Tag: M.W=200-250

Davidkova, P. published the artcileSeparation efficiency of adsorption and partition thin-layer chromatography and reversed-phase high-performance thin-layer chromatography with chemically bonded phases for alkylphenoxyalkanoic acids, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of Chromatography (1987), 410(1), 53-76, database is CAplus.

The separation of 32 alkyl-substituted phenoxyalkanoic acids from phenoxyacetic to 3-pentadecylphenoxylauric acid was studied using adsorption chromatog., 3 types of partition chromatog. (water, formamide, or liquid paraffin as stationary phases), and reversed-phase high-performance thin-layer chromatog. (RP-HPTLC) with chem. bonded phases. All these chromatog. systems were found suitable from the anal. point of view, but some differences in their suitability for the separation of lower or higher homologs or in their detection sensitivity were observed The most efficient methods seem to be RP-HPTLC and TLC on silica gel layers impregnated with formamide or DMF, resp., the former owing to the good separation of the highest lipophilic homologs and to the formation of discrete spots, permitting sharper anal. differentiation of acids with smaller R_f differences in general, and the latter owing to the highest ¦¤R_M values for the methylene groups of all the homologs in connection with high detection sensitivity. The best detection was achieved by using 2,7-dichlorofluorescein as the spray reagent followed by observation in UV light. The detection limit was 0.5-10 ¦Ìg of the acids, depending on the chromatog. system used.

Journal of Chromatography published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Davidkova, P. published the artcileTLC and HPTLC of alkyl-substituted phenoxyalkanoic acids, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Symposia Biologica Hungarica (1986), 567-78, database is CAplus.

The optimum conditions for the separation of alkyl-substituted phenoxyalkanoic acids by normal-phase partition and reversed-phase TLC and reversed-phase high-performance (HP) TLC on chem.-bonded phase were studied. The separated spots were detected by spraying with a 0.2% EtOH solution of 2,7-dichlorofluorescein.

Symposia Biologica Hungarica published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ovakimiyan, M. Zh. published the artcileOne-pot synthesis of biologically highly active triphenyl [2-(2-benzylidenhydrazinyl)propyl]phosphonium bromide, COA of Formula: C15H15OP, the publication is Hayastani Kimiakan Handes (2013), 66(3), 516-520, database is CAplus.

By interaction of triphenylprop-2-enylphosphonium bromide with benzylhydrazine in the presence of triethylamine in mild conditions [2-(2-benzylidenehydrazinyl)propyl]phosphonium bromide has been obtained. It is obvious that the resulted substance is dehydrogenation product of the initially formed adduct.

Hayastani Kimiakan Handes published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, COA of Formula: C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zakrzewska, Anna published the artcile¹³C-NMR based evaluation of the electronic and steric interactions in aromatic amines, Safety of 2,6-Diisopropyl-N,N-dimethylaniline, the publication is International Journal of Molecular Sciences (2005), 6(1-2), 52-62, database is CAplus.

Chem. shifts of the para carbon atoms, ¦Ä(¹³C-4), in a series of aromatic amines were used to calculate the ¦Ò_p, ¦Ò_R and ¦Ò^O_R substituent constants for different amino groups. 1-Pyrrolidino, N-N-di-n-butylamino and N,N-diethylamino groups were found to be the most strong electron-donors. Ortho-Substitution decreases the donor properties of the amino group. The amino groups in 2,6-di-i-propylaniline and N,N-2,6-tetramethylaniline have very weak electron-donor properties. The nitrogen atom in benzoquinuclidine and N,N-dimethyl-2,6-di-i-propylaniline have an electron-acceptor character. The calculated substituent constants of the amino groups studied are consistent with the spectral and reactivity data available in literature. Values of ¦Ä(¹⁵N) cannot be used as a direct measure of electronic effects of the N atom in anilines.

International Journal of Molecular Sciences published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C3H5BF3KO2, Safety of 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moragas, Toni published the artcileNickel-Catalyzed Carboxylation of Benzylic C-N Bonds with CO₂, Quality Control of 1860-58-8, the publication is Angewandte Chemie, International Edition (2016), 55(16), 5053-5057, database is CAplus and MEDLINE.

A user-friendly Ni-catalyzed reductive carboxylation of benzylic C-N bonds with CO₂ is described. This procedure outperforms state-of-the-art techniques for the carboxylation of benzyl electrophiles by avoiding commonly observed parasitic pathways, such as homodimerization or ¦Â-hydride elimination, thus leading to new knowledge in cross-electrophile reactions.

Angewandte Chemie, International Edition published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khairullin, R. A. published the artcileReactions of diphenyl- and diethylphosphinodithioic acids with N-alkyl-2-haloaldimines in the synthesis of new P,S- and N,P,S-containing organic compounds, SDS of cas: 140-28-3, the publication is Russian Journal of General Chemistry (2017), 87(10), 2313-2319, database is CAplus.

Diphenyl- and diethylphosphinodithioic acids, unlike the stronger O,O-dialkyl phosphorodithioic acids, react with N-alkyl-2-chloroaldimines at a 1: 1 ratio, following two pathways: nucleophilic substitution of chlorine in the primary salt by the phosphinothioylthio group and reduction of the cation of the primary salt on the C-Cl bond. Nucleophilic substitution contributes more in the case of the stronger diphenylphosphinodithioic acid, as well as in the case of a large excess of the starting chlorimine. N-Alkyl-2-bromoaldimines react only by a single pathway, specifically, reducing the cation of the primary iminium salt on the C-Br bond. New iminium salts were synthesized and converted into the corresponding aldehydes and imines. The aldehydes synthesized were converted into acetals and five-membered heterocyclic compounds

Russian Journal of General Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, SDS of cas: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khairullin, R. A. published the artcileReactions of diphenyldithiophosphinic acid with N-alkyl-2-chloro-2-methylpropanimines, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Russian Chemical Bulletin (2018), 67(5), 912-915, database is CAplus.

In contrast to O,O-dialkyldithiophosphoric acids, the reactions of more weak diphenyldithiophosphinic acid with N-alkyl-2-chloro-2-methylpropanimines at a 1 : 1 reagent ratio follow two pathways. The first route is nucleophilic substitution of the chlorine atom of the initially formed iminium salt with the diphenylthiophosphinylthio moiety and the second route is the reduction of the C-Cl bond of this iminium salt cation. The main reaction direction is nucleophilic substitution producing new iminium salts, namely, N-alkyl-2-(diphenylthiophosphinylthio)-2-methylpropaniminium chlorides. These salts were used as the starting material to synthesize new organophosphorus compounds bearing aldehyde, imine, and acetal groups and 1,3-diazolidine cycle.

Russian Chemical Bulletin published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khairullin, R. A. published the artcileSynthesis of O,O-Dialkyl S-(1,1-dimethyl-2-oxoethyl) dithiophosphates and their reactions with N-nucleophiles, Quality Control of 140-28-3, the publication is Doklady Chemistry (2016), 467(2), 131-135, database is CAplus.

O,O-Dialkyl S-(1,1-dimethyl-2-oxoethyl) dithiophosphates, 2-(dialkoxythiophosphorylthio)-substituted aldehydes with branched carbon groups, were obtained by hydrolysis of phosphoryl-containing iminium salts. The reaction with primary amines results in imines containing acetal group in different positions. Tri- and tetra-substituted perhydro-1,3-diazoles and oxazoles containing a phosphorus atom in the side chain were prepared by reacting the aldehydes with O,Nand N,N-dinucleophiles.

Doklady Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mochalov, S. S. published the artcileTransformations of para-substituted benzylcyclopropanes, allylbenzenes, and diphenylmethanes under nitration with nitric acid in acetic anhydride, COA of Formula: C13H10F2, the publication is Russian Journal of Organic Chemistry (2005), 41(3), 406-416, database is CAplus.

Electrophilic nitration of benzylcyclopropanes, allylbenzenes, and diphenylmethanes containing ortho,para-orienting substituents in the para position of the benzene ring results mainly in replacement of the cyclopropylmethyl, allyl, or benzyl group, resp. (ipso substitution). The nitration of 4-cyclopropylallylbenzene is not accompanied by nitrodealkylation, and the products are only 2- and 3-nitro-4-cyclopropylallylbenzenes.

Russian Journal of Organic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, COA of Formula: C13H10F2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Heitel, Pascal published the artcileComputer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype, Synthetic Route of 31719-76-3, the publication is ACS Medicinal Chemistry Letters (2019), 10(2), 203-208, database is CAplus and MEDLINE.

As universal heterodimer partners of many nuclear receptors, the retinoid X receptors (RXRs) constitute key transcription factors. They regulate cell proliferation, differentiation, inflammation, and metabolic homeostasis and have recently been proposed as potential drug targets for neurodegenerative and inflammatory diseases. Owing to the hydrophobic nature of RXR ligand binding sites, available synthetic RXR ligands are lipophilic, and their structural diversity is limited. Here, we disclose the computer-assisted discovery of a novel RXR agonist chemotype and its systematic optimization toward potent RXR modulators. We have developed a nanomolar RXR agonist with high selectivity among nuclear receptors and superior physicochem. properties compared to classical rexinoids that appears suitable for in vivo applications and as lead for future RXR-targeting medicinal chem.

ACS Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Synthetic Route of 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia