Catalysis-chemistry

Wakuluk-Machado, Anne-Marie published the artcilePd(OH)₂/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide, Related Products of catalysis-chemistry, the publication is Organic Process Research & Development (2020), 24(5), 713-723, database is CAplus.

A simple, efficient, cheap, and broadly applicable system for the carboxylation of benzylic bromides with carbon monoxide and water is reported. Upon simple reaction with only 2.5 wt % of Pearlman’s catalyst and 10 mol % of tetrabutylammonium bromide in THF at 110¡ãC for 4 h, a range of benzylic bromides can be smoothly converted to the corresponding arylacetic acids in good to excellent yields after simple extraction and acid-base wash. The reaction was found to be broadly applicable, scalable, and could be successfully extended to the use of ex situ-generated carbon monoxide and applied to the synthesis of the nonsteroidal anti-inflammatory drug diclofenac.

Organic Process Research & Development published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H5F3N4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zubar, Viktoriia published the artcileChemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst, Quality Control of 104-03-0, the publication is Organic Letters (2021), 23(7), 2742-2747, database is CAplus and MEDLINE.

The reduction of nitroarenes to anilines as well as azobenzenes to hydrazobenzenes using a single base-metal catalyst is reported. The hydrogenation reactions are performed with an air-and moisture-stable manganese catalyst and proceed under relatively mild reaction conditions. The transformation tolerates a broad range of functional groups, affording aniline derivatives and hydrazobenzenes in high yields. Mechanistic studies suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperative catalysis.

Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C7H5Cl2NO, Quality Control of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Csiba, I. published the artcileOrganic ammonium salts. XV. Preparation and antimicrobial activity of alkylammonium salts of 2-(N,N-dimethylamino)-esters of benzoic, phenylacetic and phenoxyacetic acids, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Cesko-Slovenska Farmacie (1986), 35(2), 61-7, database is CAplus.

The preparation of 22 new organic ammonium unsubstituted salts and p–tert-Bu substituted benzoyl-, phenylacetyl-, and phenoxyacetyloxyethylalkyldimethylammonium bromides and alkyldimethyl-p–tert-butylbenzylammonium bromides is reported, where the linear alkyl chain (R) has 8-16 C atoms. Besides the preparation of the above-mentioned compounds, soft analogs of hard antimicrobially active benzalkonium salts were investigated for the influence of structural changes on the antimicrobial activity, expressed as the min. inhibitory concentration (MIC). The test strains included Staphylococcus?aureus, Escherichia?coli and Candida?albicans. A change in the length of the alkyl chain influenced the activity against E. coli only, the course of the dependence MIC = f(R) was nonlinear, and maximum effectiveness was achieved in decyl and dodecyl derivatives This structural change did not principally influence the activity against S. aureus and C. albicans. The presence of the p–tert-Bu group in the mol. enhanced the activity against S. aureus and C. albicans, the introduction of the ester group into the mol. decreased the activity against E. coli. Interruption of the conjugation of the aromate by the CH₂ and the O-CH₂ bridge decreased the activity against E. coli; the effectiveness against S. aureus and C. albicans was not markedly changed. In comparison with the hard analog Ajatin (benzyldodecyldimethylammonium bromide) the compounds under study were more effective and comparable to Septonex (N-[1-(ethoxycarbonyl)pentadecyl]trimethylammonium bromide) in all 3 microorganisms tested. The proposed products of hydrolytic degradation of the compounds with an ester group show a low (dodecyl-2-hydroxyethyldimethylammonium bromide) or negligible (the pertinent substituted and unsubstituted acids) antimicrobial activity and from this point of view the studied ammonium salts with an ester group in the mol. can be classed into the category of soft antimicrobially effective compounds

Cesko-Slovenska Farmacie published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abbs Fen Reji, T. F. published the artcileSynthesis and cytotoxicity studies of thiazole analogs of the anticancer marine alkaloid dendrodoine, Category: catalysis-chemistry, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2008), 47B(7), 1145-1150, database is CAplus.

The synthesis and cytotoxicity evaluation of 2-N,N-dimethylamino-5-indol-3-oylthiazole as the first member of a new portfolio of the thiazole analogs of the cytotoxic marine alkaloid dendrodoine (3-N,N-dimethylamino-5-indol-3-oyl-1,2,4-thiadiazole) is described. Exploiting the opportunity arising from the replacement of the thiadiazole ring of dendrodoine by a thiazole ring which allowed further substitution on the five-membered ring, 2-N,N-dimethylamino-5-indol-3-oyl-4-phenylthiazole has also been synthesized. Structural diversity is further extended by synthesizing 5-fur-2-oyl- and 5-coumarin-3-oyl-2-N,N-dimethylaminothiazoles, as well as 5-fur-2-oyl, 5-thiophen-2-oyl, 5-(1-methylbenzimidazol-2-oyl) and 5-benzothiazol-2-oyl derivatives of 2-N,N-dimethylamino-4-phenylthiazoles. Among these new N,N-dimethylaminothiazoles, 2-N,N-dimethylamino-5-indol-3-oyl-4-phenylthiazole shows significant in vitro cytotoxicity against a panel of human cancer cell lines.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karki, Bhupal S. published the artcileVisible Light-Induced, Metal-Free Denitrative [3+2] Cycloaddition for Trisubstituted Pyrrole Synthesis, Application In Synthesis of 4230-93-7, the publication is Chemistry – An Asian Journal (2019), 14(24), 4793-4797, database is CAplus and MEDLINE.

A metal-free, regioselective synthesis of trisubstituted pyrroles has been developed through a formal [3+2] cycloaddition reaction between 2H-azirines and nitroalkenes under visible light/photoredox-catalyzed conditions. The reaction proceeds through 2H-azaallenyl radical addition on ¦Â-nitrostyrenes in a Michael fashion followed by a base-mediated denitration reaction. The directive group influence of the nitro group controls the regiochem. of the reaction.

Chemistry – An Asian Journal published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Application In Synthesis of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

McCann, Malachy published the artcileCopper(II) complexes of benzene-1,2-dioxyacetic acid (bdoaH₂): x-ray crystal structure of [Cu₂(bdoa)(phen)₄]bdoa.13H₂O (phen = 1,10-phenanthroline), Recommanded Product: 2,2-(1,2-Phenylenebis(oxy))diacetic acid, the publication is Polyhedron (1994), 13(2), 221-6, database is CAplus.

Cu(II) acetate reacts with benzene-1,2-dioxyacetic acid (bdoaH₂) in aqueous media to give [Cu(bdoa)(H₂O)₂] (1). 1 Reacts with the N-donor ligands pyridine (py), NH₃ and 1,10-phenanthroline (phen) to give [Cu(bdoa)(NH₃)₂].H₂O (2), [Cu(bdoa)(py)₂].H₂O (3) and [Cu₂(bdoa)(phen)₄]bdoa.13H₂O (4), resp. The x-ray crystal structure of the dicopper(II,II) complex 4 shows each Cu atom at the center of a distorted trigonal bipyramid comprising 4 N atoms from 2 chelating phen ligands and a single O atom from 1 of the carboxylate moieties of the bridging bdoa^2- ligand. The cyclic voltammogram of 4 shows a single reversible wave for the Cu²⁺/Cu⁺ couple at E_1/2 = +115 mV (vs. Ag/AgCl). Spectroscopic and magnetic data for the complexes are given.

Polyhedron published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Recommanded Product: 2,2-(1,2-Phenylenebis(oxy))diacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Battula, Satyanarayana published the artcileAccessing Grignard Reluctant Aldehyde in 2-Oxoaldehyde by Organocuprates to Give [1,2] Addition and Oxidative Coupling Reactions, Quality Control of 613-33-2, the publication is ACS Omega (2022), 7(6), 5069-5078, database is CAplus and MEDLINE.

Novel finding of aldehyde in 2-oxoaldehyde (2OA) is presented as it unprecedentedly disinclines to react with Grignard reagents but reacts with moderate organocuprate reagents in anaerobic condition to give [1,2] addition (¦Á-hydroxyketones) reaction. In the presence of air, the reaction produces an efficient protocol for the synthesis of 1,2-diones through a copper-catalyzed oxidative cross-coupling reaction at room temperature Mechanistic studies indicate that ¦Á-hydroxy ketone perhaps is generated before the hydrolysis step/acid work-up process. The ¦Á-keto group of 2OA causes to exhibit this peculiar aldehyde behavior toward these organometallic reagents.

ACS Omega published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Quality Control of 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Denisov, E. T. published the artcileEnergy of N-H-bond dissociation in phenothiazines and diphenylamines, SDS of cas: 1821-27-8, the publication is Russian Journal of Physical Chemistry A (2014), 88(4), 643-651, database is CAplus.

Energies of the dissociation of N-H-bonds (D_N-H) in 3 phenothiazines, phenoxazine, phenoselenoazine, and 9 diphenylamines (AmH) are determined The D_N-H values are calculated from kinetic data by means of intersecting parabolas. The rate constants of the following types of reaction are used in calculations: RO^.₂ + Am_iH, R^. + Am_iH, Am^._i + PhMe₂CH, and Am^._i + ROOH. As a rule, the results obtained for the reactions of different types are in good agreement with each other and with the results obtained using other methods.

Russian Journal of Physical Chemistry A published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, SDS of cas: 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Pu published the artcileChiral Nanostructured Bimetallic Au-Ag Films for Enantiomeric Discrimination, Related Products of catalysis-chemistry, the publication is Advanced Materials Interfaces (2022), 9(19), 2200369, database is CAplus.

Herein, the chiral nanostructured bimetallic Au-Ag films (CNAAFs) with both photomagnetic-chiral anisotropy to enantiomers (PM-ChA_C-E) and surface-enhanced Raman scattering-chiral anisotropy to enantiomers (SERS-ChA_C-E) for efficient enantiomeric discrimination are reported. The CNAAFs are synthesized by electrodeposition on n-type Si (n-Si) substrates with the assistance of N-acetyl-L/D-cysteine (S/R-NAC) as symmetry-breaking agents, which are consisted of polycrystalline Boerdijk-Coxeter-Bernal (BCB) tetrahelical structured Au-Ag alloy nanowires grown on n-Si substrates perpendicularly. The anisotropic factors of PM-ChA_C-E (g_PM-ChA) and SERS-ChA_C-E (g_SERS-ChA) of CNAAFs in the range of 0.68-1.12 and 1.45-1.89 are obtained, resp. Considering the increase of magnetic fields and SERS intensities with enantiomeric excess (ee) values of adsorbed enantiomers on the CNAAFs are higher than that of pure chiral nanostructure Au films, the enhancement of PM-ChAC-E and SERS-ChAC-E effects of CNAAFs can be attributed to the enhanced selective spin polarization coupling between CNAAFs and enantiomers. It is predicted to be due to the strong surface plasmon resonance generated by the active electrons of Ag under laser irradiation

Advanced Materials Interfaces published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H12O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ma, Sheng published the artcileDevelopment of Second-Generation Small-Molecule RhoA Inhibitors with Enhanced Water Solubility, Tissue Potency, and Significant in vivo Efficacy, Safety of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is ChemMedChem (2015), 10(1), 193-206, database is CAplus and MEDLINE.

RhoA, a member of the Rho GTPases, is involved in a variety of cellular functions and could be a suitable therapeutic target for the treatment of cardiovascular diseases. However, few small-mol. RhoA inhibitors have been reported. Based on the previously reported lead compounds, 32 new 2-substituted quinoline (or quinoxaline) derivatives were synthesized and tested in biol. assays. Six compounds showed high RhoA inhibitory activities, with IC₅₀ values of 1.17-1.84 ¦ÌM. Among these, I and II demonstrated noticeable vasorelaxation effects against phenylephrine-induced contraction in thoracic aorta artery rings, and compound I had good water solubility and showed significant in vivo efficacy, which was similar to that of 5-(1,4-diazepane-1-sulfonyl)isoquinoline (fasudil) in a subarachnoid hemorrhage-cardiovascular model. To the best of the knowledge, compound I is the first example of a small- mol. RhoA inhibitor with potent in vivo efficacy, which could serve as a good lead for designing cardiovascular agents.

ChemMedChem published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Safety of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia