Month: November 2022

Beswick, Michael A. published the artcileMetal selection of ligand functionality in [(mes)₂PO₂Li¡¤2thf]₂ and [{(Me₃Si)₂N}Cd{(mes)₂P-O}₂Li¡¤2thf] (mes = C₆H₂Me₃-2,4,6), Recommanded Product: Dimesitylphosphine oxide, the publication is Chemical Communications (Cambridge) (1997), 583-584, database is CAplus.

The reaction of LiBu with [(mes)₂P(H):O] affords the diorganophosphinate complex [(mes)₂PO₂Li¡¤2THF] (1) and [(mes)₂PLi], however, addition of [Cd{N(SiMe₃)₂}₂] to the mixture gives the diorganophosphinite complex [{(Me₃Si)₂N}Cd{(mes)₂P-O}₂Li¡¤2THF] (2). The formation of these complexes illustrates that the ligand functionality of 1 can be controlled by the character of the coordinated metal ion. 1 And 2 were characterized by x-ray crystallog. (1: triclinic, space group P1?, R₁ = 0.045; 2: monoclinic, space group C2/c, R₁ = 0.064).

Chemical Communications (Cambridge) published new progress about 23897-16-7. 23897-16-7 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Dimesitylphosphine oxide, and the molecular formula is C18H23OP, Recommanded Product: Dimesitylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nurchi, Valeria M. published the artcileComplex formation equilibria of Cu^II and Zn^II with triethylenetetramine and its mono- and di-acetyl metabolites, Application In Synthesis of 38260-01-4, the publication is Dalton Transactions (2013), 42(17), 6161-6170, database is CAplus and MEDLINE.

Triethylenetetramine (TETA) dihydrochloride, or trientine, is a therapeutic mol. that has long been used as a copper-chelating agent for the second-line treatment of patients with Wilson’s disease. More recently, it has also been employed as an exptl. therapeutic mol. in diabetes where it improves cardiac structure in patients with diabetic cardiomyopathy and left-ventricular hypertrophy. TETA is metabolized by acetylation, which leads to the formation of two main metabolites in humans and other mammals, monoacetyl-TETA (MAT) and diacetyl-TETA (DAT). These metabolites have been identified in the plasma and urine of healthy and diabetic subjects treated with TETA, and could themselves play a role in TETA-mediated copper chelation and restoration of physiol. copper regulation in diabetes. In this regard, a potentiometric and spectrophotometric study of Cu^II-complex formation equilibrium of TETA, MAT and DAT is presented here, to provide a comprehensive evaluation of the stoichiometries of the complexes formed and of their relative stability constants A potentiometric study has also been conducted on the corresponding Zn^II complexes, to evaluate any possible interference with TETA-mediated Cu^II binding by this second physiol. transition-metal ion, which is present in similar concentrations in human plasma and which also binds to TETA. An ESI-MS study of these systems has both confirmed the complex formation mechanisms established from the potentiometric and spectrophotometric results, and in addition provided direct information on the stoichiometry of the complexes formed in solution These data when taken together show that the 1 : 1 complexes formed with Cu^II and Zn^II have different degrees of protonation. The stability of the Cu^II and Zn^II complexes with the three ligands, evaluated by the parameters pCu and pZn, decreases with the introduction of the acetyl groups. Nevertheless the stability of Cu^II complexes with MAT is sufficiently high to enable its participation in copper scavenging from the patient. A speciation study of the behavior of TETA and MAT with Cu^II in the presence of Zn^II at peri-physiol. plasma concentrations is also presented. While Zn^II did not hinder copper binding, the possibility is raised that prolonged TETA treatment could possibly alter the homeostatic regulation of this essential metal ion. The lack of reliable literature stability constants concerning the Cu^II and Zn^II interaction with the major transport proteins in plasma is also briefly considered.

Dalton Transactions published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levene, P. A. published the artcileSynthesis and oxidation of tertiary hydrocarbons, Recommanded Product: 2-Butylhexanoic acid, the publication is Journal of Biological Chemistry (1918), 505-12, database is CAplus.

The investigation was evolved from the previous work of L. and Allen (C. A. 11, 1414) on the structure of branched chain fatty acids, in which an attempt was made to determine the position of the tertiary C atom by oxidation of the fatty acids themselves. As it was found that the oxidation took place at more than one point in the C chain and that consequently the products of oxidation were so numerous that it was difficult to formulate the structure of the original mol. on the basis of many fragments, it was thought that an advantage might be gained if prior to oxidation the mol. of the acid could be so transformed as to possess fewer points susceptible to the action of oxidizing agents. Transformation into the corresponding hydrocarbon seemed to offer the most promising possibilities. The work is divided into two parts, the synthesis of tertiary aliphatic hydrocarbons and the study of their behavior toward KMnO₄. The hydrocarbons were obtained by reduction of acids prepare by the malonic ester synthesis following the routine adopted in the work of L. and Allen. All the intermediate substances leading up to 2-butylhexane and to 4-butyloctane have been prepared, but only the former hydrocarbon, 2-butylhexane, is readily oxidized by an alk. KMnO₄ solution If the oxidation is carried out at 80-90¡ã the only oxidation products are HCO₂H and CO₂, but when conducted at 25¡ã butyric acid is formed which was identified as its Ag salt. The experiments on the oxidation are incomplete. Diethyl dibutylmalonate, b₁₄ 153-4¡ã (corrected). Dibutylmalonic acid crystallines from C₆H₆ in long, transparent, prismatic needles, slightly soluble in H₂O, m. 163¡ã (slight decomposition). 2-Butylhexylic acid, b. 255¡ã (corrected), b₁₆ 153¡ã, d₁₆ 0.899. Ethyl 2-butylhexylate, b₁₅ 114-5¡ã (corrected). 2-Butylhexyl alcohol, b. 218-9¡ã (corrected), d. 0.836. 2-Butylhexyl iodide, b₁₃ 124-5¡ã (corrected), d. 1.267. 2-Butylhexane, b. 165¡ã (corrected), d. 0.738. Diethyl 2-butylhexylmalonate, b₁₄ 180¡ã (corrected). 2-Butylhexylmalonic acid, transparent rhombic needles from low boiling petroleum ether, m. 88¡ã (corrected). 4-Butyloctylic acid, b₁₂ 173-4¡ã (corrected), d. 0.901. Ethyl 4-butyloctylate, b₁₀ 139¡ã (corrected). 4-Butyloctyl alcohol, b₁₅ 139¡ã, d. 0.841. 4-Butyloctyl iodide, b₈ 143¡ã, d. 1.194.

Journal of Biological Chemistry published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Recommanded Product: 2-Butylhexanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levitskaia, Tatiana G. published the artcileEvaluation of cuprimine and syprine for decorporation of radioisotopes of cesium, cobalt, iridium and strontium, Quality Control of 38260-01-4, the publication is Health Physics (2011), 101(2), 118-127, database is CAplus and MEDLINE.

Cuprimine and Syprine are therapeutics approved by the USFDA to treat copper overload in Wilson Disease (a genetic defect in copper transport) by chelation and accelerated excretion of internally-deposited copper. These oral therapeutics are based on the resp. active ingredients D-penicillamine (DPA) and N,N’-bis (2-aminoethyl) -1,2-ethanediamine dihydrochloride (Trien). Cuprimine is considered the primary treatment, although physicians are increasingly turning to Syprine as a first-line therapy. Both drugs exhibit oral systemic activity and low toxicity; their biol. effects and safety are established. Previous in vivo studies using a rodent animal model established the decorporation potential of Cuprimine and Syprine for Co and Po. Currently these studies are being expanded to evaluate the in vivo decorporation efficacy of these drugs for several addnl. radionuclides. In this report, results of this investigation are discussed using the radionuclides Cs, Co, Ir and Sr. Short-term 48-h pilot studies were undertaken to evaluate DPA and Trien for their in vivo decorporation potential using male Wistar-Han rats. In these studies, a radionuclide solution was administered to the animals by i.v. (IV) injection, followed by a single IV dose of either DPA or Trien. Control animals received the radionuclide alone. Results show effective decorporation of Co by DPA within the time frame evaluated. DPA and Trien were also modestly effective in decorporation of Cs and Sr, resp. The study did not find DPA or Trien effective for decorporation of Ir. Based on these encouraging findings, further studies to evaluate the dose-response profiles and timing of the chelator administration post exposure to radionuclides are warranted.

Health Physics published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Quality Control of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levitskaia, Tatiana G. published the artcileEvaluation of Cuprimine and Syprine for Decorporation of ⁶⁰Co and ²¹⁰Po, SDS of cas: 38260-01-4, the publication is Health Physics (2010), 98(3), 471-479, database is CAplus and MEDLINE.

The acknowledged risk of deliberate release of radionuclides into local environments by terrorist activities has prompted a drive to improve novel materials and methods for removing internally deposited radionuclides. These decorporation treatments will also benefit workers in the nuclear industry, should an exposure occur. Cuprimine and Syprine are oral therapeutics based on the active ingredients D-penicillamine and N,N’-bis-(2-aminoethyl)-1,2-ethanediamine dihydrochloride, resp. These therapeutic drugs have been used for several decades to treat Wilson’s disease, a genetic defect leading to copper overload, by chelation and accelerated excretion of internally deposited copper. Studies were undertaken to evaluate these FDA-approved drugs for the in vivo decorporation of radioactive cobalt (⁶⁰Co) and polonium (²¹⁰Po) using male Wistar-Han rats. In these studies, ⁶⁰Co or ²¹⁰Po was administered to animals by IV injection, followed by oral gavage doses of either Cuprimine or Syprine. Control animals received the radionuclide alone. For ⁶⁰Co studies, animals received a single dose of Cuprimine or Syprine, while for ²¹⁰Po studies animals were repeatedly dosed at 24-h intervals for a total of 5 doses. Results show that Syprine significantly increased urinary elimination and skeletal concentrations of ⁶⁰Co compared to controls. While Cuprimine had little effect on total excretion of ⁶⁰Co, the skeletal, kidney, liver, muscle, and stomach tissues had significantly lower radioactivity compared to control animals. The low overall excretion of ²¹⁰Po made it difficult to reliably measure urinary or fecal radioactivity and draw a definitive conclusion on the effect of Cuprimine or Syprine treatment on excretion. However, Cuprimine treatment was effective at reducing spleen levels of ²¹⁰Po compared to controls. Similarly, Syprine treatment produced statistically significant reductions of ²¹⁰Po in the spleen and skeletal tissues compared to control animals. Based on these promising findings, further studies to evaluate the dose-response pharmacokinetic profiles for decorporation are warranted.

Health Physics published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, SDS of cas: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bowley, C. C. published the artcileImproved reflective displays based on polymer-dispersed liquid crystals, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline, the publication is Journal of Optical Technology (Translation of Opticheskii Zhurnal) (2000), 67(8), 717-722, database is CAplus.

Layered dispersions of liquid crystals and polymers form a new class of materials for reflective displays, known as holog. polymer-dispersed liquid crystals (H-PDLC). Alternating layers of liquid crystal and polymer having dimensions of about 150 nm possess a variable reflectance, providing a wide reflection spectrum in the absence of a field. When an elec. field is applied, this coefficient takes an intermediate value between the refractive index of the liquid crystal and that of the polymer, smoothing out the difference between them. This article is devoted to research and development of these materials, which are promising for use in reflective displays due to their brightness, saturation, and low control voltage.

Journal of Optical Technology (Translation of Opticheskii Zhurnal) published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Arienzo, Rosa published the artcileQuinazoline and benzimidazole MCH-1R antagonists, COA of Formula: C9H7F3O3, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(5), 1403-1407, database is CAplus and MEDLINE.

Two novel series of MCH-1R antagonists were obtained by modification of previous reported 2-aminoquinoline derivatives Representative quinazoline compound I and benzimidazole derivative II were shown to be potent and selective, with promising in vitro eADME profiles.

Bioorganic & Medicinal Chemistry Letters published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, COA of Formula: C9H7F3O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bishop, Peter T. published the artcileSubstituent dependence of the reactions of [RuCl₂(PPh₃)₃] with bulky aromatic thiols, SDS of cas: 22693-41-0, the publication is Dalton Transactions (2006), 1267-1270, database is CAplus and MEDLINE.

2,4,6-Trialkylbenzenethiols (alkyl = Me (tmt), Et (tet), Prⁱ (tipt)) react with [RuCl₂(PPh₃)₃] to give Ru products with the alkyl substituents forming M-C ¦Ò bonds, carbene, carbene with a S ¦Á-heteroatom, agostic H interaction or a simple tetrahedral Ru(II) species, depending on the substituent. Thus, the preparation and crystal structure of [Ru(SC₆H₂Me₂CH₂)(tmt)₂(PPh₃)] (1), [Ru(SC₆H₂Me₂CH)(tmt)(PPh₃)₂] (2), [Ru(SC₆H₂Me₂CSC₆H₂Me₃)(tmt)(PPh₃)₂] (3), [Ru(tet)₃(PPh₃)] (4) and [Ru(tipt)₂(PPh₃)₂] (5) are reported.

Dalton Transactions published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, SDS of cas: 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Le Vaillant, Franck published the artcileRoom-Temperature Decarboxylative Alkynylation of Carboxylic Acids Using Photoredox Catalysis and EBX Reagents, Computed Properties of 1798-04-5, the publication is Angewandte Chemie, International Edition (2015), 54(38), 11200-11204, database is CAplus and MEDLINE.

The direct synthesis of alkynes from readily available carboxylic acids at room temperature under visible-light irradn was reported. The combination of an iridium photocatalyst with (alkynyl)benziodoxolone reagents allowed the decarboxylative alkynylation of carboxylic acids in good yields under mild conditions. The method was applied to silyl-, aryl-, and alkyl- substituted alkynes. It was particularly successful in the case of ¦Á-amino and ¦Á-oxo acids derived from biomass.

Angewandte Chemie, International Edition published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Berry, John F. published the artcileA molecular loop with interstitial channels in a chiral environment: exploration of the chemistry of Mo₂⁴⁺ species with chiral and non-chiral dicarboxylate anions, Category: catalysis-chemistry, the publication is Dalton Transactions (2003), 4297-4302, database is CAplus.

An enantiomerically pure chiral loop containing two units of cis-Mo₂(DAniF)₂²⁺ (DAniF = di-p-anisylformamidinate) was obtained by reacting cis-[Mo₂(DAniF)₂(NCMe)₄](BF₄)₂ with a chiral dicarboxylate easily prepared from p-, m-, and o-hydroquinone and Et (S)-lactate (H₂L1-H₂L3). The compound [cis-Mo₂(DAniF)₂]₂(L1)₂¡¤4CH₂Cl₂ (1) crystallizes in the noncentrosym. I222 space group with mols. stacking so as to form channels capable of hosting guest mols. such as CH₂Cl₂. These properties of 1, which was synthesized in high yield, makes it promising for applications in stereoselective catalysis. Similar reactions with H₂L2-3 and isomeric dicarboxylate linkers and some nonchiral ligands (HO₂CC(Me)₂O)₂-m-C₆H₄ and (HO₂CCH₂O)₂-o-C₆H₄ were studied. The nature of the products depends on the bite angle of the ligand.

Dalton Transactions published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia