate the pharmacokinetics, safety and tolerability of two different oral formulations of trientine (TETA 4HCl tablets vs TETA 2HCl capsules) in 23 healthy adult subjects receiving a single dose equivalent to 600 mg of trientine base was performed. Following oral administration, the median time to reach maximum plasma concentration (T_max) was 2.00 h (TETA 4HCl) and 3.00 h (TETA 2HCl). The rate (maximum plasma concentration [C_max]) and extent (area under the plasma concentration-time curve from time zero to infinity [AUC_0-¡Þ]) of absorption of the active moiety, trientine, were greater (by approx. 68% and 56%, resp.) for TETA 4HCl than for the TETA 2HCl formulation. The two formulations presented a similar terminal elimination rate (¦Ë_z) and a similar terminal half-life (t_1/2) for trientine. Differences between TETA 4HCl and TETA 2HCl in the levels of the two main mono- and diacetylated metabolites were less than seen for trientine. For both tested formulations, healthy male volunteers demonstrated higher trientine plasma levels but lower mono- and diacetylated metabolite levels compared with females, with no sex differences in terminal half-life (t_1/2) observed Single oral doses of both formulations were safe and well tolerated. Compared with an identical dose of a TETA 2HCl formulation, the TETA 4HCl formulation provided more rapid absorption of trientine and greater systemic exposure in healthy subjects.

European Journal of Drug Metabolism and Pharmacokinetics published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C8H6ClNO, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cheekatla, Subba Rao published the artcileAza-Oxa-Triazole Based Macrocycles with Tunable Properties: Design, Synthesis, and Bioactivity, Application of N1,N2-Dibenzylethane-1,2-diamine, the publication is Molecules (2022), 27(11), 3409, database is CAplus and MEDLINE.

A modular platform for the synthesis of tunable aza-oxa-based macrocycles was established. Modulations in the backbone and the side-chain functional groups have been rendered to achieve the tunable property. These aza-oxa-based macrocycles can also differ in the number of heteroatoms in the backbone and the ring size of the macrocycles. For the proof of concept, a library of macrocycles was synthesized with various hanging functional groups, different combinations of heteroatoms, and ring sizes in the range of 17-27 atoms and was characterized by NMR and mass spectrometry. In light of the importance of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and the significance of triazole groups for various applications, we employed the click-reaction-based macrocyclization. The competence of the synthesized macrocycles in various biomedical applications was proven by studying the interactions with the serum albumin proteins; bovine serum albumin and human serum albumin. It was observed that some candidates, based on their hanging functional groups and specific backbone atoms, could interact well with the protein, thus improving the bioactive properties. On the whole, this work is a proof-of-concept to explore the backbone- and side-chain-tunable macrocycle for different properties and applications.

Molecules published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ohki, Yasuhiro published the artcileFormation of a Nitrogenase P-cluster [Fe₈S₇] Core via Reductive Fusion of Two All-Ferric [Fe₄S₄] Clusters, Recommanded Product: 2,4,6-Triisopropylbenzenethiol, the publication is Chemistry – An Asian Journal (2012), 7(10), 2222-2224, S2222/1-S2222/9, database is CAplus and MEDLINE.

The nitrogenase P-cluster [Fe₈S₇] core can be formed from the reductive fusion of all-ferric [Fe₄S₄] clusters via phosphine desulfurization. The mol. structures of the two [Fe₈S₇] clusters were determined

Chemistry – An Asian Journal published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Recommanded Product: 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Athavan, Gayathri published the artcileDirect Evidence for Competitive C-H Activation by a Well-Defined Silver XPhos Complex in Palladium-Catalyzed C-H Functionalization, Application In Synthesis of 1206-46-8, the publication is Organometallics, database is CAplus.

Increasing evidence indicates that Ag salts can play a role in the C-H activation step of Pd-catalyzed C-H functionalization. Here the authors isolate a Ag(I) complex by C-H bond activation and demonstrate its catalytic competence for C-H functionalization. Ag carbonate, a common but highly insoluble additive, reacts with pentafluorobenzene in the presence of a bulky phosphine, XPhos, to form the C-H bond activation product Ag(C₆F₅)(XPhos). By isolating and fully characterizing this complex and the related carbonate and iodide complexes, [Ag(XPhos)]₂(¦Ì-¦Ê²,¦Ê²-CO₃) and [AgI(XPhos)]₂, well-defined Ag(I) complexes can operate in conjunction with Pd complexes to achieve C-H functionalization even at ambient temperature Reactions are tested against the standard cross-coupling of C₆F₅H with 4-iodotoluene, catalyzed by Pd acetate at 60¡ã in the presence of Ag carbonate and Xphos. Key observations are that (a) PdIPh(XPhos) reacts stoichiometrically with Ag(C₆F₅)(XPhos) to form Ph-C₆F₅ instantly at room temperature; (b) catalytic cross coupling can be achieved using 5% Ag(C₆F₅)(XPhos) as the sole Ag source; and (c) Pd acetate (typical precatalyst) can be replaced for catalytic cross coupling by the expected oxidative addition compound PdIPh(XPhos). These studies lead to a catalytic cycle in which Ag(I) plays the C-H bond activation role and Pd plays the coupling role. Also, the phosphine can be exchanged between Ag complexes, ensuring that it is recycled even though Ag carbonate is consumed during catalytic cross-coupling.

Organometallics published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Application In Synthesis of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia