Catalysis-chemistry

Surya Prakash, G. K. published the artcileReduction of carbonyl to methylene. Organosilane-Ga(OTf)₃ as an efficient reductant system, Related Products of catalysis-chemistry, the publication is Catalysis Letters (2011), 141(4), 507-511, database is CAplus.

Direct carbonyl reduction to methylene was achieved by mild reductant system obtained from the combination of organosilane and Ga(OTf)₃, a water tolerant, recyclable, catalyst. Among a series of organosilanes studied, Me₂SiHCl showed the highest efficiency. Both aromatic and aliphatic ketones were effectively reduced to the corresponding methylene products with high functional groups tolerance, under very mild conditions in a relatively short period of time with good to excellent yields.

Catalysis Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C25H23NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zagidullin, R. N. published the artcileAmido-epichlorohydrin resins. Methods for their preparation and properties, Quality Control of 38260-01-4, the publication is Khimicheskaya Promyshlennost (St. Petersburg, Russian Federation) (2011), 88(5), 257-266, database is CAplus.

A new water soluble polyamide resins were prepared from epichlorohydrin, dicarboxylic acids, and various polyamines. All resin exhibited good adhesive properties in relationship to paper, metals, leather, plastics, wood, and glass. The resins were good flocculants.

Khimicheskaya Promyshlennost (St. Petersburg, Russian Federation) published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H12Br2, Quality Control of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gak Simic, Kristina published the artcileOn the photophysical properties of a liquid crystal dimer based on 4-nitrostilbene: A combined experimental and theoretical study, Recommanded Product: 4-Nitrophenylacetic acid, the publication is Journal of Molecular Liquids (2021), 116969, database is CAplus.

A new liquid crystal dimer, 1,12-bis(4-(2-(4-nitrophenyl)ethenyl)phenoxy)dodecane, was synthesized and structurally characterized. The compound exhibited enantiotropic nematic phase. The spectroscopic properties were analyzed by UV-Vis and fluorescence techniques. Theor. calculations were used to predict the UV-Vis spectral properties of three isomers and propose a mechanism of conversion between them. The obtained results present a solid basis for the future studies on the stilbene-based liquid crystal dimers, thus affording guidelines for development of a structure-property relationship of these compounds

Journal of Molecular Liquids published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Recommanded Product: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khan, Abida published the artcileSynthesis of novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives as cyclooxygenase-2 inhibitors, Name: 3-Benzoylpropionicacid, the publication is Drug Development Research (2020), 81(5), 573-584, database is CAplus and MEDLINE.

The novel non-ulcerogenic N-substituted-phenyl-6-oxo-3-phenylpyridazine derivatives such as I [X = NNHC(S)NH₂, NNHC(S)NHPh, NNHC(O)CH₂CN, NNHPh] and II [R¹ = NH₂, CH₂CN, CH₂C(O)NH₂, etc.] were synthesized by the reaction of 4-(6-oxo-3-phenylpyridazin-1[6H]-yl)benzaldehyde I [X = O] with different hydrazines or thiazolidin-4-ones. The novel aldehyde I [X = O] was prepared by reacting 6-phenylpyridazin-3(2H)-one with 4-fluorobenzaldehyde. Compounds I [X = NNHC(S)NH₂, NNHC(S)NHPh, NNHPh] and compound II [R¹ = NH₂] were assessed for their anti-inflammatory potential and gastric ulcerogenic effects. The mol. docking investigations of compounds I [X = NNHC(S)NH₂, NNHC(S)NHPh, NNHPh] and compound II [R¹ = NH₂] were also undertaken. The compounds I [X = NNHC(S)NH₂] (IC₅₀ = 17.45 nm; p < .05), I [X = NNHC(S)NHPh] (IC₅₀ = 17.40 nm; p < .05), I [X = NNHPh] (IC₅₀ = 16.76 nm; p < .05), and II [R¹ = NH₂] (IC₅₀ = 17.15 nm; p < .05) displayed better COX-2 inhibitory activity than celecoxib (IC₅₀ = 17.79 nm; p < .05). The compounds I [X = NNHC(S)NHPh, NNHPh] and II [R¹ = NH₂] revealed no gastric ulcerogenic effects, wherein the compound I [X = NNHC(S)NH₂] produced almost negligible gastric ulcerogenic effects than celecoxib and indomethacin. All synthesized compounds such as I and II were evaluated for COX-1/COX-2 inhibition assay, among which compounds I [X = NNHC(S)NH₂, NNHC(S)NHPh, NNHPh] and compound II [R¹ = NH₂] were identified as potent and safe non-ulcerogenic COX-2 inhibitors.

Drug Development Research published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Name: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khan, Abida published the artcileDiscovery of novel pyridazine-based cyclooxygenase-2 inhibitors with a promising gastric safety profile, COA of Formula: C10H10O3, the publication is Molecules (2020), 25(9), 2002, database is CAplus and MEDLINE.

Cyclooxygenase-2 (COX-2) is implicated in the development of chronic inflammatory diseases. Recently, pyridazine derivatives have emerged as a novel prototype to develop COX-2 inhibitors. Herein, some pyridazine-based COX-2 inhibitors I [R = H₂N, H₂NC(S)NH, (4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino, (4-phenyl-1,3-thiazol-2-yl)amino, (5-[(dimethylamino)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino, etc.] were synthesized and assessed for COX-1 and COX-2 inhibitory action, gastric ulcerogenic effects, and lipid peroxidation properties. Mol. docking studies and determination of the physicochem. parameters were also carried out. The compounds I [R = (4-phenyl-1,3-thiazol-2-yl)amino] (IC₅₀ = 15.50 nM, 114.77%), I [R = (4-(4-bromophenyl)-1,3-thiazol-2-yl)amino] (IC₅₀ = 17.50 nM, 101.65%), I [R = (4-oxo-5-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)-4,5-dihydro-1,3-thiazol-2-yl)amino] (IC₅₀ = 17.10 nM, 104.03%), I [R = ((5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino] (IC₅₀ = 16.90 nM, 105.26%), and I [R = (4-oxo-3-phenyl-1,3-thiazol-2-ylidene)imino] (IC₅₀ = 17.70 nM, 100.5%) displayed better COX-2 inhibition than celecoxib (IC₅₀ = 17.79 nM, 100%). These outcomes were harmonious with the mol. docking studies of these 5 compounds These compounds also displayed comparable onset and the duration of action concerning celecoxib and indomethacin in the in vivo studies. No ulcerogenic effects were observed for I [R = (4-phenyl-1,3-thiazol-2-yl)amino, (4-oxo-5-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)-4,5-dihydro-1,3-thiazol-2-yl)amino], whereas I [R = (4-(4-bromophenyl)-1,3-thiazol-2-yl)amino, ((5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino, (4-oxo-3-phenyl-1,3-thiazol-2-ylidene)imino] showed an insignificant ulcerogenic effect compared to celecoxib. These 5 compounds displayed a better lipid peroxidation profile than celecoxib and indomethacin and appreciable calculated absorption compared to celecoxib, and have been recognized and postulated as non-ulcerogenic COX-2 inhibitors with promising physicochem. parameters and gastric safety profile. These compounds may be useful candidates to combat diseases caused by higher levels of COX-2.

Molecules published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nagalakshmi, K. published the artcileA simple and straightforward synthesis of cinnamic acids and ylidene malononitriles via Knoevenagel condensation employing DABCO as catalyst, Related Products of catalysis-chemistry, the publication is Asian Journal of Chemistry (2017), 29(7), 1561-1564, database is CAplus.

An efficient method for the synthesis of substituted cinnamic acids (E)-RHC:CHC(O)OH (R = 4-chlorophenyl, 2,6-dimethoxyphenyl, 3-nitrophenyl, furan-2-yl, etc.) and ylidene malanonitriles RC₆H₄HC:C(CN)₂ is developed via Knoevenagel condensation of aromatic aldehydes such as furan-2-carbaldehyde, 2,3,4-trimethoxybenzaldehyde, 4-hydroxybenzaldehyde with malonic acid and malononitrile in the presence of catalytic amounts of DABCO. This method has many advantages, such as mild reaction conditions, excellent yields, short reaction times and no further purification required.

Asian Journal of Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Gongshu published the artcileMagnetically recoverable 2-(aminomethyl)phenols-modified nanoparticles as a catalyst for Knoevenagel condensation and carrier for palladium to catalytic Suzuki coupling reactions, SDS of cas: 613-33-2, the publication is Applied Organometallic Chemistry (2020), 34(11), e5907, database is CAplus.

A class of magnetic nanoparticles modified by 2-(aminomethyl)phenols has been successfully designed and synthesized as a reusable catalyst for Knoevenagel reaction. Thus, nanomaterial also proved as suitable carrier for immobilization of palladium nanoparticles and the obtained composite exerted potent catalytic activity in Suzuki coupling reactions. Both of the (aminomethyl)phenols-modified nanoparticles and its related palladium nanocatalyst could be easily separated and reused for several consecutive runs by magnetic decantation without significant loss of their catalytic efficiency.

Applied Organometallic Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C7H16ClNO2, SDS of cas: 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Gong-Qing published the artcileRegioselective copper(II)-mediated bromoamination of unfunctionalized olefins: An efficient route to N-heterocyclic compounds, Application In Synthesis of 928836-00-4, the publication is Advanced Synthesis & Catalysis (2014), 356(10), 2303-2310, database is CAplus.

Bromoamination of non-functionalized olefins was realized under mild conditions using CuBr₂ as both reaction promoter and Br source. The reactions could be carried out under open air at ambient temperature, and both N-alkylated and N-tosylated substrates could be converted to the corresponding N-heterocyclic compounds in high regioselectivity and good isolated yields. A variety of biol. important structures could be obtained via subsequent nucleophilic substitution reactions.

Advanced Synthesis & Catalysis published new progress about 928836-00-4. 928836-00-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain, name is 2,2-Diallylpent-4-en-1-amine, and the molecular formula is C11H19N, Application In Synthesis of 928836-00-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Rongqiang published the artcileAssociation of fish oil containing lipid emulsions with retinopathy of prematurity: a retrospective observational study, Application of Docosahexaenoic Acid, the publication is BMC Pediatrics (2022), 22(1), 113, database is CAplus and MEDLINE.

Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness worldwide. This study aimed to investigate whether supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) in parenteral nutrition may have beneficial effects on ROP in preterm infants. A total of 89 preterm infants, admitted to Neonatal Intensive Care Unit (NICU) in Anhui Provincial Children’s Hospital from Sept. 2017 to August 2020, were recruited in the study. Based on the medical documents, the subjects were categorised into two groups: administration of the fish oil emulsion (n=43) containing soy oil, medium-chain-triglycerides (MCT), olive oil and fish oil (6g/dL, 6g/dL, 5g/dL and 3g/dL resp.), and the soy oil emulsion (n=46) containing 10g/dL of soy oil and MCT each. At 4 wk of hospitalization, ROP was screened and diagnosed. Fatty acids in erythrocytes were determined using gas chromatog. The averaged birth weight and gestational age were 1594¡À296 g and 31.9¡À2.3 wk, 1596¡À263 g and 31.6¡À2.3 wk resp. for preterm infants in the fish oil group and soy oil group. After 4 to 6 wk of hospitalization, among all the preterm infants, 52 developed ROP (all stages) indicating an incidence of ROP at 58.43%. Although the incidence of ROP with any stages showed no differences between the two groups, the severe ROP incidence in the group with fish oil emulsions (2.33%) was significantly lower than that in the group with soy oil emulsions (23.91%) (P<0.05). After 14 days of nutrition support, the preterm infants administered fish oil emulsions had an increase in erythrocyte DHA content, with a reduction in ratio of arachidonic acid (AA) to DHA and an increase of n-3 index. Supplementation of n-3 PUFAs through parenteral fish oil containing lipid emulsions resulted in an increase in erythrocyte DHA, and this might have beneficial effects on prevention of severe ROP in preterm infants.

BMC Pediatrics published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C18H28N2O7, Application of Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Xin published the artcileFlavonoids and antioxidant activity of rare and endangered fern: Isoetes sinensis, Name: 4-(Phenoxymethyl)benzoic acid, the publication is PLoS One (2020), 15(5), e0232185, database is CAplus and MEDLINE.

Isoetes sinensis Palmer is a critically endangered, first-class protected plant in China. Until now, researchers have primarily focused on the ultrastructure, phylogeny, and transcriptomes of the plant. However, flavonoid profiles and bioactivity of I. sinensis have not been extensively investigated. To develop the endangered I. sinensis for edible and medicinal purposes, flavonoid content, chem. constitution, and antioxidant activities were investigated in this study. Results revealed the following. 1) The total flavonoid content was determined as 10.74 ¡À 0.25 mg/g., 2) Antioxidant activities were stronger than most ferns, especially ABTS free radical scavenging activities. 3) Four flavones, containing apigenin, apigenin-7-glucuronide, acacetin-7-O-glcopyranoside, and homoplantageninisoetin; four flavonols, namely, isoetin, kaempferol-3-O-glucoside, quercetin-3-O-[6″-O-(3-hydroxy-3-methylglutaryl)-¦Â-D-glucopyranoside], and limocitrin-Neo; one prodelphinidin (procyanidins;) and one nothofagin (dihydrochalcone) were tentatively identified in the mass spectrometry-DAD (254nm) chromatograms. This study was the first to report on flavonoid content and antioxidant activities of I. sinensis. Stronger antioxidant activity and flavonoid content suggests that the endangered I. sinensis is an important and potentially edible and medicinal plant.

PLoS One published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C4H10O2, Name: 4-(Phenoxymethyl)benzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia