Month: December 2022

Kafka, Zdenek published the artcileNitrogen compounds of adamontane. IX. Preparation and reactions of nitrogen analogs of adamantane, Recommanded Product: 1,3,5-Triazaadamantan-7-amine, the publication is Sbornik Vysoke Skoly Chemicko-Technologicke v Praze, D: Technologie Paliv (1976), 127-57, database is CAplus.

Substituted 1-aza-, 1,3-diaza-, 1,3,5-triazaadamantanes (I), and 1,3-diazaadamantan-6-ols (II) and their derivatives were prepared and characterized by ir, gas chromatog., and paper chromatog. Reaction of Me2CO, AcONH4, and aromatic aldehydes gave tetrasubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones, which gave 1,3-diazaadamantan-6-ones on boiling with paraformaldehyde. These compounds were hydrogenated to tetracyclohexyl derivatives of II over Raney Ni. The 7-nitro derivative of I was prepared and reduced to the 7-amino derivative with Zn or Al in alk. medium. The latter compound gave 7-halo compounds and other derivatives Aromatic aldehydes and the 7-amino derivative of I gave aldimines, which were hydrogenated to secondary amines. I was stable in mineral acids but not in a reducing acid medium. Reductive methylation of the 7-amino derivative of I gave 7-alkylamino derivative The nitrile of N-(1,3,5-triaza-1-adamantyl)aminoacetic acid, prepared by cyanomethylation, was reduced to the 7-(aminomethyl)amino derivative with LiAlH4. Partial hydrogenation of the 7-nitro derivative of I gave the 7-hydroxylamino derivative, which with hexamethyldisilazane gave the trimethylsilyl derivative Oxidation with H2O2 or ozonization of the 7-nitro derivative of I gave the N-oxide.

Sbornik Vysoke Skoly Chemicko-Technologicke v Praze, D: Technologie Paliv published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Recommanded Product: 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Safar, M. published the artcileNitrogen compounds of adamantane. VIII. Chromatographic separation of azaadamantanes and their derivatives in a gas liquid system, Synthetic Route of 14707-75-6, the publication is Collection of Czechoslovak Chemical Communications (1975), 40(11), 3334-8, database is CAplus.

Gas chromatog. separation of 1-azaadamantane (I), 1,3-diazaadamantane (II), 1,3,5-triazaadamantane (III), 1,3,5,7-tetraazaadamantane (IV), and their derivatives was investigated. Elution data for I, II, III, IV, 7-substituted-1,3,5-triazaadamantanes (substituents = Cl, Br, NO2, NH2, MeNH, Me2N), adamantane, 1-bromo- and 1-aminoadamantane, and eicosane, rel. elution volumes of 7-amino-1,3,5-triazaadamantane aldimines, and homomorphic factors for I, II, III, and IV were determined A flame ionization detector and N carrier gas at 50 ml/min were used. Stainless steel columns (6 mm ¡Á 1.2 m) packed with 3 types of fillings were used: type A:12.3 g Chromaton N-AW-DMCS (particle size 0.16-0.20 mm) containing 5% (weight) SE-30 at 125 and 220¡ã, type B: 10.9 g Chromaton N-AW-HMDS (particle size 0.16-0.20 mm) with 10% (weight) OS-124 (Lachema, Brno) at 190¡ã; and type C: 9.7 g Chromaton N (particle size 0.20-0.25 mm) with 5% (weight) polyethylene glycol (mol. weight 1500) and 1% KOH at 160¡ã. Chromatog. behavior of the substances with respect to their structure and interaction with the stationary phase is discussed.

Collection of Czechoslovak Chemical Communications published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Synthetic Route of 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nasveschuk, Christopher G. published the artcileDiscovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2, Application In Synthesis of 31719-76-3, the publication is ACS Medicinal Chemistry Letters (2014), 5(4), 378-383, database is CAplus and MEDLINE.

The identification and development of a novel series of small mol. Enhancer of Zeste Homolog 2 (EZH2) inhibitors is described. A concise and modular synthesis enabled the rapid development of structure-activity relationships, which led to the identification of I as a potent, SAM-competitive inhibitor of EZH2 that dose-dependently decreased global H3K27me3 in KARPAS-422 lymphoma cells.

ACS Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Application In Synthesis of 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Atmaram Upare, Abhay published the artcileDesign, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents, Application In Synthesis of 16909-09-4, the publication is Bioorganic Chemistry (2019), 507-512, database is CAplus and MEDLINE.

The present study reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal carboxylic acid with “oxadiazole”. A series of cinnamic acid derivatives (styryl oxadiazoles) were designed and synthesized in good yields by reaction of substituted cinnamic acids with amidoximes. The synthesized styryl oxadiazoles were evaluated in vitro for anti-tubercular activity against Mycobacterium tuberculosis (Mtb) H37Ra strain. The structure-activity relationship (SAR) study has identified several compounds with mixed anti-tubercular profiles. The compound I displayed potent anti-tubercular activity (IC₅₀ = 0.045 ¦Ìg/mL). Mol. docking studies on mycobacterial enoyl-ACP reductase enzyme corroborated well with the exptl. findings providing a platform for structure based hit-to-lead development.

Bioorganic Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lelievre, Jacques published the artcileComparison of various weak polynitro acids, uncharged or anionic, in water-methanol and water-isopropanol mixtures, Quality Control of 1821-27-8, the publication is Journal de Chimie Physique et de Physico-Chimie Biologique (1970), 67(5), 917-25, database is CAplus.

The pKa of uncharged acids derived from indazole and diphenylamine and also of various anionic acids derived from this amine by fixation of a -CO2- or a -SO3- groups in various positions were determined in a continuous series of water-methanol and water-2-propanol mixtures The influence of the ionic strength on the behavior of the latter compounds is the same as expected by the classical electrostatic theory. But the decrease of the dielec. constant, linked to the insertion of organic solvents, is not expressed by a bigger decrease of their thermodynamic pKa than that of the corresponding uncharged acids. On the contrary, with the isopropanol, the meta and para charged acids have a very important maximum of acidity.

Journal de Chimie Physique et de Physico-Chimie Biologique published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Quality Control of 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Halle, Jean C. published the artcilePreparation of buffer mixtures in DMSO-water mixtures. Application to the study of nitrodiphenylamines, Safety of Bis(4-nitrophenyl)amine, the publication is Bulletin de la Societe Chimique de France (1970), 2047-53, database is CAplus.

From a study of different buffer solutions in H2O-dimethyl sulfoxide (DMSO) mixtures a selection of 14 acids was made corresponding to regularly spaced acidities and covering a large part of the usual acid-base range. These acids belong to 3 different families: carboxylic acids, phenols, and indoles. By using these buffer solutions in H2O-DMSO mixtures, the ionization of several nitrodiphenylamines was established spectrophotometrically. The relative acidity of these indicators varies largely with the composition of the solvent mixture In addition, DMSO enhances strongly the acidity of some derivatives such as 2,4,6-trinitrodiphenylamine.

Bulletin de la Societe Chimique de France published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Safety of Bis(4-nitrophenyl)amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fillaux, Odile published the artcileAcidity in water-isopropyl alcohol mixtures, Product Details of C12H9N3O4, the publication is Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques (1966), 263(17), 989-92, database is CAplus.

The use of a cell with junctions and H electrodes allows a determination of the pH in H2O-iso-PrOH mixtures The variation of pK of acids and bases in the above mixtures can be interpreted by taking into account the solvent effect of iso-PrOH.

Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Product Details of C12H9N3O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Brisset, Jean L. published the artcileAcidity-basicity in water-pyridine mixed solvents, Recommanded Product: Bis(4-nitrophenyl)amine, the publication is Journal de Chimie Physique et de Physico-Chimie Biologique (1971), 68(10), 1506-18, database is CAplus.

Water-pyridine mixtures were examined electrochem. in the range of ¡Ü97.6 weight % amine; this allows the determination of the ion product and provides data concerning the alkalinity levels. The ion product range of these mixtures is more differentiated than that of the previously investigated aqueous amine solutions, thus permitting the electrochem. study of several selected buffers which have been used to measure the acidity constants of nitro-substituted phenols, anilines, diphenylamines, and indazoles.

Journal de Chimie Physique et de Physico-Chimie Biologique published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Recommanded Product: Bis(4-nitrophenyl)amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dietrich, Bernard published the artcileAnion coordination chemistry: polyguanidinium salts as anion complexons, COA of Formula: C3H12Cl2N2, the publication is Helvetica Chimica Acta (1979), 62(8), 2763-87, database is CAplus.

A series of polyguanidinium salts [(H₂N)₂C⁺NH]_nQ nX^– [I, Q = a polyvalent group, e.g., CH₂CH₂, (CH₂)₃, 1,2-cyclohexylene, nitrilotriethylene; n = valence of Q; X = Br, Cl, picrate, etc.] were prepared by several methods, the best of which was via polynitroguanidine intermediates. Acidity constants for some I were determined and the ability of I to complex phosphate and carboxylate anions was determined by titration data. Stability constants were determined for the complexes and, with NMR data, indicated a chelate effect for the polydentate ligands.

Helvetica Chimica Acta published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, COA of Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abrahami, Renata A. published the artcileA de novo synthetic route to 1,2,3,4-tetrahydroisoquinoline derivatives, Application In Synthesis of 421-49-8, the publication is Synlett (2018), 29(15), 2066-2070, database is CAplus.

A novel synthetic approach was developed for the construction of the 1,2,3,4-tetrahydroisoquinoline framework, e.g. I (R¹ = Et, CHF₂CH₂, CF₃CH₂, CF₃CHMe, PhCH₂, etc.; R² = H, Br), possessing varied functions. The synthetic strategy is based on oxidative ring opening of the corresponding indandiols, e.g. II, followed by double reductive amination of the dicarbonyl intermediates with various primary alkyl- or fluoroalkylamines R¹NH₂.

Synlett published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Application In Synthesis of 421-49-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia