Month: November 2022

Harders, H. published the artcileUrinary copper excretion from rats following administration of aliphatic and alicyclic polyamines, Safety of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Arzneimittel-Forschung (1980), 30(2), 254-8, database is CAplus and MEDLINE.

The effect of oral aliphatic and alicyclic tetramines and tetramine analogs (with 2 N-atoms substituted by O) on Cu excretion was compared with that of D-penicillamine in rats. TETA-HCl (3,6-diazaoctan-1,8-diamine-2HCl) [38260-01-4] and BE 6184-HCl (3,7-diazanonan-1,9-diamine-3HCl) [73510-17-5] were the most active substances. However, simultaneous administration of TETA and D-penicillamine did not potentiate the cupriuretic effect. TETA, s.c. administered, was 3-fold more effective than the orally administered drug.

Arzneimittel-Forschung published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Safety of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dilman, Alexander D. published the artcileTrifluoromethylation of N-Benzoylhydrazones, Quality Control of 1206-46-8, the publication is Journal of Organic Chemistry (2008), 73(14), 5643-5646, database is CAplus and MEDLINE.

A method for the nucleophilic trifluoromethylation of N-benzoylhydrazones using Me₃SiCF₃/AcONa leading to hydrazides, e.g., I (R = H, MeO, NO₂), has been described. The C=N bond of the hydrazones is activated by difluoroboron group, which is introduced by means of boron trifluoride and allylsilane.

Journal of Organic Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Quality Control of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dilman, Alexander D. published the artcileTrifluoromethylation of Salicyl Aldimines, Name: Trimethyl(perfluorophenyl)silane, the publication is Journal of Organic Chemistry (2007), 72(22), 8604-8607, database is CAplus and MEDLINE.

A method for the nucleophilic trifluoromethylation of salicyl aldimines, which do not contain an activating group at the nitrogen atom, has been described. The reaction proceeds through the initial generation of an intramol. boron complex followed by interaction with Me₃SiCF₃ activated by sodium acetate. Thus, BF₃.OEt₂ was added dropwise to a solution of imine I and EtN(i-Pr)₂ in CH₂Cl₂. After stirring for 2 h at room temperature, the solvent was evaporated in a vacuum followed by successive addition of DMF, Me₃SiCF₃, and AcONa to give up to 86% trifluoromethylated product II.

Journal of Organic Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Name: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Fan published the artcileHalogen Bond Induced Consecutive Csp³-H Aminations via Hydrogen Atom Transfer (HAT) Relay Strategy, Quality Control of 457-68-1, the publication is Organic Letters (2020), 22(6), 2135-2140, database is CAplus and MEDLINE.

An uncommon use of halogen bonding to induce intermol. Csp³-H amination while enabling a HAT relay strategy to access privileged pyrrolidines I [R = Me, Et, 4-OMeC₆H₄; Ar = Ph, 4-FC₆H₄, 4-BrC₆H₄, etc.] directly from alkanes was disclosed. Mechanistic studies support the presence of multiple halogen bond interactions at distinct reaction stages.

Organic Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C8H19NO2, Quality Control of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ciftci, Esengul published the artcileSynthesis and characterization of Manganese(II), Cobalt(II) and Copper(II) coordination polymers with a flexible zwitterionic based ligand, COA of Formula: C14H14, the publication is Polyhedron (2021), 115419, database is CAplus.

Four new coordination polymers, formulated as {[MnCl(μ-bipna)](NO₃)·2H₂O}_n (1), {[CoCl₂(μ-bipna)]·2H₂O}_n (2), {[CuCl(μ₄-bipna)]BF₄·2H₂O}_n (3) and {[CuCl(μ₄-bipna)]ClO₄·2H₂O}_n (4) where H₂bipnaBr₂ = 1,1′-(1,1′-biphenyl-4,4′-diylbis(methylene))bis(3-carboxypyridin-1-ium) bromide, were synthesized under solvothermal conditions. Their structures were characterized by single crystal and powder x-ray diffraction analyses, IR spectra (IR) and elemental analyses. Complexes 1, 3 and 4 are isostructural and display 3-fold interpenetrated 2D â†?2D structures with sql topol. and the point symbol 4⁴.6². Complex 2 exhibits a 1D coordination polymer structure, which becomes a stacked 3D supramol. structure by hydrogen bonding and π···π interactions. The structural diversity of the compounds could be due to the conformation of the flexible zwitterionic ligands. In 2, the bipna ligand displays a cis-conformation, while in the other compounds the ligand shows a trans-conformation. The thermal and optical properties of the compounds were studied.

Polyhedron published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, COA of Formula: C14H14.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shahne, Maryam Zare published the artcileParticulate emissions of real-world light-duty gasoline vehicle fleet in Iran, Name: Coronene, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 292(Part_A), 118303, database is CAplus and MEDLINE.

Fine particulate matter cause profound adverse health effects in Iran. Road traffic is one of the main sources of particulate matter (PM) in urban areas, and has a large contribution in PM_2.5 and organic carbon concentration, in Tehran, Iran. The composition of fine PM vehicle emission is poorly known, so this paper aims to determine the mixed fleet source profile by using the analyzed data from the two internal stations and the emission factor for PM light-duty vehicles emission. Tunnels are ideal media for extraction vehicle source profile and emission factor, due to vehicles are the only source of pollutant in the urban tunnels. In this study, PM samples were collected simultaneously in two road tunnel stations and at a background site in Niyayesh tunnel in Tehran, Iran. The tunnel samples show a large contribution for some elements and ions, such as Fe (0.23μg μg^-1 OC), Al (0.02μg μg^-1 OC), Ca (0.055μg μg^-1 OC), SO4 (0.047μg μg^-1 OC), Docosane (0.0017μg μg^-1 OC), Triacontane (0.016μg μg^-1 OC), Anthracenedione (0.0003μg μg^-1 OC) and Benzo-perylene (0.0002μg μg^-1 OC). In overall, on-road gasoline vehicle fleets source profile extracted in this study is similar to composite profiles derived from roadside tunnel measurment performed in other countries during the last decades. The PM_2.5 emission factor for Tehran’s light-duty vehicle fleet has been extracted 16.23 mg km^-1. vehicle^-1 and 0.09 g kg^-1. The profile would be used for Chem. Mass Balance Model studies for Iran and other countries with a similar road traffic fleet mix. Also, it would be very suitable for use in emission inventories improvement. The results of this study can be used for choosing the best management strategies and provide comperhensive insight to fine PM traffic emission in Tehran.

Environmental Pollution (Oxford, United Kingdom) published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C39H35N5O8, Name: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ates, Havva published the artcileAdvanced oxidation of landfill leachate: Removal of micropollutants and identification of by-products, Application In Synthesis of 2051-95-8, the publication is Journal of Hazardous Materials (2021), 125326, database is CAplus and MEDLINE.

Landfill leachate contains several macropollutants and micropollutants that cannot be removed efficiently by conventional treatment processes. Therefore, an advanced oxidation process is a promising step in post or pre-treatment of leachate. In this study, the effects of Fenton and ozone oxidation on the removal of 16 emerging micropollutants including polycyclic aromatic hydrocarbons (PAHs), phthalates, alkylphenols and pesticides were investigated. The Fenton and ozone oxidation of the leachate were performed with four (reaction time: 20-90 min, Fe(II) dose: 0.51-2.55 g/L, H₂O₂ dose: 5.1-25.5 g/L and pH: 3-5) and two (ozonation time: 10-130 min and pH: 4-10) independent variables, resp. Among these operating conditions, reaction time played more significant role (p-value < 0.05) in eliminating di-(2-Ethylhexyl) phthalate, 4-nonylphenol and 4-tert-octylphenol for both processes. The results showed that Fenton and ozone oxidation processes had a high degradation potential for micropollutants except for the PAHs including four and more rings. Removal efficiencies of micropollutants by ozone and Fenton oxidation were determined in the range of 5-100%. Although the removal efficiencies of COD (COD) and some micropollutants such as phthalates were found much higher in the Fenton process than ozonation, the degradation products occurred during the Fenton oxidation were a higher mol. weight Moreover, the oxidation intermediates for the both processes were found as mainly benzaldehyde, pentanoic acid and hydro cinnamic acid as well as derivatives of naphthalenone and naphthalenediol. Also, acid ester with higher mol. weight, naphthalene-based and phenolic compounds were detected in the Fenton oxidation

Journal of Hazardous Materials published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Application In Synthesis of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Perols, Anna published the artcileSite-Specific Antibody Labeling by Covalent Photoconjugation of Z Domains Functionalized for Alkyne-Azide Cycloaddition Reactions, SDS of cas: 1395786-30-7, the publication is ChemBioChem (2015), 16(17), 2522-2529, database is CAplus and MEDLINE.

Antibodies are extensively used in research, diagnostics, and therapy, and for many applications the antibodies need to be labeled. Labeling is typically performed by using amine-reactive probes that target surface-exposed lysine residues, resulting in heterogeneously labeled antibodies. An alternative labeling strategy is based on the IgG (IgG)-binding protein domain Z, which binds to the Fc region of IgG. Introducing the photoactivable amino acid benzoylphenylalanine (BPA) into the Z domain makes it possible for a covalent bond to be be formed between the Z domain and the antibody on UV irradiation, to produce a site-specifically labeled product. Z₃₂BPA was synthesized by solid-phase peptide synthesis and further functionalized to give alkyne-Z₃₂BPA and azide-Z₃₂BPA for Cu^I-catalyzed cycloaddition, as well as DBCO-Z₃₂BPA for Cu-free strain-promoted cycloaddition The Z₃₂BPA variants were conjugated to the human IgG1 antibody trastuzumab and site-specifically labeled with biotin or fluorescein. The fluorescently labeled trastuzumab showed specific staining of the membranes of HER2-expressing cells in immunofluorescence microscopy.

ChemBioChem published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C25H21N3O4, SDS of cas: 1395786-30-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gonzalez-Perez, Jose A. published the artcileMolecular features of organic matter in diagnostic horizons from andosols as seen by analytical pyrolysis, Application of 2,4,6-Trimethoxybenzenethiol, the publication is Journal of Analytical and Applied Pyrolysis (2007), 80(2), 369-382, database is CAplus.

Andosols are usually formed from volcanic substrates, with thick A horizons high in organic carbon mainly in the form of stabilized humic fractions. The peculiar properties of these soils are, to large extent, affected by poorly crystalline materials like allophanes, imogolite and other Fe and Al oxyhydroxides that induce intense organo-mineral interactions which are considered to play a relevant role in OM protection against biodegradation as regards other soils developed under similar climatic conditions. Little is known about the mol. composition of this stabilized OM in a soil scenario often considered as an efficient C-sink in terms of C sequestration processes. Whole soil samples in addition to isolated humic and fulvic acids from organic A horizons of three soils with andic properties and one non-andic soil (Sodic Cambisol) from the island of Tenerife (Canary Islands, Spain) were analyzed by double shot pyrolysis-gas chromatog.-mass spectrometry (Py-GC/MS) in order to get some insight on the mol. composition of different structural domains of progressive structural stability. Clear differences were found between soils, both in thermal desorption and pyrolysis behavior of humic substances. In general the results suggest large yields of aliphatic (both alkyl and carbohydrate-derived pyrolysis compounds) pointing to high-performance processes of incorporation of aliphatic humic constituents in andosols probably favored by interactions with amorphous minerals, whereas in non-andic soils the latter are comparatively less stabilized and are removed in early pyrolysis stages as if they occurred as loosely joined, thermoevaporation-released products. In fact, compared to Cambisol, humic and fulvic acids from andic soils led to comparatively richer pyrograms and compound assemblages. The lack of similar amounts of these loosely joined, mainly aliphatic structures after thermal desorption of the whole andic soils indicate an origin for humic substances based on rapid sequestration of C-forms of recent (litter or microbial) origin.

Journal of Analytical and Applied Pyrolysis published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Application of 2,4,6-Trimethoxybenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rocha, Ana Fatima Braga published the artcileTreatment administered to newborns with congenital syphilis during a penicillin shortage in 2015, Fortaleza, Brazil, Computed Properties of 140-28-3, the publication is BMC Pediatrics (2021), 21(1), 166, database is CAplus and MEDLINE.

Between 2014 and 2016, Brazil experienced a severe shortage in penicillin supply, resulting in a lack of treatment among some pregnant women and newborns with syphilis and the use of non-evidence-based regimens. This study evaluated all live births in Fortaleza reported with CS in 2015 in order to identify the different therapeutic regimens used in newborns during this period of penicillin shortage. A retrospective cross-sectional study design was conducted using manually extracted data from medical chart review of maternal and infant cases delivered in 2015 from all public maternity hospitals in the city of Fortaleza. Data collection occurred from June 2017 to July 2018. A total of 575 congenital syphilis cases were reported to the municipality of Fortaleza during 2015 and 469 (81.5%) were analyzed. Of these, only 210 (44.8%) were treated with a nationally-recommended treatment. As alternative therapeutic options, ceftriaxone was used in 65 (13.8%), Cefazolin in 15 (3.2%) and the combination of more than one drug in 179 (38.2%). Newborns with serum VDRL titers �:16 (p = 0.021), who had some clin. manifestation at birth (p = 0.003), who were born premature (p < 0.001), with low birth weight (p = 0.010), with jaundice indicative of the need for phototherapy (p = 0.019) and with hepatomegaly (p = 0.045) were more likely to be treated with penicillin according to national treatment guidelines compared to newborns treated with other regimens. During the period of shortage of penicillin in Fortaleza, less than half of the infants reported with CS were treated with a nationally-recommended regimen, the remaining received treatment with medications available in the hospital of birth including drugs that are not part of nationally or internationally-recommended treatment recommendations.

BMC Pediatrics published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Computed Properties of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia