Month: November 2022

Watile, Rahul A. published the artcileIntramolecular substitutions of secondary and tertiary alcohols with chirality transfer by an iron(III) catalyst, Formula: C10H10O3, the publication is Nature Communications (2019), 10(1), 1-9, database is CAplus and MEDLINE.

A simple, inexpensive, and environmentally benign iron(III) catalyst promotes the direct intramol. substitution of enantiomerically enriched secondary and tertiary alcs. with O-, N-, and S-centered nucleophiles, e.g., (1S)-3-[2-[(4-methoxyphenyl)amino]phenyl]-1-phenylpropan-1-ol to generate valuable 5-membered, 6-membered and aryl-fused 6-membered heterocyclic compounds, e.g., I with chirality transfer and water as the only byproduct has been demonstrated. The power of the methodol. is demonstrated in the total synthesis of (+)-lentiginosine from D-glucose where iron-catalysis is used in a key step. Adoption of this methodol. will contribute towards the transition to sustainable and bio-based processes in the pharmaceutical and agrochem. industries.

Nature Communications published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C8H5F3N4, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Meikle, Peter J. published the artcilePreparation of polysaccharide-enzyme conjugates for competitive binding assays, Application In Synthesis of 10517-44-9, the publication is Glycoconjugate Journal (1990), 7(3), 207-18, database is CAplus.

A variety of bacterial O-polysaccharides were covalently linked to enzymes and it was demonstrated with three discrete monoclonal antibodies that enzyme-glycoconjugates function as convenient labeled antigens in direct enzyme immunoassays, particularly competitive assays that quantify bacterial O-antigens. Two strategies, each involving reductive amination, were used to couple O-polysaccharides to enzymes, while retaining high enzymic activity. Reduction of the Schiff base formed between 1,3-diaminopropane and the terminal reducing ketodeoxyoctanoic acid (KDO) residue present in the majority of the lipopolysaccharide (LPS) core domains, following mild acid removal of Lipid A, offered the most direct route to mono-aminated polysaccharide. Alternatively, mild periodate oxidation of KDO and heptose residues generated multiple aldehyde targets for Schiff base formation, without affecting the O-antigenic determinant. Hetero- and homobifunctional coupling reagents, sulfosuccinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate and disuccinimidyl suberate, activated polysaccharide for coupling to enzymes at amino and sulphydryl sites and produced conjugates that retained at least 95% of the original enzymic activity. The most suitable enzyme conjugates, especially for competitive inhibition EIA were those bearing one polysaccharide chain, and these were easily prepared from horse-radish peroxidase. Although the extent of conjugation of activated polysaccharide to ¦Â-galactosidase and alk. phosphatase could be controlled by reaction stoichiometry, the use of these enzymes were a less effective utilization of valuable antigen and enzyme.

Glycoconjugate Journal published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Application In Synthesis of 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Roshchin, A. I. published the artcilePalladium-catalyzed reactions of diphenyldifluorosilane and diphenyldiethoxysilane with aryl halides in aqueous dimethylformamide, COA of Formula: C12H10F2Si, the publication is Doklady Akademii Nauk (1994), 334(5), 602-4, database is CAplus.

Cross-coupling reactions of ArBr (Ar = e.g., 2-O₂NC₆H₄, 4-AcC₆H₄, 2-KO₂CC₆H₄) with Ph₂SiF₂ in presence of 2 mol % PdCl₂ and KF in aqueous DMF at 120¡ã afforded high yields of the corresponding biaryls ArPh (up to 95%). Reaction of 4-IC₆H₄Me with Ph₂Si(OEt)₂ in presence of PdCl₂ and KF afforded up to 71% 4-MeC₆H₄Ph.

Doklady Akademii Nauk published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, COA of Formula: C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Andres, Miriam published the artcileStructure-activity relationships and structure-kinetic relationships of pyrrolopiperidinone acetic acids as CRTh2 antagonists, Product Details of C3H6F3N, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(21), 5111-5117, database is CAplus and MEDLINE.

Pyrrolopiperidinone acetic acids, e.g. I [R = Me, Et, Ph, etc.] were identified as highly potent CRTh2 receptor antagonists. In addition, many of these compounds displayed slow-dissociation kinetics from the receptor. Structure-kinetic relationship studies allowed optimization of the kinetics to give potent analogs with long receptor residence half-lives of up to 23 h. Low permeability was a general feature of this series, however oral bioavailability could be achieved through the use of ester prodrugs.

Bioorganic & Medicinal Chemistry Letters published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Product Details of C3H6F3N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Datta, Mrityunjoy published the artcileFast and efficient synthesis of sulfinamides by the oxidation of sulfenamides using potassium fluoride and m-chloroperoxybenzoic acid, Computed Properties of 19117-31-8, the publication is Synthetic Communications (2012), 42(12), 1760-1769, database is CAplus.

A procedure for the synthesis of N-alkyl-, N-cycloalkyl-, N,N-dialkyl-, and N-arylarenesulfinamides from the corresponding sulfenamides using KF/m-chloroperoxybenzoic acid in CH₃CN-H₂O was described. High efficiency (fast reactions, ease of manipulation, and good yields) and absence of over-oxidation are the major advantageous features of this protocol.

Synthetic Communications published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C10H15NS, Computed Properties of 19117-31-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rudinger-Adler, E. published the artcileSynthesis of several phenoxymethylphenyl derivatives with local anesthetic activity, Quality Control of 31719-76-3, the publication is Arzneimittel-Forschung (1979), 29(4), 591-4, database is CAplus and MEDLINE.

A series of 4-(phenoxymethyl)procaine derivatives, 4-PhOCH₂C₆H₄QCH₂CH₂NR₂ (I; NR₂ = NEt₂, NBu₂, 4-methyl-1-piperazinyl, Q = CO₂; NR₂ = NEt₂, Q = CO₂, CONH, COCH₂, OCH₂), were prepared and evaluated for local anesthetic activity. The local anesthetic activity decreased in the stated order of NR₂ in the 1st series of I and in the stated order of Q in the 2nd series.

Arzneimittel-Forschung published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Quality Control of 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wieczorek, Achim published the artcileRigid tetrazine fluorophore conjugates with fluorogenic properties in the inverse electron demand Diels-Alder reaction, Safety of (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, the publication is Organic & Biomolecular Chemistry (2014), 12(24), 4177-4185, database is CAplus and MEDLINE.

1,2,4,5-Tetrazine fluorophore derivatives with structurally rigid mol. designs were synthesized using Sonogashira and Stille cross-coupling as well as copper-catalyzed azide-alkyne cycloaddition The synthesized bichromophoric systems exhibit low fluorescence quantum yields due to quenching by the tetrazine. The extent of fluorescence quenching observed for those systems depends on the distance between the fluorophore and the tetrazine. The decreased fluorescence is “turned on” by conversion of the tetrazine in the inverse electron demand Diels-Alder cycloaddition Time resolved spectroscopy indicated resonance energy transfer between BODIPY and the tetrazine as the underlying quenching mechanism. The synthesized conjugates were successfully applied in protein labeling experiments

Organic & Biomolecular Chemistry published new progress about 1466420-02-9. 1466420-02-9 belongs to catalysis-chemistry, auxiliary class Copper-Free Click Chemistry,Tetrazine, name is (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, and the molecular formula is C10H6Br2, Safety of (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jia, Jingwen published the artcileA cobalt covalent organic framework: a dual-functional atomic-level catalyst for visible-light-driven C-H annulation of amides with alkynes, Synthetic Route of 118-90-1, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2022), 10(21), 11514-11523, database is CAplus.

Herein, a synthesis of a dual-functional cobalt covalent organic framework (CoCOF-SYNU-1) for visible-light-driven C-H annulation of amides with alkynes was reported. An at.-level cobalt center ensures the occurrence of powerful chelation with amides and subsequent precise C-H activation, while the photoactive covalent organic framework was responsible for absorbing visible light to accelerate the catalytic cycle. In the presence of CoCOF-SYNU-1, visible-light-driven regioselective [4 + 2] C-H annulation proceeded smoothly, delivering a wide range of isoquinolin-1(2H)-one derivatives I [R¹ = n-Pr, n-Bu, Ph, etc.; R² = H, n-Pr, trimethylsilyl, etc.; R³ = H, 6-Me, 8-I, etc.; Q = 8-quinolyl] with high efficiency. Significantly, due to the inherent heterogeneous nature and good stability of CoCOF-SYNU-1, the reaction exhibited excellent catalyst recyclability and practicability.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Synthetic Route of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Qing-Wei published the artcileFluorodecarboxylation for the synthesis of trifluoromethyl aryl ethers, COA of Formula: C12H16O3, the publication is Angewandte Chemie, International Edition (2016), 55(33), 9758-9762, database is CAplus and MEDLINE.

The synthesis of mono-, di-, and trifluoromethyl aryl ethers by fluorodecarboxylation of the corresponding carboxylic acids is reported. AgF₂ induces decarboxylation of aryloxydifluoroacetic acids, and AgF, either generated in situ or added sep., serves as a source of fluorine to generate the fluorodecarboxylation products. The addition of 2,6-difluoropyridine increased the reactivity of AgF₂, thereby increasing the range of functional groups and electronic properties of the aryl groups that are tolerated. The reaction conditions used for the formation of trifluoromethyl aryl ethers also served to form difluoromethyl and monofluoromethyl aryl ethers.

Angewandte Chemie, International Edition published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16N2O2, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Padmanabhan, S. published the artcileRelative affinities of divalent polyamines and of their N-methylated analogs for helical DNA determined by sodium-23 NMR, HPLC of Formula: 10517-44-9, the publication is Biochemistry (1991), 30(30), 7550-9, database is CAplus and MEDLINE.

Interactions of divalent polyamines with double-helical DNA in aqueous solution are investigated by monitoring the decrease in ²³Na NMR relaxation rates as NaDNA is titrated with H₃N⁺-(CH₂)_m^-+NH₃, where m = 3, 4, 5, or 6. Analogous measurements are made for the same homologous series of methylated polyamines (methonium ions). The dependence of the ²³Na relaxation rates on the amount of added divalent cation (M²⁺) is analyzed quant. in terms of a two-state model. The sodium ions are assumed to be in rapid exchange between a bound state, where they are close enough to DNA so that it affects their relaxation rate, and a free state in bulk solution, where their relaxation rate is the same as in solutions containing no DNA. The distribution of Na⁺ and M²⁺ between these states is described quant. in terms of an ion-exchange parameter: D_Mú·(p_B^M)(1 – p_B^Na)ⁿ/(p_B^Na)ⁿ(1 = p_B^M), where p_B^Na and p_B^M are the fractions of Na⁺ and M²⁺ that are close enough to DNA to be considered bound (by the NMR criterion), and n is the number of sodium ions displaced from DNA by the binding of one M²⁺ ion. For each of the polyamines and methonium ions investigated here, equations derived from this two-state model yield acceptable fittings of the titration curves if r_Na^o, the number of sodium ions bound per DNA phosphate when no competing cations are present, is assigned a value between 0.6 and 1.00. Within this range, changing the value assigned to r_Na^o does change the best-fitted values of D_M determined for the polyamines (D_H) and for the methonium ions (D_Me) but does not alter the following conclusions about the trends in these parameters. (1) For polyamines and methonium ions of the same m, D_H exceeds D_Me by factors that are significantly larger for m = 3 and 4 than for m = 5 and 6. (2) D_H For m = 3 and 4 is larger than D_H for m = 5 and 6. (3) D_Me For m = 3 and 4 is smaller than D_Me for m = 5 and 6.

Biochemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, HPLC of Formula: 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia