Tag: M.W=200-250

Limanov, V. E. published the artcileSynthesis and bactericidal activity of salts of higher aliphatic amines, Recommanded Product: Dodecylamineacetate, the publication is Khimiko-Farmatsevticheskii Zhurnal (1983), 17(6), 675-9, database is CAplus.

Title salts were prepared by mixing the components in a nonpolar solvent. Their bactericidal activity decreased in the order secondary amine > primary amine > quaternary ammonium > tertiary amine salt.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Recommanded Product: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ehm, Christian published the artcileHow a Thermally Unstable Metal Hydrido Complex Can Yield High Catalytic Activity Even at Elevated Temperatures, Computed Properties of 312-40-3, the publication is Chemistry – A European Journal (2016), 22(27), 9305-9310, database is CAplus and MEDLINE.

Despite their instability in ethereal solvents, organotitanium hydride catalysts are successfully employed in catalysis at moderate to high temperatures (110 ¡ãC), even in the presence of alcs. It is shown computationally (bond dissociation energy (BDE) anal. and energetic profile for regeneration) and exptl. (EPR studies and kinetic studies), with the specific example of hydrodefluorination (HDF), that despite the long standing belief, regeneration of Ti-H bonds from Ti-F bonds using silanes is endergonic. The resulting low concentration of Ti-H species is crucial for the catalytic stability of those systems. The resting state in the catalysis is a Ti-F species. The most promising silanes for regeneration are not the ones that have the strongest Si-F bond, but the ones that show the largest difference in Si-F and Si-H BDEs.

Chemistry – A European Journal published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Computed Properties of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Padwa, Albert published the artcileRhodium(II)-catalyzed cyclization reactions of alkynyl-substituted ¦Á-diazo ketones, Safety of Allyldiphenylphosphine oxide, the publication is Journal of Organic Chemistry (1991), 56(7), 2523-30, database is CAplus.

Treatment of several o-alkynyl-substituted ¦Á-diazoacetophenone derivatives with rhodium(II) carboxylates results in the formation of substituted indenones. The simplest mechanism accounting for the results involves addition of a rhodium-stabilized carbenoid onto the acetylenic ¦Ð-bond to generate a vinyl carbenoid directly or possibly a highly strained cyclopropene derivative The vinyl carbenoid was found to undergo addition to a neighboring alkene tethered on the side chain to give an indenyl-substituted bicyclo[3.1.0]hexane derivative A number of related systems were examined so as to probe the scope and generality of the process. Treatment of 2-[CH₂:CHCH:CH(CH₂)₃Cú·C]C₆H₄COCHN₂ with rhodium(II) mandelate afforded a benzocyclopent[g]azulenone derivative I. The formation of this compound involves a divinylcyclopropane intermediate that readily undergoes a Cope rearrangement under the reaction conditions. The rhodium-catalyzed reaction of 2-[MeCO(CH₂)₃Cú·C]C₆H₄COCHN₂ in the presence of N-phenylmaleimide afforded a mixture of two cycloadducts II and III. Product II can be accounted for in terms of a cyclization of the vinyl carbenoid onto the oxygen atom of the neighboring carbonyl group to give a resonance-stabilized dipole. 1,3-Dipolar cycloaddition of the carbonyl ylide across the activated ¦Ð-bond of N-phenylmaleimide affords the observed product. The structure of II was confirmed by x-ray anal. The second cycloadduct III is formed by a 1,2-hydrogen shift of the initially produced vinyl carbenoid. The resulting diene undergoes a subsequent Diels-Alder reaction with N-phenylmaleimide.

Journal of Organic Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Safety of Allyldiphenylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Garcia, Joel published the artcilePhysical Properties of Eu²⁺-Containing Cryptates as Contrast Agents for Ultrahigh-Field Magnetic Resonance Imaging, Synthetic Route of 5411-14-3, the publication is European Journal of Inorganic Chemistry (2012), 2012(12), 2135-2140, database is CAplus and MEDLINE.

The kinetic stabilities and relaxivities of a series of Eu²⁺-containing cryptates have been investigated. Transmetallation studies, which monitored the change in the longitudinal relaxation rate of water protons in the presence of Ca²⁺, Mg²⁺, and Zn²⁺, demonstrated that the cryptate structure influenced the stability, and two of the cryptates studied were inert to transmetalation in the presence of these endogenous ions. The efficacy of these cryptates was determined at different magnetic field strengths, temperatures, and pH values. Cryptate relaxivity was found to be higher at ultrahigh field strengths (7 and 9.4 T) relative to clin. relevant field strengths (1.4 and 3 T), but the efficiency of these cryptates decreased as the temperature increased. In addition, a variation in pH did not yield significant changes in the efficacy of the cryptates. These studies establish a foundation of important properties that are necessary to develop effective pos. contrast agents for magnetic resonance imaging from Eu²⁺-containing cryptates.

European Journal of Inorganic Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Synthetic Route of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Changqing published the artcileHighly Stereoselective Cationic Cyclization Assisted by a Sulfenyl Group. Scope, Limitation, and Mechanism, Quality Control of 22693-41-0, the publication is Journal of Organic Chemistry (1996), 61(2), 494-502, database is CAplus and MEDLINE.

When 8-acetoxy-2-methyl-9-(phenylthio)-2-nonene (1) was treated with an acid, followed by a base, alkylative cyclization proceeded to give a mixture of 1,2-disubstituted cyclohexanes. The stereochem. of the reaction was only slightly affected by the leaving group and the reaction conditions, such as the temperature, solvent, and acid. However, the bulkiness of the sulfenyl group had a great effect on the stereochem. course of the reaction. High trans selectivity was attained when a derivative of 1 with a bulkier sulfenyl group was used as a substrate. On the other hand, the length and rigidity of the carbon chain of the substrate also had a major effect on the stereochem. of the reaction; a high cis selectivity was observed when a one-carbon-fewer analog of 1 or a derivative with one more double bond in the carbon chain than in 1 was used as the substrate. The reaction proceeded via a 6,5- or 5,5-fused-ring intermediate. The sulfenyl-group-assisted reaction could be a useful method for the stereoselective cyclization of acetates of ¦Á-sulfenylated secondary alcs.

Journal of Organic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Quality Control of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Narkevich, V. B. published the artcileEffects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57BL/6 mice: a comparative study, Related Products of catalysis-chemistry, the publication is Eksperimental’naya i Klinicheskaya Farmakologiya (2008), 71(5), 8-12, database is CAplus and MEDLINE.

The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied. Significant interstrain differences in the content of norepinephrine (NE), dopamine (DA), serotonin (5-HT) as well as in the levels of their metabolites in hippocampus, hypothalamus, striatum and frontal cortex of C57Bl/6 and BALB/C mice were demonstrated. In particular, the content of 5-HT and its metabolite 5-oxyindolacetic acid (5-HIAA) in hippocampus of BALB/C mice (with passive stress response) was higher than in the same structure of C57Bl/6 (stress-susceptible) animals. The injection of selank (0.3 mg/kg) led to an increase in the NE level in the hypothalamus of both mice strains. At the same time, selank produced opposite effects on the content of DA metabolites: the concentrations of dioxyphenylacetic (DO-PAC) and homovanillic (HVA) acids were found to increase in frontal cortex and hippocampus of C57Bl/6 mice, while the same parameters in BALB/C mice were demonstrated to decrease. Selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice, but did not affect these parameters in C57Bl/6 animals. The obtained results are indicative of selectivity of the anxiolytic effects of selank.

Eksperimental’naya i Klinicheskaya Farmakologiya published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ovseenko, L. V. published the artcileStructure formation in the solutions of aliphatic amines by solubilization of monohydric alcohols, Formula: C14H31NO2, the publication is Kolloidnyi Zhurnal (1993), 55(6), 70-3, database is CAplus.

The influence of aliphatic alcs. (n-hexanol, n-octanol) on micellar properties was studied for solutions of primary aliphatic amine acetates with alkyl chain lengths C₁₂-C₁₈. Small amounts of the alcs. decrease the CMC₁ of amine salt and increase the CMC₂, broadening the region of spherical micelle existence. This in turn influences the state of these collectors in concentrated electrolyte solutions, and their adsorption and flotation activities.

Kolloidnyi Zhurnal published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ovseenko, L. V. published the artcileBulk properties of solutions of the acetates of primary aliphatic amines, Name: Dodecylamineacetate, the publication is Kolloidnyi Zhurnal (1992), 54(1), 121-4, database is CAplus.

The colloid-chem. properties of aqueous primary aliphatic amine acetates containing C₁₂-C₁₈ hydrocarbon radicals were studied by conductometric and viscosimetric methods. The critical concentrations of spherical micelle formation (CCM_I) and of the transition of micelles from the spherical to nonspherical form (CCM_II) were determined This is accompanied by a decrease in the molar volume of a hydrated micelle and by a change in the structural-rheol. properties of the system.

Kolloidnyi Zhurnal published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Name: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Brand, Yaneth M. published the artcileCombretastatin A-4: the antitubulin agent that inspired the design and synthesis of styrene and spiroisatin hybrids as promising cytotoxic, antifungal and antiviral compounds, COA of Formula: C10H11NO4, the publication is Journal of the Brazilian Chemical Society (2020), 31(5), 999-1010, database is CAplus.

The design of a series of styrene and spiroisatin hybrids was based on the structure of combretastatin A-4 1. This library of 20 compounds were synthesized with the pharmacophoric units: 3,4,5-trimethoxy or/and 4-hydroxy-3-methoxy Ph moities in their structure. Thereby, the libraries of beta-nitrostyrenes 10a-10c, spiroisatin-dihydroquinolines 14a-14c, spiroisatinthiazolidinones 17a-17c and spiroisatin-nitropyrrolizidines 20a-20k were evaluated for their in vitro cytotoxic, anti-proliferative, antifungal and antiviral activities. Biol. results revealed that among these compounds, beta-nitrostyrenes 10a-10c exhibited significant cytotoxicity (HeLa and Jurkat tumor cells) and antifungal (T. mentagrophytes) activities. Moreover, the spiroisatindihydroquinoline 14a and 14c showed promising cytotoxicity (U937 cells). 14a-14c mols. were active against human herpesviruses serotypes 1 and 2 (HHV-1 and HHV-2), but only 14a and 14b were effective against dengue virus serotype 2 (DENV-2). The spiroisatin-nitropyrrolizidine 20c exhibited moderate anti-herpetic activity, while 17c spiroisatin-thiazolidinone derivative also reduced the infection of HHV-1 and DENV-2. Finally, the mol. docking showed that these kind of mols. interact with the subunit a/beta-tubulin.

Journal of the Brazilian Chemical Society published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, COA of Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Puerto Galvis, Carlos E. published the artcileRegio- and stereoselective synthesis of spirooxindole 1′-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using the zebrafish (Danio rerio) embryo model, Category: catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2013), 11(42), 7372-7386, database is CAplus and MEDLINE.

A highly regio- and stereoselective method has been developed and expanded for the synthesis of a 20-membered library of spirooxindole 1′-nitro pyrrolizidines, e.g. I, via 1,3-dipolar cycloaddition of azomethine ylides, generated in situ by a decarboxylative route from a common set of diverse isatins and L-proline derivatives, with substituted ¦Â-nitrostyrenes under aqueous medium. Among various reaction conditions, water proved to be necessary for the interaction of the reagents as well as heating the reaction at 90¡ã for one hour, during which time the desired products were obtained in good yields and with excellent regio- and stereoselectivities. We subsequently applied in silico drug discovery computational methods to (i) identify the ADME properties, based on Lipinski’s rule, (ii) screen the toxicol. profile, and (iii) predict the penetration through the blood brain barrier (BBB) of the synthesized compounds Next, the LC₅₀ values of all these spirocyclic oxindoles were determined in zebrafish embryos cultured individually in buffer solutions of each compound and, finally, the phenotypes induced by these mols. in the zebrafish embryos at concentrations below their LC₅₀ were analyzed at 48, 72 and 96 h post fertilization.

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia