Month: December 2022

Van Goethem, Sebastiaan published the artcileStructure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?, Quality Control of 457-68-1, the publication is Journal of Medicinal Chemistry (2011), 54(16), 5737-5746, database is CAplus and MEDLINE.

This work represents the first directed study to identify modification points in the topol. of a representative DPP8/9-inhibitor, capable of rendering selectivity for DPP8 over DPP9. The availability of a DPP8-selective compound would be highly instrumental for studying and untwining the biol. roles of DPP8 and DPP9 and for the disambiguation of biol. effects of nonselective DPP-inhibitors that have mainly been ascribed to blocking of DPPIV’s action. The cell-permeable DPP8/9-inhibitor 7 was selected as a lead and dissected into several substructures that were modified sep. for evaluating their potential to contribute to selectivity. The obtained results, together with earlier work from our group, clearly narrow down the most probable DPP8-selectivity imparting modification points in DPP8/9 inhibitors to parts of space that are topol. equivalent to the piperazine ring system in 7. This information can be considered of high value for future design of compounds with maximal DPP8 selectivity.

Journal of Medicinal Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C18H35NO, Quality Control of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kobayashi, Hiroko published the artcileSimultaneous quantitation of thioureas in rat plasma by high-performance liquid chromatography, Application of 1,1-Dimethylthiourea, the publication is Journal of Chromatography (1981), 207(2), 281-5, database is CAplus and MEDLINE.

A method is described for the isolation, identification, and determination of thioureas in rat plasma by high-performance liquid chromatog. (HPLC) without derivatization. Plasma in EtOH was centrifuged at 3000 rpm, the organic phase evaporated to dryness, the residue dissolved in CHCl₃, applied to silica gel column, the column washed with CHCl₃ and with 3% MeOH in CHCl₃ where 1,3-diethylthiourea [105-55-5], ethylenethiourea [96-45-7], 1,3-dimethylthiourea [534-13-4], and 1,1-dimethylthiourea [6972-05-0] were eluted. Thiourea [62-56-6], methylthiourea [598-52-7], and ethylthiourea [625-53-6] were eluted with 10% MeOH in CHCl₃. These fractions were concentrated and subjected to HPLC. For the simultaneous determination of these thioureas, 240 nm was selected as a reasonable wavelength to monitor the chromatograms.

Journal of Chromatography published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tandiary, Michael Andreas published the artcileDeoxygenation of tertiary and secondary benzylic alcohols into alkanes with triethylsilane catalyzed by solid acid tin(IV) ion-exchanged montmorillonite, Application In Synthesis of 457-68-1, the publication is Tetrahedron Letters (2014), 55(30), 4160-4162, database is CAplus.

We discovered an efficient protocol for the conversion of tertiary and secondary benzylic alcs. into the corresponding alkanes in good to quant. yields by employing tin(IV) ion-exchanged montmorillonite (Sn-Mont) as a solid acid catalyst and Et₃SiH as the hydride source. The reaction is likely to proceed via the S_N1-type reaction mechanism, i.e., the formation of carbenium ions, followed by the addition of a hydride from the silane. The work-up of the reaction only requires simple filtration of the solid acid without any neutralization of the acid catalyst.

Tetrahedron Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C7H12ClNO, Application In Synthesis of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Uzelac, Marina published the artcileTandem Mn-I Exchange and Homocoupling Processes Mediated by a Synergistically Operative Lithium Manganate, Application of 4,4′-Dimethyldiphenyl, the publication is Angewandte Chemie, International Edition (2021), 60(6), 3247-3253, database is CAplus and MEDLINE.

Pairing lithium and manganese(II) to form lithium manganate [Li₂Mn(CH₂SiMe₃)₄] enables the efficient direct Mn-I exchange of aryliodides, affording transient (aryl)lithium manganate intermediates which in turn undergo spontaneous C-C homocoupling at room temperature to furnish sym. (bis)aryls in good yields under mild reaction conditions. The combination of EPR with X-ray crystallog. studies has revealed the mixed Li/Mn constitution of the organometallic intermediates involved in these reactions, including the homocoupling step which had previously been thought to occur via a single-metal Mn aryl species. These studies show Li and Mn working together in a synergistic manner to facilitate both the Mn-I exchange and the C-C bond-forming steps. Both steps are carefully synchronized, with the concomitant generation of the alkyliodide ICH₂SiMe₃ during the Mn-I exchange being essential to the aryl homocoupling process, wherein it serves as an in situ generated oxidant.

Angewandte Chemie, International Edition published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C9H21NO3, Application of 4,4′-Dimethyldiphenyl.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Casellas, Helene published the artcileCrystallographic evidence of theoretically novel anion-¦Ð interactions, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is New Journal of Chemistry (2006), 30(11), 1561-1566, database is CAplus.

The reaction of Cu(NO₃)₂¡¤3H₂O with the multidentate ligand N,N’,N”,N”’-tetrakis{2,4-bis(di-2-pyridylamino)-1,3,5-triazin-6-yl}triethylenetetramine (dpatta) in acetonitrile at high temperature and pressure gave the tetranuclear coordination compound [Cu₄(dpatta)(NO₃)₄](NO₃)₄¡¤12H₂O (1), whose crystal structure exhibits remarkable anion-¦Ð interactions which were calculated, considering the unexpected position of the anion toward the aromatic ring.

New Journal of Chemistry published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hirokawa, Sakutaro published the artcileCrystal structure of trimethylenediamine dihydrochloride, Safety of Propane-1,3-diamine dihydrochloride, the publication is Memoirs of the Defense Academy, Mathematics, Physics, Chemistry and Engineering (Yokosuka, Japan) (1968), 8(1), 485-98, database is CAplus.

Trimethylenediamine dihydrochloride, H2N(CH2)3NH2.2HCl, crystallizes in the orthorhombic system with a = 8.53, b = 9.36, c = 9.40 A., and space group Pbcn. The structure was determined by using the 3-dimensional Fourier function, and anisotropic refinement of the structure was carried out by using the least-sqs. method. The trimethylene-diammonium ion possesses a 2-fold axis included in the mol. plane, which passes through the central C atom. The ion is not coplanar; both the N atoms depart from the mol. plane by 0.128 A. Three N-H…Cl hydrogen bonds make a 3-dimensional network as in similar structures.

Memoirs of the Defense Academy, Mathematics, Physics, Chemistry and Engineering (Yokosuka, Japan) published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Safety of Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Minji published the artcileChanges in the liver transcriptome and physiological parameters of Japanese Black steers during the fattening period, Product Details of C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 4029, database is CAplus and MEDLINE.

We investigated the physiol. changes during the fattening period and production characteristics in Japanese Black steers bred and raised using the typical feeding system in Japan. Here, 21 Japanese Black steers aged 12 mo were used, with exptl. period divided into early (12-14 mo of age), middle (15-22 mo), and late fattening phases (23-30 mo). The liver transcriptome, blood metabolites, hormones, and rumen fermentation characteristics were analyzed. Blood triglyceride and non-esterified fatty acid concentrations increased, whereas blood ketone levels decreased, with fattening phases. Blood insulin increased with fattening phases and was pos. correlated with carcass weight and marbling in late fattening phases. Rumen fermentation characteristics showed high propionate levels and low butyrate levels in late fattening phases, likely due to increased energy intake. Genes related to glucose metabolism, such as SESN3, INSR, LEPR, and FOXO3, were down-regulated in late fattening phases. Genes related to lipid metabolism, such as FABP4, were up-regulated, whereas FADS1 and FADS2 were down-regulated. These findings suggest that the physiol. changes resulted from changes in the energy content and composition of diets. Liver metabolism changed with changes in fat metabolism Insulin was strongly associated with physiol. changes and productivity in Japanese Black cattle.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Product Details of C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fujiwara, Masazumi published the artcileDetermination of the d-tensor components of a single crystal of N-benzyl-2-methyl-4-nitroaniline, Category: catalysis-chemistry, the publication is Japanese Journal of Applied Physics, Part 1: Regular Papers, Brief Communications & Review Papers (2007), 46(4A), 1528-1530, database is CAplus.

Linear and 2nd-order nonlinear optical (NLO) properties of a single crystal of N-benzyl-2-methyl-4-nitroaniline (BNA) were determined The refractive indexes of the crystal were measured in the visible to near IR region. The Marker-fringe and phase-matching methods were used to determine the magnitudes of the d-tensor components for the 2nd harmonic generation when excited the crystals at 1064 nm. They were d₃₃₃ = 234 ¡À 31, d₃₂₂ = 15.6 ¡À 0.9, and d₃₁₁ ? 0 pm/V. The value of d₃₃₃ is the largest value reported for any yellow-colored NLO materials and suggests that crystals of BNA will be very effective for terahertz wave generation.

Japanese Journal of Applied Physics, Part 1: Regular Papers, Brief Communications & Review Papers published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shimizu, Kazuki published the artcileBoron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1¦Á inhibitors, HPLC of Formula: 1798-04-5, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(4), 1453-1456, database is CAplus and MEDLINE.

A series of boron-containing phenoxyacetanilide derivatives I [R¹ = BPin, B(OH)₂; R² = Me, Et, Ph, Cy, 1-adamantyl, t-Bu, o-carboranyl] were synthesized as hypoxia-inducible factor (HIF)-1¦Á inhibitors. Among the compounds synthesized, carboranylphenoxyacetanilide I [R¹ = B(OH)₂; R² = o-carboranyl (II)] was found to be a potent inhibitor against HIF-1¦Á accumulation under hypoxic conditions and inhibited the hypoxia-induced HIF-1 transcriptional activity in HeLa cells (IC₅₀ = 0.74 ¦ÌM). Compound II (GN26361) suppressed hypoxia-induced HIF-1¦Á accumulation and vascular endothelial growth factor mRNA expression in a concentration-dependent manner without affecting the expression of HIF-1¦Á mRNA.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C5H5BO4S, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Stepanov, A. A. published the artcileElectrochemical silylation of unsaturated organofluoric compounds, Related Products of catalysis-chemistry, the publication is Russian Journal of Electrochemistry (Translation of Elektrokhimiya) (2000), 36(2), 190-192, database is CAplus.

Organofluoric compounds are electrolyzed in a diaphragm-less cell filled with aprotic solvent containing trimethylchlorosilane. The following substances are trimethylsilylated in the electrolysis: C₆F₆, C₆F₅Cl, C₆F₅H, C₆F₅CF₃, C₅F₅N, CFCl:CFCl, and CF₂:CFBr, with the introduction of one trimethylsilyl group. The silylation mechanism is established. In some cases, the silylation product yield is increased on a Cu cathode.

Russian Journal of Electrochemistry (Translation of Elektrokhimiya) published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C17H18N3NaO3S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia