Month: November 2022

Jacquet, Olivier published the artcileCO₂ as a C₁-building block for the catalytic methylation of amines, Product Details of C14H23N, the publication is Chemical Science (2013), 4(5), 2127-2131, database is CAplus.

A novel catalytic reaction was designed to use, for the first time, CO₂ as a C₁ feedstock in the synthesis of N-methylamines. Simple zinc catalysts, based on com. available zinc salts and ligands, prove highly efficient in promoting both a 6 electron reduction of carbon dioxide and the formation of a C-N bond, using hydrosilanes and amines.

Chemical Science published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Product Details of C14H23N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karlsson, S. published the artcilePhase Behavior and Characterization of the System Acetic Acid-Dodecylamine-Water, HPLC of Formula: 2016-56-0, the publication is Langmuir (2001), 17(12), 3573-3578, database is CAplus.

The phase behavior of carboxylic acid/alkylamine mixtures in H₂O is largely dictated by a proton transfer from the acid to the amine, which will lead to charged species. If the distribution of C atoms is unequal between the acid and the amine, the result will be an ionic surfactant with an organic counterion. The phase diagram for the ternary system HOAc-dodecylamine-H₂O at 298.2 K was determined Dodecylamine forms a lamellar phase with H₂O, but when HOAc is added up to an equimol. ratio between acid and amine, 3 new phases appear. These phases are an isotropic solution phase, a hexagonal liquid crystalline phase, and a cubic liquid crystalline phase. These 3 phases are not able to incorporate any excess amine. The solution phase shows the existence of micelles, which are spherical at high dilution, but show an elongation close to the phase border to the hexagonal phase.

Langmuir published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, HPLC of Formula: 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Davis, Franklin A. published the artcileChemistry of the sulfur-nitrogen bond. 12. Metal-assisted synthesis of sulfenamide derivatives from aliphatic and aromatic disulfides, Application In Synthesis of 19117-31-8, the publication is Journal of Organic Chemistry (1977), 42(6), 967-72, database is CAplus.

R1SNR2 (R, R1 = alkyl, aryl) (?25) were prepared by treating R12S2 with excess R2NH in MeOH or AcOEt in the presence of AgNO3, AgOAc, or HgCl2. Recovery of Ag was 65-75%. 3,4-Cl2C6H3SNH2 and 3-O2NC6H4SNH2 were obtained by reaction of the corresponding disulfides with NH3 in the presence of AgNO3. Similar treatment of Ph2S2 or (4-ClC6H4)2S2 gave (PhS)2NH and (4-ClCl6H4S)2NH, resp. AgNO3-assisted reaction of aliphatic disulfides with NH3 and PhCHO, PhCOMe, or 2-HOC6H4CHO afforded the resp. R1SN:CR2 in low yield.

Journal of Organic Chemistry published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C10H15NS, Application In Synthesis of 19117-31-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dahiya, Amit published the artcileGold-Catalyzed Chemoselective Couplings of Polyfluoroarenes with Aryl Germanes and Downstream Diversification, Application In Synthesis of 1206-46-8, the publication is Journal of the American Chemical Society (2020), 142(17), 7754-7759, database is CAplus and MEDLINE.

This report describes the chemoselective coupling of polyfluoroarenes with aryl germanes in the presence of aromatic C-I, C-Br, C-Cl, C-OTf, and C-SiMe₃ groups, as well as demonstrates the further downstream diversification to give richly functionalized and highly fluorinated polyarenes. The strategy relies on an in situ Umpolung of the F_nArH, followed by selective Au^(I)/Au^(III)-catalyzed coupling with electron-poor or -rich aryl germanes, even in the presence of challenging ortho-substituents, and widens the currently available coupling space in oxidative gold catalysis to previously inaccessible electron-poor/electron-poor biaryls.

Journal of the American Chemical Society published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Application In Synthesis of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lindner, Ekkehard published the artcileStudies on steric and electronic effects on the reactivity of acetyl(diorganyl)-phosphines and their oxides, Name: Dimesitylphosphine oxide, the publication is Chemische Berichte (1980), 113(10), 3268-74, database is CAplus.

Acetylphosphines MeCOPRR¹ (R = Ph, R¹ = PhCH₂, cyclohexyl, Me₃C or R = R¹ = m-CF₃C₆H₄ or mesityl) were prepared by reaction of MeCOCl with Me₃SiPRR¹ or HPRR¹ in the presence Et₃N. Only acetyldimesitylphosphine is stable to mol. oxygen. The corresponding oxides MeCOP(O)RR¹ (I) are formed by reaction of Ac₂O with HP(O)RR¹ and can be hydrolyzed with stoichiometric amounts of H₂O to give AcOH and HP(O)RR¹. I (R = Ph, R¹ = PhCH₂ or cyclohexyl, R = R¹ = m-CF₃C₆H₄) react further with HP(O)RR¹ to give alcs. HOCMe[P(O)RR¹]₂. Steric and electronic effects of the R and R¹ groups correlate with the reactivity of the prepared compounds

Chemische Berichte published new progress about 23897-16-7. 23897-16-7 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Dimesitylphosphine oxide, and the molecular formula is C18H23OP, Name: Dimesitylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lindner, Ekkehard published the artcileStudies on steric and electronic effects on the reactivity of diorganyl(trifluoroacetyl)phosphines and their oxides, Related Products of catalysis-chemistry, the publication is Chemische Berichte (1980), 113(8), 2769-78, database is CAplus.

Reactions of phosphines CF₃COPRR¹ (I; R = Ph, R¹ = PhCH₂, cyclohexyl, Me₃C; R = R¹ = m-CF₃C₆H₄, mesityl) with O₂ showed that only the mesityl compound is not oxidized. I (R = R¹ = m-CF₃C₆H₄, mesityl) react with 30% H₂O₂ to give, resp., (m-CF₃C₆H₄)₂P(O)OH and adduct HP(O)(C₆H₂Me₃-2,4,6)₂.1.5H₂O₂. Oxides CF₃COP(O)RR¹ (II; R = Ph, R¹ = Me₃C; R = R¹ = mesityl) are hydrolyzed with stoichiometric amounts H₂O to give CF₃CO₂H and HP(O)RR¹, whereas II (R = Ph, R¹ = PhCH₂, cyclohexyl; R = R¹ = m-CF₃C₆H₄) react with hydrolytically formed secondary phosphine oxides to give alcs. CF₃C[P(O)RR¹]₂OH (III). III (R = R¹ = m-CF₃C₆H₄) is transformed immediately into the phosphinate CF₃CH[P(O)RR¹][OP(O)RR¹]. The preparation of the starting phosphines and their oxides is described and their reactivity related to electronic and steric effects.

Chemische Berichte published new progress about 23897-16-7. 23897-16-7 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Dimesitylphosphine oxide, and the molecular formula is C18H23OP, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Brugarolas, P. published the artcileSynthesis of meta-substituted [¹⁸F]3-fluoro-4-aminopyridine via direct radiofluorination of pyridine N-oxides, Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(44), 7150-7152, database is CAplus and MEDLINE.

A methodol. for the preparation of 3-fluoro-4-aminopyridine was developed via two-step procedure involving fluorination of 3-bromo-4-nitropyridine N-oxide to yield 3-fluoro-4-nitropyridine N-oxide as an intermediate in first step and its reduction via catalytic hydrogenation in second step. Furthermore, this approach was successfully applied for the preparation of [¹⁸F]3-fluoro-4-aminopyridine. The use of pyridine N-oxides for the preparation of fluoropyridines was unprecedented in chem. literature and had potential to offer a new way for the synthesis of these important structures in pharmaceuticals and radiopharmaceuticals.

Chemical Communications (Cambridge, United Kingdom) published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cherian, Gita published the artcileEvaluation of two types of ingredients from marine fish rest raw materials in broiler diets: effects on live performance and meat lipid composition, Application In Synthesis of 6217-54-5, the publication is Journal of Applied Poultry Research (2022), 31(3), 100261, database is CAplus.

The current study investigated the effect of incorporating two ingredients derived from different types of marine fish rest raw materials in the diet of broiler chickens on live performance, carcass yield, muscle fatty acid (FA) composition, lipid peroxidation products, and blood metabolites. A total of ninety (n = 90), one-day-old Cobb chicks were fed a corn-soybean meal-based diet with no marine rest raw material (Control), 5% deboned Pacific hake meal (Diet 1), or 5% Pacific surimi washwater meal (Diet 2) for 42 d (30 birds per treatment kept in 6 replicate pens with 5 chicks per pen). For bird performance (feed consumption, weight gain), each replicate pen was considered as the exptl. unit. For determining yield, blood metabolites, and lipid anal., one bird collected from each replicate is considered as the exptl. unit. Bodyweight gain and feed:gain were determined at the starter (1-10), grower (11-21), and finisher (22-42) phases. For all response variables, the effects of Control vs. Diet 1 and Diet 2 were compared sep. using anal. of variance. P values were considered significant at ¡Ü0.05. No difference was observed in the body weight gain and feed:gain at day 10 (P > 0.05). At day 21, Diet 1 and Diet 2 birds were higher in body weight than Control (P < 0.05). At day 42, Diet 1 birds were highest in body weight (3,018 g) when compared to Control (2,728 g) (P < 0.05) and was not different from Diet 2 (2,912 g) (P > 0.05). Overall, feed:gain was lowest in Diet 2 (1.52) (P < 0.05) and was not different from Diet 1. A 2 to 5-fold increase in n-3 FA was observed in the breast and thigh muscle of Diet 1 and Diet 2 compared to Control (P < 0.05). Docosahexaenoic acid (DHA, 22:6 n-3) was the major long chain FA in the breast and thigh muscle and addition of marine rest raw material led to >10-fold increase in the breast and thigh muscle DHA in Diet 1 and Diet 2 when compared to Control (P < 0.05). The total lipid content of thigh muscle was lower in Diet 1 and Diet 2 compared to Control (P < 0.05). No difference was observed in the total lipid content of breast muscle (P > 0.05). The relative organ weight and yield of breast and thigh muscles were not different among the three treatments (P > 0.05). No difference was observed in moisture and cholesterol content in breast and thigh muscles (P > 0.05). Blood cholesterol was lower in Diet 1 than Control (P < 0.05). Lipid peroxidation products measured as thiobarbituric acid reactive substances (TBARS) were lower in the breast muscle of Diet 1 and Diet 2 compared to Control (P < 0.05). However, no effect of diet on thigh muscle TBARS was observed (P > 0.05). As consumer demands for n-3 FA-rich poultry products are on the rise, products derived from marine rest raw materials may serve as feed supplement that could be used in broiler chicken diets for enriching edible tissues with n-3 FA while increasing bird live performance and promoting ecol. poultry production

Journal of Applied Poultry Research published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Application In Synthesis of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mann, Mandeep K. published the artcileDiscovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain, Synthetic Route of 2051-95-8, the publication is Journal of Medicinal Chemistry (2019), 62(22), 10144-10155, database is CAplus and MEDLINE.

USP5 disassembles unanchored polyubiquitin chains to recycle free mono-ubiquitin, and is one of twelve ubiquitin-specific proteases featuring a zinc finger ubiquitin-binding domain (ZnF-UBD). This distinct structural module has been associated with substrate positioning or allosteric modulation of catalytic activity, but its cellular function remains unclear. We screened a chem. library focused on the ZnF-UBD of USP5, crystallized hits in complex with the protein, and generated a preliminary structure-activity relationship which enables the development of more potent and selective compounds This work serves as a framework for the discovery of a chem. probe to delineate the function of USP5 ZnF-UBD in proteasomal degradation and other ubiquitin signaling pathways in health and disease.

Journal of Medicinal Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Synthetic Route of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Amici, Giuseppe published the artcileEffect of hypocholesterolemic substances on lipid content in organs of rats on a high fat diet, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Minerva Medica (1966), 57(96), 4056-64, database is CAplus and MEDLINE.

Groups of 10 rats were fed the following diets: (1) standard pellets and H2O; (2) diet 1 with phenylethylacetic acid or ¦Á-phenylbutyric acid (I) (700 mg./kg./24 hrs.); (3) excess lipid-containing diet; (4) diet 3 with I; (5) diet 3 with ¦Â-benzal butyramide (II) (260 mg./kg./24 hrs.); (6) diet 3 with ¦Á-methyl-¦Ã-phenylbutyric acid (III) (260 mg./kg./24 hrs.). Five rats in each group were examined after 20 days and 5 after 40 days on the diets. Body weight, total blood cholesterol (TBC); wet and dry weight of liver, lungs, testes, adrenals, and aorta, and their content of total fatty acids (TFA), total cholesterol (TC), esterified cholesterol (EC), free cholesterol (FC), and phospholipids (PL) was determined Cholesterol-lowering compounds decreased TC and EC in all examined organs under the conditions of diet 2. An initial increase in TFA was followed by a decrease below control levels. PL increased in the liver, lungs, and testes and decreased in the adrenals and aorta. Diets 4, 5, and 6 inhibited the increase in TFA, TC, EC, and PL levels in the liver, lungs, and the aorta. TBC, body weight, and wet and dry weight increases induced by diet 3 were also inhibited by diets, 4, 5, and 6. The effects were particularly marked with diet 5, where TFA, TC, and EC levels lower than control values under diet 1 were observed. Response to diet 3 was different in the testes and adrenals than in other organs: dry and wet weight did not increase, TC and EC decreased and TFA increased less than elsewhere. PL decreased in the adrenals and increased slightly in the testes. I, II, and III inhibited the increase in TFA levels of testes and adrenals, but did not decrease the TC and EC levels, which were found instead to be relatively higher. It is suggested that I, II, and III (II being the more potent) are particularly effective in decreasing the TFA, TC, and EC content of the liver, lungs, and aorta, i.e. the organs where the deposition of exogenous lipids selectively occurs. 57 references.

Minerva Medica published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia