Catalysis-chemistry

Wang, Yi-Feng published the artcileCopper-Catalyzed Aerobic [3+2]-Annulation of N-Alkenyl Amidines, Recommanded Product: 2,2-Diallylpent-4-en-1-amine, the publication is Journal of the American Chemical Society (2012), 134(8), 3679-3682, database is CAplus and MEDLINE.

A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines. E.g., in presence of CuI and 2,2′-bipyridine, [3+2]-annulation of amidine PhC(:NH)NHCH₂CPh₂CH₂CPh:CH₂, prepared from 2,2,2-trifluoroethyl benzimidate hydrochloride and 2,2,4-triphenyl-4-penten-1-amine, gave 85% bicyclic amidine (I). These cyclic amidines could be converted into monobenzyl-protected vicinal diamines by reduction with lithium aluminum hydride. E.g., reduction of I gave 83% monobenzyl-protected vicinal diamine (II).

Journal of the American Chemical Society published new progress about 928836-00-4. 928836-00-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain, name is 2,2-Diallylpent-4-en-1-amine, and the molecular formula is C19H23BO3, Recommanded Product: 2,2-Diallylpent-4-en-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Cui published the artcileDesign, synthesis and anti-cancer evaluation of novel podophyllotoxin derivatives as potent tubulin-targeting agents, SDS of cas: 1798-04-5, the publication is Medicinal Chemistry Research (2018), 27(2), 351-365, database is CAplus.

A series of podophyllotoxin derivatives (M1-M16) that were selectively acylated by various phenoxy acids at the C-4 position of podophyllotoxin were synthesized, and their biol. activities were also evaluated. Among them, compound M4 showed the most potent anti-cancer activity against HeLa cells with an IC₅₀ value of 1.64 ¡À 0.41 ¦ÌM. Addnl., flow cytometry anal. results indicated that it could cause a remarkable cell cycle arrest at G2/M phase, but the effect on apoptosis inducing was not significant. Moreover, the expression of cell cycle relative protein CDK1 was up regulated while cyclin B1 and Cdc25C, two proteins required for mitotic initiation were down regulated. Furthermore, the confocal assay and extracellular polymerized tubulin expression anal. also demonstrated that M4 was a potent tubulin polymerization inhibitor and the effect was comparable to that of colchicine. Finally, docking simulation results showed that M4 could nicely bind to the colchicine binding site of tubulin which further confirmed the tubulin inhibition activity of M4. Podophyllotoxin-phenoxyacid analogs.

Medicinal Chemistry Research published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Qiuju published the artcileComparative study of female Chinese mitten crabs based on their sizes and weights, Related Products of catalysis-chemistry, the publication is Journal of Food Science and Technology (New Delhi, India) (2022), 59(7), 2572-2583, database is CAplus and MEDLINE.

The Chinese mitten crab (Eriocheir sinensis) is an important aquaculture species in China. While the price of a large crab will generally be 2-5 times higher than that of smaller crabs, it remains unknown whether nutritional quality is affected by market price. To investigate the effect of size on nutritional composition, adult female crabs were collected and assigned to grades I-IV according to decreasing size. The results showed that meat yield and conditional factors were significantly (P < 0.05) reduced with the decreasing size. The different sizes did not significantly (P > 0.05) affect levels of moisture, crude protein (except for hepatopancreatic crude protein), and total lipid. Grade III crabs had the largest hepatopancreatic crude protein level, which was significantly (P < 0.05) increased compared with grade I crabs. A balanced amino acid composition was found in grade IV crabs, while crabs from grades II and IV had the highest essential amino acids score. Levels of highly unsaturated fatty acids, including C22:6n3, and the ratios of n-3 polyunsaturated fatty acids (PUFA)/n-6 PUFA and C22:6n3 (DHA)/C20:5n3 (EPA) in the hepatopancreas were significantly (P < 0.05) increased in grade III crabs compared with the other grades. In conclusion, among the four grades smaller female crabs (average weight: 93-112 g, grades III-IV) displayed an optimal nutritional quality.

Journal of Food Science and Technology (New Delhi, India) published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C7H6Cl2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qin, Yangzhong published the artcileMechanistic Investigation and Optimization of Photoredox Anti-Markovnikov Hydroamination, Application In Synthesis of 22693-41-0, the publication is Journal of the American Chemical Society (2021), 143(27), 10232-10242, database is CAplus and MEDLINE.

The reaction mechanism and the origin of the selectivity for the photocatalytic intermol. anti-Markovnikov hydroamination of unactivated alkenes with primary amines to furnish secondary amines have been revealed by time-resolved laser kinetics measurements of the key reaction intermediates. We show that back-electron transfer (BET) between the photogenerated aminium radical cation (ARC) and reduced photocatalyst complex (Ir(II)) is nearly absent due to rapid deprotonation of the ARC on the sub-100 ns time scale. The selectivity for primary amine alkylation is derived from the faster addition of the primary ARCs (as compared to secondary ARCs) to alkenes. The turnover of the photocatalyst occurs via the reaction between Ir(II) and a thiyl radical; the in situ formation of an off-cycle disulfide from thiyl radicals suppresses this turnover, diminishing the efficiency of the reaction. With these detailed mechanistic insights, the turnover of the photocatalyst has been optimized, resulting in a >10-fold improvement in the quantum yield. These improvements enabled the development of a scalable flow protocol, demonstrating a potential strategy for practical applications with improved energy efficiency and cost-effectiveness.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Application In Synthesis of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nguyen, Suong T. published the artcilePCET-Enabled Olefin Hydroamidation Reactions with N-Alkyl Amides, COA of Formula: C15H24S, the publication is ACS Catalysis (2019), 9(5), 4502-4507, database is CAplus and MEDLINE.

Olefin aminations are important synthetic technologies for the construction of aliphatic C-N bonds. Here we report a catalytic protocol for olefin hydroamidation that proceeds through transient amidyl radical intermediates that are formed via proton-coupled electron transfer (PCET) activation of the strong N-H bonds in N-alkyl amides by an excited-state iridium photocatalyst and a dialkyl phosphate base. This method exhibits a broad substrate scope, high functional group tolerance, and amenability to use in cascade polycyclization reactions. The feasibility of this PCET protocol in enabling the intermol. anti-Markovnikov hydroamidation reactions of unactivated olefins is also demonstrated.

ACS Catalysis published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, COA of Formula: C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yan, Fei-fei published the artcileTriorganotin coordination polymers based on three dicarboxylate ligands containing flexible S-S bonds: synthesis, structures and in vitro antitumor activity, Safety of 2,2′-Dithiodibenzoic acid, the publication is Journal of Organometallic Chemistry (2019), 156-162, database is CAplus.

Six new triorganotin complexes, [(R₃Sn)₂(O₂CC₅H₃NS)₂]_n (R = Me: 1; n-Bu: 2), [(R₃Sn)₂(O₂CC₆H₄S)₂]_n (R = Me: 3; n-Bu: 4), [(R₃Sn)₂(O₂CCH₂S)₂]_n (R = Me: 5; n-Bu: 6) have been obtained by the reaction of R₃SnCl (R = Me, n-Bu) with the corresponding dicarboxylate ligands (H₂L¹ = 6,6′-dithiodinicotinic acid, H₂L² = 2,2′-dithiodibenzoic acid, H₂L³ = dithiodiglycolic acid). All the compounds were characterized by elemental anal., IR, NMR, and X-ray crystallog. The structural anal. reveals that complexes 1–6 display various 2D metal-organic framework structures including wave-like, corrugated and double-layer, which is attributed to the twisting of the ligands around flexible S-S bonds. Addnl., in vitro cytotoxic investigation of complexes 1–6 were also conducted by employing human cervix cell lines (HeLa) and human lung cancer cells (A549).

Journal of Organometallic Chemistry published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C20H28B2O4S2, Safety of 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Haifeng published the artcileAsymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D₁, D₂ and serotonin 5-HT_1A multi-action profile, Category: catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry (2013), 21(4), 856-868, database is CAplus and MEDLINE.

An effective and rapid method for the microwave-assisted preparation of the key intermediate for the total synthesis of tetrahydroprotoberberines (THPBs) including l-stepholidine (l-SPD) was developed. Thirty-one THPB derivatives with diverse substituents on A and D ring were synthesized, and their binding affinity to dopamine D₁, D₂ and serotonin 5-HT_1A and 5-HT_2A receptors were determined Compounds (I) and (II) were identified as partial agonists at the D₁ receptor with K_i values of 50 and 6.3 nM, while both compounds act as D₂ receptor antagonists (K_i = 305 and 145 nM, resp.) and 5-HT_1A receptor full agonists (K_i = 149 and 908 nM, resp.). These two THPBs compounds exerted antipsychotic actions in animal models. Further electrophysiol. studies employing single-unit recording in intact animals demonstrated that I-excited dopaminergic (DA) neurons are associated with its 5-HT_1A receptor agonistic activity. These results suggest that these two compounds targeted to multiple neurotransmitter receptors may present novel lead drugs with new pharmacol. profiles for the treatment of schizophrenia.

Bioorganic & Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C19H21N3O3S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Zhentao published the artcileSilver-catalyzed decarboxylative chlorination of aliphatic carboxylic acids, Computed Properties of 1949-41-3, the publication is Journal of the American Chemical Society (2012), 134(9), 4258-4263, database is CAplus and MEDLINE.

Decarboxylative halogenation of carboxylic acids, the Hunsdiecker reaction, is one of the fundamental functional group transformations in organic chem. As the initial method requires the preparations of strictly anhydrous silver carboxylates, several modifications have been developed to simplify the procedures. However, these methods suffer from the use of highly toxic reagents, harsh reaction conditions, or limited scope of application. In addition, none is catalytic for aliphatic carboxylic acids. In this Article, we report the first catalytic Hunsdiecker reaction of aliphatic carboxylic acids. Thus, with the catalysis of Ag(Phen)₂OTf, the reactions of carboxylic acids with t-Bu hypochlorite afforded the corresponding chlorodecarboxylation products in high yields under mild conditions. This method is not only efficient and general, but also chemoselective. Moreover, it exhibits remarkable functional group compatibility, making it of more practical value in organic synthesis. The mechanism of single electron transfer followed by chlorine atom transfer is proposed for the catalytic chlorodecarboxylation.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C8H10S, Computed Properties of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Xiyan published the artcileAllylic carbon-phosphorus bond formation catalyzed by nickel complexes, Computed Properties of 4141-48-4, the publication is Journal of Molecular Catalysis (1987), 41(1-2), 235-43, database is CAplus.

Formation of allylic carbon-phosphorus bonds catalyzed by nickel(0) complexes are described. The method describes the nickel(0)-catalyzed reaction of allylic acetates or carbonates with HP(O)R¹R² (R¹,R² = alkyl, aryl or alkoxy group) in the presence of N,O-bis(trimethylsilyl)acetamide. Phosphinates and phosphine oxides can be synthesized in a similar way. The mechanism of the reaction is briefly discussed.

Journal of Molecular Catalysis published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Computed Properties of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Yao published the artcileSynthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2018), 33(1), 290-302, database is CAplus and MEDLINE.

Small mol. cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis, structure-activity relationship study and biol. evaluation of a series of tacrine-cinnamic acid hybrids as new ChEIs. All target compounds are evaluated for their in vitro cholinesterase inhibitory activities. The representatives which show potent activity on cholinesterase, are evaluated for the amyloid ¦Â-protein self-aggregation inhibition and in vivo assays. The optimal compound , , and (human AChE IC₅₀ = 10.2 ¡À 1.2, 16.5 ¡À 1.7, and 15.3 ¡À 1.8 nM, resp.) show good performance in ameliorating the scopolamine-induced cognition impairment and preliminary safety in hepatotoxicity evaluation. These compounds deserve further evaluation for the development of new therapeutic agents against AD.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia