Tag: M.W=200-250

Zhun’, V. I. published the artcileReaction of Germanium Tetrachloride with Chloro(phenyl)silanes in the Presence of Aluminum Chloride, Recommanded Product: Difluorodiphenylsilane, the publication is Russian Journal of General Chemistry (2005), 75(6), 867-869, database is CAplus.

The effect of the quantity of AlCl₃ on the direction and depth of reaction of GeCl₄ with chloro(phenyl)silanes Ph_nSiCl_4-n (n = 1-3) was studied to show that radical exchange between Ge and Si is initiated only if the mixture contains ¡Ý2.5-5% of AlCl₃. With trichloro(phenyl)silane, the radical exchange is initiated at 5% of AlCl₃ and results in exclusive formation of trichloro(phenyl)germane. The reactions of GeCl₄ with dichlorodiphenylsilane and chlorotriphenylsilane in the presence = 2.5-7.5% of AlCl₃ give dichlorodiphenylgermane as the major product, and at AlCl₃ concentrations of >10% the major product becomes trichloro(phenyl)germane.

Russian Journal of General Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C23H20BN, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Focsaneanu, Kathy-Sarah published the artcilePotential analytical applications of differential fluorescence quenching: Pyrene monomer and excimer emissions as sensors for electron deficient molecules, Safety of 2,6-Diisopropyl-N,N-dimethylaniline, the publication is Photochemical & Photobiological Sciences (2005), 4(10), 817-821, database is CAplus and MEDLINE.

Quenching of the monomer and excimer emissions from pyrene allows excellent discrimination in the detection of electron-deficient mols.; this characteristic could be used to detect explosives and for rapid screening of complex samples suspected of containing explosives. The method responds to electron deficient mols. other than nitro compounds (e.g., 1,4-dicyanobenzene), giving some false positives; in this case, however, the method is unlikely to lead to false negatives, a desirable characteristic in security-related applications.

Photochemical & Photobiological Sciences published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Safety of 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Metz, Alexander published the artcileFrom Determinants of RUNX1/ETO Tetramerization to Small-Molecule Protein-Protein Interaction Inhibitors Targeting Acute Myeloid Leukemia, Related Products of catalysis-chemistry, the publication is Journal of Chemical Information and Modeling (2013), 53(9), 2197-2202, database is CAplus and MEDLINE.

We identified the first small-mol. protein-protein interaction inhibitors of RUNX1/ETO tetramerization applying structure-based virtual screening guided by predicted hot spots and pockets in the interface. A 3D similarity screening revealed specific hot spot mimetics, one of which prevents the proliferation of RUNX1/ETO-dependent SKNO-1 cells at low micromolar concentration Using solely a protein-protein complex structure to start with, this strategy can be the first step in any comparable structure-based endeavor to identify protein-protein interaction inhibitors.

Journal of Chemical Information and Modeling published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ergueden, Jens Kerim published the artcilePhosphoryl functionalized bishomoallyl alcohols by ring opening of epoxides with lithiated allyldiphenylphosphine oxide, Category: catalysis-chemistry, the publication is Synthesis (1996), 707-710, database is CAplus.

Epoxides are attacked by the lithiated anion of allyldiphenylphosphane oxide in 1,2-dimethoxyethane as solvent in a BF₃.OEt₂ promoted ring opening reaction to afford a mixture of regioisomeric bishomoallyl alcs. (¦Á- and ¦Ã-attack of the nucleophile) in good overall yields. When toluene is used as reaction medium a pronounced preference for ¦Ã-attack of the anion is observed Thus, BF₃.OEt₂ promoted reaction of CH₂:CHCH:P(OLi)Ph₂ with ethyloxirane in DMF gave Ph₂P(O)CH(CH:CH₂)CH₂CHMeOH (diastereomeric mixture) along with Ph₂P(O)CH:CHCH₂CH₂CHMeOH, whereas similar reaction with (tosyloxyethyl)oxirane in PhMe gave Ph₂P(O)CH:CHCH₂CH₂CH(CH₂CH₂OTs)OH.

Synthesis published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Herrmann, U. published the artcileAggregation of alkylammonium carboxylates and aerosol-OT in apolar solvents studied using absorption and fluorescence probes, Computed Properties of 2016-56-0, the publication is Journal of the American Chemical Society (1979), 101(10), 2665-9, database is CAplus.

By using optical probes, the aggregation of 16 alkylammonium (C₁₀ to C₁₄) carboxylates (C₂ to C₁₁) was studied in dry C₆H₆, C₆H₁₂, and CCl₄, and of as Aerosol-OT in C₆H₆. At the very low concentrations of the absorption (Acridine Orange and iodinee) and fluorescence probes used (octyl-, dodecyl-, and tetradecylammonium 8-anilino-1-naphthalenesulfonates), only the I probe has a significant effect on the aggregation of the surfactant. Critical micelle concentrations were determined by the Corrin-Harkins method, and in a few cases aggregation numbers and association constants were calculated by Adams’ method by using vapor pressure osmometric results. For the alkylamonium carboxylkates the onset of aggregation is gradual, leading to small aggregates (average aggregation number n? = 3) with the monomer population and n? dependent on the concentration In these systems the concept of critical micelle concentration is used only in a operational sense. For Aerosol-OT the onset of micelle formation is sharper, leading to larger aggregates (n? = 10) with the monomer pouplation and aggregation number independent of the concentration The effects of the solvent, the nature of the probe, and the length of the alkylammonium and counterion chains on the aggregation tendency are discussed.

Journal of the American Chemical Society published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Computed Properties of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bock, Harald published the artcileSynthesis, NMR spectroscopic characterization and reactions of 2,6-difluorophenylxenon fluoride, 2,6-F₂C₆H₃XeF, SDS of cas: 1206-46-8, the publication is Journal of Fluorine Chemistry (2006), 127(10), 1440-1445, database is CAplus.

[2,6-F₂C₆H₃Xe][BF₄] is quant. transferred into 2,6-F₂C₆H₃XeF in reactions with [NMe₄]F. The latter has been isolated as a colorless solid which is stable in dichloromethane solution at room temperature for approx. 1 h. 2,6-F₂C₆H₃XeF readily reacts with Me₃SiX (X = Cl, Br, CN, NCO, OCOCF₃, OSO₂CF₃, C₆F₅, 2,6-F₂C₆H₃) to give compounds of general compositions 2,6-F₂C₆H₃XeX which were identified by multinuclear NMR experiments Evidence was found for C₆H₅Xe(2,6-F₂C₆H₃) as a product of the reaction with C₆H₅SiF₃.

Journal of Fluorine Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, SDS of cas: 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Royer, Aaron M. published the artcileIron acyl thiolato carbonyls: structural models for the active site of the [Fe]-hydrogenase (Hmd), Product Details of C15H24S, the publication is Journal of the American Chemical Society (2010), 132(47), 16997-17003, database is CAplus and MEDLINE.

Phosphine-modified thioester derivatives are shown to serve as efficient precursors to phosphine-stabilized ferrous acyl thiolato carbonyls, which replicate key structural features of the active site of the hydrogenase Hmd. The reaction of Ph₂PC₆H₄C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph₂PC₆H₄CO)(CO)₃ (1) and the diferrous diacyl Fe₂(SPh)₂(CO)₃(Ph₂PC₆H₄CO)₂, which carbonylates to give 1. For the extremely bulky arylthioester Ph₂PC₆H₄C(O)SC₆H₃-2,6-(2,4,6-trimethylphenyl)₂, oxidative addition is arrested and the Fe(0) adduct of the phosphine is obtained. Complex 1 reacts with cyanide to give Et₄N[Fe(SPh)(Ph₂PC₆H₄CO)(CN)(CO)₂] (Et₄N[2]). NMR ¹³C and ³¹P NMR spectra indicate that substitution is stereospecific and cis to P. The IR spectrum of [2]^– in ¦Í_CN and ¦Í_CO regions very closely matches that for Hmd^CN. XANES and EXAFS measurements also indicate close structural and electronic similarity of Et₄N[2] to the active site of wild-type Hmd. Complex 1 also stereospecifically forms a derivative with TsCH₂NC, but the adduct is more labile than Et₄N[2]. Tricarbonyl 1 was found to reversibly protonate to give a thermally labile derivative, IR measurements of which indicate that the acyl and thiolate ligands are probably not protonated in Hmd.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Product Details of C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Golchoubian, Hamid published the artcileSolvato- and thermochromism study in oxalato-bridged dinuclear copper(II) complexes of bidentate diamine ligands, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Polyhedron (2017), 68-75, database is CAplus.

Two new oxalato complexes [Cu₂(L)₂(¦Ì-ox)(MeOH)₂](ClO₄)₂ (1) and [Cu₂(L)₂(¦Ì-ox)](NO₃)₂ (2), where ox = oxalato and L = N,N’-dibenzylethane-1,2-diamine, were prepared and characterized by elemental anal., IR and UV-visible spectroscopies and molar conductance measurements. The crystal structure of compound 1 was determined by single-crystal x-ray anal. The compounds are solvatochromic and their solvatochromism was studied with different solvent parameter models using the stepwise multiple linear regression (SMLR) method with SPSS/PC software. The donor power of the solvent plays the most important role in the observed pos. solvatochromism of the compounds The complexes show irreversible thermochromism in solution due to the substitution of the weakly coordinated counterions and coordinated solvents by solvent mols.

Polyhedron published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Neumann, William L. published the artcileSynthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer¡äs disease treatment, Name: 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is RSC Medicinal Chemistry (2021), 12(8), 1352-1365, database is CAplus and MEDLINE.

Somatostatin receptor-4 (SST₄) is highly expressed in brain regions affiliated with learning and memory. SST₄ agonist treatment may act to mitigate Alzheimer¡äs disease (AD) pathol. An integrated approach to SST₄ agonist lead optimization is presented herein. High affinity and selective agonists with biol. efficacy were identified through iterative cycles of a structure-based design strategy encompassing computational methods, chem., and preclin. pharmacol. 1,2,4-Triazole derivatives of our previously reported hit (4) showed enhanced SST₄ binding affinity, activity, and selectivity. Thirty-five compounds showed low nanomolar range SST₄ binding affinity, 12 having a K_i < 1 nM. These compounds showed >500-fold affinity for SST₄ as compared to SST_2A. SST₄ activities were consistent with the resp. SST₄ binding affinities (EC₅₀ < 10 nM for 34 compounds). Compound 208 (SST₄K_i = 0.7 nM; EC₅₀ = 2.5 nM; >600-fold selectivity over SST_2A) display a favorable physiochem. profile, and was advanced to learning and memory behavior evaluations in the senescence accelerated mouse-prone 8 model of AD-related cognitive decline. Chronic administration enhanced learning with i.p. dosing (1 mg kg^-1) compared to vehicle. Chronic administration enhanced memory with both i.p. (0.01, 0.1, 1 mg kg^-1) and oral (0.01, 10 mg kg^-1) dosing compared to vehicle. This study identified a novel series of SST₄ agonists with high affinity, selectivity, and biol. activity that may be useful in the treatment of AD.

RSC Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Name: 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sanchez-Carnerero, Esther M. published the artcileSpeeding up heterogeneous catalysis with an improved highly reusable catalyst for the preparation of enantioenriched secondary alcohols, COA of Formula: C16H20N2, the publication is Reactive & Functional Polymers (2017), 23-30, database is CAplus.

A new catalytic heterogeneous system, very efficient and highly reusable, for the preparation of enantioenriched secondary alcs. through the addition of diethylzinc to benzaldehyde has been developed. This system is based on a chiral bis(hydroxyamide) ligand supported on crosslinked polystyrene. The catalyst has been shown to be very efficient, leading to the corresponding secondary alc. with an enantiomeric excess of 93% in a time as short as 2 h and using just 4% of the heterogeneous catalyst and just 1.5 equiv of the organozinc reagent. We have demonstrated that the new catalyst is very stable and can be efficiently recycled with no decrease in yield or enantioselectivity. The presented system has an unquestionable interest for the potential transfer of the reaction to the industry by using catalytic fluidized-bed reactors.

Reactive & Functional Polymers published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia