Month: November 2022

Ohki, Yasuhiro published the artcileSynthesis and Characterization of Bioinspired [Mo₂Fe₂]-Hydride Cluster Complexes and Their Application in the Catalytic Silylation of N₂, Product Details of C15H24S, the publication is Chemistry – A European Journal (2017), 23(53), 13240-13248, database is CAplus and MEDLINE.

The hydride-supported [Mo₂Fe₂] cluster complex {Cp*Mo(PMe₃)}₂{FeN(SiMe₃)₂}₂(H)₈ (2a; Cp*=η⁵-C₅Me₅) and its [Mo₂Mn₂] congener 2b were synthesized from the reactions of Cp*Mo(PMe₃)(H)₅ (1) with M{N(SiMe₃)₂}₂ (M=Fe, Mn). The amide-to-thiolate ligand-exchange reactions of complex 2a with bulky thiol reagents (HSR; R=2,4,6-iPr₃C₆H₂ (Tip), 2,6-(SiMe₃)₂C₆H₃ (Btp)) furnished the corresponding hydride-supported [Mo₂Fe₂](SR)₂ cluster complexes. The [Mo₂Fe₂] clusters served as catalyst precursors for the reductive silylation of N₂ and yielded â‰?5-69 equiv of N(SiMe₃)₃ relative to the [Mo₂Fe₂] clusters. Treatment of complexes 2a and b with an excess of CNtBu resulted in the formation of dinuclear Mo-Fe and Mo-Mn complexes, which indicated that the [Mo₂M₂] cores (M=Fe, Mn) split into two dinuclear species upon accommodation of substrates.

Chemistry – A European Journal published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Product Details of C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Durgaryan, A. A. published the artcileSynthesis and study of polymers containing amino, azo, and p-phenylene groups in the main chain, HPLC of Formula: 1821-27-8, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2011), 54(10), 64-69, database is CAplus.

Conducting polymers containing both, amino- and azo-groups, in the main chain exhibit unique properties of combined polyaniline and polyazoarylenes. New conducting polymers were prepared and the effect of the mol. structure and dopant (I) concentration on the elec. conductivity was investigated. Poly(azo-1,4-phenylenimino-1,4-phenylene) was obtained by the reduction of 4,4′-dinitrodiphenylamine with Zn and poly(azo-1,4-phenylenacetylimino-1,4-phenylene) was synthesized by the diazotization of 4,4′-diaminodiphenylamine and subsequent coupling with N-acetyldiphenylamine.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, HPLC of Formula: 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takahashi, Eiki published the artcileThe discovery of potent glycine transporter type-2 inhibitors: Design and synthesis of phenoxymethylbenzamide derivatives, HPLC of Formula: 31719-76-3, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(18), 4603-4606, database is CAplus and MEDLINE.

The authors describe the discovery of phenoxymethylbenzamide derivatives as a novel class of glycine transporter type-2 (GlyT-2) inhibitors. The authors found a hit compound (human GlyT-2, IC₅₀ = 4040 nM) in their library and converted its 1-[[(2-naphthalenyl)methyl]-4-piperidinyl]-3-pyrrolidine group to an 1-(N,N-dimethylaminopropyl)piperidine group and its tert-Bu group to a trifluoromethyl group to obtain N-[1-[3-(dimethylamino)propyl]-4-piperidinyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide. This compound showed good inhibitory activity against human GlyT-2 (IC₅₀ = 15.3 nM) and exhibited antiallodynia effects in a mouse neuropathic pain model. The title compounds thus formed included N-(1′-methyl[1,4′-bipiperidin]-4-yl)-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide, N-[1-[3-(dimethylamino)propyl]-4-piperidinyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide. The synthesis of the target compounds was achieved by a reaction of 4-(phenoxymethyl)benzoic acid derivatives with amines, such as 1-[1-(phenylmethyl)-4-piperidinyl]-3-pyrrolidinamine, 1′-methyl-[1,4′-bipiperidin]-4-amine, 4-amino-N,N-dimethyl-1-piperidinepropanamine, 4-amino-1-piperidineethanol and similar compounds

Bioorganic & Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H31NO2, HPLC of Formula: 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yokoyama, Masataka published the artcileSynthesis of heterocycles using a new immonium salt derived from N,N-dimethylthiourea, Computed Properties of 6972-05-0, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1982), 1059-62, database is CAplus.

Treatment of Me₂NCSNH₂ with NaH, CS₂ and MeI in THF gave Me₂NC(SMe):N⁺MeCS₂Me I^– (I), which underwent cyclocondensation reactions with nucleophiles to give heterocycles including triazolines, an oxadiazole, a thiazole, a triazine, a benzoxadiazepine and a benzothiadiazepine. E.g., I was refluxed in EtOH with N₂H₄ for 4 h to give 74% triazolinethione II. Similar treatment of I with HSCH₂CO₂Et-LiN(CHMe₂)₂ in THF at -70° for 1 h and at room temperature for 1 h gave 47% thiazole III.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C14H28O5S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lindstedt, Philip R. published the artcileEnhancement of the anti-aggregation activity of a molecular chaperone using a rationally designed post-translational modification, Related Products of catalysis-chemistry, the publication is ACS Central Science (2019), 5(8), 1417-1424, database is CAplus and MEDLINE.

Protein behavior is closely regulated by a plethora of post-translational modifications (PTMs). It is therefore desirable to develop approaches to design rational PTMs to modulate specific protein functions. Here, we report one such method, and we illustrate its successful implementation by potentiating the anti-aggregation activity of a mol. chaperone. Mol. chaperones are a multifaceted class of proteins essential to protein homeostasis, and one of their major functions is to combat protein misfolding and aggregation, a phenomenon linked to a number of human disorders. In this work, we conjugated a small-mol. inhibitor of the aggregation of α-synuclein, a process associated with Parkinson’s disease (PD), to a specific cysteine residue on human Hsp70, a mol. chaperone with five free cysteines. We show that this regioselective conjugation augments in vitro the anti-aggregation activity of Hsp70 in a synergistic manner. This Hsp70 variant also displays in vivo an enhanced suppression of α-synuclein aggregation and its associated toxicity in a Caenorhabditis elegans model of PD.

ACS Central Science published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bardin, V. V. published the artcilePolyfluorophenylation of halosilanes, -germanes and -stannanes, Quality Control of 1206-46-8, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1989), 2153-4, database is CAplus.

Reaction of R₃MX (R = Me, Et; M = Si, Ge, Sn; X = Cl, Br) with 4-R¹C₆F₄Br (R¹ = F, PrO, CF₃) in pentane containing P(NEt₂)₃ gave 4-R¹C₆F₄MR₃. Thus, reaction of C₆F₅Br with Me₃MCl (M = Si, Ge, Sn) gave 50-66% C₆F₅MMe₃.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Quality Control of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bardin, V. V. published the artcileReactions of (triethylgermyl)pentafluorobenzene and perfluorotetraphenylgermane with nucleophiles, COA of Formula: C9H9F5Si, the publication is Zhurnal Obshchei Khimii (1990), 60(8), 1820-6, database is CAplus.

Oxygen- or nitrogen-containing nucleophiles attack the Ge atom in Et₃GeC₆F₅, while sulfur-, carbon-, and hydrogen-containing nucleophiles attack the C-4 atom of the C₆F₅ group. (C₆F₅)₄Ge undergoes C_aryl-Ge bond cleavage in reactions with O– and S-nucleophiles, while reactions with C-nucleophiles give complex mixtures of products from cleavage and defluorination. Piperidine reacts with (C₆F₅)₄Ge by substitution of an F atom, apparently due to steric screening of Ge.

Zhurnal Obshchei Khimii published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, COA of Formula: C9H9F5Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuo, Ying Che published the artcileNew methods and reagents in organic synthesis. 26. Reductive desulfonylation of α-sulfonylacetates, Application In Synthesis of 1949-41-3, the publication is Chemical & Pharmaceutical Bulletin (1982), 30(8), 2787-92, database is CAplus.

α-Acyl-α-benzylsulfonyldiazomethanes RCOC(:N₂)SO₂CH₂Ph (R = Ph, PhCH₂CH₂, Me₂CH, cyclohexyl) have been converted to RCH(CO₂H)SO₂CH₂Ph (I, same R) by Wolff rearrangement. Reductive removal of the benzylsulfonyl group of I (R = PhCH₂CH₂, Me₂CH, cyclohexyl) can be achieved by Na-EtOH in THF. HO₂CCRMeSO₂CH₂Ph (same R), prepared from benzyl α-benzylsulfonyl-α-substituted acetates, were also benzylsulfonylated under similar reductive conditions. The overall process, in combination with the Arndt-Eistert synthesis of α-sulfonylacetates from acyl chlorides and benzylsulfonyldiazomethane, provides a new, safe method for the homologation of carboxylic acids.

Chemical & Pharmaceutical Bulletin published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Application In Synthesis of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Luo, Na published the artcileπ-Face Promoted Catalysis in Water: From Electron-deficient Molecular Cages to Single Aromatic Slides, COA of Formula: C16H20N2, the publication is Chemistry – An Asian Journal (2021), 16(22), 3599-3603, database is CAplus and MEDLINE.

Exploiting noncovalent π-interactions particularly emerging anion-π interactions to drive efficient catalysis is fascinating. Even with exciting progresses, can anion-π activation operate in water remains elusive. Herein, design, synthesis and catalytic studies of a class of water-soluble electron-deficient mol. cages and relevant aromatic slide compounds is reported. The prism-like cages contain three divided, long, cationic aromatic walls which constitute three highly electron-deficient V-shape cavities. They were efficiently synthesized in two steps from a parent triformyl cage in gram-scale. Crystal structure showed the π-walls bind to the counter bromide through strong anion-π interactions. Just 5 mol% of cages were effective in catalyzing decarboxylative Aldol reactions of aldehydes and malonic acid half thioesters in water but not in organic solvents, showing a pronounced hydrophobic amplification effect. Meantime, a series of single π-slides resembling the π-wall of the cage performed equally well, while those lacking an extended π-surface were ineffective, highlighting the essential role of electron-deficient π-face on promoting the conversion.

Chemistry – An Asian Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rao, K. Hanumantha published the artcileFlotation of mica minerals and selectivity between muscovite and biotite while using mixed anionic/cationic collectors, Computed Properties of 2016-56-0, the publication is Minerals & Metallurgical Processing (1990), 7(3), 127-32, database is CAplus.

Selective flotation of muscovite from a material containing muscovite 15.4, biotite 13%, and quartz and feldspar gangue by using a mixed collector system of Na oleate and dodecylamine acetate is described. Muscovite floats in preference to biotite, when the pulp is initially conditioned with oleate followed by amine at basic pH values. A product containing 63% muscovite with a recovery of 93% was obtained, while using 75-150 oleate and 96 g/ton amine. The biotite grade and recovery are �0 and 20%, resp. High selectivity between muscovite and siliceous gangue is obtained. A final product containing 95% muscovite with an overall recovery of 75% is obtained when the flotation concentrate is subjected to magnetic separation The possibility of separating muscovite from biotite by using a mixture of collectors is discussed.

Minerals & Metallurgical Processing published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Computed Properties of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia