Tag: M.W=200-250

Kumar, Amit published the artcileSilicon Fluorides for Acid-Base Catalysis in Glycosidations, Application In Synthesis of 312-40-3, the publication is Advanced Synthesis & Catalysis (2012), 354(8), 1489-1499, database is CAplus.

Adduct formation between alcs. as glycosyl acceptors and phenylsilicon trifluoride (PhSiF₃) as catalyst permits acid-base-catalyzed glycosidations with O-glycosyl trichloroacetimidates as glycosyl donors. In this way, from various glycosyl donors and acceptors 1,2-trans- and some 1,2-cis-glycosides could be obtained with high anomeric selectivity. A preference for an intramol. bimol. nucleophilic substitution (S_N2-type) reaction course with concomitant donor and acceptor activation is supported by the results.

Advanced Synthesis & Catalysis published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Application In Synthesis of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Henriet, Theo published the artcileSolid state stability and solubility of triethylenetetramine dihydrochloride, Application In Synthesis of 38260-01-4, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2016), 511(1), 312-321, database is CAplus and MEDLINE.

The API triethylenetetramine dihydrochloride used as an alternative treatment of Wilson’s disease is sensitive to water and it exhibits polymorphism. As this may become an issue for the drug formulation, the phys. stability has been studied by differential scanning calorimetry, high-pressure thermal anal., dynamic vapor sorption, and X-ray diffraction as a function of temperature In addition, high-pressure liquid chromatog. and mass spectrometry have been used to study the purity and chem. stability of the API. A pressure-temperature phase diagram of the pure compound has been constructed and it can be concluded that form II is monotropic in relation to form I, which is the only stable solid. The solubilities of the different solid forms have been determined with the help of a temperature – composition phase diagram. The API is very soluble, at 20¡ã C about 10% of the saturated solution with respect to the dihydrate consists of API and the solubility of the pure form I is twice as high. Moreover, it has been shown that at 20 ¡ãC, a relative humidity above 40% induces the formation of the dihydrate and at 70% a saturated solution appears. At higher temperatures, the formation of the dihydrate appears at lower relative humidity values. A clear link has been established between the API’s chem. stability, its phys. stability and the relative humidity in the air. Humidity levels above 40% are detrimental to the quality of the API.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karthick, S. published the artcileTerahertz generation and optical properties of N-benzyl-2-methyl-4-nitroaniline single crystals in 0.1-2.0 THz range for photonic applications, Name: N-Benzyl-2-methyl-4-nitroaniline, the publication is Materials Letters (2019), 95-98, database is CAplus.

We report on the THz generation and optical characterizations such as index of refraction, absorption coefficients of indigenously grown, potentially NLO active N-benzyl-2-methyl-4-nitroaniline (BNA) single crystals grown from four different solvents such as N, N DMF (DMF), Methanol (MeOH), Acetonitrile (ACN) and ACN: DMF (1:1) in an intentionally selected frequency range of 0.1-2.0 THz at room temperature (RT). The DMF was identified to be a promising candidate as it facilitated reduction in the inclusions. The powder Second Harmonic Generation (SHG) measurements performed on BNA polycrystalline samples revealed that their efficiencies were about 8.4 and 2.3 times higher than KDP and Urea samples resp. The absorption coefficients and refractive indexes made in this technol. important THz range using the BNA crystals grown from selected solvents exhibited, interestingly, solvent dependency.

Materials Letters published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Name: N-Benzyl-2-methyl-4-nitroaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Miller, David C. published the artcileAnti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines, Formula: C15H24S, the publication is Journal of the American Chemical Society (2019), 141(42), 16590-16594, database is CAplus and MEDLINE.

A photocatalytic method for the intermol. anti-Markovnikov hydroamination of unactivated olefins with primary alkyl amines to selectively furnish secondary amine products is reported. These reactions proceed through aminium radical cation (ARC) intermediates and occur at room temperature under visible light irradiation in the presence of an iridium photocatalyst and an aryl thiol hydrogen atom donor. Despite the presence of excess olefin, high selectivities are observed for secondary over tertiary amine products, even though the secondary amines are established substrates for ARC-based olefin amination under similar conditions.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Formula: C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Araujo, Raquel Silva published the artcileCloxacillin benzathine-loaded polymeric nanocapsules: Physicochemical characterization, cell uptake, and intramammary antimicrobial effect, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2019), 110006, database is CAplus and MEDLINE.

The present work shows the development and evaluation of the veterinary antibiotic cloxacillin benzathine loaded into poly-¦Å-caprolactone nanocapsules, as a potential new treatment strategy to manage bovine intramammary infections, such as mastitis. Staphylococcus aureus-induced mastitis is often a recurrent disease due to the persistence of bacteria within infected cells. The mean diameter of NC varied from 241 to 428 nm and from 326 to 375 nm, when determined by dynamic light scattering and by at. force microscopy, resp. In vitro release studies from the NC were performed in two media under sink conditions: PBS with 1% polyethylene glycol or milk. Free CLOXB dissolution occurred very fast in both media, while drug release from the NC was slower and incomplete (below 50%) after 9 h. CLOXB release kinetics from polymeric NC was fitted with the Korsmeyer-Peppas model indicating that CLOXB release is governed by diffusion following Fick’s law. Antimicrobial effect of the intramammary administration of CLOXB-PCL NC in cows with mastitis resulted in no clin. signs of toxicity and allowed complete pathogen elimination after treatment. The in vivo results obtained in this work suggest that CLOXB-PCL NC could be a promising formulation for the treatment of intramammary infections in cattle, considering their physicochem. properties, release profiles and effects on bovine mastitis.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sauer, Scott J. published the artcileDirect Carbon-Carbon Bond Formation via Reductive Soft Enolization: A Kinetically Controlled syn-Aldol Addition of ¦Á-Halo Thioesters and Enolizable Aldehydes, Related Products of catalysis-chemistry, the publication is Journal of the American Chemical Society (2010), 132(40), 13997-13999, database is CAplus and MEDLINE.

The direct addition of enolizable aldehydes and ¦Á-halo thioesters to produce ¦Â-hydroxy thioesters enabled by reductive soft enolization is reported. The transformation is operationally simple and efficient and has the unusual feature of giving high syn-selectivity, which is the opposite of that produced for (thio)esters under conventional conditions. Moreover, excellent diastereoselectivity results when a chiral nonracemic ¦Á-hydroxy aldehyde derivative is used.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nishida, Masakazu published the artcileMultiple pentafluorophenylation of 2,2,3,3,5,6,6-heptafluoro-3,6-dihydro-2H-1,4-oxazine with an organosilicon reagent: NMR and DFT structural analysis of oligo(perfluoroaryl) compounds, Recommanded Product: Trimethyl(perfluorophenyl)silane, the publication is Helvetica Chimica Acta (2006), 89(11), 2671-2685, database is CAplus.

The reagent Me₃Si(C₆F₅) was used for the preparation of a series of perfluorinated, pentafluorophenyl-substituted 3,6-dihydro-2H-1,4-oxazines (2-8), which, otherwise, would be very difficult to synthesize. Multiple pentafluorophenylation occurred not only on the heterocyclic ring of the starting compound 1 (Scheme), but also in para position of the introduced C₆F₅ substituent(s) leading to compounds with one to three nonafluorobiphenyl (C₁₂F₉) substituents. While the tris(pentafluorophenyl)-substituted compound 3 could be isolated as the sole product by stoichiometric control of the reagent, the higher-substituted compounds 5-8 could only be obtained as mixtures The structures of the oligo(perfluoroaryl) compounds were confirmed by ¹⁹F- and ¹³C-NMR, MS, and/or X-ray crystallog. DFT simulations of the ¹⁹F- and ¹³C-NMR chem. shifts were performed at the B3LYP-GIAO/6-31++G(d,p) level for geometries optimized by the B3LYP/6-31G(d) level, a technique that proved to be very useful to accomplish full NMR assignment of these complex products.

Helvetica Chimica Acta published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Recommanded Product: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nishida, Masakazu published the artcileReactions of Highly Branched Perfluoroolefins with (Pentafluorophenyl)trimethylsilane: Characterization of the Unique Structural Properties of Perfluorinated Super-Congested Systems, Computed Properties of 1206-46-8, the publication is Asian Journal of Organic Chemistry (2016), 5(7), 927-937, database is CAplus.

Hexafluoropropene trimers were reacted with C₆F₅Si(CH₃)₃ to provide not only pentafluorophenyl but also perfluorophenylene derivatives [F(C₆F₄)_nC₉F₁₇; n = 2-9] by successive pentafluorophenylation of perfluoroaryl rings. Their structures, including rotational isomers, were determined by MS, ¹⁹F and ¹³C-{¹⁹F} NMR spectroscopy, and/or X-ray crystallog. and were further confirmed by B3LYP-GIAO calculation of NMR shieldings. Formation of a pair of gear-meshed rotamers with clockwise and counterclockwise conformations was identified by NMR measurements for the structures having geminal (CF₃)₂CF groups at the C=C bond. That the predominantly formed counterclockwise rotamer was gradually converted to the clockwise rotamer over 50 days at room temperature through a synchronized movement of gears was also confirmed by NMR measurements. A comparison between the X-ray structure and B3LYP calculations showed some structural differences that arise from the crystal packing.

Asian Journal of Organic Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Computed Properties of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Iwasaki, Takanori published the artcileMulticomponent Coupling Reaction of Perfluoroarenes with 1,3-Butadiene and Aryl Grignard Reagents Promoted by an Anionic Ni(II) Complex, Product Details of C9H9F5Si, the publication is Organic Letters (2016), 18(19), 4868-4871, database is CAplus and MEDLINE.

In the presence of in situ-generated anionic nickel catalysts, aryl Grignard reagents such as 4-fluorophenylmagnesium bromide, 1,3-butadiene, and perfluoroarenes such as perfluorobenzene underwent diastereoselective and chemoselective three-component coupling reactions to yield (aryl)(perfluoroaryl)octadienes such as I. A thermally unstable anionic nickel complex II?Li(12-crown-4)₂⁺ was prepared from PhLi, 1,3-butadiene, Ni(cod)₂, and 12-crown-4 and its crystal structure determined and used as a catalyst for the three-component coupling reaction.

Organic Letters published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Product Details of C9H9F5Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nishimine, Takayuki published the artcileKinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon-Assisted C-F Bond Cleavage, Synthetic Route of 1206-46-8, the publication is Angewandte Chemie, International Edition (2014), 53(2), 517-520, database is CAplus and MEDLINE.

Under optimized reaction conditions, the synthesis of the target compounds was achieved by a reaction of trimethyl(trifluoromethyl)silane with Morita-Baylis-Hillman-reaction products [¦Â-fluoro-¦Á-(methylene)benzenepropanoic acid ester derivatives] using (9S)-(9”S)-9,9”-[1,4-phthalazinediylbis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan] [i.e., (DHQD)₂PHAL] as catalyst. The products thus formed included (¦ÂS)-¦Á-methylene-¦Â-(trifluoromethyl)benzenepropanoic acid Me ester (I), (¦ÂR)-¦Á-methylene-¦Â-(trifluoromethyl)benzenepropanoic acid Me ester and (¦ÂR)-¦Â-fluoro-¦Á-(methylene)benzenepropanoic acid Me ester, (¦ÂS)-¦Â-fluoro-¦Á-(methylene)benzenepropanoic acid Me ester. The corresponding enantiomers were obtained using (9S,9”S)-9,9”-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan] [(DHQD)₂PYR] as catalyst.

Angewandte Chemie, International Edition published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Synthetic Route of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia