Month: December 2022

Cao, Xiaosong published the artcileTandem Functionalization in a Highly Branched Polymer with Layered Structure, Category: catalysis-chemistry, the publication is Chemistry – A European Journal (2018), 24(22), 5974-5981, database is CAplus and MEDLINE.

A hyperbranched polymer with multilayer structure was developed to demonstrate the possibility of highly efficient tandem functionalization reactions at different domains within one nanostructured platform. The polymer scaffold was constructed by chain-growth copper-catalyzed azide-alkyne cycloaddition polymerization of three functional monomers with sequential monomer addition in one pot. Subsequent reactions with different monomer units resulted in efficient functionalization of each segment with construction of a highly sophisticated polymer structure by a robust procedure. As a proof of concept, the ability of this polymer structure to quant. load six species of guest mols. through three different types of conjugation reactions was demonstrated.

Chemistry – A European Journal published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Xiaoyan published the artcileGC-MS analysis and antifungal activity of essential oils from aerial parts of Senecio laetus Edgew. of Yunnan Province, Recommanded Product: 4,4′-Dimethyldiphenyl, the publication is Zhonghua Zhongyiyao Xuekan (2021), 39(2), 98-101, database is CAplus.

Objective Senecio Laetus Edgew. is a kind of medicinal plant of Senecio L. in Compositae. It has the functions of promoting blood circulation, detumescence, dispelling wind and dehumidifying. The aim of this study was to evaluate the antifungal activity of Senecio L. and analyze the essential oils from Senecio L. in Yunnan province by GC-MS. Methods The volatile oil from the aerial part of Senecio L. was extracted by steam distillation and the in vitro anti-Candida albicans activity was evaluated. The chem. constituents of the volatile oil were qual. analyzed by gas chromatog.-mass spectrometry (GC-MS). Results It showed that the essential oils from Senecio L. could reverse resistance of fluconazole to Candida albicans significantly. Further GC-MS anal. of volatile oil obtained 74 compounds, accounting for 73.3% of the total distillation peak area. These compounds were mainly terpenoids, aromatic and aliphatic compounds Conclusion The aerial parts of Senecio L. from Yunnan Province were analyzed by GC-MS for the first time. A total of 74 chem. constituents of volatile oil were obtained. The results provided theor. and exptl. data for drugs with synergistic anti-fungal effect in combination with existing anti-fungal drugs. This study provided a scientific basis for further research on the medicinal value of Senecio L. in the future.

Zhonghua Zhongyiyao Xuekan published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C12H16O3, Recommanded Product: 4,4′-Dimethyldiphenyl.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Lihong published the artcileSensitive Fluorescence Probe with Long Analytical Wavelengths for ¦Ã-Glutamyl Transpeptidase Detection in Human Serum and Living Cells, Application In Synthesis of 10510-54-0, the publication is Analytical Chemistry (Washington, DC, United States) (2015), 87(16), 8353-8359, database is CAplus and MEDLINE.

A new sensitive fluorescent probe (I) with long anal. wavelengths for ¦Ã-glutamyl transpeptidase (GGT) assay has been developed by incorporating the ¦Ã-glutamyl group as a recognition unit into the fluorophore of cresyl violet (CV). The detection mechanism of I is based on the GGT-catalyzed cleavage of the ¦Ã-glutamyl group, followed by the release of CV, which leads to a distinct color change from light yellow to pink and a large fluorescence enhancement at 615 nm (¦Ë_ex = 585 nm). Under the optimized conditions, the fluorescence intensity of I is directly proportional to the activity of GGT at 1-50 U/L with a detection limit of 5.6 mU/L. By virtue of its high sensitivity and long anal. wavelengths, I has been used to directly determine GGT in human serum samples from both healthy people and liver cancer patients, and the obtained results accord well with those acquired by com. GGT fluorometric assay kit. I has also been employed to image endogenous GGT in living cells. Notably, with the authors’ probe, the expression level of GGT in HepG2 cells under the action of sodium butyrate (an anticancer drug) was studied by fluorescence confocal microscopy, revealing that sodium butyrate can induce the upregulation of GGT in HepG2 cells in a dose- and time-dependent manner. This behavior of sodium butyrate has further been confirmed by lysate assay and inhibitor experiment I is rather simple and may find a wide use in the determination of GGT in clin. and biol. samples.

Analytical Chemistry (Washington, DC, United States) published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Application In Synthesis of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gong, Qiuyu published the artcileUltrasensitive Fluorescent Probes Reveal an Adverse Action of Dipeptide Peptidase IV and Fibroblast Activation Protein during Proliferation of Cancer Cells, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Analytical Chemistry (Washington, DC, United States) (2016), 88(16), 8309-8314, database is CAplus and MEDLINE.

Dipeptide peptidase IV (DPPIV) and fibroblast activation protein (FAP) are isoenzymes. Evidence shows that DPPIV is related to antitumor immunity, and FAP may be a drug target in cancer therapy, making it seem that the two enzymes might have a synergistic role during the proliferation of cancer cells. Surprisingly, herein, the authors find an adverse action of DPPIV and FAP in the proliferation process by analyzing their changes with two tailor-made ultrasensitive fluorescent probes. First, the up-regulation of DPPIV and down-regulation of FAP in cancer cells under the stimulation of genistein are detected. Then, the authors find that MGC803 cells with a higher FAP but lower DPPIV level than SGC7901 cells exhibit a faster proliferation rate. Importantly, inhibiting the DPPIV expression with siRNA increases the proliferation rate of MGC803 cells, whereas the FAP inhibition decreases the rate. These findings suggest that the two enzymes play an adverse role during the proliferation of cancer cells, which provides the authors a new viewpoint for cancer studies.

Analytical Chemistry (Washington, DC, United States) published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhou, Xinxing published the artcileAdsorption mechanism of polycyclic aromatic hydrocarbons using wood waste-derived biochar, Computed Properties of 191-07-1, the publication is Journal of Hazardous Materials (2022), 128003, database is CAplus and MEDLINE.

The polycyclic aromatic hydrocarbons (PAHs) have been attracted increasing attentions due to their carcinogenicity and teratogenicity. Adsorption is widely considered one of the most potential technologies for PAHs removal. In this study, we prepared two kinds of oxygen-rich biochar derived from waste wood to investigate the PAHs adsorption performance, and the mol. simulation was used to build the 16 priority PAHs, 23 nitrated PAHs, 9 oxygenated PAHs adsorption model. The surface adsorption performance of oxygen-rich biochar significantly depends on the pyrolysis conditions. The main out-comings demonstrated that the adsorption of naphthalene (C10H8) mols. first occurred, and the optimal adsorption positions of oxygen-rich biochar strongly adhered to functional groups of carboxyl and hydroxyl. Moreover, benzene ring, -COOH, and -CH₃ of biochar were the main adsorbed functional groups for PAHs adsorption. The oxygen-rich biochar had the targeted-adsorption effect on PAHs removal especially sym. PAHs, and the targeted-adsorption mechanism was finally proposed. The research is beneficial to guide the removal of PAHs from polluted water and mitigate the environmental pollution caused by biomass waste mismanagement, simultaneously.

Journal of Hazardous Materials published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C16H12O, Computed Properties of 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Shuangshuang published the artcileAggregation-induced emissive carbon dots gels for octopus-inspired shape/color synergistically adjustable actuators for soft robots, Related Products of catalysis-chemistry, the publication is Angewandte Chemie, International Edition (2021), 60(40), 21890-21898, database is CAplus and MEDLINE.

Some living organisms such as the octopus have fantastic abilities to simultaneously swim away and alter body color/morphol. for disguise and self-protection, especially when there is a threat perception. However, it is still quite challenging to construct artificial soft actuators with octopus-like synergistic shape/color change and directional locomotion behaviors, but such systems could enhance the functions of soft robotics dramatically. Herein, we proposed to utilize unique hydrophobic carbon dots (CDs) with rotatable surface groups to construct the aggregation-induced emission (AIE) active glycol CDs polymer gel, which could be further employed to be interfacially bonded to an elastomer to produce anisotropic bilayer soft actuator. When putting the actuator on a water surface, glycol spontaneously diffused out from the gel layer to allow water intake, resulting in a color change from a blue dispersion fluorescence to red AIE and a shape deformation, as well as a large surface tension gradient that can promote its autonomous locomotion. Based on these findings, artificial soft swimming robots with octopus-like synergistic shape/color change and directional swimming motion were demonstrated. This study provides an elegant strategy to develop advanced multi-functional bio-inspired intelligent soft robotics.

Angewandte Chemie, International Edition published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C10H10CoF6P, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Niu, Changrong published the artcileSynthesis of bisamide bisester-bis(crown ether) compounds, Application In Synthesis of 5411-14-3, the publication is Wuhan Daxue Xuebao, Ziran Kexueban (1998), 44(6), 711-713, database is CAplus.

Three new bisamides-bis(crown ether) compounds I (ortho, meta, para) are synthesized by the reaction of o, m, p-phenylenedioxydiacetyl dichloride with 4′-aminobenzo-15-crown-5; three new bisesters-bis(crown ether) compounds are synthesized by the condensation of o, m, p-phenylenedioxydiacetyl dichloride with 6-hydroxyldibenzo-16-crown-5.

Wuhan Daxue Xuebao, Ziran Kexueban published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Application In Synthesis of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Zhiyi published the artcileDesign, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid derivatives, Application In Synthesis of 1798-04-5, the publication is European Journal of Medicinal Chemistry (2009), 44(11), 4726-4733, database is CAplus and MEDLINE.

A series of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (norfloxacin) derivatives I (R = 2-furanyl, 3-pyridinyl, 2-ClC₆H₄OCH₂, etc.) were prepared according to the principle of combining bioactive substructures, and tested for activity against five plant pathogenic bacteria and three fungi in vitro. The preliminary bioassays indicated that almost all the synthesized target compounds retained the antibacterial activities of norfloxacin and had some antifungal activities as seen with carboxamide compounds The activities of compounds I (R = 2-furanyl, Ph) against Xanthomonas oryzae were better than norfloxacin and all tested compounds had better antibacterial activities as compared to the agricultural streptomycin sulfate (a com. bactericide) against X. oryzae, Xanthomonas axonopodis and Erwinia aroideae. Addnl., compounds I [R = (E)-2-(5-methylfuran-2-yl)ethenyl, (E)-4-MeOC₆H₄CH:CH] displayed good antifungal activities against Rhizoctonia solani and their inhibition of growth reached 83% and 94% resp. at the concentration of 200 mg/L.

European Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C10H18O, Application In Synthesis of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kupriyanova, Olga V. published the artcileSynthesis and determination of analytical characteristics and differentiation of positional isomers in the series of N-(2-methoxybenzyl)-2-(dimethoxyphenyl)ethanamine using chromatography-mass spectrometry, Category: catalysis-chemistry, the publication is Drug Testing and Analysis (2020), 12(8), 1154-1170, database is CAplus and MEDLINE.

N-(2-Methoxybenzyl)-2,5-dimethoxyphenethylamines (NBOMes) are synthetic phenethylamine derivatives emerging on the global drug market and reported to be associated with untoward effects in people who use drugs. Its action involves agonism at serotonin 5-HT_2A receptors, affecting cognitive and behavioral processes. However, certain isomers of NBOMes may not show any psychoactive effects. They are not controlled by legislation and can be tested as pharmaceutical drugs. This study deals with the differentiation among positional isomers of 25H-NBOMe differing in the position of the two methoxy groups in the phenylethyl moiety of the mol., using chromatog.-mass spectrometry methods. The gas chromatog. anal. showed that the isothermal mode was more efficient than the usually applied temperature-programming mode for the separation of the mentioned isomers. Electron ionization mass spectra of 25H-NBOMe isomers were highly similar, often resulting in a high probability of erroneous identification. However, mass spectra of their trifluoroacetyl or pentafluoropropanoyl derivatives were easily identified as they contained fragments with many significant differences. The proposed anal. using liquid chromatog.-tandem mass spectrometry could distinguish the isomers of 25H-NBOMe without the need for any derivatization.

Drug Testing and Analysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kupriyanova, Olga V. published the artcilePotential of chromatography and mass spectrometry for the differentiation of three series of positional isomers of 2-(dimethoxyphenyl)-N-(2-halogenobenzyl)ethanamines, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Drug Testing and Analysis (2022), 14(6), 1102-1115, database is CAplus and MEDLINE.

N-(2-substituted benzyl)-2,5-dimethoxyphenethylamines often cause severe poisonings which has led to their legal prohibition in many countries. At the same time, their positional isomers can be studied as potential therapeutic drugs. In this regard, the search for various approaches to differentiate these isomers is an important practical task, the solution of which would guarantee from identification errors during laboratory anal. In this paper, the possibilities of differentiation of isomers varying in the position of two methoxy groups in the phenylethyl part of the mol. are considered on the example of compounds of NBF, NBCl, and NBBr series by chromatog.-mass spectrometry methods. Gas or liquid reverse-phase chromatog. in the proposed chromatog. separation modes has demonstrated their ability to resolve this problem reliably. Data on retention indexes of isomeric compounds and their derivatives can serve as an addnl. identification criterion for gas chromatog.-mass spectrometry (GC-MS) anal. Differentiation of NBF and NBCl isomers using electron ionization (EI) mass spectra is feasible only if both the spectrum of the compound and its N-trifluoroacetyl derivative are registered; differentiation of NBBr positional isomers under these conditions does not require obtaining the derivatives Using electrospray ion source, the compounds can easily be differentiated based on the distinctive features of their collision induced dissociation (CID) spectra recorded at low energy values, which also does not require the synthesis of derivatives The data presented in current paper will be useful for anal. in laboratories providing the determination of narcotic drugs.

Drug Testing and Analysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia