Month: November 2022

Lavery, Christopher B. published the artcilePlatinum-Catalyzed Alkene Cyclohydroamination: Evaluating the Utility of Bidentate P,N/P,P Ligation and Phosphine-Free Catalyst Systems, Safety of 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, the publication is Organometallics (2010), 29(22), 6125-6128, database is CAplus.

The efficacy of phosphine-free Pt precatalysts including PtCl₂ and (COD)PtCl₂ in promoting the cyclohydroamination of primary as well as secondary alkyl/arylamines tethered to ¦Á-olefins is demonstrated for the first time. Further catalytic studies examining the use of phenylene-P,N co-ligands, as well as neutral, cationic, and formally zwitterionic complexes derived from the new ligand precursor 1-PPh₂-2-P(tBu)₂-indene, revealed comparable reactivity in Pt-catalyzed cyclohydroamination catalysis relative to these phosphine-free catalysts.

Organometallics published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, Safety of 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mayr, Toni published the artcileOptimized Trientine-dihydrochloride Therapy in Pediatric Patients With Wilson Disease: Is Weight-based Dosing Justified?, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Pediatric Gastroenterology and Nutrition (2021), 72(1), 115-122, database is CAplus and MEDLINE.

The aim of the study was to investigate the efficacy and safety of trientine-dihydrochloride (TD) in pediatric patients with Wilson disease (WD) and the effect of different weight-based dosages on their clin. and biochem. outcome. We retrospectively reviewed the clin. data of 31 children with WD receiving TD therapy ages under 18 years at the time of diagnosis. Outcome measures included parameters of copper metabolism and liver function tests. To examine the impact of different weight-based dosages, 2 dosage subgroups were analyzed. Group 1 received less than 20mg/kg TD per day, group 2 more than 20mg¡¤kg^-1¡¤day^-1. Median follow-up was 60 (5-60) months in the total study group. During TD therapy, nonceruloplasmin-bound copper was reduced from mean 1.53 (0.01-6.95) at baseline to 0.62 (0.01-4.57) ¦Ìmol/l. 24h-urinary copper excretion diminished to 1.85 (0.8-9.6) ¦Ìmol/day approximating the therapeutic goal of 1.6¦Ìmol/day. Seven of 31 patients (22.6%) required discontinuation of TD treatment, in 4 cases it was because of adverse events (ulcerative colitis, gingival and breast hypertrophy, hirsutism, elevation of transaminases). Investigations about weight-based dosage showed no significant difference of any laboratory parameter between the 2 cohorts. But in terms of clin. safety, adverse effects because of TD were only found in 6.7% of children in group 1 (<20mg¡¤kg^-1¡¤day^-1, median follow-up 60 [14-60] months), it was 63.6%. TD proves to be an efficacious alternative chelating agent for children with WD. Weight-based dosages above the recommended 20mg¡¤kg^-1¡¤day^-1 may increase the rate of adverse effects in pediatric patients.

Journal of Pediatric Gastroenterology and Nutrition published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yuan, Kedong published the artcileArylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids ¦Â-fluoride elimination, Product Details of C14H14, the publication is Chemical Science (2021), 12(4), 1363-1367, database is CAplus and MEDLINE.

PdII/CuI co-catalyze an arylation reaction of gem-difluoroalkenes using arylsulfonyl chlorides to deliver ¦Á,¦Á-difluorobenzyl products. The reaction proceeded through a ¦Â,¦Â-difluoroalkyl-Pd intermediate that typically underwent unimol. ¦Â-F elimination to deliver monofluorinated alkene products in a net C-F functionalization reaction. However to avoid ¦Â-F elimination, the ¦Â,¦Â-difluoroalkyl-Pd intermediate were offered, an alternate low-energy route involving ¦Â-H elimination to ultimately deliver difluorinated products in a net arylation/isomerization sequence. Overall, this reaction enabled exploration of new reactivities of unstable fluorinated alkyl-metal species, while also providing new opportunities for transforming readily available fluorinated alkenes into more elaborate substructures.

Chemical Science published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C8H10S, Product Details of C14H14.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Akhmetov, Vladimir published the artcileAcenaphthenoannulation Induced by the Dual Lewis Acidity of Alumina, Category: catalysis-chemistry, the publication is Chemistry – A European Journal (2022), 28(31), e202200584, database is CAplus and MEDLINE.

Authors have discovered a dual (i. e., soft and hard) Lewis acidity of alumina that enables rapid one-pot ¦Ð-extension through the activation of terminal alkynes followed by C-F activation. The tandem reaction introduces an acenaphthene fragment – an essential moiety of geodesic polyarenes. This reaction provides quick access to elusive non-alternant polyarenes such as ¦Ð-extended buckybowls and helicenes through three-point annulation of the 1-(2-ethynyl-6-fluorophenyl)naphthalene moiety. The versatility of the developed method was demonstrated by the synthesis of unprecedented structural fragments of elusive geodesic graphene nanoribbons.

Chemistry – A European Journal published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Weinert, Charles S. published the artcileSynthesis, structures and reactivity of novel germanium(II) aryloxide and arylsulfide complexes, Quality Control of 22693-41-0, the publication is Dalton Transactions (2003), 532-539, database is CAplus.

The protonolysis reactions between Ge[N(SiMe₃)₂]₂ and substituted phenols give rise to new germanium(II) aryloxide complexes [Ge(OAr)₂]_n (n = 2, ArO = OC₆H₂Me₃-2,4,6 (1) or OC₆H₃ⁱPr₂-2,6 (2); n = 1, ArO = OC₆H₃Ph₂-2,6 (3) or OC₆HPh₄-2,3,5,6 (4)). The solid state structures of 1–3 and 4¡¤3C₆H₆ were determined by x-ray diffraction and compared to their spectroscopic properties. Compounds 1 and 2 contain bridging aryloxide ligands and the environment about the germanium atoms is pyramidal. Compound 1 reacts with benzil to yield a five-coordinate germanium complex [Ge(OC₆H₂Me₃-2,4,6)(O₂C₂Ph₂)(O₂C₂HPh₂)] (5), while compound 4 reacts with the same reagent to give [Ge(OC₆HPh₄-2,3,5,6)₂(O₂C₂Ph₂)] (6). The x-ray crystal structures of 5¡¤C₆H₆ and 6¡¤0.5C₆H₆ also were determined Compound 4 also undergoes an oxidative addition reaction with CH₃I to yield the germane [Ge(OC₆HPh₄-2,3,5,6)₂(Me)(I)] (7). A novel arylsulfidegermane, [HGe(SC₆H₂ⁱPr₃-2,4,6)₃] (8), was isolated in the reaction between Ge[N(SiMe₃)₂]₂ and HSC₆H₂ⁱPr₃-2,4,6 and was characterized by NMR spectroscopy and an x-ray crystal structure.

Dalton Transactions published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C9H9NO, Quality Control of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Manz, Thomas A. published the artcileThe nature of aryloxide and arylsulfide ligand bonding in dimethyltitanium complexes containing cyclopentadienyl ligation, Related Products of catalysis-chemistry, the publication is Dalton Transactions (2005), 668-674, database is CAplus and MEDLINE.

A series of dimethyltitanium compounds [CpTi(EAr)Me₂] (E = O, S) ligated by one ¦Ç⁵-cyclopentadienyl (Cp) and one aryloxide (OAr) or aryl sulfide (SAr) were prepared and structurally characterized. Reaction of [CpTiCl₃] with LiSAr afforded [CpTi(SAr)Cl₂], which was methylated to give [CpTi(SAr)Me₂] (1, 2; Ar = 2,4,6-Me₃C₆H₂, 2,4,6-ⁱPr₃C₆H₂). The same complexes 1 and 2 were formed by protonolysis of CpTiMe₃ by HSAr. Crystal structures of 1 and 2 are reported; the structures are compared with known structures of the aryloxy-complexes. Exptl. structures were compared to those predicted by d. functional theory (DFT). Bonding in the aryl sulfide systems was found to be significantly different from bonding in the aryloxide systems. The aryloxide ligands exhibited wide Ti-O-Ar angles (¡Ý150¡ã) with the Ar group oriented proximal to the Cp group. DFT computations revealed two conformers for the aryl sulfide systems. Aryl sulfides with the Ar group proximal to the Cp group had a predicted Ti-S-Ar angle of ?120¡ã while those with the Ar group distal to the Cp group had a measured and predicted Ti-S-Ar angle of ?100¡ã. Mol. and natural bond orbital (NBO) analyses were employed to explain the nature of ligand bonding in these systems.

Dalton Transactions published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ye, Xinming published the artcileEngineering two nitrogen-containing polyhedral oligomeric silsesquioxanes (N-POSSs) to enhance the fire safety of epoxy resin endowed with superior thermal stability, Recommanded Product: 3-(Trimethoxysilyl)propan-1-amine, the publication is Polymer Degradation and Stability (2022), 109946, database is CAplus.

Despite remarkable advances in developing flame retardants and smoke suppressants for epoxy resin (EP), engineering nitrogen-containing polyhedral oligomeric silsesquioxane (N-POSS) to impart superior fire safety properties to EP has remained an intractable challenge. In this work, two nitrogen-containing polyhedral oligomeric silsesquioxanes (N-POSSs), namely, aminoethyl-aminopropyl-hepta-Ph polyhedral oligomeric silsesquioxane (AEAP-POSS) and aminopropyl-hepta-Ph polyhedral oligomeric silsesquioxane (AP-POSS), were synthesized through the “corner-capping” reaction. The mol. structures of N-POSSs were fully characterized by FTIR, ¹H NMR, ²⁹Si NMR and MALDI-TOF MS, and the synthesized AEAP-POSS and AP-POSS were introduced into EP to solve the shortcomings of flammability. TGA results showed that the incorporation of 4 wt% N-POSS nanoparticles distinctly improved the char residue at 800¡ãC, which significantly enhanced the thermal stability of the EP composites. When 4 wt% of AP-POSS was introduced into EP, reductions in the peak of heat release rate (p-HRR), fire growth index (FGI), peak of smoke production rate (p-SPR), and the peak of CO production rate (p-COP) reached to 60.6%, 70.2%, 52.3% and 60.4%, resp. Subsequently, TG-FTIR and XPS were utilized to investigate the flame retardancy and smoke suppression mechanism. Our work presented a considerable advancement for the facile fabrication of flame retardants based on nitrogen-containing polyhedral oligomeric silsesquioxane compounds

Polymer Degradation and Stability published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C7H10BNO4S, Recommanded Product: 3-(Trimethoxysilyl)propan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lorusso, Emanuela published the artcileInvestigation of aminolysis routes on PET fabrics using different amine-based materials, Application of 3-(Trimethoxysilyl)propan-1-amine, the publication is Nano Select (2022), 3(3), 594-607, database is CAplus.

In this study, functionalization of PET fabrics with amino groups was achieved by aminolysis. Aminolysis routes were explored using different amine-based materials including ethylenediamine (EDA), triaminotriethylamine (TAEA) and (3-aminopropyl)trimethoxysilane (APTMS), (3-trimethoxy-silylpropyl)diethylentriamine (TRIAMO) in addition to amino-functionalized silica nanoparticles as amino-silane based reagents. The samples were deeply characterized by SEM, AFM, and XPS. Abrasion and tensile tests were carried out to evaluate the mech. properties of the modified fabrics. Results showed that aminolysis conducted with EDA and TAEA as amino based reagents lower the performances of PET, while dense coatings can be deposited on the fibers by amino silane-based reagents that act as protective layers. APTMS modified PET presented improved abrasion resistance compared to the native PET. The antibacterial activity of the PET surfaces functionalized with the different amino groups was also evaluated using the gram-neg. bacterium A. fischeri antibacterial assay. The results showed improved antibacterial performances of the native textile treated with APTMS and TAEA based reagents.

Nano Select published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Application of 3-(Trimethoxysilyl)propan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Hanqiao published the artcileTranscriptomic analysis of Vigna radiata in response to chilling stress and uniconazole application, Safety of (S)-2-Amino-4-(methylthio)butanoic acid, the publication is BMC Genomics (2022), 23(1), 205, database is CAplus and MEDLINE.

Chilling injury of mung bean (Vigna radiata (L.)) during the blooming and podding stages is a major agricultural threat in Northeast China. Uniconazole (UNZ) can alleviate water deficit stress in soybean and waterlogging stress in mung bean. However, there has been no report on the effect of UNZ application on the growth and transcriptomic profile of mung bean under chilling stress. UNZ application before chilling stress at the R1 stage alleviated the decline in mung bean yield. UNZ delayed the decrease in leaf chlorophyll content under chilling stress at the R1 stage and accelerated the increase in leaf chlorophyll content during the recovery period. Eighteen sep. RNA-Seq libraries were generated from RNA samples collected from leaves exposed to six different treatment schemes. The numbers of DEGs specific for UNZ treatment between D1 + S vs. D1 and D4 + S vs. D4 were 708 and 810, resp. GO annotations showed that photosynthesis genes were obviously enriched among the genes affected by chilling stress and UNZ application. KEGG pathway enrichment anal. indicated that 4 pathways (cutin, suberin and wax biosynthesis; photosynthesis; porphyrin and chlorophyll metabolism; and ribosome) were downregulated, while plant-pathogen interaction was upregulated, by chilling stress. UNZ application effectively prevented the further downregulation of the gene expression of members of these 4 KEGG pathways under chilling stress. UNZ application effectively delayed the decrease in photosynthetic pigment content under chilling stress and accelerated the increase in photosynthetic pigment content during the recovery period, thus effectively limiting the decline in mung bean yield. UNZ application effectively prevented the further downregulation of the gene expression of members of 4 KEGG pathways under chilling stress and increased mung bean tolerance to chilling stress.

BMC Genomics published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Safety of (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Yun published the artcileN-Heterocyclic carbene-palladium(II)-1-methylimidazole complex catalyzed Suzuki-Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water, Application of Bis(4-fluorophenyl)methane, the publication is Organic & Biomolecular Chemistry (2013), 11(14), 2266-2272, database is CAplus and MEDLINE.

An easily available N-heterocyclic carbene-palladium(II)-1-methylimidazole complex (I) showed efficient catalytic activity in the Suzuki-Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water under mild conditions, providing an alternative method for the synthesis of diarylmethane derivatives, which widely exist in mols. with pharmaceutical activities and are also frequently found as subunits in supramols. Under the optimal conditions, all reactions performed well to give the desired products in moderate to almost quant. yields in an environmentally benign medium within 12 h, extending their applications toward potentially industrial processes.

Organic & Biomolecular Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C15H15OP, Application of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia