Tag: M.W=200-250

Hsu, I-Nan published the artcileDissociation constants of four disubstituted cinnamic acids, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Journal of the Indian Chemical Society (1967), 44(6), 540-1, database is CAplus.

The apparent pK values of trans-2,3-dimethoxycinnamic acid, trans-2,4-dimethoxycinnamic acid, trans-3,4-dimethoxycinnamic acid, and trans-3,5-dimethoxycinnamic acid were calculated at various concentrations, and extrapolation to a bulk concentration of 0 gives pK 4.37 ¡À 0.03, 4.80 ¡À 0.03, 4.53 ¡À 0.03, and 4.36 ¡À 0.003, resp. It is assumed that the activity coefficient of the undissociated acid is unity. Inductive and mesomeric effects are discussed.

Journal of the Indian Chemical Society published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Dejian published the artcileFacile and Reversible Cleavage of C-F Bonds. Contrasting Thermodynamic Selectivity for Ru-CF₂H vs F-Os:CFH, Application of Trimethyl(perfluorophenyl)silane, the publication is Journal of the American Chemical Society (2000), 122(37), 8916-8931, database is CAplus.

In the presence of a catalytic amount of F^– (CsF), Me₃SiR_f (R_f = CF₃ and C₆F₅) exchanges R_f with fluoride of the 16-electron complexes MHF(CO)L₂ (M = Ru, Os; L = PⁱPr₃, P^tBu₂Me) to give Me₃Si-F and the unsaturated pentafluorophenyl complexes, MH(C₆F₅)(CO)L₂, or (when R_f = CF₃) saturated fluorocarbene complexes, MHF(CF₂)(CO)L₂, via ¦Á-F migration. X-ray crystal structure and solution ¹⁹F NMR studies reveal that, in the ground state, the three atoms of the CF₂ group lie in a plane perpendicular to the P-Ru-P axis so that the ¦Ð-back-donation is maximized and the carbene substituents are inequivalent. Having hydride trans to the CF₂ ligand, MHF(CF₂)(CO)L₂ is a kinetic product, which converts to a thermodn. isomer. For Ru, the final product is a 16e complex, RuF(CF₂H)(CO)L₂, formed by combination of CF₂ and hydride. For Os, the product is an 18e complex, OsF₂(:CFH)(CO)L₂, resulting from exchange of one carbene fluoride with the hydride. The distinct difference between Os and Ru demonstrates the principle that 3rd-row transition metals show a pronounced tendency toward a higher oxidation state. The isomerization mechanism involves phosphine dissociation as a slow step. Coordinatively saturated RuHF(CF₂)(CO)L₂ reacts with CO within the time of mixing to give the F and CF₂ recombination product, RuH(CF₃)(CO)₂L₂. This unexpectedly fast carbonylation reaction, as well as ¹⁹F spin saturation transfer experiments, reveals the existence of a fast ¦Á-F migration equilibrium between RuHF(CF₂)(CO)L₂ and RuH(CF₃)(CO)L₂ in solution In sharp contrast, the Os analog does not have such a fast equilibrium, and therefore it does not react with CO at room temperature At higher temperature, reaction occurs forming the hydride and fluoride exchanged product, Os(CHF₂)(F)(CO)₂L₂. The contrasting behavior of Ru vs. Os regarding stability of fluoroalkyl and fluorocarbene is discussed on the basis of the theor. calculations, which also provide insight into the isomerization of RuHF(CF₂)(CO)L₂. Hydrogenolysis of Ru(CF₂H)F(CO)L₂ liberates CH₂F₂, forming RuHF(CO)L₂.

Journal of the American Chemical Society published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Application of Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Enterling, Detlev published the artcileSubstitution and ring coupling in the cyclotrisilazane system, Formula: C12H10F2Si, the publication is Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie (1978), 33B(5), 527-32, database is CAplus.

Fluorosilanes, chlorodiorganylboranes and chlorotrimethylstannane react with lithiated cyclotrisilazanes with LiF elimination and substitution. Thus, reaction of I with F₃SiCHMeEt gave 85% II. Mixed substituted compounds are obtained by the reaction of lithiofluorosilylcyclotrisilazanes with other fluorosilanes. Reaction of I with 2-chloro-1,3,4,5,6-pentamethylborazine gave III. The reaction of IV with BuLi gave V.

Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Formula: C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Walter, Simone published the artcileSynthesis of unsymmetrical trisilylamines with rotational barriers, Formula: C12H10F2Si, the publication is Zeitschrift fuer Naturforschung, B: Chemical Sciences (1991), 46(9), 1149-60, database is CAplus.

Bis- and tris(fluorosilyl)amines with bulky groups are prepared in the reaction of lithiated di-tert-butylfluorosilylamine with fluorosilanes. Tris(fluorosilyl)amines with 3 different silyl groups could be synthesized stepwise in these reactions. In all tris(fluorosilyl)amines a rotational barrier is observed by NMR spectroscopy at room temperature The compounds (Me₃C)₂SiFN(SiFRR¹) (R = R¹ = Me; R = F, R¹ = CMe) and (Me₃C)₂SiFN(SiFR₂)SiF₂R¹ [I; R = CMe₃, R¹ = CMe₃, Ph (II)] show only one structural isomer, whereas the compounds I [R = CMe₃, R¹ = F (III); R = CHMe₂, R¹ = Ph; R = Ph, R¹ = Me] show 2 structural isomers. The crystal structures of II and III were determined

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C9H17NO, Formula: C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Frohn, H. J. published the artcileReactions of pentafluorophenylxenon(II) hexafluoroarsenate [C₆F₅Xe]⁺[AsF₆]^– with aromatic compounds, Name: Trimethyl(perfluorophenyl)silane, the publication is Journal of Fluorine Chemistry (1993), 64(3), 201-15, database is CAplus.

Pentafluorophenylxenon(II) hexafluoroarsenate, [C₆F₅Xe]⁺[AsF₆]^–, reacts (MeCN, 20¡ã) with aromatic compounds C₆H₅X (X = Me, F, CF₃, NO₂ and CN), yielding isomeric mixtures of polyfluorinated biphenyls XC₆H₄C₆F₅. When X = I, iodopentafluorobenzene is also formed, whereas trimethylsilylbenzene (X = SiMe₃) is only converted to C₆H₅C₆F₅ and C₆F₅H. These results are compared with the data for radical pentafluorophenylation and for fluorination reactions of the corresponding aromatic compounds with XeF₂. Polyfluoroarom. compounds C₆F₆, C₆F₅H, C₆F₅I, C₆F₅CN and C₆F₅SiMe₃ do not react with [C₆F₅Xe]⁺[AsF₆]^– under the same conditions.

Journal of Fluorine Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Name: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lupp, Amelie published the artcileIn vitro investigations on the interactions of different fomocaine metabolites with rat microsomal cytochrome P450, HPLC of Formula: 31719-76-3, the publication is Nova Acta Leopoldina (2003), 87(329), 253-264, database is CAplus.

Fomocaine is an ether-type local anesthetic used in dermatol. practice for surface anesthesia. In view of possible new (systemic) applications, e.g. in the therapy of migraine or as an antiarrhythmic, knowledge of interactions also of its metabolites with the cytochrome P 450 system and thus with the metabolism of endogenous or other foreign substances is of importance. Thus, in the present study effects of thirteen fomocaine metabolites on liver P 450 mediated monooxygenase functions were assessed by measuring the influence on the model reactions ethoxyresorufin O-deethylation, ethoxycoumarin O-deethylation, pentoxyresorufin O-depentylation and ethylmorphine N-demethylation. Possible (potentially beneficial) antioxidative capacities of the compounds were evaluated by the influence on luminol and lucigenin amplified chemiluminescence, H₂O₂ production, and stimulated lipid peroxidation in rat liver microsomes and on rat whole blood chemiluminescence. Fomocaine inhibited all four model reactions for P 450 mediated monooxygenase functions in micromolar concentrations In general, the effects of the metabolites were much less pronounced than those of fomocaine. Only 2-hydroxyfomocaine yielded similar effects as fomocaine. A noticeable inhibition of the model reactions was also seen with 4-hydroxyfomocaine. This effect was, however, already distinctly less than that of fomocaine. The overall antioxidative capacity of fomocaine was not very pronounced. Many of the metabolites, especially those containing a phenolic group, displayed a stronger antioxidative capacity than fomocaine. Again, effects were most pronounced with 2-hydroxy- and 4-hydroxyfomocaine. Considering all effects of the metabolites tested, it is to be expected that after systemic application biotransformation of fomocaine to these metabolites will lead to a decrease in the overall interactions with the P 450 system and to an increase in the antioxidative capacity on the whole.

Nova Acta Leopoldina published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, HPLC of Formula: 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lelikova, V. E. published the artcileDonor-acceptor properties of organosilicon compounds. III. Binary systems of aprotic solvents with some alkyl(aryl)fluoro-, methylphenyldichloro-, tetraethoxy-, and trimethylphenylsilanes, SDS of cas: 312-40-3, the publication is Zhurnal Obshchei Khimii (1973), 43(6), 1300-4, database is CAplus.

The property-composition curves for the binary systems of solvents, e.g., OP(NMe2)3, Me2NAc, Me2SO, MeNO2, PhNO2, PhF, AcPh, and pyridine, with MeSiPhCl2, Si(OEt)4, Me3SiPh, Ph2SiF2, PhSiF3, Et3SiF, and MeSiPhF2 were determined The plots of variation of nd and d. showed that interaction took place only in cases in which a SiF bond existed, or in which MeSiPhCl2 was a component. The acceptor ability of fluorosilanes decreased in the order: PhSiF3, Ph2SiF2, MeSiPhF2, Et3SiF. MeSiPhCl2 was superior to its difluoro analog with respect to donor-acceptor reactions.

Zhurnal Obshchei Khimii published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, SDS of cas: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Park, Seol Rin published the artcile2-Methylacrylamide as a bioisoster of thiourea group for 1,3-dibenzylthioureido TRPV1 receptor antagonists, HPLC of Formula: 1798-04-5, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(11), 2080-2083, database is CAplus and MEDLINE.

In order to replace thiourea group with the more drug-like moiety for 1,3-dibenzylthioureas having TRPV1 antagonist activity, we introduced a set of functional groups between the two aromatic rings based on bioisosteric replacement. The synthesized bioisosteres of 1,3-dibenzylthioureas were tested for their antagonist activities on TRPV1 by ⁴⁵Ca²⁺-influx assay using neonatal rat cultured spinal sensory neurons. Among the tested 14 kinds of bioisosters, 2-methylacrylamide group was the best candidate to replace thiourea group. Compound 7c, 2-methylacrylamide analog of ATC-120, showed as potent as ATC-120 in its antagonist activity. In addition, 2-methylacrylamide analog 7e having vinyl moiety showed the most potent activity with 0.022¦ÌM of IC₅₀ value, indicating that thiourea group of 1,3-dibenzylthioureas could be replaced to 2-methylacrylamide without loss of their potencies.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Jee-Hyun published the artcileSynthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/¦Â-catenin pathway, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(15), 3529-3532, database is CAplus and MEDLINE.

We synthesized (+)-decursin derivatives substituted with cinnamoyl- and Ph propionyl groups originating from (+)-CGK062 and screened them using a cell-based assay to detect relative luciferase reporter activity. Of this series, compound I, in which a 3-acetoxy cinnamoyl group was introduced, most potently inhibited (97.0%) the Wnt/¦Â-catenin pathway. Specifically, compound I dose-dependently inhibited Wnt3a-induced expression of the ¦Â-catenin response transcription (CRT) and increased ¦Â-catenin degradation in HEK293 reporter cells. Furthermore, compound I suppressed expression of the downstream ¦Â-catenin target genes cyclin D1 and c-myc and suppressed PC3 cell growth in a concentration-dependent manner.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kang, Ki-Tae published the artcileOne-Pot Catalytic Enantioselective Synthesis of Functionalized Tetrahydroquinolines by Aza-Michael/Michael Cascade Reactions of N-Protected 2-Aminophenyl ¦Á,¦Â-Unsaturated Esters with Nitroolefins, Application of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Synthesis (2014), 46(24), 3365-3373, database is CAplus.

A highly enantioselective synthesis of functionalized tetrahydroquinolines with useful biol. properties was developed by asym. organocatalytic aza-Michael/Michael cascade reactions of nitroolefins with N-protected 2-aminophenyl ¦Á,¦Â-unsaturated esters in the presence of a chiral thiourea catalyst. The reaction gave the corresponding highly functionalized tetrahydroquinolines in good yields, excellent diastereoselectivities (>30:1 dr), and high enantioselectivities (¡Ü99% ee).

Synthesis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Application of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia