Month: December 2022

Sun, Yushan published the artcileChemistry of ocean resources. XI. Effect of some organic molecules on the chemical behavior of potassium ion in low-concentration solution and seawater and corresponding potassium trapping mechanism, Quality Control of 5411-14-3, the publication is Haiyang Xuebao (Zhongwenban) (1987), 9(1), 127-31, database is CAplus.

The enrichment of K⁺ from low-concentration solutions and seawater was studied with (2RS,3RS)-(¡À)-tartaric acid (I), (2R,2S)-(¡À)-malic acid, succinic acid, maleic acid, adipic acid, glucaric acid, citric acid, galactaric acid, O,O‘-ortho-dihydroxybenzenediacetic acid (II), O,O‘-meta-dihydroxybenzenediacetic acid, O,O‘-para-dihydroxybenzenediacetic acid, 1,1’-dihydroxybiphenyl-O,O‘-diacetic acid, and 1,1’-dihydroxybinaphthalene-O,O‘-diacetic acid (III). I, II, and III gave high enrichment efficiency by complexation.

Haiyang Xuebao (Zhongwenban) published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C20H40O2, Quality Control of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Wei-Chi published the artcilePalladacycles bearing tridentate CNS-type benzamidinate ligands as catalysts for cross-coupling reactions, Name: 2-(Methylthio)ethanamine hydrochloride, the publication is Dalton Transactions (2012), 41(10), 3022-3029, database is CAplus and MEDLINE.

Three pendant benzamidines, [PhC(:NPh){NH(E)}] [E = (CH₂)₂SMe (1); (CH₂)₂S^tBu (2); o-C₆H₄SMe (3)], are described. Reactions of 1, 2 or 3 with one molar equiv Pd(OAc)₂ in CH₂Cl₂ give the palladacyclic complexes [PhC{NH(¦Ç¹-C₆H₄)}{:N(E)}]Pd(OAc) [E = (CH₂)₂SMe (4); (CH₂)₂S^tBu (5); o-C₆H₄SMe (6)], as mononuclear Pd complexes, resp. A minor product described as 5‘, {[PhC{NPh}{N(CH₂)₂S^tBu}]Pd(OAc)}₂, was isolated as a benzamidinate-bridged dinuclear Pd complex upon recrystallizing from Et₂O/hexane solution Treatment of 1, 2 or 3 with one molar equiv PdCl₂ in the presence of NEt₃ in CH₂Cl₂ gives the palladacyclic complexes [PhC{NH(¦Ç¹-C₆H₄)}{:N(E)}]PdCl [E = (CH₂)₂SMe (7); (CH₂)₂S^tBu (8); o-C₆H₄SMe (9)], as mononuclear Pd complexes, resp. The crystal and mol. structures are reported for compounds 5, 5‘ and 6–8. The application of these palladacyclic complexes to the Suzuki and Heck coupling reactions was examined

Dalton Transactions published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C12H10FeO4, Name: 2-(Methylthio)ethanamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Xin published the artcileAsymmetric synthesis of a structurally and stereochemically complex spirooxindole pyran scaffold through an organocatalytic multicomponent cascade reaction, SDS of cas: 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2012), 48(85), 10487-10489, database is CAplus and MEDLINE.

A novel and convenient organocatalytic tandem reaction has been developed for the asym. assembly of saturated aldehydes (or enals), nitroolefins and isatins to produce six-membered oxa-spirooxindole backbones bearing four contiguous stereogenic centers and multiple functional groups with high stereoselectivity, e.g. I.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C6H5BN2O3, SDS of cas: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Xin published the artcileAsymmetric Synthesis of Oxa-spirocyclic Indanones with Structural Complexity via an Organocatalytic Michael-Henry-Acetalization Cascade, Formula: C10H11NO4, the publication is Synlett (2014), 25(1), 143-147, database is CAplus.

The highly enantioselective preparation of drug-like oxa-spirocyclic indanone derivatives employing a multicomponent cascade reaction of aldehydes, nitro alkenes, and ninhydrin is described. This approach utilizes an organocatalytic Michael reaction followed by a Henry-acetalization sequence that yields the desired chiral spirocyclic backbone, bearing four contiguous stereogenic centers and multiple functional groups, in good yields and high stereoselectivities (up to 99% ee and 95:5 dr).

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C12H16O3, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Xiangfei published the artcileOxidative stabilities of grass carp oil: possible mechanisms of volatile species formation in hydroperoxylated metabolites at high temperature, Related Products of catalysis-chemistry, the publication is European Food Research and Technology (2022), 248(8), 2079-2095, database is CAplus.

The mechanisms of volatile species formation for hydroperoxylated metabolites of unsaturated fatty acids in grass carp oil were investigated. All oil samples were heated at 110 ¡ãC for 8 various durations. The hydroperoxylated metabolites were evaluated by ultra-performance liquid chromatog. coupled with time-of-flight mass spectrometry, solid-phase microextraction gas chromatog. mass spectrometry and conventional chem. indicators. Compared to fresh fish oil, the content of monounsaturated fatty acids and saturated fatty acids with higher oxidation stability in the heating samples was significantly increased (P < 0.05), while the content of polyunsaturated fatty acids was significantly reduced (P < 0.05). A total of 35 triglycerides were determined, of these, the relative content of carbon numbers (CNs) 54, 56 and 58 was dramatically decreased, while CN50 and CN52 were gradually increased. Partial least-squares discriminant anal. indicated that continuous heating had different effects on volatile substances and twelve volatile species variables associated with lipid oxidation from the eight various heating periods were identified. In addition, sixteen oxidized metabolites were identified and their content was significantly increased (P < 0.05), except the 13-HODE, 9-HOTrE, 5-HETE and 12-HETE. The metabolic pathways of grass carp oil under continuous heating were clarified based on critical volatile components and oxidized metabolites, intending to reveal the oxidation paradigm of oil exposed to high temperatures

European Food Research and Technology published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Todorov, Petar published the artcileSynthesis and characterization of new 5,5¡ä-dimethyl- and 5,5¡ä-diphenylhydantoin-conjugated hemorphin derivatives designed as potential anticonvulsant agents, Application In Synthesis of 71989-31-6, the publication is New Journal of Chemistry (2022), 46(5), 2198-2217, database is CAplus.

Herein, the synthesis and characterization of some novel N-modified hybrid analogs of hemorphins containing a C-5 substituted hydantoin residue as potential anticonvulsants and for the blockade of sodium channels are presented. Their structure-property relationships are highlighted by electrochem. and Fourier transform IR spectroscopy (FT-IR) anal. methods. The lipophilicity and mol. docking of voltage-gated sodium channels were also determined The new series of 5,5-dimethyl- and 5,5-diphenylhydantoin-conjugated hemorphin derivatives were obtained as C-terminal amides via solid-phase peptide synthesis, an Fmoc-strategy using 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate (TBTU). The anticonvulsant activity of the hybrid-peptides (0.25, 0.5 and 1 ¦Ìg) was tested by maximal electroshock (MES) and 6 Hz psychomotor seizure tests using male ICR mice. None of the compounds tested showed neurotoxicity in the rotarod test. The reference drug phenytoin was used as a pos. control. The most active compound Ph-5 showed 100% efficacy against the 6 Hz-induced psychomotor seizures at a dose of 1.0 ¦Ìg and tonic seizures in the MES test at a lower dose of 0.5 ¦Ìg. This analog of VV-hemorphin-5 contained a 5,5-diphenylhydantoin residue at the N-terminus and a hydrophobic Val-Val-Tyr-Pro-Trp-Thr-Gln-CONH₂ amino acid sequence of the peptide mol. The quant. data for the 6 Hz test demonstrated that the peptide Ph-5 exhibited a median ED (ED50) value of 0.358 ¦Ìg and PI >13.97, and ED50 of 0.25 ¦Ìg and PI >20.35 in the MES test, resp. Results from the docking study suggest that the neuropeptide Ph-5 is a potent inhibitor of sodium channels, and blockade of voltage-gated sodium channels could be the mechanism of action of the hybrid-peptide derivatives with anticonvulsant activity.

New Journal of Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C7H13NO2, Application In Synthesis of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kolodziuk, Robert published the artcilePalladium-catalyzed Suzuki cross-coupling of aryl halides with aryl boronic acids in the presence of glucosamine-based phosphines, Formula: C3H8N2S, the publication is Journal of Organometallic Chemistry (2003), 687(2), 384-391, database is CAplus.

Carbohydrate-substituted phosphines are easily obtained in quite good yields by coupling of protected or non-protected D-glucosamine with the corresponding diphenylphosphino acid. These neutral ligands, in association with palladium acetate, are very active catalysts in the Suzuki cross-coupling reaction. The polyhydroxy phosphines are more active than the peracetylated phosphines. The process tolerates electron-rich as well as electron-poor substituents. Excellent turnovers, up to 97 000 are observed

Journal of Organometallic Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jie published the artcileDesign, synthesis and antitumor activity of novel cis-furoquinoline derivatives, Recommanded Product: Bis(4-nitrophenyl)amine, the publication is Letters in Drug Design & Discovery (2012), 9(4), 379-388, database is CAplus.

A series of novel cis-furoquinoline derivatives, e. g. I, was synthesized and tested for antitumor activities in vitro against HepG2 cells, Lu-04 cells and Leu02 cells to evaluate structure-activity relationships. Assay-based antiproliferative activity study revealed that several compounds had significant cytotoxicity, among which 3 compounds were the most active and deserved further study as potential anticancer agents.

Letters in Drug Design & Discovery published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Recommanded Product: Bis(4-nitrophenyl)amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kraynack, Erica A. published the artcileIntermolecular pinacol coupling of sulfur-substituted aldehydes by vanadium-zinc complex [V₂Cl₃(THF)₆]₂(Zn₂Cl₆). The effect of the substitution at sulfur on the stereochemical outcome of the coupling reaction, Category: catalysis-chemistry, the publication is Journal of Organic Chemistry (1993), 58(22), 6114-17, database is CAplus.

Pinacol cross-couplings of sulfur-substituted aldehydes with aliphatic aldehydes have been investigated. Addition of the sulfur aldehyde to a solution of [V₂Cl₃(THF)₆]₂(Zn₂Cl₆) and the aliphatic aldehyde provides unsym. 1,2-diols in good yield (55-97%). Stereoselectivity in these reactions is influenced by changing the substituent R³ in sulfonyl (R³SO₂)-substituted aldehydes.

Journal of Organic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bhagat, Ujjawal Kumar published the artcileRegiospecific Aza-Michael Addition of 4-Aryl-1H-1,2,3-triazoles to Chalcones: Synthesis of 2,4-Disubstituted 1,2,3-Triazoles in Basic Medium, Synthetic Route of 4230-93-7, the publication is Synlett (2018), 29(1), 99-105, database is CAplus.

A novel metal-free and base-mediated method to display the donor ability of 1,2,3-triazoles for the synthesis of 2,4-disubstituted 1,2,3-triazoles was developed. A DABCO-promoted aza-Michael addition of 4-aryl NH-1,2,3-triazoles to ¦Á,¦Â-unsaturated ketones (chalcones) is presented. The reactions proceeded with complete regiospecificity in a 3:1 mixture of acetonitrile and methanol at 85¡ã to provide 2,4-disubstituted 1,2,3-triazoles as Michael adducts, and the addition products 1,3-diaryl-(4-aryl-2 H-1,2,3-triazol-2-yl)propan-1-ones were isolated in high yields.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia