Month: December 2022

Huang, Di published the artcileScreening organic contaminants in soil by two-dimensional gas chromatography high-resolution time-of-flight mass spectrometry: A non-target analysis strategy and contaminated area case study, Synthetic Route of 613-33-2, the publication is Environmental Research (2022), 112420, database is CAplus and MEDLINE.

Thousands of organic substances that are used in industrial applications ultimately enter the soil and may neg. affect human health. Limited numbers of target pollutants are usually monitored in environmental media because of anal. limitations. In this study, a non-target screening method for quickly analyzing multiple soil samples from a contaminated area (a chem. industry park) by two-dimensional gas chromatog. high-resolution time-of-flight mass spectrometry was developed. The types of compounds present in the soil samples were preliminarily analyzed through data simplification and visual assessment. A total of 81 organic compounds with detection frequencies ¡Ý40% in the samples from the chem. industry park were selected for identification, including 38 PAHs, 26 oxygenated organic compounds, eight N-containing compounds, and nine other compounds Potential sources of the organic compounds in the industrial park were investigated. Some pharmaceutical and organic synthetic intermediates in the soil were affected by nearby chem. plants. After assessing the relative abundances and detection frequencies, 36 pollutants that may pose potential risks to the environment were preliminarily identified. The results of the study were helpful for assessing environmental risks around Yangkou industrial park and they will be helpful when assessing risks in other contaminated areas.

Environmental Research published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Synthetic Route of 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Miller, David C. published the artcileAnti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines, Formula: C15H24S, the publication is Journal of the American Chemical Society (2019), 141(42), 16590-16594, database is CAplus and MEDLINE.

A photocatalytic method for the intermol. anti-Markovnikov hydroamination of unactivated olefins with primary alkyl amines to selectively furnish secondary amine products is reported. These reactions proceed through aminium radical cation (ARC) intermediates and occur at room temperature under visible light irradiation in the presence of an iridium photocatalyst and an aryl thiol hydrogen atom donor. Despite the presence of excess olefin, high selectivities are observed for secondary over tertiary amine products, even though the secondary amines are established substrates for ARC-based olefin amination under similar conditions.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Formula: C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Talari, Kalpana published the artcileGas chromatography-mass spectrometric determination of organic acids by ion pair liquid extraction followed by in-situ butylation from aqua feed samples, Name: 2-Methylbenzoic acid, the publication is European Journal of Mass Spectrometry (2022), 28(1-2), 25-34, database is CAplus and MEDLINE.

A rapid and sensitive anal. method was developed to quant. determine organic acids (OAs) from fish feed samples extracted by ion-pair (IP) solvent extraction, followed by in-situ butylation and gas chromatog.-mass spectrometric (GC-MS) anal. The extraction of OAs was carried out with acetonitrile containing 10 mM tetrabutylammonium hydroxide (TBAH), and the analytes were derivatized to their Bu esters in the injection port of the GC-MS system. The developed method was validated in the range of 1-5000 ng/g, with recoveries ranging from 93-117%. The limit of detection (LOD) and limit of quantification (LOQ) of the method was 1-5 ng/g and 2-10 ng/g, resp., yielding good linearity (R² > 0.9990) and precision with a relative standard deviation less than 10%. The proposed method was successfully applied to analyze OAs in sinking and floating fish feed samples. The analyzed samples showed the presence of benzoic, succinic, fumaric, glutaric, adipic, and phthalic acids in sinking feed samples; and benzoic, succinic, adipic, phthalic acids in floating feed samples, resp.

European Journal of Mass Spectrometry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C10H14O2, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karthick, S. published the artcileTerahertz generation and optical properties of N-benzyl-2-methyl-4-nitroaniline single crystals in 0.1-2.0 THz range for photonic applications, Name: N-Benzyl-2-methyl-4-nitroaniline, the publication is Materials Letters (2019), 95-98, database is CAplus.

We report on the THz generation and optical characterizations such as index of refraction, absorption coefficients of indigenously grown, potentially NLO active N-benzyl-2-methyl-4-nitroaniline (BNA) single crystals grown from four different solvents such as N, N DMF (DMF), Methanol (MeOH), Acetonitrile (ACN) and ACN: DMF (1:1) in an intentionally selected frequency range of 0.1-2.0 THz at room temperature (RT). The DMF was identified to be a promising candidate as it facilitated reduction in the inclusions. The powder Second Harmonic Generation (SHG) measurements performed on BNA polycrystalline samples revealed that their efficiencies were about 8.4 and 2.3 times higher than KDP and Urea samples resp. The absorption coefficients and refractive indexes made in this technol. important THz range using the BNA crystals grown from selected solvents exhibited, interestingly, solvent dependency.

Materials Letters published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Name: N-Benzyl-2-methyl-4-nitroaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chaudhuri, Dipankar published the artcileChemical synthesis of a potent antimicrobial peptide Murepavadin using a tandem native chemical ligation/desulfurization reaction, COA of Formula: C20H19NO4, the publication is Journal of Organic Chemistry (2021), 86(21), 15242-15246, database is CAplus and MEDLINE.

Classical approaches for the backbone cyclization of polypeptides require conditions that may compromise the chirality of the C-terminal residue during the activation step of the cyclization reaction. Here, we describe an efficient epimerization-free approach for the Fmoc-based (Fmoc = 9-fluorenyl-methoxycarbonyl) synthesis of murepavadin using intramol. native chem. ligation in combination with a concomitant desulfurization reaction. Using this approach, bioactive murepavadin was produced in a good yield in two steps. The synthetic peptide antibiotic showed potent activity against different clin. isolates of P. aeruginosa. This approach can be easily adapted for the production of murepavadin analogs and other backbone-cyclized peptides.

Journal of Organic Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, COA of Formula: C20H19NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Henriet, Theo published the artcileSolid state stability and solubility of triethylenetetramine dihydrochloride, Application In Synthesis of 38260-01-4, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2016), 511(1), 312-321, database is CAplus and MEDLINE.

The API triethylenetetramine dihydrochloride used as an alternative treatment of Wilson’s disease is sensitive to water and it exhibits polymorphism. As this may become an issue for the drug formulation, the phys. stability has been studied by differential scanning calorimetry, high-pressure thermal anal., dynamic vapor sorption, and X-ray diffraction as a function of temperature In addition, high-pressure liquid chromatog. and mass spectrometry have been used to study the purity and chem. stability of the API. A pressure-temperature phase diagram of the pure compound has been constructed and it can be concluded that form II is monotropic in relation to form I, which is the only stable solid. The solubilities of the different solid forms have been determined with the help of a temperature – composition phase diagram. The API is very soluble, at 20¡ã C about 10% of the saturated solution with respect to the dihydrate consists of API and the solubility of the pure form I is twice as high. Moreover, it has been shown that at 20 ¡ãC, a relative humidity above 40% induces the formation of the dihydrate and at 70% a saturated solution appears. At higher temperatures, the formation of the dihydrate appears at lower relative humidity values. A clear link has been established between the API’s chem. stability, its phys. stability and the relative humidity in the air. Humidity levels above 40% are detrimental to the quality of the API.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Dawei published the artcileTemplation and Concentration Drive Conversion Between a Fe^II₁₂L₁₂ Pseudoicosahedron, a Fe^II₄L₄ Tetrahedron, and a Fe^II₂L₃ Helicate, Safety of Coronene, the publication is Journal of the American Chemical Society (2022), 144(3), 1106-1112, database is CAplus and MEDLINE.

authors report the construction of three structurally distinct self-assembled architectures: Fe^II₁₂L₁₂ pseudoicosahedron 1, Fe^II₂L₃ helicate 2, and Fe^II₄L₄ tetrahedron 3, formed from a single triazatriangulenium subcomponent A under different reaction conditions. Pseudoicosahedral capsule 1 is the largest formed through subcomponent self-assembly to date, with an outer-sphere diameter of 5.4 nm and a cavity volume of 15 nm³. The outcome of self-assembly depended upon concentration, where the formation of pseudoicosahedron 1 was favored at higher concentrations, while helicate 2 exclusively formed at lower concentrations The conversion of pseudoicosahedron 1 or helicate 2 into tetrahedron 3 occurred following the addition of a CB₁₁H₁₂^– or B₁₂F₁₂^2- template.

Journal of the American Chemical Society published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C12H16O3, Safety of Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Safar, M. published the artcileNitrogen compounds of adamantane. VII. New preparation of 7-nitro-1,3,5-triazaadamantane and derivatives by hydrogenation and ozonization, Product Details of C7H14N4, the publication is Collection of Czechoslovak Chemical Communications (1975), 40(7), 2179-82, database is CAplus.

Reflux of hexamethylenetetramine, 80% aqueous EtOH, 98-100% HCO2H, and MeNO2 gave 65% I (R = NO2) which was hydrogenated (over PtO2 or Pd/C in EtOH) to I (R = NH2) or (over Pd/C in H2O) to I (R = NHOH). Quaternization of I (R = NO2) with MeI or EtI gave 7-nitro-1,3-diaza-5-alkylazoniaadamantane iodide (alkyl = Me, Et). Reaction of I (R = NO2) with O3 in H2O or 30% H2O2 in AcOH gave the corresponding N-oxide. I (R = NHCH2CN and NHCH2CH2NH2) were also prepared

Collection of Czechoslovak Chemical Communications published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Product Details of C7H14N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kafka, Zdenek published the artcileNitrogen compounds of adamantane. Part XII. Study of reactivity of some 1,3,5-triazaadamantane derivatives, COA of Formula: C7H14N4, the publication is Collection of Czechoslovak Chemical Communications (1978), 43(1), 151-5, database is CAplus.

The reactivities of 7-nitro-1,3,5-triazaadamantane (I) and 7-amino-1,3,5-triazaadamantane (II), prepared by hydrogenation of I.HCl or I.HBr over PtO₂, were studied. Boiling II with HC(OEt)₃ in AcOH or with aqueous HCO₂H gave as the main product 7-(dimethylamino)-1,3,5-triazaadamantane, whereas analogous treatment of I yielded 3-methyl-5-nitro-1,3,7-triazabicyclo[3.3.1]nonane (III). Hydrogenation of III gave 3-methyl-5-amino-1,3,7-triazabicyclo[3.3.1]nonane.

Collection of Czechoslovak Chemical Communications published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, COA of Formula: C7H14N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kafka, Zdenek published the artcileNitrogeneous compounds of adamantane. XI. Paper chromatography and thin-layer chromatography of some derivatives of 1,3,5-triazaadamantane, Application In Synthesis of 14707-75-6, the publication is Sbornik Vysoke Skoly Chemicko-Technologicke v Praze, D: Technologie Paliv (1977), 119-26, database is CAplus.

1,3,5-Triazaadamantane (I), nitro and amino derivatives of I, and their quaternary salts were separated by paper chramatog. (Whatman number 1, 20¡ã, descending) and thin-layer chromatog. on silica gel and Al2O3 (ascending). RF values are given for I, 7-nitro-1,3,5-triazabicyclononane (II), II N-oxide, 3,7-diacetyl-5-nitro-1,3,7-triazaadamantane (III), III N-oxide, 7-amino-1,3,5-triazaadamantane (IV), IV nicotinate, IV isonicotinate, IV adipate, IV glutarate, 7-nitro-1,3-diaza-5-methylazoniaadamantane iodide, 7-nitro-1,3-diaza-5-ethylazoniaadamantane iodide, 7-amino-1,3-diaza-5-methylazoniaadamantane iodide, 7-amino-1,3-diaza-5-ethylazoniaadamantane iodide, and N,N’-bis(1,3,5-triaza-7-adamantyl) urea for 13 binary and ternary solvent systems used in paper chromatog. The quaternary salts and bicyclononane derivatives were separated with HCl or AcOH containing systems.

Sbornik Vysoke Skoly Chemicko-Technologicke v Praze, D: Technologie Paliv published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Application In Synthesis of 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia