Month: December 2022

Zhang, Hao published the artcileSynthesis and herbicidal activity of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives, HPLC of Formula: 1798-04-5, the publication is Youji Huaxue (2015), 35(1), 159-166, database is CAplus.

In order to find new herbicidal leading compounds, a series of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives were designed and synthesized via the strategy of linking active sub-structures which are chlorophthalim and phenoxy carboxylic ester. The target compounds were synthesized from starting material 2-chloro-4-fluoro-5-nitrophenol in four steps, and their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay results indicated that most compounds exhibited excellent herbicidal activities at 1,500 g/ha in both pre- and post-emergence treatments against Abutilon theophrasti and Amaranthus retroflexus. On the basis of advanced screening tests, compound 6d exhibited 100% inhibitory effect against Abutilon theophrasti and Amaranthus retroflexus at 750 g/ha, compounds 7a and 7i were much more effective against Abutilon theophrasti than com. acifluorfen with 80%-86% inhibitory activity at 22.5 g/ha.

Youji Huaxue published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C10H2F12NiO4, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Longjiang published the artcileEfficient Suzuki-Miyaura cross-coupling reaction by loading trace Pd nanoparticles onto copper-complex-derived Cu/C-700 solid support, HPLC of Formula: 613-33-2, the publication is Journal of Colloid and Interface Science (2022), 608(Part_3), 2463-2471, database is CAplus and MEDLINE.

The development of efficient carbon-carbon cross-coupling catalysts with low noble metal amounts attracts much attention recently. Herein, a Cu/C-700/Pd nanocomposite is obtained by loading trace Pd²⁺ onto carbon support derived from a novel mononuclear copper complex, {[Cu(POP)₂(Phen)₂]BF₄}. The as-prepared nanomaterial features the facial structure of highly dispersed copper phosphide nanoparticles as well as Pd nanoparticles via neighboring Cu-Pd sites. The Cu/C-700/Pd nanocomposite shows excellent catalytic activity (99.73%) and selectivity in Suzuki-Miyaura cross-coupling reaction, at trace Pd loading (0.43 mol%). Compared with the reported palladium nano catalysts, its advantages are proved. The appealing gateway to this stable, innovative and recyclability, Cu/C-700/Pd nanostructure recommends its beneficial utilization in carbon-carbon coupling and other environmentally friendly processes.

Journal of Colloid and Interface Science published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C6H12N2O, HPLC of Formula: 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Jing published the artcileCobalt-catalyzed oxidative arylmethylation of phosphorylamides, Recommanded Product: Bis(4-fluorophenyl)methane, the publication is Tetrahedron (2018), 74(35), 4558-4568, database is CAplus.

A cobalt-catalyzed strategy for N-arylmethylation of phosphorylamides was herein achieved with the assistance of azodiisobutyronitrile as the radical initiator and di-tert-Bu peroxide as the oxidant. Both methylarenes and diaryl methanes were compatible under the oxidative conditions, expressing broad substrate scope (51 examples) and high efficiency (up to 87% yield).

Tetrahedron published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C24H29N5O3, Recommanded Product: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zou, Peihui published the artcileDirect current exerts electricidal and bioelectric effects on Porphyromonas gingivalis biofilms partially via promoting oxidative stress and antibiotic transport, Safety of 1,1-Dimethylthiourea, the publication is Journal of Microbiology (Seoul, Republic of Korea) (2022), 60(1), 70-78, database is CAplus and MEDLINE.

Low elec. current can inhibit certain microbial biofilms and enhance the efficacy of antimicrobials against them. This study investigated the electricidal and bioelec. effects of d.c. (DC) against Porphyromonas gingivalis biofilms as well as the underlying mechanisms. Here, we firstly showed that DC significantly suppressed biofilm formation of P. gingivalis in time- and intensity-dependent manners, and markedly inhibited preformed P. gingivalis biofilms. Moreover, DC enhanced the killing efficacy of metronidazole (MTZ) and amoxicillin with clavulanate potassium (AMC) against the biofilms. Notably, DC-treated biofilms displayed upregulated intracellular ROS and expression of ROS related genes (sod, feoB, and oxyR) as well as porin gene. Interestingly, DC-induced killing of biofilms was partially reversed by ROS scavenger N-dimethylthiourea (DMTU), and the synergistic effect of DC with MTZ/AMC was weakened by small interfering RNA of porin gene (si-Porin). In conclusion, DC can exert electricidal and bioelec. effects against P. gingivalis biofilms partially via promotion of oxidative stress and antibiotic transport, which offers a promising approach for effective management of periodontitis.

Journal of Microbiology (Seoul, Republic of Korea) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C4H10O2, Safety of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Juan published the artcileSynthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxane moiety as a novel class of potent methionine aminopeptidase type II inhibitors, Application In Synthesis of 1772-76-5, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(10), 2876-2879, database is CAplus and MEDLINE.

A series of 1,3,4-oxadiazole derivatives containing 1,4-benzodioxane moiety have been designed, synthesized and evaluated for their antitumor activity. Most of the synthesized compounds were proved to have potent antitumor activity and low toxicity. Among them, compound I showed the most potent biol. activity against Human Umbilical Vein Endothelial cells, which was comparable to the pos. control. The results of apoptosis and flow cytometry (FCM) demonstrated that compound I induce cell apoptosis by the inhibition of MetAP2 pathway. Mol. docking was performed to position compound I into MetAP2 binding site in order to explore the potential target.

Bioorganic & Medicinal Chemistry Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C10H9NO, Application In Synthesis of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Gangwei published the artcileVisualization of Sulfane Sulfur in Plants with a Near-Infrared Fluorescent Probe, Quality Control of 119-80-2, the publication is ACS Sensors (2019), 4(2), 434-440, database is CAplus and MEDLINE.

Sulfane sulfur species are an important type of reactive sulfur species. These compounds have unique reactivity to attach reversibly to other sulfur atoms and exhibit regulatory effects in diverse biol. systems. Recent studies have suggested that sulfane sulfurs are involved in signal transduction processes of hydrogen sulfide (H₂S). The development of probes for selective, rapid, and sensitive detection of sulfane sulfur is of great significance for studying their physiol. and pathol. roles in biol. systems, especially in plant systems for which physiol. research has lagged behind. However, so far there is still a lack of sufficient chem. tools for directly tracking and measuring sulfane sulfur in biol. systems, and in particular, the detection of sulfane sulfur in living plant tissues is still challenging. Herein, the authors report a near-IR fluorescent probe, SSNIP, for the selective imaging of sulfane sulfur. SSNIP is capable of detecting sulfane sulfur at physiol. concentrations in both aqueous buffer and living human cells. Then, with SSNIP, the authors demonstrate the fluorescent monitoring of endogenous sulfane sulfur in plant tissues such as Arabidopsis thaliana roots for the first time. Furthermore, the application of SSNIP in evaluating the level of sulfane sulfur in Arabidopsis thaliana roots at different growth stages is performed. The results show that the level of sulfane sulfur in Arabidopsis thaliana roots correlates well with their growth stages, which suggests that sulfane sulfurs might act as actual signaling mols. to promote plant growth and root elongation. In addition, it reveals potential applications for the biol. and pathol. studies of sulfane sulfur, especially in plant physiol.

ACS Sensors published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Quality Control of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Sheng published the artcileElectrochemical Formation of N-Acyloxy Amidyl Radicals and Their Application: Regioselective Intramolecular Amination of sp² and sp³ C-H Bonds, Recommanded Product: O-Pivaloylhydroxylamine trifluoromethanesulfonate, the publication is Organic Letters (2018), 20(12), 3443-3446, database is CAplus and MEDLINE.

Electrochem. generation of N-acyloxy amidyl radicals via an inner-sphere electron-transfer process is described for the first time. With NaBr as the catalyst and electrolyte, the in situ generated amidyl radicals undergo intramol. C(sp²/sp³)-H aminations to give lactams with unprecedented regio- and chemoselectivities. Moreover, the synthetic utility of current method is demonstrated by the synthesis of PJ34 and Phenaglaydon.

Organic Letters published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C7H13NO2, Recommanded Product: O-Pivaloylhydroxylamine trifluoromethanesulfonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kou, Xinyue published the artcileConstruction of Multi-color fluorescent carbon dots by Aggregation-Induced emission, Application In Synthesis of 119-80-2, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2022), 121430, database is CAplus and MEDLINE.

Aggregation-induced emission luminogens (AIEgens) have garnered significant attention because of their outstanding photophys. characteristics. AIEgens are used in fluorescence imaging, sensors, tumor treatment, and other related fields. However, the synthese of these AIEgens are relatively complicated and requires expensive raw materials. These drawbacks limit their applications and development to a certain extent. In this study, using cheap and convenient materials, we developed a new type of carbon dots (O-CDs) using a one-step solvothermal method, which has the potential to become a new AIEgen. O-CDs exhibit different fluorescence colors in different solvents, and they exist as monomers in ethylic acid and, ethanol alc., etc., exhibiting blue fluorescence. After adding water, the fluorescence of O-CDs gradually turns orange red, because the internal rotation of the disulfide bond mols. is restricted and the AIE effect occurs. Using the unique AIE performance of O-CDs, we fabricated an anti-counterfeiting luminous ink, that can be used for encryption in the reversible double switch mode.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Application In Synthesis of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Lu published the artcileMn(III)-Mediated Radical Cyclization of o-Alkenyl Aromatic Isocyanides with Boronic Acids: Access to N-Unprotected 2-Aryl-3-cyanoindoles, Application In Synthesis of 613-33-2, the publication is Organic Letters (2021), 23(15), 5826-5830, database is CAplus and MEDLINE.

The synthesis of N-unprotected 2-aryl-3-cyanoindoles was realized via the Mn(III)-mediated radical cascade cyclization of o-alkenyl aromatic isocyanides with boronic acids. A possible mechanism involving a sequential intermol. radical addition, intramol. cyclization, and cleavage of the C-C bond under mild reaction conditions is proposed. Mechanism studies show that H₂O or O₂ might provide the oxygen source for the elimination of benzaldehyde.

Organic Letters published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Application In Synthesis of 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Haikong published the artcileHigh frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis, Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Emerging Microbes & Infections (2015), 4(2), e10, database is CAplus and MEDLINE.

The preferred drugs for the treatment of syphilis, benzathine and procaine penicillin, have not been available in Shanghai for many years, and currently, the incidence of syphilis is increasing. Alternative antibiotics for patients with syphilis during the benzathine and procaine penicillin shortage include macrolides. The failure of macrolide treatment in syphilis patients has been reported in Shanghai, but the reason for this treatment failure remains unclear. The authors used polymerase chain reaction technol. to detect a 23S rRNA A2058G mutation in Treponema pallidum in 109 specimens from syphilis patients. The use of azithromycin/erythromycin in the syphilis patients and the physicians’ prescription habits were also assessed based on two questionnaires regarding the use of macrolides. A total of 104 specimens (95.4%) were pos. for the A2058G mutation in both copies of the 23S rRNA gene, indicating macrolide resistance. A questionnaire provided to 122 dermatologists showed that during the penicillin shortage, they prescribed erythromycin and azithromycin for 8.24 ¡À 13.95% and 3.21 ¡À 6.37% of their patients, resp., and in the case of penicillin allergy, erythromycin and azithromycin were prescribed 15.24 ¡À 22.89% and 7.23 ¡À 16.60% of the time, resp. A second questionnaire provided to the syphilis patients showed that 150 (33.7%), 106 (23.8%) and 34 (7.6%) individuals had used azithromycin, erythromycin or both, resp., although the majority did not use the drugs for syphilis treatment. The authors’ findings suggest that macrolide resistance in Treponema pallidum is widespread in Shanghai. More than half of the syphilis patients had a history of macrolide use for other treatment purposes, which may led to the high prevalence of macrolide resistance. Physicians in China are advised to not use azithromycin for early syphilis.

Emerging Microbes & Infections published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia