Month: December 2022

Khairullin, R. A. published the artcileReactions of diphenyl- and diethylphosphinodithioic acids with N-alkyl-2-haloaldimines in the synthesis of new P,S- and N,P,S-containing organic compounds, SDS of cas: 140-28-3, the publication is Russian Journal of General Chemistry (2017), 87(10), 2313-2319, database is CAplus.

Diphenyl- and diethylphosphinodithioic acids, unlike the stronger O,O-dialkyl phosphorodithioic acids, react with N-alkyl-2-chloroaldimines at a 1: 1 ratio, following two pathways: nucleophilic substitution of chlorine in the primary salt by the phosphinothioylthio group and reduction of the cation of the primary salt on the C-Cl bond. Nucleophilic substitution contributes more in the case of the stronger diphenylphosphinodithioic acid, as well as in the case of a large excess of the starting chlorimine. N-Alkyl-2-bromoaldimines react only by a single pathway, specifically, reducing the cation of the primary iminium salt on the C-Br bond. New iminium salts were synthesized and converted into the corresponding aldehydes and imines. The aldehydes synthesized were converted into acetals and five-membered heterocyclic compounds

Russian Journal of General Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, SDS of cas: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Narode, Hanuman published the artcileVanillin containing 9H-fluoren sulfone scaffolds: Synthesis, biological evaluation and molecular docking study, Product Details of C20H19NO4, the publication is Results in Chemistry (2022), 100269, database is CAplus.

Vanillin containing 9H-fluoren sulfone scaffolds I [R = Fmoc-Gly, Fmoc-Pro, Fmoc-Phe, etc.] were prepared by coupling a sulfone amine with carboxylic acid group of amino acids in presence of peptide coupling reagent hexafluorophosphate benzotriazole tetra-Me uronium (HBTU). All eight compounds I synthesized vanillin containing 9H-fluoren sulfone scaffolds were evaluated for their biol. activities, namely, antibacterial, antifungal and antimalarial. The antibacterial evaluation revealed that compounds I [R = Fmoc-Ala, Fmoc-Ser(t-Bu), Fmoc-Pro, Fmoc-Leu, Fmoc-D-Val, Fmoc-Met] exhibited potency against tested pathogenic bacteria, especially against Staphylococcus aureus. Compounds I [R = Fmoc-Ala, Fmoc-Val, Fmoc-Phe] manifested considerable antifungal activities against Candida albicans, Aspergillus niger and A. clavatus. Moreover, the antimalarial result demonstrated excellent antimalarial activities for compounds I [R = Fmoc-Ala, Fmoc-Val] against Plasmodium falciparum with IC₅₀ less than the standard quinine. Further, mol. docking study was performed to find mol. level interaction of compounds with malarial drug target enzyme P. falciparum dihydrofolate reductase-thymidylate synthase (pfdher-ts). Interestingly, for all tested sulfone scaffolds the docking energy was found between -8.6 to -10.6 kcal/mol, which was higher than both of the standard drugs’ (quinine and chloroquine) docking energy, i.e. -8.4 and -6.9, resp. The results of this study confirmed the importance of the sulfone class of compounds in the treatment of parasitic infections and microbial infections.

Results in Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Product Details of C20H19NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moragas, Toni published the artcileNickel-Catalyzed Carboxylation of Benzylic C-N Bonds with CO₂, Quality Control of 1860-58-8, the publication is Angewandte Chemie, International Edition (2016), 55(16), 5053-5057, database is CAplus and MEDLINE.

A user-friendly Ni-catalyzed reductive carboxylation of benzylic C-N bonds with CO₂ is described. This procedure outperforms state-of-the-art techniques for the carboxylation of benzyl electrophiles by avoiding commonly observed parasitic pathways, such as homodimerization or ¦Â-hydride elimination, thus leading to new knowledge in cross-electrophile reactions.

Angewandte Chemie, International Edition published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zakrzewska, Anna published the artcile¹³C-NMR based evaluation of the electronic and steric interactions in aromatic amines, Safety of 2,6-Diisopropyl-N,N-dimethylaniline, the publication is International Journal of Molecular Sciences (2005), 6(1-2), 52-62, database is CAplus.

Chem. shifts of the para carbon atoms, ¦Ä(¹³C-4), in a series of aromatic amines were used to calculate the ¦Ò_p, ¦Ò_R and ¦Ò^O_R substituent constants for different amino groups. 1-Pyrrolidino, N-N-di-n-butylamino and N,N-diethylamino groups were found to be the most strong electron-donors. Ortho-Substitution decreases the donor properties of the amino group. The amino groups in 2,6-di-i-propylaniline and N,N-2,6-tetramethylaniline have very weak electron-donor properties. The nitrogen atom in benzoquinuclidine and N,N-dimethyl-2,6-di-i-propylaniline have an electron-acceptor character. The calculated substituent constants of the amino groups studied are consistent with the spectral and reactivity data available in literature. Values of ¦Ä(¹⁵N) cannot be used as a direct measure of electronic effects of the N atom in anilines.

International Journal of Molecular Sciences published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C3H5BF3KO2, Safety of 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Verdirosa, Federica published the artcile1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-¦Â-Lactamase Inhibitors, SDS of cas: 118-90-1, the publication is ChemMedChem (2022), 17(7), e202100699, database is CAplus and MEDLINE.

Metallo-¦Â-lactamases (MBLs) are increasingly involved as a major mechanism of resistance to carbapenems in relevant opportunistic Gram-neg. pathogens. Unfortunately, clin. efficient MBL inhibitors still represent an unmet medical need. We previously reported several series of compounds based on the 1,2,4-triazole-3-thione scaffold. In particular, Schiff bases formed between diversely 5-substituted-4-amino compounds and 2-carboxybenzaldehyde were broad-spectrum inhibitors of VIM-type, NDM-1 and IMP-1 MBLs. Unfortunately, these compounds were unable to restore antibiotic susceptibility of MBL-producing bacteria, probably because of poor penetration and/or susceptibility to hydrolysis. To improve their microbiol. activity, we synthesized and characterized compounds where the hydrazone-like bond of the Schiff base analogs was replaced by a stable Et link. This small change resulted in a narrower inhibition spectrum, as all compounds were poorly or not inhibiting NDM-1 and IMP-1, but showed a significantly better activity on VIM-type enzymes, with Ki values in the ¦ÌM to sub-¦ÌM range. The resolution of the crystallog. structure of VIM-2 in complex with one of the best inhibitors yielded valuable information about their binding mode. Interestingly, several compounds were shown to restore the ¦Â-lactam susceptibility of VIM-type-producing E. coli laboratory strains and also of K. pneumoniae clin. isolates. In addition, selected compounds were found to be devoid of toxicity toward human cancer cells at high concentration, thus showing promising safety.

ChemMedChem published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C10H9NO, SDS of cas: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ovakimiyan, M. Zh. published the artcileOne-pot synthesis of biologically highly active triphenyl [2-(2-benzylidenhydrazinyl)propyl]phosphonium bromide, COA of Formula: C15H15OP, the publication is Hayastani Kimiakan Handes (2013), 66(3), 516-520, database is CAplus.

By interaction of triphenylprop-2-enylphosphonium bromide with benzylhydrazine in the presence of triethylamine in mild conditions [2-(2-benzylidenehydrazinyl)propyl]phosphonium bromide has been obtained. It is obvious that the resulted substance is dehydrogenation product of the initially formed adduct.

Hayastani Kimiakan Handes published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, COA of Formula: C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Davidkova, P. published the artcileTLC and HPTLC of alkyl-substituted phenoxyalkanoic acids, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Symposia Biologica Hungarica (1986), 567-78, database is CAplus.

The optimum conditions for the separation of alkyl-substituted phenoxyalkanoic acids by normal-phase partition and reversed-phase TLC and reversed-phase high-performance (HP) TLC on chem.-bonded phase were studied. The separated spots were detected by spraying with a 0.2% EtOH solution of 2,7-dichlorofluorescein.

Symposia Biologica Hungarica published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Davidkova, P. published the artcileSeparation efficiency of adsorption and partition thin-layer chromatography and reversed-phase high-performance thin-layer chromatography with chemically bonded phases for alkylphenoxyalkanoic acids, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of Chromatography (1987), 410(1), 53-76, database is CAplus.

The separation of 32 alkyl-substituted phenoxyalkanoic acids from phenoxyacetic to 3-pentadecylphenoxylauric acid was studied using adsorption chromatog., 3 types of partition chromatog. (water, formamide, or liquid paraffin as stationary phases), and reversed-phase high-performance thin-layer chromatog. (RP-HPTLC) with chem. bonded phases. All these chromatog. systems were found suitable from the anal. point of view, but some differences in their suitability for the separation of lower or higher homologs or in their detection sensitivity were observed The most efficient methods seem to be RP-HPTLC and TLC on silica gel layers impregnated with formamide or DMF, resp., the former owing to the good separation of the highest lipophilic homologs and to the formation of discrete spots, permitting sharper anal. differentiation of acids with smaller R_f differences in general, and the latter owing to the highest ¦¤R_M values for the methylene groups of all the homologs in connection with high detection sensitivity. The best detection was achieved by using 2,7-dichlorofluorescein as the spray reagent followed by observation in UV light. The detection limit was 0.5-10 ¦Ìg of the acids, depending on the chromatog. system used.

Journal of Chromatography published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lomozik, Lechoslaw published the artcileCopper(II) ions as a factor interfering in the interaction between bioligands in systems with adenosine and polyamines, Related Products of catalysis-chemistry, the publication is Journal of Inorganic Biochemistry (1996), 63(3), 191-206, database is CAplus.

Noncovalent interactions were found to occur in metal-free adenosine-polyamine systems. Overall stability constants and equilibrium constants of adduct formation were determined The ranges in which the adducts occur overlap with the ranges in which nucleoside is deprotonated while polyamine is protonated. Stability constants and complex distribution in the Cu/Ado/PA (PA = polyamine) systems were identified. The coordination mode of the complexes in solution was determined Unlike in 1,3-diaminopropane (tn), putrescine (Put) and 1,7-diamino-4-azaheptane (3,3-tri), in the systems containing spermidine (Spd), the coordination dichotomy between the N(1) and N(7) atoms of the nucleoside disappeared. In some complexes occurring in the systems with tn, 3,3-tri (but not with Put and Spd), coordination with nitrogen atoms at axial positions was detected in solution Generally, however, a tendency to form square-planar structures dominates. Differences in the coordination mode of complexes in solution and solid complexes were determined

Journal of Inorganic Biochemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bregier-Jarzebowska, R. published the artcileInteractions of diamines with adenosine-5′-triphosphate (ATP) in the systems including copper(II) ions, Recommanded Product: Propane-1,3-diamine dihydrochloride, the publication is Journal of Inorganic Biochemistry (2016), 73-82, database is CAplus and MEDLINE.

Interactions were studied in the systems ATP/tn and ATP/Put (tn = 1,3-diaminopropane, Put = putrescine) whereas the complexation reactions in ternary systems Cu(II)/ATP/tn and Cu(II)/ATP/Put. Results of the potentiometric and spectroscopic studies evidenced the formation of adducts of the type (ATP)H_x(PA), where PA = diamine. The thermodn. stability of the complexes and the mode of interactions were determined The interaction products are (ATP)H₃(tn) (1), (ATP)H₂(tn) (2), (ATP)H₃(Put) (3), and (ATP)H₂(Put) (4). On the basis of anal. of changes in the positions of NMR signals, in the pH range of (ATP)H₃(Put) (3) formation, the preferred centers of the interaction between ATP and Put are the endocyclic nitrogen atoms from the nucleotide. However, the shorter diamine tn in the entire pH range reacts with the phosphate groups from ATP. The pos. centers of noncovalent interactions are the protonated -NH⁺_x groups from amines. In both complexes Cu(ATP)H₂(tn) (9) and Cu(ATP)H₃(Put) (11) formed in ternary systems at pH < 6.5, the amines are in the outer sphere of coordination with the noncovalent interaction with anchoring Cu(ATP). Only the phosphate groups from the nucleotide take part in metalation. At higher pH in the range of Cu(ATP)(PA) complex formation, significant differences in the reactions of the two amines appear. The shorter one (tn) binds Cu(II) ions with two nitrogen atoms, while putrescine coordinates in the monofunctional mode, which is undoubtedly related to the differences in lengths of methylene chain. This explains the considerable differences in the stability of Cu(ATP)(tn) (10) and Cu(ATP)(Put) (12). In both complexes the nucleotide is coordinated through phosphate groups. As a result of noncovalent interactions ATP forms mol. complexes with 1,3-diaminopropane and 1,4-diaminobutane (putrescine). Significant differences in the mode of interactions between the two diamines were observed in ATP/diamine binary systems and in ternary systems Cu(II)/ATP/diamine, at high pH.

Journal of Inorganic Biochemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Recommanded Product: Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia