Month: December 2022

Adam, Waldemar published the artcilePhotolysis and thermolysis of di-n-butylmalonyl peroxide. Evidence for ¦Á-lactone intermediates, COA of Formula: C10H20O2, the publication is Journal of Organic Chemistry (1978), 43(20), 3886-90, database is CAplus.

Photolysis and thermolysis of di-n-butylmalonyl peroxide (I) affords ¦Á-lactone II as a reaction intermediate. In a nonprotic solvent such as C₆H₆ or n-hexane II polymerizes to give polyester III, while in MeOH or EtOH it is trapped nucleophilically in the form of ROCBu₂CO₂H (R = Me, Et). Some of the ¦Á-lactone decarbonylates into 5-nonanone, but only small amounts decarboxylate to give 4-nonene, presumably via its carbene. In the thermal decomposition of I in MeOH and EtOH ¦Á-lactone formation is competed for by solvolytic reaction. This solvolytic process predominates over ¦Á-lactone formation in the thermolysis of I in EtOH.

Journal of Organic Chemistry published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, COA of Formula: C10H20O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Disadee, Wannaporn published the artcileOne-pot cascade synthesis of azabicycles via the nitro-Mannich reaction and N-alkylation, Category: catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2018), 16(5), 707-711, database is CAplus and MEDLINE.

A one-pot, metal-free process for the synthesis of azabicycles is developed. The key transformations involved a cascade of double intramol. cyclizations via the nitro-Mannich reaction and N-alkylation, providing various ring systems of azabicycles in yields up to 81% and an isomeric ratio of 62 : 1. This approach offers considerable advantages in terms of the handling of small mols., the flexibility to introduce a functionalized side chain, and gives direct access to various azabicycles.

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Churukian, Charles J. published the artcileA simple colloidal silver method (autometallographic technique) for demonstrating inorganic mercury in brain sections, Application of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Journal of Histotechnology (2000), 23(4), 337-339, database is CAplus.

Standard methods for mercury measurement estimate total mercury burden in tissues but are not informative about cellular localization, for which histochem. techniques are needed. Because the main target of the toxic effects of mercury is the nervous system, it is of particular interest to localize its reservoir within the brain. This paper presents a simple, autometallog. method for demonstrating inorganic mercury in paraffin sections of brain by utilizing a buffered colloidal silver solution that contains hydroquinone. Formalin fixed, paraffin processed brain sections are cut at 7 ¦Ìm and hydrated with deionized water. The sections are placed in a buffered colloidal silver nitrate solution containing hydroquinone and kept in a 37¡ã oven for 18 to 20 min. They are then washed immediately in hot running water and rinsed in deionized water. Following treatment with 2% sodium thiosulfate for 1 min, they are rinsed in deionized water and counterstained with nuclear fast red for 3 min or with cresyl violet acetate for 5 min. After the slides are rinsed in deionized water, they are dehydrated in alc., cleared in xylene, and mounted with synthetic resin. Mercury stains black and the results are consistent and reliable.

Journal of Histotechnology published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Application of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Talotta, Carmen published the artcileSynthesis and supramolecular features of hybrid POM/onium solid-state assemblies, COA of Formula: C16H20N2, the publication is Supramolecular Chemistry (2016), 28(5-6), 403-417, database is CAplus.

Polyoxomolybdate-based organic-inorganic hybrid architectures were synthesized and characterized by x-ray crystallog. The supramol. assemblies present rows of metallic clusters H-bonded by ammonium cations, with a 1:2 molybdate/ammonium ratio. The organic moieties of the ammonium cations establish hydrophobic contact among them such as van der Waals, C-H¡¤¡¤¡¤¦Ð and ¦Ð¡¤¡¤¡¤¦Ð interactions that stabilize the supramol. architectures. In particular, for compound (5) the n-alkyl tails pack closely together giving a lipid-like bilayer. In compound (6), the aromatic Ph rings of the organic cation allow the stabilization of the supramol. architecture by C-H¡¤¡¤¡¤¦Ð and ¦Ð¡¤¡¤¡¤¦Ð interactions. Regarding the x-ray structure of the compound (11), the tetraanionic octa-molybdate [Mo₈O₂₆]^4- cluster is surrounded by four Et-triphenyl-phosphonium cations. Running along the b-axis open channels are occupied by DMF solvent mols. A soaking experiment in n-pentane with the corresponding crystals of compound 11 afforded a crystal structure very different from the native one.

Supramolecular Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C5H6BNO2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Park, Jin-Seok published the artcileExtraction of edible oils and amino acids from eel by-products using clean compressed solvents: An approach of complete valorization, Quality Control of 6217-54-5, the publication is Food Chemistry (2022), 132949, database is CAplus and MEDLINE.

Green extraction methodologies using supercritical carbon dioxide (SC-CO₂) and subcritical water were used to valorize Conger myriaster skin (CMS). The omega-3 fatty acid content in CMS oil extracted using SC-CO₂ was 18.62 ¡À 0.08%, and vitamin A, D, E, and K₂ contents were 467.38 ¡À 0.46¦Ìg/100 g, 8.31 ¡À 0.02 mg/100 g, 143.42 ¡À 4.61 mg/100 g, and 1.27 ¡À 0.05 mg/100 g, resp. De-oiled CMS was hydrolyzed using subcritical water at temperatures ranging from 160 to 280¡ãC. Total protein, total sugar, and Maillard reaction product contents reached maximum values of 409.31 ¡À 2.86 mg bovine serum albumin (BSA)/g at 190¡ãC, 8.31 ¡À 0.31 mg glucose/g at 280¡ãC, and 0.240 ¡À 0.003 (Abs_420nm) at 220¡ãC, resp. The highest antioxidant activity was observed at 280¡ãC. Free amino acids were abundant in the hydrolyzates. Oil extraction from CMS using supercritical and subcritical fluids represents an effective and economical source of functional materials.

Food Chemistry published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Quality Control of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kar, Supratik published the artcileQSAR modeling of toxicity of diverse organic chemicals to Daphnia magna using 2D and 3D descriptors, SDS of cas: 6972-05-0, the publication is Journal of Hazardous Materials (2010), 177(1-3), 344-351, database is CAplus and MEDLINE.

One of the major economic alternatives to exptl. toxicity testing is the use of quant. structure-activity relationships (QSARs) which are used in formulating regulatory decisions of environmental protection agencies. In this background, we have modeled a large diverse group of 297 chems. for their toxicity to Daphnia magna using mechanistically interpretable descriptors. Three-dimensional (3D) (electronic and spatial) and two-dimensional (2D) (topol. and information content indexes) descriptors along with physicochem. parameter log K _o/w (n-octanol/water partition coefficient) and structural descriptors were used as predictor variables. The QSAR models were developed by stepwise multiple linear regression (MLR), partial least squares (PLS), genetic function approximation (GFA), and genetic PLS (G/PLS). All the models were validated internally and externally. Among several models developed using different chemometric tools, the best model based on both internal and external validation characteristics was a PLS equation with 7 descriptors and three latent variables explaining 67.8% leave-one-out predicted variance and 74.1% external predicted variance. The PLS model suggests that higher lipophilicity and electrophilicity, less neg. charge surface area and presence of ether linkage, hydrogen bond donor groups and acetylenic carbons are responsible for greater toxicity of chems. The developed model may be used for prediction of toxicity, safety and risk assessment of chems. to achieve better ecotoxicol. management and prevent adverse health consequences.

Journal of Hazardous Materials published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, SDS of cas: 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Conway, John H. published the artcileRegiodivergent Iridium(III)-Catalyzed Diamination of Alkenyl Amides with Secondary Amines: Complementary Access to ¦Ã- or ¦Ä-Lactams, Safety of O-Pivaloylhydroxylamine trifluoromethanesulfonate, the publication is Journal of the American Chemical Society (2018), 140(1), 135-138, database is CAplus and MEDLINE.

¦Ã,¦Ä-Unsaturated N-pivaloylhydroxamates such as H₂C:CHCH₂CH₂CONHOCOt-Bu underwent iridium-catalyzed diamination of the alkene with exogenous secondary amines such as N-methylaniline at 21¡ã in hexafluoroisopropanol (HFIP) or 2,2,2-trifluoroethanol (TFE) to yield either ¦Ã-(aminomethyl)-¦Ã-lactams such as I or ¦Ã-amino-¦Ä-lactams such as II regioselectively. Using the iridium complex of a (trifluoromethylphenyl)tetramethylcyclopentadiene as catalyst allowed ¦Á-substituted-¦Ã,¦Ä-unsaturated amides to be regioselectively and diastereoselective diaminated to cis-¦Ã-amino-¦Ä-lactams. On the basis of of mechanistic experiments, the relative rates of Ir(V)-nitrenoid formation and attack on the amido-Ir-coordinated alkene by the exogenous amine are proposed to determine the reaction selectivity.

Journal of the American Chemical Society published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, Safety of O-Pivaloylhydroxylamine trifluoromethanesulfonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Iancu, Gabriela Mariana published the artcileEvolution of syphilis incidence in Sibiu county (Romania) over a period of 10 years (2009-2018), HPLC of Formula: 140-28-3, the publication is Experimental and Therapeutic Medicine (2021), 22(2), 803, database is CAplus and MEDLINE.

Syphilis is the most common sexually transmitted disease that mainly affects socially active people, with a fluctuating worldwide incidence over the years. A retrospective study was conducted over a period of 10 years (2009-2018) that included 396 patients with syphilis diagnosed and monitored by Sibiu County Emergency Clin. Hospital, Romania. During this period (2009-2018), we observed a decrease in the new cases of syphilis by 35.90%, and the average syphilis incidence was 9.90 new cases per 100,000 inhabitants. Syphilis was diagnosed more frequently in men with an average age of 35.39 years, from urban areas, with and educational level of grades 9-12, unmarried, workers, or without occupation. Out of the 396 patients with syphilis, about 6% were HIV coinfected. Over half of the HIV coinfected cases were declared MSM (men who have sex with men), and 40% of these cases were registered in 2018. The most common clin. stage of syphilis was the latent form (67.93%). Regarding the syphilis treatment regimen, we noted the transition from the classic regimen with benzathine-penicillin G (100% in 2009) to alternative therapies (mainly with cephalosporins) in 2018 (56.86%). Our findings showed that in the last 10 years in our county, the incidence of syphilis had a downward trend, but with an increase in syphilis-HIV co-infection and neurosyphilis cases.

Experimental and Therapeutic Medicine published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sakharov, Pavel A. published the artcileRegiodivergent Synthesis of Butenolide-Based ¦Á- and ¦Â-Amino Acid Derivatives via Base-Controlled Azirine Ring Expansion, Product Details of C8H7NO4, the publication is Organic Letters (2020), 22(8), 3023-3027, database is CAplus and MEDLINE.

A series of 5-aminobutenolides I [R¹ = Me, Ph, 4-ClC₆H₄, 3,4-(MeO)₂C₆H₃, etc.; R² = MeO, 1-pyrrolidinyl; R³ = MeO₂C, Ph, 4-O₂NC₆H₄, 2-thienyl, etc.] and II (R¹ = MeO₂C, Ph, 4-BrC₆H₄, etc.; R² = MeO, Ph, 1-pyrrolidinyl; R³ = MeO₂C, 4-ClC₆H₄, 4-O₂NC₆H₄) has been synthesized from 2-bromo-2H-azirine-2-carboxylic esters/amides III and arylacetic acids R³CH₂CO₂H. The reaction regioselectivity can be switched by a change of the basic catalyst, making it possible to prepare both butenolide-based ¦Á- and ¦Â-amino acid derivatives I and II. The change in the regioselectivity is interpreted in terms of the stability and reactivity of the enolates formed during the S_N²‘ substitution of the bromine in the azirine by the carboxylate ion.

Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Product Details of C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kalishomi, R. Ghavidel published the artcileHeterogeneous Fe₃O₄@Si-NHC-Pd Catalyst: Synthesis, Characterization, and Catalytic Activity in the Suzuki-Miyaura Cross-Coupling Reaction under Mild Conditions, Quality Control of 613-33-2, the publication is Russian Journal of General Chemistry (2021), 91(6), 1140-1146, database is CAplus.

A novel Fe₃O₄@Si-NHC-Pd catalyst with N-heterocyclic carbenes (NHCs) moiety as an alternative ligand to phosphines for metal complexes has been synthesized and characterized by various methods. Synthesis of metal nanoparticles has been accomplished without aggregation, and the prepared catalyst has been applied in the Suzuki-Miyaura cross-coupling reaction of boronic acids and aryl halides in water using Et₃N as a base. The catalyst has demonstrated high efficiency at room temperature and can be easily removed from the reaction media using an external magnetic field and recycled at least five times without significant decrease of its activity.

Russian Journal of General Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Quality Control of 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia