Month: November 2022

Martin, M. L. published the artcileApplication of nitrogen-15 spectroscopy and dynamic NMR to the study of ureas, thioureas, and their Lewis acid adducts, Synthetic Route of 6972-05-0, the publication is Organic Magnetic Resonance (1980), 13(6), 396-402, database is CAplus.

Rotational barriers and ¹⁵N chem. shifts in 34 ureas and thioureas were measured, and several previously unobsd. rotational barriers were detected using lanthanide reagents or a high-field spectrometer. Nearly constant effects on the rotational activation energy and the ¹⁵N shift were produced on going from ureas to the corresponding thioureas, and correlations were observed between the ¦¤G? and ¦Ä(¹⁵N) values. The results are discussed in terms of lone-pair delocalization, and anomalies with respect to the general behavior may be due to the effect of steric torsion in crowded structures on ¹⁵N shifts and rotation barriers.

Organic Magnetic Resonance published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Synthetic Route of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Juszkiewicz, A. published the artcileUltrasonic velocity hydration numbers of polyamines, Quality Control of 10517-44-9, the publication is Ultrasonics (1990), 28(6), 391-3, database is CAplus and MEDLINE.

Ultrasonic velocity hydration numbers of diamines, triamines, and tetraamines and hydrochlorides of these amines were determined by measuring the maximum velocity of ultrasound in aqueous-ethanolic solutions The results are interpreted on the basis of the hydrogen-bonded framework model of the water structure.

Ultrasonics published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Quality Control of 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Macke, Jeffrey D. published the artcileSulfinic acids and related compounds. 19. Synthesis and properties of 1-propane-, 1-butane-, and 1-pentanesulfinates terminally substituted with di- and trisulfide functions, Synthetic Route of 77189-99-2, the publication is Journal of Organic Chemistry (1988), 53(2), 396-402, database is CAplus.

RSS(CH₂)_nSO₂Na (I; R = HO₂CCH₂CH₂, Ph, 4-MeC₆H₄; n = 3-5) were prepared as potential antiradiation agents (no data) in 53-85% yield by reaction of thiosulfonates II with RSNa. Studies of the disproportionation of I suggest that the principal process occurring is homolysis with light but heterolysis with heat. NaO₂S(CH₂)_nSSS(CH₂)_nSO₂Na (III; n = 3-5) were prepared in 73-85% yield by reaction of Na₂S with II. When heated in water, III rearranged to NaO₂S(CH₂)_nSS(CH₂)_nSO₂SNa.

Journal of Organic Chemistry published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Synthetic Route of 77189-99-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Boissier Pierre Simon, Jacques R. published the artcileThe psychoanaleptic action of some derivatives of phenyl-ethylamine which cause anorexia, Synthetic Route of 3115-28-4, the publication is Therapie (1965), 20(2), 297-309, database is CAplus.

Twelve phenylethylamine derivatives were administered orally and peritoneally to mice (0.5 ml./20 g.) and rats (1 ml./100 g.) and their behavior and the toxicity of the drugs were studied. Also antagonistic action against barbiturates was evaluated, and did not parallel the change in dosage. The stimulating action was observed in the following decreasing orders: d-amphetamine (I), dl-amphetamine (II), pipradrol (III), oxazimedrine (IV), levophacetoperan (V), ephedrine (VI), phenylpropanolamine (VII), amphepramon (VIII), chlorphentermine (IX), phendimetrazine (X), benzphetamine (XI), phenfluoramine (XII). The toxicity is greatest in I, was 25-67% less in II, VII, V, III, VI, IX, VIII, X, and IV were slightly toxic. XI and XII were practically nontoxic. All compounds are encephalic excitation agents.

Therapie published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Synthetic Route of 3115-28-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kronenberger, Thales published the artcileDesign, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors, Related Products of catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry (2020), 28(15), 115600, database is CAplus and MEDLINE.

The fragment MB872 I [R¹ = H; R² = 3-C(O)OH; W = O; Y = CH₂] was used as a prototype for analog development by bioisosterism/retro-bioisosterism, which resulted in substituted 3-benzoic acid derivatives I [R¹ = H, OH, OMe, NO₂; R² = 3-C(O)OH, 4-C(O)OH, 3-C(O)OMe, 4-C(O)OMe, 3-NO₂; W = O, S, NH, CH₂; Y = O, CH₂]. Compounds I were active against MtDHFR, with IC₅₀ values ranging from 7 to 40¦ÌM, where compound I [R¹ = H; R² = 3-C(O)OH; W = NH; Y = CH₂] not only had the best inhibitory activity (IC₅₀ = 7¦ÌM), but also was 71-fold more active than the original fragment MB872. The compound I [R¹ = H; R² = 3-C(O)OH; W = NH; Y = CH₂] inhibition kinetics indicated an uncompetitive mechanism, which was supported by mol. modeling which suggested that the compounds I could access an independent backpocket from the substrate and competitive inhibitors. Thus, based on these results, substituted 3-benzoic acid derivatives I had strong potential to be developed as novel MtDHFR inhibitors and also anti-TB agents.

Bioorganic & Medicinal Chemistry published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gaspar, Rafael D. L. published the artcileLuminescent oxygen probes based on Tb^III complexes chemically bonded to polydimethylsiloxane, Safety of Allyldiphenylphosphine oxide, the publication is Sensors and Actuators, B: Chemical (2019), 557-568, database is CAplus.

In this work, the functionalization degree of siloxane crosslinkers by allyldiphenylphosphine oxide (adppo) and its effect on the performance of a lanthanide-based optical oxygen sensor were evaluated. Linear poly(dimethyl-co-hydromethylsiloxane) (PMS) and cyclic tetramethylcyclotetrasiloxane (D4i) crosslinkers were functionalized with different concentrations of adppo to chem. bond the [Tb(dcba)₃]¡¤1/2H₂O (dcba = dichlorobenzoate) complex. Mech. stable luminescent silicone membranes were obtained after the curing of the poly(dimethylsiloxane)-vinyl terminated siloxane backbone with the pre-functionalized crosslinkers. Sensing materials exhibit green emission upon 350 nm excitation, and their luminescent properties are dependent of functionalization degree of the crosslinkers. The luminescent sensor materials show fully reversible response and non-linear Stern-Volmer plots, which are fitted by two quenching parameter model, with highest KSV of 0.08930%^-1 when using functionalized D4i as crosslinker and complex concentration of 0.75%.

Sensors and Actuators, B: Chemical published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Safety of Allyldiphenylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Malabarba, Adriano published the artcileSynthesis and biological activity of N⁶³-carboxypeptides of teicoplanin and teicoplanin aglycone, Category: catalysis-chemistry, the publication is Journal of Antibiotics (1989), 42(12), 1800-16, database is CAplus and MEDLINE.

A series of peptide derivatives of teicoplanin A2 (CTA) and deglucoteicoplanin (TD) was prepared by condensation of the 63-carboxy function with the ¦Á-amino group of selected amino acids and their derivatives The modification of the ionic character of CTA and TD influenced their in vitro and in vivo antimicrobial properties to a different extent, depending on the structure of the amino acidic moiety at C-63. A certain effect on binding strength to Ac-L-Lys(Ac)-D-Ala-D-Ala-OH, a synthetic model of the antibiotic’s target peptide, was also observed

Journal of Antibiotics published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Corriu, R. J. P. published the artcileUse of antimony(V) fluoride intercalated in graphite as fluorinating reagent in organosilicon and -germanium chemistry, Product Details of C12H10F2Si, the publication is Journal of Organometallic Chemistry (1980), 192(3), 347-52, database is CAplus.

The use of SbF₅ intercalated in graphites as fluorinating reagent of organosilicon and -germanium derivatives is described. Whereas Si-O and Si-Cl bonds are readily cleaved, Si-H and Si-S bonds are only reactive in bifunctional silanes. Ge-X bonds (X = Br, Cl, OR, H) are unreactive. Allyl-silicon and allyl-germanium bonds are broken under mild conditions and in high yields, leading to the corresponding fluorosilane or fluorogermane. With bifunctional silanes, the difluorinated derivatives are always obtained.

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Product Details of C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Woods, Caleb M. published the artcileAllosteric Activation of Cytochrome P450 3A4 by ¦Á-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis, Application of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Biochemistry (2011), 50(46), 10041-10051, database is CAplus and MEDLINE.

Cytochrome P 450 3A4 (CYP3A4) is the dominant xenobiotic metabolizing CYP. Despite great interest in CYP enzymol., two in vitro aspects of CYP3A4 catalysis are still not well understood, namely, sequential metabolism and allosteric activation. We have therefore investigated such a system in which both phenomena are present. Here we report that the sequential metabolism of Nile Red (NR) is accelerated by the heterotropic allosteric effector ¦Á-naphthoflavone (ANF). ANF increases the rates of formation for NR metabolites M1 and M2 and also perturbs the metabolite ratio in favor of M2. Thus, ANF has as an allosteric effect on a kinetic branch point. Co-incubating deuterium-labeled NR and unlabeled M1, we show that ANF increases k_cat/k_off ?1.8-fold in favor of the k_cat of M2 production Steady-state metabolic experiments are analyzed using a kinetic model in which the enzyme and substrates are not in rapid equilibrium, and this distinction allows for the estimation of rates of catalysis for the formation of both the primary (M1) and secondary (M2) products, as well as the partitioning of enzyme between these states. These results are compared with those of earlier spectroscopic investigations of NR and ANF cooperativity, and a mechanism of ANF heteroactivation is presented that involves effects on substrate off rate and coupling efficiency.

Biochemistry published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C4H6BrFO2, Application of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Perez, Bianca C. published the artcileRecycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues, COA of Formula: C9H7NO4, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(24), 6769-6772, database is CAplus and MEDLINE.

Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogs of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogs are a good start towards development of affordable antitumor leads.

Bioorganic & Medicinal Chemistry Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia