Catalysis-chemistry

Armstrong, Susan K. published the artcileStereocontrolled synthesis of homoallylic amines using phosphine oxides and isoxazolines, Category: catalysis-chemistry, the publication is Tetrahedron Letters (1991), 32(33), 4171-4, database is CAplus.

Allylic diphenylphosphine oxides, e.g., Ph₂P(O)CHMeCH:CH₂, undergo stereoselective 1,3-dipolar cycloadditions with nitrile oxides, e.g., PhCNO to give ¦¤²-isoxazolines, e.g., I. These may be reduced, also stereoselectively, to ¦Ä-amino-¦Â-hydroxyalkyldiphenylphosphine oxides, e.g., II. Stereospecific Wittig-Horner type elimination of Ph₂PO₂^– from the amino alcs., e.g., II, gives homoallylic amines, e.g., III, with controlled double bond geometry.

Tetrahedron Letters published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Satchell, D. P. N. published the artcileQuantitative aspects of Lewis acidity. I. A spectroscopic study of the equilibrium in solution between stannic halides and aromatic amines, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of the Chemical Society (1964), 4134-42, database is CAplus.

Stannic chloride, bromide, and iodide, and substituted anilines (B) interact reversibly, in dilute solution in o-dichlorobenzene, to form 1B:1SnHal₄ adducts. From concentrated solutions, solids are precipitated These are normally brightly colored, and for the primary anilines studied have a 2B:1SnHal₄ stoichiometry. For secondary and tertiary anilines the stoichiometry found was 1:1. Steric factors probably prevent octahedral structures involving 2 bulkily substituted N atoms. Equilibrium constants were measured for the interactions in solution and, in all, 23 bases were studied, mostly with stannic chloride. The general order of increasing basicity toward a given stannic halide is very similar to that exhibited toward Broensted acids, though relative basicities are by no means exactly the same. The order of acid strength is SnCl₄ > SnBr₄ > SnI₄ and toward a given base the resp. equilibrium constants are roughly in the ratios 20,000:20:1. From a spectroscopic and structural viewpoint, the adducts fall into 2 types: “anilinium” type species involving spectral behavior similar to that attendant on anilinium-ion formation, and charge-transfer species which exhibit new, long-wavelength absorption. The former adducts result from strong acid-strong base pairs, while progressive weakening of either partner favors charge-transfer interaction. Solvent effects on the charge-transfer absorption and the related equilibrium constants were studied. A number of new pK_a values for aqueous solution are also reported.

Journal of the Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Siddiqui, Anees A. published the artcileSynthesis and hypotensive activity of some 6-(substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones, Quality Control of 15732-75-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2004), 43B(7), 1574-1579, database is CAplus.

6-Aryl-4-methyl-2,3-dihydropyridazin-3-ones, e.g., I, were synthesized by cyclization of appropriate ¦Â-aroyl-2-methylene propionate with hydrazine hydrate in the presence of sodium acetate. The title compounds were tested for hypotensive activity, non-invasively, by tail-cuff method and were found to possess significant hypotensive activity in normotensive rats.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 15732-75-9. 15732-75-9 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ketone, name is 2-Methylene-4-oxo-4-phenylbutanoic acid, and the molecular formula is C4H3Cl2N3, Quality Control of 15732-75-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Chengqian published the artcilePd(II)-catalyzed cascade Heck/intramolecular C(sp²)-H amidation reaction: An efficient route to 4-aryl-2-quinolinones, Computed Properties of 1772-76-5, the publication is Tetrahedron (2017), 73(2), 204-211, database is CAplus.

A Pd(II)-catalyzed cascade Heck/intramol. C(sp²)-H amidation reaction is described for the synthesis of 4-aryl-2-quinolinone derivatives Substituted cinnamamides containing 2-(pyridin-2-yl)ethanamine units reacts with aryl iodides to form intermediates by Heck reaction. Then, the intermediate undergoes intramol. amidation via a C(sp²)-H activated process promoted by an orientation group.

Tetrahedron published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C7H5ClN2S, Computed Properties of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Mingming published the artcileAdaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy, Category: catalysis-chemistry, the publication is Journal of Controlled Release (2021), 35-47, database is CAplus and MEDLINE.

Radiotherapy is one of the conventional tumor treatments, while its abscopal therapeutic efficacy is severely hampered by the immunosuppressive tumor microenvironment. To address this challenge, we herein report on the morphol.-adaptable peptide-based therapeutics for efficiently reversing the immunosuppression in the combinatorial radio-immunotherapy through simultaneous checkpoint blocking and induction of immunogenic cell death. The peptide-based therapeutics were created via co-assembling a pentapeptide containing a 4-amino proline residue with its derivatives containing IDO-1 inhibitor NLG919. The resulting therapeutics underwent pH-adaptable morphol. transformation between nanofibrils and nanoparticles and released NLG919 upon GSH cleavage. In vivo studies confirmed that the pH-adaptable morphologies of the therapeutics facilitated their tumor accumulation and retention at tumor sites compared to morphol.-persistent counterparts, thus resulting in efficient delivery of IDO-1 inhibitors. Simultaneously treating the tumor-bearing mice with the therapeutics and external ¦Ã-ray radiation boosted the tumor immunogenicity via inducing ICD cascade of the tumor cells and reverse the immunosuppressive tumor microenvironment due to the inhibition of IDO-1 for depletion of tryptophan. Our findings strongly demonstrate that the morphol.-adaptable peptide-based therapeutics exhibit the capability to reverse the immunosuppressive tumor microenvironment during irradiation, thus providing a new strategy for the combinatorial radio-immunotherapy.

Journal of Controlled Release published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Bo published the artcileNi-Catalyzed C-P Coupling of Aryl, Benzyl, or Allyl Ammonium Salts with P(O)H Compounds, Product Details of C15H15OP, the publication is Journal of Organic Chemistry (2019), 84(3), 1500-1509, database is CAplus and MEDLINE.

A methodol. that allows for the construction of C-P bonds via the nickel-catalyzed cross-coupling of organoammonium salts with appropriate phosphorus nucleophiles has been developed. Aryl-, pyridyl-, benzyl-, and allyl-ammonium triflates can be employed as the electrophiles. The employed phosphorus-based nucleophiles included diaryl/dibutyl phosphine oxide, dialkyl phosphonates, and Et phenylphosphinate. Functional groups OMe, CN, CF₃, F, Cl, C(O)NMe₂, and C(O)^tBu were tolerated.

Journal of Organic Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C12H17NS2, Product Details of C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhou, Zihong published the artcileDevelopment of a Quality Controllable and Scalable Process for the Preparation of 7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol: A Key Intermediate for Baloxavir Marboxil, Category: catalysis-chemistry, the publication is Organic Process Research & Development (2019), 23(12), 2716-2723, database is CAplus.

A novel six-step synthesis of 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol is described. Starting with 3,4-difloro-2-methylbenzoic acid and using di-Ph disulfide as an ideal sulfur source effectively solve the problems such as harsh reaction conditions, usage of smelly thiophenol, which might restrict the known process from pilot plant application. Large-scale applicability of this new route has been successfully demonstrated on kilogram-scale production to afford 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol with 98.04% purity in 75% overall yield. Meanwhile, the corresponding impurity profile was thus studied in detail and well documented.

Organic Process Research & Development published new progress about 2136287-65-3. 2136287-65-3 belongs to catalysis-chemistry, auxiliary class Fluoride,sulfides,Carboxylic acid,Benzene, name is 3,4-Difluoro-2-((phenylthio)methyl)benzoic acid, and the molecular formula is C19H14N2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Zhe published the artcileGram-scale synthesis of carboxylic acids via catalytic acceptorless dehydrogenative coupling of alcohols and hydroxides at an ultralow Ru loading, Synthetic Route of 118-90-1, the publication is Applied Catalysis, A: General (2022), 118443, database is CAplus.

Acceptorless dehydrogenative coupling (ADC) of alcs. and water/hydroxides is an emergent and graceful approach to produce carboxylic acids. Therefore, it is of high demand to develop active and practical catalysts/catalytic systems for this attractive transformation. Herein, the design and fabrication of a series of cyclometallated N-heterocyclic carbene-Ru (NHC-Ru) complexes via ligand tuning of [Ru-1], the superior complex in the previous work. Gratifyingly, gram-scale synthesis of carboxylic acids was efficiently enabled at an ultralow Ru loading (62.5 ppm) in open air. Moreover, effects of distinct ancillary NHC ligands and other parameters on this catalytic process were thoroughly studied, while further systematic studies were carried out to provide rationales for the activity trend of [Ru-1]-[Ru-7]. Finally, determination of quant. green metrics illustrated that the present work exhibited superiority over representative literature reports. Hopefully, this study could provide valuable input for researchers who are engaging in metal-catalyzed ADC reactions.

Applied Catalysis, A: General published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C2H2N4O2, Synthetic Route of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Biao published the artcileSynthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity, Related Products of catalysis-chemistry, the publication is European Journal of Medicinal Chemistry (2021), 113225, database is CAplus and MEDLINE.

Pyruvate dehydrogenase kinases (PDKs) are promising therapeutic targets that have received increasing attentions in cancer metabolism In this paper, synthesis and biol. evaluation of a series of novel dichloroacetophenones I (R¹ = cyclopropylamine, piperidin-1-yl, phenylamino, etc.) as potent PDKs inhibitors is reported. Structure-activity relationship anal. enabled to identify a potent compound II, which inhibited PDKs with an EC₅₀ value of 0.09¦ÌM, and reduced various cancer cells proliferation with IC₅₀ values ranging from 1.1 to 3.8¦ÌM, while show weak effect against non-cancerous L02 cell (IC₅₀ > 10¦ÌM). In the A375 xenograft model, II displayed an obvious antitumor activity at a dose of 5 mg/kg, but with no neg. effect to the mice weight Mol. docking suggested that II formed direct hydrogen bond interactions with Ser75 and Gln61 in PDK1, and meanwhile the aniline skeleton in II was sandwiched by the conserved hydrophobic residues Phe78 and Phe65, which contribute to the biochem. activity improvement. Moreover, II induced A375 cell apoptosis and cell arrest in G1 phase, and inhibited cancer cell migration. In addition, II altered glucose metabolic pathway in A375 cell by decreasing lactate formation and increasing ROS production and OCR consumption, which could serve as a potential modulator to reprogram the glycolysis pathway in cancer cell.

European Journal of Medicinal Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C9H21NO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fu, Zheng-Jun published the artcileDual-layer membrane with hierarchical hydrophobicity and transport channels for nonpolar organic solvent nanofiltration, Product Details of C10H6F17N, the publication is AIChE Journal (2021), 67(4), e17138, database is CAplus.

Nonpolar solvent separation is widely used in petroleum, chem., food industries, but traditional separation methods consume intensive energy. State-of-art organic solvent nanofiltration membranes require complex modifications for nonpolar solvent transport. For the first time, we propose the concurrent modification of the surface, interface and support layer of dual-layer membranes with three additives (perfluorodecylamine, fluoro substituted aromatic amine, silica nanoparticles) in a one-step cocasting process. A delamination-free dual-layer membrane was obtained with a hierarchical hydrophobicity and transport channels. The novel designed structure elevated the pure n-hexane permeance (28.75 L m^-2 hr^-1 bar^-1) by 3 orders of magnitude with a high lecithin rejection (98.7%). This method of synergistically controlling the hierarchical structures and properties of dual-layer membranes can significantly shorten the preparation process of high-performance nonpolar solvent nanofiltration membranes.

AIChE Journal published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, Product Details of C10H6F17N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia