Month: December 2022

Carreiro, Elisabete P. published the artcileChiral monooxazolines as modular copper(I)-heterocomplex building blocks: investigations on the catalytic asymmetric cyclopropanation of alkenes, Application In Synthesis of 16909-09-4, the publication is Tetrahedron (2011), 67(25), 4640-4648, database is CAplus.

Novel chiral monodentate oxazoline ligands I [R = Me, Ph, 2,4-(MeO)₂C₆H₃; R¹ = Ph, PhCH₂, i-Pr] have been synthesized in good yields. The catalytic activity of these monodentate oxazoline/Cu catalysts was evaluated in the catalytic asym. cyclopropanation of styrene and ¦Á-methylstyrene, giving moderate to good enantioselectivities (up to 74% ee for the trans-cyclopropane product) and full conversions (up to 100%). In an attempt to enhance the enantioselectivities of the cyclopropanations, heterocombinations of these ligands were used. Unfortunately, with the data set that was used in this study, no improvements were observed However, to gain an insight into the nature of the active catalyst present under these circumstances, NMR, mass spectrometric and computational studies were carried out and indicated the presence of bidentate heterocomplexes in the equilibrium mixture Anal. of the stereoselectivities (ees and des) did not prove very useful in pinpointing the identity of the active chiral catalyst and only afforded a very weak conclusion. In order to ascertain the importance of the ¦Ð-¦Ð interactions, the monodentate oxazoline ligands I [R = Me; R¹ = Ph, i-Pr] were synthesized and screened in these reactions. Their stereoselectivity was compared to the one of ligands I [R = 2,4-(MeO)₂C₆H₃; R¹ = PhCH₂, i-Pr]. The results suggest the presence of weak ¦Ð-¦Ð interactions.

Tetrahedron published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Maresh, Justin J. published the artcileChemoselective Zinc/HCl Reduction of Halogenated ¦Â-Nitrostyrenes: Synthesis of Halogenated Dopamine Analogues, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Synlett (2014), 25(20), 2891-2894, database is CAplus.

A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 ¡ãC. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cao, Yan published the artcileCoronene surface for delivery of Favipiravir: Computational approach, Safety of Coronene, the publication is Inorganic Chemistry Communications (2022), 109133, database is CAplus.

Delivery of pharmaceutical compounds has been always an important issue to be solved by appropriate methodologies. In this regard, coronene surface was investigated in this work for possible delivery of favipiravir (FAV) as a well-known drug for medication of COVID-19 pandemic. To this aim, d. functional theory (DFT) calculations were performed to explore surfaces of two representative carbon coronene (C) and boron nitride coronene (BN) models for adsorption of FAV drug. Consequently, complex formations of FAV@C and FAV@BN were examined using the computed mol. and at. parameters. The results indicated that the FAV could interact with both of C and BN surfaces, but with better favorability of FAV@BN complex formation in comparison with FAV@C complex formation. Addnl., mol. orbitlas features indicated that the electronic behavior of FAV@BNC complex could be close to the original FAV in contrast with the results of FAV@CC complex. The evaluated diagrams of d. of states (DOS) showed benefit of the employed models for sensor applications. The obtained features of quantum theory of atoms in mol. (QTAIM) affirmed formations interactions between substances and their strengths. Finally, FAV@BN complex was proposed as proper compound for further investigations of drug delivery processes.

Inorganic Chemistry Communications published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Safety of Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nandy, Saikat published the artcileThe possibility of a fully automated procedure for radiosynthesis of fluorine-18-labeled fluoromisonidazole using a simplified single, neutral alumina column purification procedure, Name: Tetrabutylammonium hydrogencarbonate, the publication is Applied Radiation and Isotopes (2010), 68(10), 1937-1943, database is CAplus and MEDLINE.

A novel fully automated radiosynthesis procedure for [¹⁸F]Fluoromisonidazole using a simple alumina cartridge-column for purification instead of conventionally used semi-preparative HPLC was developed. [¹⁸F]FMISO was prepared via a one-pot, two-step synthesis procedure using a modified nuclear interface synthesis module. Nucleophilic fluorination of the precursor mol. 1-(2′-nitro-1′-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonylpropanediol (NITTP) with no-carrier added [¹⁸F]fluoride followed by hydrolysis of the protecting group with 1 M HCl. Purification was carried out using a single neutral alumina cartridge-column instead of semi-preparative HPLC. The maximum overall radiochem. yield obtained was 37.49¡À1.68% with 10 mg NITTP (n=3, without any decay correction) and the total synthesis time was 40¡À1 min. The radiochem. purity was greater than 95% and the product was devoid of other chem. impurities including residual aluminum and acetonitrile. The biodistribution study in fibrosarcoma tumor model showed maximum uptake in tumor, 2 h post injection. Finally, PET/CT imaging studies in normal healthy rabbit, showed clear uptake in the organs involved in the metabolic process of MISO. No bone uptake was observed excluding the presence of free [¹⁸F]fluoride. The reported method can be easily adapted in any com. FDG synthesis module.

Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Name: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Subbaramaiah, K. published the artcileElectrical properties of spray-deposited CuIn(S_1-xSe_x)₂ thin films, Application In Synthesis of 6972-05-0, the publication is Materials Letters (1994), 20(1-2), 29-33, database is CAplus.

CuIn(S_1-xSe_x)₂ thin films with x = 0.0, 0.3, 0.5, 0.7, 0.9 and 1.0 were prepared by a spray pyrolysis method. The films are p-type, single phase, near stoichiometric and chalcopyrite in structure. The activation energies of these films are determined from elec. conductivity data. The possible defect levels are V_In and Cu_In. No Hall voltage is detected in CuIn(S_1-xSe_x)₂ thin films in the entire range.

Materials Letters published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C16H24BF4Ir, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Appa, Rama Moorthy published the artcileStructure controlled Au@Pd NPs/rGO as robust heterogeneous catalyst for Suzuki coupling in biowaste-derived water extract of pomegranate ash, SDS of cas: 613-33-2, the publication is Applied Organometallic Chemistry (2021), 35(5), e6188, database is CAplus.

This article explored the aptness of water extract of pomegranate ash (WEPA) of agro-waste origin as an effective media for a heterogeneous reduced graphene oxide (rGO)-supported Au-Pd bimetallic nanoparticles (NPs)-catalyzed Suzuki coupling without the need of addnl. ligand, base, and additives at room temperature Morphol. and structural details of Au-Pd bimetallic nanoparticles/rGO were evaluated using a suite of electron microscopy, X-ray diffraction and cyclic voltammetry techniques. A facile chem. reduction method using methylamine borane as a reducing agent gave 5.8 nm-sized Au-Pd bimetallic particles on the rGO surface with an Au@Pd core-shell morphol. The structural, synergistic, and support capabilities offered by core-shell structured Au@Pd NPs/rGO could made a pos. contribution in achieving Suzuki coupling reactions in very short times (5-30 min) with a good to excellent yields of biaryls Ar¹Ar² [Ar¹ = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, etc.; Ar² = Ph, 4-ClC₆H₄, 2,4-di-FC₆H₄, etc.] (91-99%). The catalyst had been easily recovered by phase separation and reused for three consecutive times without losing its effective catalytic property up to two cycles.

Applied Organometallic Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, SDS of cas: 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lalithamba, H. S. published the artcileEfficient Application of Green Synthesized CeO₂ Nanoparticles for the Preparation of Selenoester Derivatives of Protected Amino Acids and Production of Biodiesel from Annona squamosa Oil, Computed Properties of 71989-31-6, the publication is Journal of Electronic Materials (2022), 51(7), 3650-3659, database is CAplus.

Eco-friendly nano-cerium oxide was synthesized via a simple and efficient solution combustion route using novel aqueous Brahma Kamal leaf extract and characterized by several techniques including powder x-ray diffraction, Fourier transform IR spectroscopy, photoluminescence, UV visible spectroscopy, energy-dispersive x-ray diffraction, SEM, and transmission electron microscopy. The nanomaterial exhibited an excellent catalytic activity in the synthesis of selenoesters of amino acids through the reaction of corresponding amino acyl chloride derivatives with the in situ-generated NaHSe, followed by addition of ¦Á-bromo esters. Wide ranges of unsym. selenoester derivatives of amino acids were afforded with good to excellent yields, and the structures were characterized by high-resolution mass spectroscopy, ¹H and ¹³C NMR spectroscopy, and Fourier transform IR spectroscopy techniques. Furthermore, nano-CeO₂ exhibits tremendous catalytic activity in the production of biodiesel from Annona squamosa oil and achieved around 89% biodiesel yield. The biodiesel produced satisfies ASTM standards

Journal of Electronic Materials published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Computed Properties of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Winkelmann, E. published the artcileChemotherapeutically active nitro compounds. Part 2: nitrodiphenyl sulfones, Recommanded Product: Bis(4-nitrophenyl)amine, the publication is Arzneimittel-Forschung (1976), 26(8), 1543-7, database is CAplus and MEDLINE.

The 58 4-nitro-4′-aminodiphenyl sulfones and related compounds tested had a spectrum of tuberculostatic and antimalarial activity similar to that of 4,4′-diaminodiphenyl sulfone (DDS) [80-08-0], but offered no significant advantages over DDS. The tested compounds were presumably reduced to DDS derivatives in vivo. For example, 4-nitro-4′-formamidodiphenyl sulfone (I) [6784-23-2] at 150 mg/kg orally was highly effective against Mycobacterium bovis and Plasmodium berghii infections in mice.

Arzneimittel-Forschung published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C14H10O4, Recommanded Product: Bis(4-nitrophenyl)amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

DeBerardinis, Albert M. published the artcileVitamin D3 analogues that contain modified A- and seco-B-rings as hedgehog pathway inhibitors, Product Details of C15H14O3, the publication is European Journal of Medicinal Chemistry (2015), 156-171, database is CAplus and MEDLINE.

The hedgehog (Hh) signaling pathway is a developmental signaling pathway that has been implicated as a target for anti-cancer drug development in a variety of human malignancies. Several natural and synthetic vitamin D-based seco-steroids have been identified as potent inhibitors of Hh signaling with chemotherapeutic potential. These include the previously characterized analog 4, which contains the northern CD-ring/side chain region of vitamin D3 (VD3) linked to an aromatic A-ring mimic through an ester bond. To further explore structure-activity relationships for this class of VD3-based Hh pathway inhibitors, we have designed, synthesized and evaluated several series of compounds that modify the length, composition, and stereochem. orientation of the ester linker. These studies have identified compounds 54 and 55, which contain an amine linker and an aromatic A-ring incorporating a para-phenol, as new lead compounds with enhanced potency against the Hh pathway (IC₅₀ values = 0.40 and 0.32 ¦ÌM, resp.).

European Journal of Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Product Details of C15H14O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ouvry, Gilles published the artcileSubstituted allyl diphenylphosphine oxides as radical allylating agents, Synthetic Route of 4141-48-4, the publication is Angewandte Chemie, International Edition (2006), 45(30), 5002-5006, database is CAplus and MEDLINE.

The radical addition of dithiocarbonates to branched allyl diphenylphosphine oxides may be followed by elimination of a diphenylphosphinoyl radical, thereby giving rise to allylated products. Highly functionalized structures can thus be rapidly assembled under mild conditions and from cheap and readily available substrates and reagents.

Angewandte Chemie, International Edition published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Synthetic Route of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia