Month: December 2022

Li, Ya-Lan published the artcileChemo- and Site-Selective Fischer Esterification Catalyzed by B(C₆F₅)₃, Related Products of catalysis-chemistry, the publication is Asian Journal of Organic Chemistry (2021), 10(6), 1424-1427, database is CAplus.

A direct and catalytic dehydrative esterification of carboxylic acids RC(O)OH [R = hept-1-yn-1-yl, 2-(naphthalen-2-yl)ethyl, (1-methyl-1H-indol-3-yl)methyl, 1-([(benzyloxy)carbonyl]amino)ethyl, etc.] with alcs. R¹OH (R¹ = Et, cyclohexyl, 2,3-dihydroxypropyl, etc.) is described. B(C₆F₅)₃ is shown to be a highly effective catalyst for the Fischer esterification, providing esters RC(O)OR¹ in high to excellent yields. This esterification shows excellent chemo- and site-selective monoesterification of various polyols R¹OH without any protection step, including bio-derived mol. glycerol.

Asian Journal of Organic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tejo, Ciputra published the artcileDearylation of arylphosphine oxides using a sodium hydride-iodide composite, COA of Formula: C15H15OP, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(14), 1782-1785, database is CAplus and MEDLINE.

A new protocol for the dearylation of arylphosphine oxides was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). Reaction of triarylphosphine oxides Ar₂PPh with NaH/LiI afforded sodium phosphinites Ar₂PONa, which were trapped with alkyl halides RX to give diarylalkylphosphine oxides Ar₂P(O)R in good to excellent yields. The transient sodium phosphinite could be functionalized with a range of electrophiles in a one-pot fashion.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C17H19N3O6, COA of Formula: C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Thirunavukkarasu, Rajasekar published the artcileInfluence of extracellular protein isolated from fish gut associated bacteria as an enhancer of growth and innate immune system in Mugil cephalus, HPLC of Formula: 63-68-3, the publication is Scientific Reports (2022), 12(1), 3217, database is CAplus and MEDLINE.

The cultural microbiomes of 27 bacteria colonies were isolated from Mugil cephalus for anal. of the antibacterial and antagonistic activities. A potent probiotic bacterium was characterized using16S r RNA sequencing. The potent strain was added to fish diet to perform the challenge test and to study the growth and immunol. parameter. The extracellular proteins from the probiotic were collected and characterized using MALDI TOF/TOF. Out of G27, G9 strain inhibited all the five pathogenic strains. An isolated bacterium was identified as Bacillus subtilis PRBD09 with accession number KF765648. After 35 days of feeding period B. subtilis PRBD09 enhance the both cellular and humoral immune responses, which responsible for survive of the Mugil cephalus against Aeromonas hydrophila infection. The MALDI TOF sample 08 and 09 were recognized as hypothetical proteins based on the MALDI TOF sample. A cytidinedeaminase was found in samples 10, 11, and 12. Extracellular proteins may be involved for the immunol. increase in Mugil cephalus against Aeromonas hydrophila, according to the current research.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C13H10O3, HPLC of Formula: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ojha, Subhadra published the artcilePd-Catalyzed desulfitative arylation of olefins by N-methoxysulfonamide, Category: catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2022), 20(6), 1292-1298, database is CAplus and MEDLINE.

A novel Pd-catalyzed protocol for the desulfitative Heck-type reaction of N-methoxy aryl sulfonamides with alkenes was reported. The cross-coupling reaction was performed successfully with a variety of olefins to obtain aryl alkenes RCH=CHR¹ [R = Ph, 4-ClC₆H₄, 2-thienyl, etc.; R¹ = CN, COOH, CO₂Me, etc.]. Different substituents on the aromatic ring of N-methoxysulfonamides were also found to be compatible with the reaction conditions. Expectedly, the reaction proceeded through CuCl₂-promoted generation of the nitrogen radical and subsequent desulfonylation under thermal conditions to afford the aryl radical for the Pd-catalyzed coupling reaction. N-Methoxysulfonamide was further exploited for the synthesis of sym. biaryls in the presence of CuCl₂.

Organic & Biomolecular Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vanjari, Rajeshwer published the artcileGold(I)-mediated rapid cyclization of propargylated peptides via imine formation, Category: catalysis-chemistry, the publication is Journal of the American Chemical Society (2022), 144(11), 4966-4976, database is CAplus and MEDLINE.

In fundamental research and drug discovery, there is still a need for effective and straightforward chem. approaches for generating cyclic peptides. The divergent synthesis of cyclic peptides remains a challenge, in particular when cyclization is carried out in the presence of unprotected side chains and a nonpeptidic component within the cycle is needed. Herein, we describe a novel and efficient strategy based on Au(I)-mediated cyclization of unprotected peptides through rapid (30-60 min) amine addition on a propargyl group to generate an imine linkage. Mechanistic insights reveal that the reaction proceeds via regioselective Markovnikov’s addition of the amine on the Au(I)-activated propargyl. This strategy was successfully applied to prepare efficiently (56-94%) over 35 diverse cyclic peptides having different sequences and lengths. We have also achieved stereoselective reduction of cyclic imines employing chiral ligands. The practicality of our method was extended for the synthesis of cyclic peptides that bind Lys48-linked di-ubiquitin chains with high affinity, leading to apoptosis of cancer cells.

Journal of the American Chemical Society published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C13H19N5OS, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Xiu published the artcileControllable Single and Double Difluoromethylene Insertions into C-Cu Bonds: Copper-Mediated Tetrafluoroethylation and Hexafluoropropylation of Aryl Iodides with TMSCF₂H and TMSCF₂Br, Related Products of catalysis-chemistry, the publication is Journal of the American Chemical Society (2022), 144(27), 12202-12211, database is CAplus and MEDLINE.

The selective difluoromethylene insertion into a C-Cu bond is a challenging task and is currently limited to either a single CF₂ insertion into CuCF₃ or double CF₂ insertions into CuC₆F₅ (or (Z)-CF₃CF = CFCu). Achieving both selective single and double CF₂ insertions into the same C-Cu bond is even more difficult. Herein, highly controllable single and double CF₂ insertions into CuCF₂H species with a TMSCF₂Br reagent have been described, affording two previously unknown fluoroalkylcopper species “Cu(CF₂)_nCF₂H” (n = 1 and 2) independently under different reaction conditions. This work represents the first example of both single and double CF₂ insertions into the same C-Cu bond in a highly selective manner. The synthetic value of the obtained “Cu(CF₂)_nCF₂H” (n = 1 and 2) species is demonstrated by their reactions with aryl iodides, halogenation agents, and cinnamyl chloride, which enables the direct transfer of HCF₂CF₂ and HCF₂CF₂CF₂ moieties into organic mols. The key to controllable fluorocarbon chain elongation from C₁ to C₂ and from C₁ to C₃ is presumably attributed to the different reactivities of “Cu(CF₂)_nCF₂H” species (n = 0, 1, 2 and 3) and the loading of the TMSCF₂Br reagent.

Journal of the American Chemical Society published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C3H5BN2O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Huamin published the artcileCopper-catalyzed oxidative coupling of carboxylic acids with formamides for the synthesis of ¦Á,¦Â-unsaturated amides, SDS of cas: 1772-76-5, the publication is Tetrahedron Letters (2013), 54(49), 6679-6681, database is CAplus.

A novel and efficient protocol for the synthesis of ¦Á,¦Â-unsaturated amides was developed using catalytic amounts of Cu(OAc)₂ and TBHP as oxidant. Oxidative coupling of various unsaturated carboxylic acids with N,N-disubstituted formamides furnished the desired products in good yields.

Tetrahedron Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, SDS of cas: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ntasi, Georgia published the artcileMolecular signatures written in bone proteins of 79 AD victims from Herculaneum and Pompeii, COA of Formula: C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 8401, database is CAplus and MEDLINE.

An extensive proteomic anal. was performed on a set of 12 bones of human victims of the eruption that in AD 79 rapidly buried Pompeii and Herculaneum, allowing the detection of mol. signatures imprinted in the surviving protein components. Bone collagen survived the heat of the eruption, bearing a piece of individual biol. history encoded in chem. modifications. Here we show that the human bone proteomes from Pompeii are more degraded than those from the inhabitants of Herculaneum, despite the latter were exposed to temperatures much higher than those experienced in Pompeii. The anal. of the specimens from Pompeii shows lower content of non-collagenous proteins, higher deamidation level and higher extent of collagen modification. In Pompeii, the slow decomposition of victims soft tissues in the natural dry-wet hydrogeol. soil cycles damaged their bone proteome more than what was experienced at Herculaneum by the rapid vanishing of body tissues from intense heat, under the environmental condition of a permanent waterlogged burial context. Results herein presented are the first proteomic analyses of bones exposed to eruptive conditions, but also delivered encouraging results for potential biomarkers that might also impact future development of forensic bone proteomics.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Heuser, Michael published the artcileSafety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results, Formula: C17H37NO3, the publication is Leukemia (2020), 34(11), 2903-2913, database is CAplus and MEDLINE.

The mutant IDH1 (mIDH1) inhibitor BAY1436032 demonstrated robust activity in preclin. AML models, supporting clin. evaluation. In the current dose-escalation study, BAY1436032 was orally administered to 27 mIDH1 AML subjects across 4 doses ranging from 300 to 1500 mg twice-daily. BAY1436032 exhibited a relatively short half-life and apparent non-linear pharmacokinetics after continuous dosing. Most subjects experienced only partial target inhibition as indicated by plasma R-2HG levels. BAY1436032 was safe and a maximum tolerated dose was not identified. The median treatment duration for all subjects was 3.0 mo (0.49-8.5). The overall response rate was 15% (4/27; 1 CRp, 1 PR, 2 MLFS), with responding subjects experiencing a median treatment duration of 6.0 mo (3.9-8.5) and robust R-2HG decreases. Thirty percent (8/27) achieved SD, with a median treatment duration of 5.5 mo (3.1-7.0). Degree of R-2HG inhibition and clin. benefit did not correlate with dose. Although BAY1436032 was safe and modestly effective as monotherapy, the low overall response rate and incomplete target inhibition achieved at even the highest dose tested do not support further clin. development of this investigational agent in AML.

Leukemia published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Adams, Gregory L. published the artcileDevelopment of ProTx-II analogs as highly selective peptide blockers of Na_v1.7 for the treatment of pain, HPLC of Formula: 71989-31-6, the publication is Journal of Medicinal Chemistry (2022), 65(1), 485-496, database is CAplus and MEDLINE.

Inhibitor cystine knot peptides, derived from venom, have evolved to block ion channel function but are often toxic when dosed at pharmacol. relevant levels in vivo. The article describes the design of analogs of ProTx-II that safely display systemic in vivo blocking of Na_v1.7, resulting in a latency of response to thermal stimuli in rodents. The new designs achieve a better in vivo profile by improving ion channel selectivity and limiting the ability of the peptides to cause mast cell degranulation. The design rationale, structural modeling, in vitro profiles, and rat tail flick outcomes are disclosed and discussed.

Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, HPLC of Formula: 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia