Catalysis-chemistry

Gu, Chengyihan published the artcileVisible-light-mediated amidation from carboxylic acids and tertiary amines via C-N cleavage, Quality Control of 118-90-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(39), 5873-5876, database is CAplus and MEDLINE.

Synthesis of tertiary amides RC(O)NR₁R₂ [R = Ph, 4-MeC₆H₄, 4-PhC₆H₄, etc.; R¹ = R² = Et, n-Pr; R¹R² = CH₂(CH₂)₃CH₂] via iridium photocatalyzed amidation of carboxylic acids and tertiary amines through C-N bond cleavage was reported. A wide scope of structurally diverse carboxylic acids participated smoothly in the reaction, providing the desired tertiary amides with moderate-to-good yields (up to 93% yield). This amidation strategy provided an alternative way to address the regioselectivity between nucleophilic functional groups, thus complementing the functional group compatibility of classical amidation protocols. Its synthetic robustness was also proved by the late-stage modification of several complex mols. and gram-scale applications.

Chemical Communications (Cambridge, United Kingdom) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Shuting published the artcileDocosahexaenoic acid supplementation represses the early immune response against murine cytomegalovirus but enhances NK cell effector function, Computed Properties of 6217-54-5, the publication is BMC Immunology (2022), 23(1), 17, database is CAplus and MEDLINE.

Docosahexaenoic acid (DHA) supplementation is beneficial for several chronic diseases; however, its effect on immune regulation is still debated. Given the prevalence of cytomegalovirus (CMV) infection and because natural killer (NK) cells are a component of innate immunity critical for controlling CMV infection, the current study explored the effect of a DHA-enriched diet on susceptibility to murine (M) CMV infection and the NK cell effector response to MCMV infection. Male C57BL/6 mice fed a control or DHA-enriched diet for 3 wk were infected with MCMV and sacrificed at the indicated time points postinfection. Compared with control mice, DHA-fed mice had higher liver and spleen viral loads at day 7 postinfection, but final MCMV clearance was not affected. The total numbers of NK cells and their terminal mature cell subset (KLRG1⁺ and Ly49H⁺ NK cells) were reduced compared with those in control mice at day 7 postinfection but not day 21. DHA feeding resulted in higher IFN-¦Ã and granzyme B expression in splenic NK cells at day 7 postinfection. A mechanistic anal. showed that the splenic NK cells of DHA-fed mice had enhanced glucose uptake, increased CD71 and CD98 expression, and higher mitochondrial mass than control mice. In addition, DHA-fed mice showed reductions in the total numbers and activation levels of CD4⁺ and CD8⁺ T cells. These results suggest that DHA supplementation represses the early response to CMV infection but preserves NK cell effector functions by improving mitochondrial activity, which may play critical roles in subsequent MCMV clearance.

BMC Immunology published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C8H5F3O2S, Computed Properties of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Tong published the artcileHigh-efficiency synthesis of sulfenamides and disulfides by electrochemical dehydrogenative coupling, Related Products of catalysis-chemistry, the publication is Environmental Chemistry Letters, database is CAplus.

Catalytic dehydrogenative coupling of thiols with amines to produce sulfenamides and disulfides is an important reaction in the industry. Classical synthesis of sulfenamides involves the reaction between amine nucleophiles and sulfonyl chlorides, which are not widely available, toxic and unstable, and the reaction requires a combination of oxidizing and chlorinating reagents. Here authors describe an environmentally benign protocol for the efficient electrochem. dehydrogenative coupling of thiols with amines or thiols to form compounds possessing S-N or S-S bonds. Authors used potassium iodide as electrocatalyst in methanol for a greener reaction. The reaction operates under ambient conditions in the absence of oxidants, acids/bases or toxic/explosive electrolytes. Results show that most produced sulfenamides R¹SNHR² (R¹ = Ph, benzothiazole-2-yl, 2-thiazolyl, etc.; R² = t-Bu, n-Bu, c-hexyl, etc.) and disulfides RSSR (R = 4-FC₆H₄, 4-MeOC₆H₄, benzothiazole-2-yl, etc.) are generated in yields up to 99%.

Environmental Chemistry Letters published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C7H7BClFO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Min published the artcileImaging and evaluation of sulfane sulfur in acute brain ischemia using a mitochondria-targeted near-infrared fluorescent probe, Formula: C14H10O4S2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2018), 6(17), 2608-2619, database is CAplus and MEDLINE.

Ischemia is a pathol. condition owing to the deficiency of blood supply to a limited area of tissue. Ischemia can induce burst production of reactive oxygen species and lead to oxidative damage. As a family member of reactive sulfur species, sulfane sulfur plays important physiol. roles in many biol. events including synthesis of cofactors, modulation of enzyme activities, sulfuration of tRNA, and especially regulation of the intracellular redox state. We hypothesize that the endogenous level of sulfane sulfur will be adjusted to deal with ischemia-induced oxidative damage. Therefore, the bioimaging of sulfane sulfur real-time changes during ischemia is important for better understanding its physiol. processes. Herein, we describe the development of a mitochondria-targeted fluorescent probe Mito-SH that allowed for selective and sensitive detection of sulfane sulfur. Mito-SH is designed on the basis of the tautomerization of sulfane sulfur to thiosulfoxide, which ensures its high selectivity and sensitivity. A lipophilic triphenylphosphonium cation is selected as the mitochondria-targeted moiety, which can precisely navigate Mito-SH into mitochondria. The emission profile of azo-BODIPY fluorophore locates at the near-IR region, which deeply penetrates tissue and effectively avoids the interference of biol. background. Mito-SH exhibits the desirable combination of selectivity, sensitivity and excellent fluorescence response upon reaction with sulfane sulfur in cells. By employing Mito-SH, we evaluate the real-time sulfane sulfur dynamic changes under oxygen-glucose deprivation. Finally, Mito-SH has been successfully used for imaging sulfane sulfur changes caused by acute ischemia in mice.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Formula: C14H10O4S2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zuo, Dongxu published the artcileHighly Chemoselective Transamidation of Unactivated Tertiary Amides by Electrophilic N-C(O) Activation by Amide-to-Acyl Iodide Re-routing, Computed Properties of 118-90-1, the publication is Angewandte Chemie, International Edition (2022), 61(24), e202202794, database is CAplus and MEDLINE.

The challenging transamidation of unactivated tertiary amides has been accomplished via cooperative acid/iodide catalysis. Most crucially, the method provides a novel manifold to re-route the reactivity of unactivated N,N-dialkyl amides through reactive acyl iodide intermediates, thus reverting the classical order of reactivity of carboxylic acid derivatives This method provides a direct route to amide-to-amide bond interconversion with excellent chemoselectivity using equivalent amounts of amines. The combination of acid and iodide has been identified as the essential factor to activate the amide C-N bond through electrophilic catalytic activation, enabling the production of new desired transamidated products with wide substrate scope of both unactivated amides and amines, including late-stage functionalization of complex APIs (>80 examples). Authors anticipate that this powerful activation mode of unactivated amide bonds will find broad-ranging applications in chem. synthesis.

Angewandte Chemie, International Edition published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H15ClN2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jing, Xiaobi published the artcileSynthesis and characterization of 2-phenyl-6-hydrazinyl-3-pyridazinone derivatives, Application In Synthesis of 1798-04-5, the publication is Youji Huaxue (2010), 30(6), 904-907, database is CAplus.

A method for the preparation of 2-phenyl-6-hydrazine-3-pyridazinone derivatives was designed and the synthesis of the target compounds was achieved involving a rearrangement reaction of acetyl hydrazine derivatives in the presence of sodium hydroxide in ethanol and formation of hydrazone compounds and the product structures (i.e., pyridazine hydrazine derivatives) were confirmed by IR, ¹H-NMR, ¹³C-NMR. The rearrangment reaction of 2-[(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl)oxy]acetic acid hydrazide thus gave 6-hydrazinyl-2-phenyl-3(2H)-pyridazinone.

Youji Huaxue published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Application In Synthesis of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yuan, Gankun published the artcileA novel hierarchical targeting and controllable smart nanoparticles for enhanced in situ nuclear photodynamic therapy, Name: Fmoc-Pro-OH, the publication is Nano Research (2022), 15(5), 4212-4223, database is CAplus.

Photodynamic therapy (PDT) is a promising and non-invasive treatment for various cancers. Although nuclear PDT has considerable therapeutic prospects, it is still hindered by the non-specific recognition of tumor tissues or the degradation of nuclear targeting cationic groups by enzymes in the blood. Herein, a hierarchical targeted and controlled release strategy is proposed by using folate-modified poly-¦Â-cyclodextrin (poly-¦Â-CD) as a nano-carrier for loading nuclear localization signals (NLSs)-conjugated photosensitizer PAP (PAP = pyropheophorbide a-PAAKRVKLD). Excitingly, the obtained FA-CD@PAP (FA = folic acid) and nanoparticles (NPs) can specifically recognize tumor cells overexpressing folate receptors (FR) to remarkedly enhance the intracellular accumulation. Furthermore, the encapsulated PAP can be released under acidic conditions to realize precise nuclear localization. The reactive oxygen species (ROS) generated by the intranuclear-accumulated PAP upon irradiation can oxidize and destroy DNA chains or DNA repair enzymes instantaneously, which can directly induce cell death. As a result, FA-CD@PAP NPs exhibit excellent tumor regression and negligible side effects. This work provides an intelligent nuclear-targeted delivery strategy for in situ nuclear PDT with extremely prominent efficacy and high biol. safety.

Nano Research published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C10H18BNO4, Name: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Wencong published the artcilePreparation of room-temperature self-healing elastomers with high strength based on multiple dynamic bonds, Application of 2,2′-Dithiodibenzoic acid, the publication is European Polymer Journal (2021), 110614, database is CAplus.

As far as the self-healing elastomers are concerned, there is a contradiction between mech. strength and self-healing performance because it’s hard to acquire strong intermol. interaction and flexible segments motion concurrently. How to prepare room-temperature self-healing elastomers with high strength remains an enormous challenge. Herein, we synthesized room-temperature self-healing thermoplastic polyurethanes (TPUs) incorporated with multiple hydrogen bonds, reversible disulfide bonds and coordination bonds simultaneously. The prepared elastomers exhibit a tensile strength of over 16.1 MPa and a fracture strain of 771%, which are robust in comparison to most previous reports. The multiple dynamic bonds endow the elastomers with a high self-healing efficiency (94%) within 24 h at room temperature The self-healing mechanism was expounded from the perspective of the aggregate structure such as the degree of aggregation, the degree of microphase separation and mol. dynamics. It can be calculated by the dynamic mech. anal. that the activation energy of the target elastomer is lower than that of samples without dynamic interactions, which is of advantage to self-healing properties.

European Polymer Journal published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C19H14N2, Application of 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ren, Wenlong published the artcilePd-Catalyzed Regioselective Branched Hydrocarboxylation of Terminal Olefins with Formic Acid, Application In Synthesis of 1949-41-3, the publication is Organic Letters (2022), 24(3), 886-891, database is CAplus and MEDLINE.

A regioselective Pd-catalyzed hydrocarboxylation of terminal olefins with HCOOH was described. A wide variety of branched carboxylic acids can readily be obtained with high regioselectivities under mild reaction conditions. The reaction is operationally simple and requires no handling of toxic CO. The ligand and LiCl are important factors for reaction reactivity and selectivity.

Organic Letters published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Application In Synthesis of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Chi-Tien published the artcileZinc complexes containing coumarin-derived anilido-aldimine ligands as catalysts for ring opening polymerization of L-lactide, Synthetic Route of 6950-53-4, the publication is Molecules (2015), 20(4), 5313-5328, database is CAplus and MEDLINE.

The coumarin-derived ligand precursors L¹H-L⁶H have been prepared Treatment of these ligand precursors with 1.2 equivalent of ZnEt₂ in toluene affords zinc Et complexes (LZnEt) 1-6 (where L = coumarin-derived ligands bearing different functional groups). Reaction of ligand precursor L³H with 1.5 equivalent of Zn[N(SiMe₃)₂]₂ in toluene affords the zinc amide complex, L³ZnN(SiMe₃)₂, 7. All these compounds were characterized by NMR spectroscopy and elemental anal. The mol. structures are reported for 1 and 7. The catalytic activities of complexes 1-7 towards the ring opening polymerization of L-lactide in the presence of 9-AnOH have been investigated.

Molecules published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Synthetic Route of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia