Tag: M.W=200-250

Spaller, William C. published the artcileTetrahydroxydiboron-Mediated Palladium-Catalyzed Deoxygenative Transfer Hydrogenation of Aryl Ketones, Name: Bis(4-fluorophenyl)methane, the publication is Advanced Synthesis & Catalysis (2022), 364(15), 2571-2575, database is CAplus.

A palladium-catalyzed deoxygenative transfer hydrogenation of ketones ArC(O)R (Ar = Ph, 4-phenylphenyl, naphthalen-2-yl, etc.: R = Me, Ph, cyclobutyl, etc.) using B₂(OH)₄ as the sole additive was described. Deuterium labeling experiments using B₂(OD)₄ show that the incorporated protons originate exclusively from the diboron reagent. Spectroscopic evidence implicates the intermediacy of a borate ester. A variety of aromatic ketones can be deoxygenated using this approach.

Advanced Synthesis & Catalysis published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C10H18O, Name: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Peng, Xiangyu published the artcileDevelopment and utilization of a novel hydrogen bonding enhanced collector in the separation of apatite from quartz, COA of Formula: C14H31NO2, the publication is Minerals Engineering (2022), 107477, database is CAplus.

In the light of the adsorption difference of cationic collectors on quartz and apatite, an addnl. hydrogen bond functional group can be introduced into the traditional collector mol.-dodecylammonium acetate (DDA) to achieve high-efficient separation of minerals. In this study, a new surfactant-N-(2-hydroxy-1, 1-dimethylethyl) dodecylamine (HDMEA) was synthesized in our laboratory and acted as a new-type amine collector in the reverse flotation separation of apatite from quartz. The results of micro-flotation tests indicated that the separation performance of HDMEA was significantly better than that of DDA. When the concentration of HDMEA was 20 mg/L at pH 6.43, the apatite with 38.57% grade and 95.8% recovery could be achieved in mixed-flotation tests. The adsorption mechanism of DDA and HDMEA on quartz and apatite was comparably explored by the measurements of zeta potential, FTIR, contact angle, and AFM as well as the DFT calculations These results demonstrated that improving the hydrogen bonds adsorption on quartz (by -NH- and -OH groups) and increasing the steric-hindrance effect on apatite help to achieve efficient flotation separation of quartz and apatite.

Minerals Engineering published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, COA of Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Yong-Gang published the artcilePalladium/Copper-Catalyzed Oxidative Arylation of Terminal Alkenes with Aroyl Hydrazides, SDS of cas: 4141-48-4, the publication is Chemistry – A European Journal (2014), 20(10), 2765-2769, database is CAplus and MEDLINE.

An unprecedented oxidative arylation reaction of terminal alkenes with simple aroyl hydrazides has been developed under aerobic conditions for a stereoselective synthesis of 1,2-disubstituted alkenes. A range of aroyl hydrazides underwent palladium/copper-catalyzed oxidative Mizoroki-Heck reaction with terminal alkenes open to air in a 1:1 mixture of DMSO and acetonitrile to give structurally diverse 1,2-disubstituted alkenes in moderate to excellent yields with excellent regio- and E-selectivity. The reaction tolerated a wide variety of functional groups, such as alkoxy, hydroxy, amino, fluoro, chloro, bromo, cyano, nitro, ester, amide, imide, phosphine oxide, and sulfone groups, and, moreover, mol. oxygen and DMSO were demonstrated to serve as terminal oxidants. This study provides a useful method for the stereoselective synthesis of 1,2-disubstituted alkenes by a direct transformation of the vinylic carbon-hydrogen bonds (C-H bonds) in terminal alkenes.

Chemistry – A European Journal published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C8H14O4, SDS of cas: 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Zijian published the artcileCopper-Catalyzed (Di)Arylmethylation of Phosphorylamides Under Oxidative Conditions, Synthetic Route of 457-68-1, the publication is European Journal of Organic Chemistry (2018), 2018(48), 6857-6866, database is CAplus.

A compatible and practical (di)arylmethylation of phosphorylamides was successfully accessed in the presence of copper iodide as the catalyst, azodiisobutyronitrile as the radical initiator, and di-tert-Bu peroxide as the oxidant. Both methylarenes and diaryl methanes were compatible under the oxidative conditions, enjoying broad functional groups tolerance (51 examples) and good efficiency (up to 90 % yields).

European Journal of Organic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C40H35N7O8, Synthetic Route of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Yajun published the artcileIdentification and structure-activity studies of 1,3-Dibenzyl-2-aryl imidazolidines as novel Hsp90 inhibitors, Product Details of C16H20N2, the publication is Molecules (2019), 24(11), 2105, database is CAplus and MEDLINE.

Hsp90 (Heat shock protein 90) is involved in various processes in cancer occurrence and development, and therefore represents a promising drug target for cancer therapy. In this work, a virtual screening strategy was employed, leading to the identification of a series of compounds bearing a scaffold of 1,3-dibenzyl-2-aryl imidazolidine as novel Hsp90 inhibitors. Compound 4a showed the highest binding affinity to Hsp90a (IC₅₀ = 12 nM) in fluorescence polarization (FP) competition assay and the strongest anti-proliferative activity against human breast adenocarcinoma cell line (MCF-7) and human lung epithelial cell line (A549) with IC₅₀ values of 21.58 M and 31.22 M, resp. Western blotting assays revealed that these novel Hsp90 inhibitors significantly down-regulated the expression level of Her2, a client protein of Hsp90, resulting in the cytotoxicity of these novel Hsp90 inhibitors. The mol. docking study showed that these novel Hsp90 inhibitors bound to the ATP (ATP) binding site at the N-terminus of Hsp90. Furthermore, structure-activity relationship studies indicated that the N-benzyl group is important for the anti-cancer activity of 1,3-dibenzyl-2-aryl imidazolidines.

Molecules published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Product Details of C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Yong published the artcileAn Efficient Synthesis of N,N,N-Substituted 1,4,7-Triazacyclononane, HPLC of Formula: 140-28-3, the publication is European Journal of Organic Chemistry (2018), 2018(13), 1546-1551, database is CAplus.

A new and efficient synthetic approach is reported for various N,N,N-substituted 1,4,7-triazacyclononanes (TACN) in moderate to excellent yields, with optimization of the reaction sequences and conditions of the intermediate 1,4,7-tribenzyl-1,4,7-triazonane-2,6-dione reduction with LiAlH₄, removal of benzyl with Pd/C, and alkylation reactions. This reaction scheme provides a convenient and flexible method to prepare various N,N,N-substituted TACN derivatives

European Journal of Organic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Jianglong published the artcileCu(II)-Catalyzed Ligand-Free Oxidation of Diarylmethanes and Second Alcohols in Water, Safety of Bis(4-fluorophenyl)methane, the publication is Chinese Journal of Chemistry (2017), 35(9), 1391-1395, database is CAplus.

A simple and efficient Cu(II)-catalyzed ligand-free oxidation of diarylmethanes, e.g., 9H-xanthene and secondary alcs., e.g., 2,3-dihydro-1H-Inden-1-ol using 70% tert-Bu hydroperoxide (TBHP) in water were developed. A series of diarylmethanes were directly oxidized into diaryl ketones, e.g., 9H-xanthen-9-one in 67%-98% yields. Addnl., various secondary alcs. were also transformed into the desired products in 48%-98% yields. Importantly, the catalytic system in the absence of any organic solvent, surfactant, or phase transfer agent, had a wide substrate scope and a high tolerance for various functional groups.

Chinese Journal of Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C25H47NO8, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Bo published the artcileSyntheses and structure-activity relationship studies of N-substituted-¦Â-D-glucosaminides as selective cytotoxic agents, Application In Synthesis of 16909-09-4, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(23), 7110-7113, database is CAplus and MEDLINE.

Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups, e.g. I (R = H, R¹ = Me, OMe; R = OMe, R¹ = H), were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds I (R = H, R¹ = Me, OMe) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them, e.g. I (R = OMe, R¹ = H), showed strong inhibition against HT1080.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C7H10O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Mei published the artcileBiomimetic synthesis and anti-inflammatory effects of horsfiequinone A, Related Products of catalysis-chemistry, the publication is Tetrahedron Letters (2021), 152756, database is CAplus.

Inspired by the oxy-tyrosinase type II copper enzyme, a biomimetic synthesis of the natural product horsfiequinone A (I) has been achieved using CuOTf/DBED/O₂ catalyzed oxidation as a key step. The synthetic route furnished 1 in 33% overall yield (64% brsm) from com. available para-hydroxybenzaldehyde. Moreover, revisiting the biol. activity of 1 resulted in the discovery of its in vitro inhibitory activity towards nitric oxide (NO) production in LPS-induced RAW264.7 cells with an IC₅₀ value of 4.42 ¡À 0.81¦ÌM. The anti-inflammatory effect of 1 was further supported by an iNOS expression inhibition assay and mol. docking simulation.

Tetrahedron Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H9N3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Ren-Zhe published the artcileAsymmetric O-propargylation of secondary aliphatic alcohols, Safety of Difluorodiphenylsilane, the publication is Nature Catalysis (2020), 3(8), 672-680, database is CAplus.

Here, we report the development of a base-free, Cu-catalyzed propargylic substitution reaction that enables the efficient, asym. O-propargylation of secondary aliphatic alcs. Mechanistic studies implied key factors to slow down the undesired decomposition process of electrophiles in this reaction, which opened up the possibility of using secondary aliphatic alcs. as nucleophilic substrates. This asym. O-alkylation reaction proceeds under almost neutral conditions, tolerates a broad scope of functional groups and showed remarkable chemoselectivities. This method was amenable to the modification of natural products and com. drugs. The products obtained was readily elaborated to various classes of enantioenriched ¦Á,¦Á’-disubstituted ethers that were difficult to access by other methods.

Nature Catalysis published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Safety of Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia