Tag: M.W=200-250

Komarova, N. V. published the artcileKinetics of the polyesterification of phenylenedioxyacetic acids and glycerol, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1984), 27(2), 232-4, database is CAplus.

The polycondensation of phenylenebis(oxyacetic acids) (I) with glycerin??[56-81-5] in equimolar ratio at 140-190¡ã was a 3rd-order reaction described by an Arrhenian equation up to the gel point. The polycondensation rates for I were significantly higher than those for phthalic anhydride as the result of a neg. inductive effect by the oxyphenyl group in I. Of the I studied 1,3-phenylenebis(oxyacetic?acid) [102-39-6] was more reactive than 1,2-phenylenebis(oxyacetic?acid) [5411-14-3] or 5-methyl-1,3-phenylenebis(oxyacetic?acid) [87425-59-0].

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Santra, Soumava published the artcileStructural Exploration of (3S,6S)-6-Benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine Analogues: Identification of Potent Triple Monoamine Reuptake Inhibitors as Potential Antidepressants, Computed Properties of 457-68-1, the publication is ChemMedChem (2012), 7(12), 2093-2100, database is CAplus and MEDLINE.

To further explore the basic structural motifs (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine and (2S,4R,5R)-2-benzhydryl-5-(benzylamino)tetrahydro-2H-pyran-4-ol, developed by our research group, for monoamine transport inhibition, we designed and synthesized various structurally altered analogs. The new compounds were tested for their affinities for the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET) in rat brain by measuring their capacity to inhibit the uptake of [³H]DA, [³H]5-HT, and [³H]NE, resp. Our results point to novel compounds with a TUI, DNRI, SNRI, or SSRI profile. Among the TUIs, compound 2 g exhibited a balanced potency for all three monoamine transporters (K_i: 60, 79, and 70.3 nM for DAT, SERT, and NET, resp.). In the rat forced swim test, compound 2 g produced a significant decrease in immobility in drug-treated rats relative to vehicle, indicating a potential antidepressant property.

ChemMedChem published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Computed Properties of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Boger, Dale L. published the artcileHigher order iminodiacetic acid libraries for probing protein-protein interactions, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid, the publication is Bioorganic & Medicinal Chemistry (1998), 6(8), 1347-1378, database is CAplus and MEDLINE.

Full details of the preparation of iminodiacetic acid diamide dimer (2040 compounds), trimer (560 compounds), and tetramer (1596 compounds) libraries by multistep convergent solution-phase synthesis for studying protein-protein interactions are provided. The libraries were assembled in a format providing small 8-10 compound mixtures and the deconvolution of many of the small mixtures to identify screening leads by resynthesis of the individual components were conducted for 320 of the individual compounds to date. A representative example of the subsequent exploration of the structure-activity relationships for an identified receptor binding antagonist (200 addnl. individual compounds) and steps taken for potential elaboration to a receptor dimerization agonist are defined with preparation of representative linked dimers (70 compounds).

Bioorganic & Medicinal Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Si-Jie published the artcileCopper-Catalyzed Cross-Coupling of Benzylic C-H Bonds and Azoles with Controlled N-Site Selectivity, Safety of Bis(4-fluorophenyl)methane, the publication is Journal of the American Chemical Society (2021), 143(36), 14438-14444, database is CAplus and MEDLINE.

A copper-catalyzed method that achieves site-selective cross-coupling of pyrazoles and other N-H heterocycles with substrates bearing (hetero)benzylic C-H bonds was reported. Excellent N-site selectivity was achieved, with preferred site controlled by identity of co-catalytic additives. This cross-coupling strategy featured broad scope for both N-H heterocycle and benzylic C-H coupling partners, enabling application of this method to complex mol. synthesis and medicinal chem.

Journal of the American Chemical Society published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vasilopoulos, Aristidis published the artcileCopper-Catalyzed C-H Fluorination/Functionalization Sequence Enabling Benzylic C-H Cross Coupling with Diverse Nucleophiles, Synthetic Route of 457-68-1, the publication is Organic Letters (2020), 22(15), 5753-5757, database is CAplus and MEDLINE.

Alkylbenzenes underwent regioselective fluorination with N-fluorobenzenesulfonimide in the presence of CuOAc and bathophenanthroline mediated by methylboronic acid and lithium carbonate in chlorobenzene to yield secondary and tertiary benzylic fluorides. The benzylic fluorides generated in these reactions were reactive electrophiles in the presence of the hydrogen-bond donor hexafluoroisopropanol or the Lewis acid BF₃¡¤Et₂O, yielding benzylic ethers, alcs., protected amines, and diarylalkanes directly from the alkylarenes.

Organic Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C22H23BO4, Synthetic Route of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Huaifeng published the artcileDiverse catalytic reactivity of a dearomatized PN³P*-nickel hydride pincer complex towards CO₂ reduction, Synthetic Route of 2909-77-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(81), 11395-11398, database is CAplus and MEDLINE.

A dearomatized PN³P*-nickel hydride complex has been prepared using an oxidative addition process. The first nickel-catalyzed hydrosilylation of CO₂ to methanol has been achieved, with unprecedented turnover numbers Selective methylation and formylation of amines with CO₂ were demonstrated by such a PN³P*-nickel hydride complex, highlighting its versatile functions in CO₂ reduction

Chemical Communications (Cambridge, United Kingdom) published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Synthetic Route of 2909-77-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Lin published the artcileFormal Total Synthesis of N-Methylmaysenine, SDS of cas: 4141-48-4, the publication is Organic Letters (2009), 11(8), 1809-1812, database is CAplus and MEDLINE.

A novel synthetic approach for the formal total synthesis of N-methylmaysenine has been developed through the asym. synthesis of I. Key steps involve the Ti-mediated vinylogous Mukaiyama aldol reaction of chiral ketene silyl N,O-acetal with ¦Â-dithiane-substituted aldehyde, an aldol condensation, and a ring-closing metathesis reaction.

Organic Letters published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C10H16O2, SDS of cas: 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Xiong published the artcileThe influence of isomerism on the self-assembly behavior and complexation property of 1,3-alternate tetraaminopyridyl-thiacalix[4]arene derivatives, Synthetic Route of 1798-04-5, the publication is Tetrahedron (2008), 64(27), 6230-6237, database is CAplus.

A series of 1,3-alternate conformation thiacalix[4]arenes containing different isomeric aminopyridyl pendent arms have been synthesized. It was found that their self-assembly behaviors and complexation properties strongly depended on the structures of aminopyridyl pendent arms. The crystal structures demonstrate that tetra(meta-aminopyridyl)-thiacalix[4]arene motif is capable of forming intramol. hydrogen bondings between the sp² nitrogen donors in the meta position of the aminopyridyl groups and the facing amide N-H of the adjacent aminopyridyl groups, and self-assembles via C-H¡¤¡¤¡¤O weak hydrogen bondings and C-H¡¤¡¤¡¤¦Ð interaction to generate a double stranded rectilineal networks. By contrast, in the case of tetra(para-aminopyridyl)-thiacalix[4]arene, the presence of para-aminopyridyl units enables the formation of N-H¡¤¡¤¡¤N strong hydrogen bondings between the individual mols. leading to the solid-state structure with water-bridged double strands. Their complexation properties had been also studied by measurement of the stability constants for their complexation in a range of metal cations and investigation of their binding models via ¹H NMR titration and ESI-MS experiments It was found that the three ligands exhibited high and selective extractability toward Ag⁺, and their stoichiometry of ligand to Ag⁺ was 1:1, while the meta-aminopyridyl derivative showed the best extraction capacity and possessed the most efficient binding sites.

Tetrahedron published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Synthetic Route of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Kyeong published the artcileDiscovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors, SDS of cas: 1798-04-5, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(24), 7456-7460, database is CAplus and MEDLINE.

A novel series of benzimidazole derivatives was prepared and evaluated for their diacylglycerol acyltransferase (DGAT) inhibitory activity using microsome from rat liver. Among the newly synthesized compounds, a furfurylamine containing benzimidazole carboxamide showed the most potent DGAT inhibitory effect (IC₅₀= 4.4 ¦ÌM) and inhibited triglyceride formation in HepG2 cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fedtke, M. published the artcileOxidative inhibitors. I. Ring-alkylated aromatic amines. Preparation of ring alkylated aniline derivatives, Category: catalysis-chemistry, the publication is Journal fuer Praktische Chemie (Leipzig) (1965), 29(3-6), 259-70, database is CAplus.

tert-Bu radical was introduced into aromatic amines by heating at 200-50¡ã with isobutylene in an autoclave at maximum 100 atm. using Al, AlCl₃, or HgCl₂ as catalyst. PhNH₂ gave 41.3% p-tert-BuC₆H₄NH₂ (b₁₆ 124¡ã, n²⁰_D 1.5373; acetate m. 171¡ã; benzoate m. 169-71¡ã) and 17% 2,4- and 2,6-(Me₃C)₂C₆H₃NH₂. p-Toluidine gave 41% 2,4-Me(Me₃C)C₆H₃NH₂ (b₁ 85¡ã, n²⁰_D 1.5360; acetate m. 167%; benzoate m. 173¡ã). p-Toluidine gave 41.2% 4,2-Me(Me₃C)C₆H₃NH₂ (b₁ 81¡ã, n²⁰_D 1.5368; acetate m. 162-4¡ã) and 1.6% 4,2,6-Me(Me₃C)₂C₆H₂NH₂ (b₁ 100-20¡ã, m. 128-9¡ã). Similarly ArNMe₂ gave the following alkylated N,N-dimethylamines (alkyl, % yield, b.p. or m.p., and n²⁰_D given): p-tert-Bu, 29.3, b₁₂ 123¡ã, 1.5293; 2,6-Et₂, 79.8, b₃ 90¡ã, 1.5095; 2,6-(iso-Pr₂, 81.6, b_2.5 86¡ã, 1.5002; 2,4-(tert-Bu)₂, 35-9, m. 77-8¡ã, –; 4,2,6-MeEt₂, 78.0, b₃ 92¡ã, 1.5084; 4,2,6-Me(iso-Pr)₂, 59.1, m. 47.58.5,–.

Journal fuer Praktische Chemie (Leipzig) published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia