Tag: M.W=200-250

Wang, He published the artcileMetal-Free 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-Mediated Cross-Dehydrogenative-Coupling (CDC) of Benzylic C(sp³)-H Bonds and Vinylic C(sp²)-H Bonds: Efficient One-Pot Synthesis of 1H-Indenes, Recommanded Product: Bis(4-fluorophenyl)methane, the publication is Advanced Synthesis & Catalysis (2014), 356(14-15), 3157-3163, database is CAplus.

A novel 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-promoted intermol. cross-dehydrogenative coupling reaction of alkyl C(sp³)-H bonds not adjacent to heteroatoms with vinylic C(sp²)-H bonds has been developed. This new strategy provides a new, environmentally friendly, and efficient protocol for the synthesis of polysubstituted 1H-indenes in a single step via a radical-initiated two C(sp²)-C(sp²) and C(sp²)-C(sp³) bond formation process.

Advanced Synthesis & Catalysis published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C14H21BO2, Recommanded Product: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Wenhao published the artcileDual Nickel- and Photoredox-Catalyzed Reductive Cross-Coupling of Aryl Halides with Dichloromethane via a Radical Process, Formula: C13H10F2, the publication is Organic Letters (2020), 22(21), 8643-8647, database is CAplus and MEDLINE.

The first catalytic strategy to harness a new chloromethane radical from dichloromethane under dual Ni/photoredox catalytic conditions has been developed. Compared with traditional two-electron reductive process associated with metallic reductants, this method via a single-electron approach can proceed under exceptionally mild conditions (visible light, ambient temperature, no strong base) and exhibits complementary reactivity patterns. It affords a broad scope of many functional groups, including alkenyl, which suffers cyclopropanation in previous routes. The diarylmethane-d2 compounds can be readily available with this transformation.

Organic Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C12H6NNaO4, Formula: C13H10F2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lin, H. K. published the artcileProcess mineralogy of scandium and europium-containing iron-making slag, Application In Synthesis of 2016-56-0, the publication is Minerals & Metallurgical Processing (1997), 14(2), 18-20, database is CAplus.

During slow-cooling crystallization of ironmaking blast-furnace slags, most rare earth elements recrystallize in an artificial “mineral” identified as calcium cerite. Scandium (Sc) and europium (Eu), however, concentrate in a sheetlike “mineral”. The mineralogy of this sheetlike “mineral” was studied. It was identified as being in the mica group and was called a rare earth-bearing barium fluorophlogopite. It can be effectively recovered from the slag by flotation using dodecylammonium acetate or a combination of dodecylammonium acetate and sodium oleate as collectors.

Minerals & Metallurgical Processing published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Application In Synthesis of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Wenjuan published the artcileIron-Catalyzed C-C Bond Cleavage and C-N Bond Formation, Application of Bis(4-fluorophenyl)methane, the publication is Advanced Synthesis & Catalysis (2013), 355(1), 181-190, database is CAplus.

A novel approach for C-N bond formation was developed by iron-catalyzed C-C bond cleavage. Anilines and sulfonamides reacted smoothly with 2-substituted 1,3-diphenylpropane-1,3-diones to afford N-alkylation products, in which the 1,3-dicarbonyl group acts as a leaving group in the presence of an iron catalyst. E.g., in presence of FeCl₃.6H₂O, alkylation of 4-O₂NC₆H₄NH₂ by I gave 90% II. The reversible C-C bond cleavage plays a driving force to give the thermodynamically stable products. The method is complementary to the previous methods for C-N bond formation.

Advanced Synthesis & Catalysis published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Application of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Ziqi published the artcileMineralogy and flotation properties of phlogopite slags containing rare earths, barium, and fluorine, Formula: C14H31NO2, the publication is Kuangchan Zonghe Liyong (1988), 66-72, database is CAplus.

The mineralogy and flotation properties of phlogopites containing rare earths, Ba, and F formed during crystallization of blast-furnace slags were studied. The surface elec. properties of the phlogopites in aqueous solutions were determined Dodecylamine acetate was used as a collecting agent for flotation.

Kuangchan Zonghe Liyong published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C17H29BO2, Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hou, Huan-Fu published the artcilecatena-Poly[[[diaquacadmium]-¦Ì-2,2′-(1,2-phenylenedioxy)diacetato] monohydrate], COA of Formula: C10H10O6, the publication is Acta Crystallographica, Section E: Structure Reports Online (2011), 67(3), m342, Sm342/1-Sm342/10, database is CAplus and MEDLINE.

In the title coordination complex, {[Cd(C₁₀H₈O₆)(H₂O)₂]¡¤H₂O}_n the Cd^II atom is seven-coordinated in a distorted pentagonal-bipyramidal geometry, the pentagonal plane comprising four O-atom donors from the 2,2′-(1,2-phenylenedioxy)diacetate chelate ligand together with a bridging carboxylate O-atom donor, with the axial sites occupied by two H₂O mols. The resulting helical chains extend along the b axis and are interconnected by extensive O-H¡¤¡¤¡¤O H-bonding interactions, which also involve the H₂O mol. of solvation, giving a three-dimensional structure. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, COA of Formula: C10H10O6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Bao-Yong published the artcileSynthesis and characterization of four coordination polymers constructed with d¹⁰ metals and mixed flexible ligands under solvothermal conditions, Computed Properties of 5411-14-3, the publication is Inorganica Chimica Acta (2012), 58-65, database is CAplus.

Solvothermal reactions of flexible 1,2-phenylenedioxydiacetic acid (H₂PDA) or hydroquinone-O,O’-diacetic acid (H₂QDA) with zinc nitrate or cadmium nitrate in the presence of auxiliary 1,1′-(1,4-butanediyl)bis(imidazole) (BBI) ligand gave rise to four coordination polymers, namely, {[Zn(PDA)(BBI)]¡¤3H₂O}_n (1), {[Zn(PDA)(BBI)]¡¤DMF}_n (2), {[Cd₂(QDA)(BBI)]¡¤4H₂O}_n (3), [Cd(QDA)(BBI)]_n (4). All the compounds were characterized by elemental anal., IR and single-crystal x-ray diffraction methods. Compound 1 exhibits a puckered (2D) (4, 4) grid net with a Schlafli symbol of 4⁴ 6². Compound 2 has the dinuclear Zn₂(PDA)₂ “loops” which are further connected by BBI ligands into 2D sheet along (0 1 -1) plane with a Schlafli symbol of 2.6⁵. Interestingly, the Zn₂(PDA)₂ “loops” are penetrated by BBI ligands of the other equivalent net. Thus an unusual 2D polyrotaxane-like structure is formed containing rotaxane-like motifs. Compound 3 possesses a three-dimensional (3D) diamond-type network with a Schlafli symbol of 6⁶. Compound 4 has the dinuclear cadmium core as the node and shows a 3D threefold interpenetrating 8-connected unimodal network with a Schlafli symbol of 3⁶4¹⁸5³6. The structural differences of these complexes give some insights into the effect of solvent on the construction of coordination polymers with the same components under solvothermal conditions. In addition, the fluorescent properties of 1–4 were also investigated.

Inorganica Chimica Acta published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C42H63O3P, Computed Properties of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Gaozhi published the artcileDiscovery of a New Inhibitor of Myeloid Differentiation 2 from Cinnamamide Derivatives with Anti-Inflammatory Activity in Sepsis and Acute Lung Injury, Name: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Journal of Medicinal Chemistry (2016), 59(6), 2436-2451, database is CAplus and MEDLINE.

Acute inflammatory diseases, including acute lung injury and sepsis, remain the most common life-threatening illness in intensive care units worldwide. Cinnamamide has been incorporated in several synthetic compounds with therapeutic potentials including anti-inflammatory properties. However, the possible mechanism and direct mol. target of cinnamamides for their anti-inflammatory effects were rarely investigated. In this study, we synthesized a series of cinnamamides and evaluated their anti-inflammatory activities. The most active compound, 2i, was found to block LPS-induced MD2/TLR4 pro-inflammatory signaling activation in vitro and to attenuate LPS-caused sepsis and acute lung injury in vivo. Mechanistically, we demonstrated that 2i exerts its anti-inflammatory effects by directly targeting and binding MD2 in Arg90 and Tyr102 residues and inhibiting MD2/TLR4 complex formation. Taken together, this work presents a novel MD2 inhibitor, 2i, which has the potential to be developed as a candidate for the treatment of sepsis, and provides a new lead structure for the development of anti-inflammatory agents targeting MD2.

Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Name: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Leimbacher, Markus published the artcileDiscovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library, Application In Synthesis of 1860-58-8, the publication is Chemistry – A European Journal (2012), 18(25), 7729-7737, S7729/1-S7729/120, database is CAplus and MEDLINE.

Libraries of chem. compounds individually coupled to encoding DNA tags (DNA-encoded chem. libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chem. library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic anal. of selection strategies and statistically robust identification of binding mols. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by mol. docking. Our findings suggest that DNA-encoded chem. libraries allow the facile identification of drug-like ligands principally to any protein of choice, including mols. capable of disrupting high-affinity protein-protein interactions.

Chemistry – A European Journal published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Application In Synthesis of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Jianguo published the artcileSynthesis of Cyclic Ethers with Fluorinated Side Chains, Computed Properties of 1206-46-8, the publication is Inorganic Chemistry (1996), 35(6), 1590-601, database is CAplus and MEDLINE.

Di-tert-Bu peroxide initiated free radical addition of THF to various fluorinated alkenes (CF₂:CH₂, CF₂:CFH, CH₂:CHCF₃, CF₂:CFCF₃, CF₂:CFC₅F₁₁, CF₂:CFOCF₂CF(CF₃)OCF₂CF₂SO₂F) gives either bidirectional addition products 2-R-THF (R = CF₂CH₃ (1), CH₂CHF₂ (2), CF₂CH₂F (3), and CFHCHF₂ (4)) or unidirectional products (R = CH₂CH₂CF₃ (5), CF₂CHFCF₃ (6), CF₂CHFC₅F₁₁ (7), and CF₂CHFOCF₂CF(CF₃)OCF₂CF₂SO₂F (8)) depending on the structure of the alkene. Reaction of dioxane with CF₂:CFOCF₂CF(CF₃)OCF₂CF₂SO₂F gives a single product 2-R-dioxane, R = CF₂CHFOCF₂CF(CF₃)OCF₂CF₂SO₂F (9). In the case of hexafluoropropene or perfluoroallylbenzene, reaction with an excess of THF gives only the monosubstituted products 2-R-THF (R = CF₂CHFCF₃ (6) and CF₂CFHCF₂C₆F₅ (11)) resp. When THF is reacted with a 3:1 M excess of the same two perfluoroalkenes, the disubstituted products 2,5-R₂-THF (R = CF₂CHFCF₃ (10) and CF₂CFHCF₂C₆F₅ (12)) are formed resp. When 18-crown-6 is reacted in the same way with fluoroalkenes in a 1:1 molar ratio, the monosubstituted products 18-crown-6-CH₂CH₂CF₃ (13), 18-crown-6-CF₂CHFCF₃ (14), 18-crown-6-CF₂CFHCF₂C₆F₅ (15), and 18-crown-6-CF₂CHFOCF₂CF(CF₃)OCF₂CF₂SO₂F (16) were obtained. Polyfluorinated 18-crown-6 products containing three and two polyfluroalkyl/aryl groups were prepared when 18-crown-6 is reacted with a 3:1 M excess of perfluoropropene and perfluoroallylbenzene to give 18-crown-6-(CF₂CHFCF₃)₃ (17) and 18-crown-6-(CF₂CFHCF₂C₆F₅)₂ (18), resp. (Pentafluorophenoxy)trimethylsilane reacts with 11 in the presence of a catalytic amount of CsF to give compound 2-R-THF, R = CF₂CFHCF₂C₆F₄OC₆F₅ (19). Two mols. of 11 are bridged by reaction with Me₃SiOCH₂CF₂CF₂CH₂OSiMe₃ to give THF-CF₂CFHCF₂C₆F₄OCH₂CF₂CF₂CH₂OC₆F₄CF₂CHFCF₂-THF (20), while 12 forms the macroheterocycle 2,5-R’-THF, R’ = -CF₂CFHCF₂C₆F₄OCH₂CF₂CF₂CH₂OC₆F₄CF₂CFHCF₂– (21) under similar reaction conditions. The La triflate complexes of 18-crown-6 (22) and 18-crown-6(CF₂CFHCF₃) (23) were prepared and the structures were obtained via single-crystal x-ray anal. Although crystals suitable for single-crystal x-ray anal. could not be formed, La triflate complexes were formed with polyfluorinated ethers 15 and 16 to give the fluorinated complexes La(OSO₂CF₃)₃(18-crown-6-CF₂CFHCF₂C₆F₅)(H₂O) (24) and [La(18-crown-6-CF₂CFHOCF₂C(CF₃)FOCF₂CF₂SO₂F)]³⁺[CF₃SO₃^–]₃ (25) resp. The acid salt La[N(SO₂CF₃)₂]₃ (26) was also prepared and characterized, and reacted with dibenzo-18-crown-6 to give the complex dibenzo-18-crown-6-La[N(SO₂CF₃)₂]₃ (27).

Inorganic Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Computed Properties of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia