Catalysis-chemistry

Zhang, Jun published the artcileConstruction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C-H activations for modular click chemistry libraries, SDS of cas: 1293990-73-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(69), 8656-8659, database is CAplus and MEDLINE.

A strategy developed for sequential C-H activations of indole to construct novel 2-alkynyl aza-spiro[4,5]indole scaffolds, which incorporated both alkyne and spiro-units into indole. Gram-scale synthesis and a one-pot, three-step synthesis demonstrated the utility of this protocol. Hybrid conjugates with an oseltamivir derivative further offered a powerful tool for the construction of a versatile spiroindole-containing library via click chem.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C10H19NO3, SDS of cas: 1293990-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yinruizhi published the artcileTranscriptome profiling revealed candidate genes, pathways and transcription factors related to nitrogen utilization and excessive nitrogen stress in perennial ryegrass, COA of Formula: C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 3353, database is CAplus and MEDLINE.

Ryegrass (Lolium perenne L.), a high-quality forage grass, is a good nutrient source for herbivorous livestock. However, improving nitrogen use efficiency and avoiding nitrate toxicity caused by excessive nitrogen are continual challenges in ryegrass production The mol. mechanism underlying the response of ryegrass to nitrogen, especially excessive nitrogen, remains unclear. In this study, the transcriptomic changes under different nitrogen levels were investigated in perennial ryegrass by high-throughput next-generation RNA sequencing. Phenotypic characterization showed that treatment with half of the standard N concentration (N0.5) led to a better growth state than the other three treatments. The treatments with the standard N concentration (N1) and treatments with ten times higher than the standard N concentration (N10) contained excessive nitrogen, which placed stress on plant growth. Anal. of differentially expressed genes indicated that 345 and 104 genes are involved in the regulation of nitrogen utilization and excessive nitrogen stress, resp. KEGG enrichment anal. suggested that “photosynthesis-antenna proteins” may respond pos. to appropriate nitrogen conditions, whereas “steroid biosynthesis”, “carotenoid biosynthesis” and “C5-branched dibasic acid metabolism” were identified as the top significantly enriched pathways in response to excessive nitrogen. Addnl., 21 transcription factors (TFs) related to nitrogen utilization were classified into 10 families, especially the AP2-EREBP and MYB TF families. Four TFs related to excessive nitrogen stress were identified, including LOBs, NACs, AP2-EREBPs and HBs. The expression patterns of these selected genes were also analyzed. These results provide new insight into the regulatory mechanism of ryegrass in response to nitrogen utilization and excessive nitrogen stress.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rashidian, Mohammad published the artcileEnzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics, Application In Synthesis of 1466420-02-9, the publication is Angewandte Chemie, International Edition (2016), 55(2), 528-533, database is CAplus and MEDLINE.

Antibodies are currently the fastest-growing class of therapeutics. Although naked antibodies proved valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half-life. They have been conjugated to toxic payloads, PEGs, or radioisotopes to increase and optimize their therapeutic efficacy. Although nonspecific conjugation is suitable for most in vitro applications, it has become evident that site specifically modified antibodies may have advantages for in vivo applications. Herein the authors describe a novel approach in which the antibody fragment is tagged with two handles: one for the introduction of a fluorophore or ¹⁸F isotope, and the second for further modification of the fragment with a PEG moiety or a second antibody fragment to tune its circulatory half-life or its avidity. Such constructs, which recognize Class II MHC products and CD11b, showed high avidity and specificity. They were used to image cancers and could detect small tumors.

Angewandte Chemie, International Edition published new progress about 1466420-02-9. 1466420-02-9 belongs to catalysis-chemistry, auxiliary class Copper-Free Click Chemistry,Tetrazine, name is (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, and the molecular formula is C12H12F3N5O2, Application In Synthesis of 1466420-02-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qi, Xin published the artcileSecond Natural Rubber with Self-Reinforcing Effect Based on Strain-Induced Crystallization, COA of Formula: C14H10O4S2, the publication is Macromolecules (Washington, DC, United States) (2022), 55(7), 2758-2767, database is CAplus.

Natural rubber (NR) has a strategic position in the rubber industry due to its excellent properties, but it faces the problem of insufficient output and difficulty in recycling. Here, a high-performance elastomer was prepared by the simple epoxidation modification of biobased Eucommia ulmoides gum (EUG). For the first time, it was found that epoxidized EUG (EEUG) with epoxy degree of 12.3%-17.4% no longer crystallized at room temperature but had the ability to strain-induced crystallization (SIC). As a result, its vulcanizates showed excellent tensile strength (17 MPa), toughness (37.8 MJ m^-3) and elasticity (strain recovery values >97%) without filler reinforcement, which is comparable with vulcanized NR. The SIC of EEUG was studied by synchrotron radiation wide-angle X-ray diffraction (SR-WAXD), and its performance was also compared with NR under the reinforcement of carbon black. In addition, through crosslinking by disulfide bonds, EEUG could be used to prepare high-performance (tensile strength of 10.5 MPa, toughness of 30.7 MJ m^-3), recyclable green elastomers. This new kind of elastomer can be used as the second natural rubber, which is of great significance to solve the problem of insufficient production and difficult recovery of NR.

Macromolecules (Washington, DC, United States) published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, COA of Formula: C14H10O4S2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ponou, Josiane published the artcileSeparation of palladium and silver from semiconductor solid waste by means of liquid-liquid extraction using dodecyl amine acetate as a surfactant collector, Computed Properties of 2016-56-0, the publication is Separation and Purification Technology (2018), 86-93, database is CAplus.

Liquid-liquid-powder extraction (LLPE) is the process of transferring fine solid particles from one liquid phase to another immiscible liquid in contact across the liquid-liquid boundary using a surface-active agent as a collector. LLPE was applied to semiconductor fine solid waste to extract valuable Pd and Ag particles from Al using dodecyl amine acetate (DAA) surfactant as collector, kerosene as an organic phase and pure water as the aqueous hydrophilic phase. Metal concentrations in each phase was dependent on solution pH, and the recovery of Pd and Ag was highly dependent on this parameter. However, a pH of 10 was optimal for separation of precious metals from Al, with Pd and Ag concentrating in the kerosene phase under this condition. The metal distribution as a function of DAA dosage at pH 10, showed that Pd and Al reached their maximum extraction percentages at a DAA dosage of 0.15%, whereas the Ag extraction percentage reached a maximum at a dosage of 0.2%. Thus, 0.15% was determined to be the optimum DAA dosage, which gave Pd and Ag concentrations 6.05 and 3.6 times higher than the feed, resp., with resp. extraction percentages of 87.78 ¡À 3.72% and 87.42 ¡À 3.81%. Moreover, 74.52 ¡À 7.72% of Al could be separated from Pd and Ag.

Separation and Purification Technology published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Computed Properties of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yan, Li-Jun published the artcileChemically Sustainable and Green One-Pot Multicomponent Synthesis of Highly Functionalized Polycyclic N-Fused-Pyrrolidine Heterocycles, Category: catalysis-chemistry, the publication is ChemistrySelect (2018), 3(2), 662-665, database is CAplus.

An eco-friendly, highly-efficient, atom-economical three-component cascade reaction of acenaphthenequinone, ¦Â-nitroolefins RCH=CHNO₂ (R = 2,4-dichlorophenyl, furan-2-yl, 1-methylindol-3-yl, etc.) and ¦Á-amino acids I (X = CH₂, CH₂CH₂, S; n = 1, 2) in MeOH/H₂O is developed for the synthesis of novel functionalized polycyclic N-fused-pyrrolidine derivatives II. All products are obtained by filtration in the absence of column chromatog. and recrystallization Due to its operational simplicity, this green and chem. sustainable reaction can be easily applied toward the design and synthesis of target mols. for the discovery of novel biol. active compounds

ChemistrySelect published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C14H26O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mahalingam, Devalingam published the artcilePhase 1 open-label, multicenter study of first-in-class ROR¦Ã Agonist LYC-55716 (cintirorgon): safety, tolerability, and preliminary evidence of antitumor activity, Application In Synthesis of 2055536-64-4, the publication is Clinical Cancer Research (2019), 25(12), 3508-3516, database is CAplus and MEDLINE.

Transcription factor retinoic acid receptor-related orphan receptor ¦Ã (ROR¦Ã) regulates type 17 effector T-cell differentiation and function and is key to immune cell regulation. A phase 1 study evaluated the safety and tolerability of LYC-55716 (cintirorgon), a first-in-class, oral, small-mol. ROR¦Ã agonist in adults with relapsed/refractory metastatic cancer. Patients received 28-day treatment cycles of oral LYC-55716; dose and dosing regimen were determined according to pharmacokinetic profile and safety. No dose-limiting toxicities occurred among the 32 enrolled patients who received LYC-55716 150 mg BID to 450 mg BID. Treatment-related adverse events (AE) were primarily grade 1-2 and included diarrhea (n = 11), fatigue (n = 7), anemia (n = 4), decreased appetite (n = 4), and nausea (n = 4). Grade 3 AEs were anemia (n = 2), elevated gamma-glutamyl transferase (n = 1), and hypophosphatemia (n = 1). Two patients (NSCLC and sarcomatoid breast cancer) had confirmed partial responses; 11 had disease stabilization for 2 to 12 mo (6 received >4 mo of treatment). Ese data support the safety and tolerability of LYC-55716 and selection of 450 mg BID dose for a phase 2a study assessing LYC-55716 clin. activity, safety, and biomarkers in patients with NSCLC, head and neck, gastroesophageal, renal cell, urothelial, and ovarian cancers.

Clinical Cancer Research published new progress about 2055536-64-4. 2055536-64-4 belongs to catalysis-chemistry, auxiliary class Metabolic Enzyme,ROR, name is (S)-3-(6-(3-(Difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid, and the molecular formula is C27H23F6NO6S, Application In Synthesis of 2055536-64-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qiang, Ting published the artcileModulation of hyperglycemia by sodium alginate is associated with changes of serum metabolite and gut microbiota in mice, Category: catalysis-chemistry, the publication is Carbohydrate Polymers (2022), 119359, database is CAplus and MEDLINE.

Previous studies showed that sodium alginates of different mol. weights reduced postprandial glucose differently. We hypothesize that the differential modulation of hyperglycemia by sodium alginates with different mol. weights may be associated with their differential regulations of serum metabolites and gut microbiota. In this work, high-fat diet-fed mice were supplemented with high- and low-mol.-weight sodium alginate (H-SA, 3350 kDa; L-SA, 131 kDa). Blood glucose/lipid parameters, serum metabolites and gut microbiota were measured. Compared with L-SA, H-SA more significantly reduced fasting blood glucose, HOMA-IR, total cholesterol and body fat; H-SA more significantly enriched serum metabolites, including certain lipids, branched-chain amino acids, and vitamin D and E derivatives These changes were correlated with the differential modulation of gut microbiota by H-SA and L-SA. In conclusion, the differential effects of sodium alginates with different mol. weights in alleviating hyperglycemia were associated with their differential modulations of serum metabolites and gut microbiota.

Carbohydrate Polymers published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zheng, Zhuo Qun published the artcileAlkylation of ammonium salts catalyzed by imidazolium-based ionic liquids, Recommanded Product: Dodecylamineacetate, the publication is Advanced Synthesis & Catalysis (2007), 349(7), 1095-1101, database is CAplus.

Quaternary ammonium salts were synthesized from ammonium salts and dialkyl carbonates over imidazolium ionic liquid catalysts. The reaction gave almost stoichiometric amounts of the quaternary ammonium salts for halides and nitrates. It was found that the electron-donating property of the alkyl moieties of ammonium cations, the electrophilic nature of the alkyl group of the carbonate, the acidity of the acid which the anion of the ammonium salt corresponds to, and the steric hindrance of the ammonium salts and the dialkyl carbonates are the key factors that influence the yields of quaternary ammonium salts. Strong electron-donating alkyl groups on the nitrogen atom of the ammonium salt, electron-withdrawing groups on the methylene carbon of dialkyl carbonate, and weaker steric hindrance of the starting ammonium salts and dialkyl carbonates favor the alkylation reaction of ammonium salts.

Advanced Synthesis & Catalysis published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C10H16Br3N, Recommanded Product: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Ying-Zi published the artcileEnantioselective synthesis of bicyclo[2.2.2]octane-1-carboxylates under metal free conditions, HPLC of Formula: 4230-93-7, the publication is Organic Chemistry Frontiers (2015), 2(3), 274-278, database is CAplus.

A new tandem reaction was realized that permits rapid access to a wide range of bicyclo[2.2.2]octane-1-carboxylates in good to excellent yields with excellent enantioselectivities under metal free, mild, and operationally simple conditions. An open transition state was deemed operative in this highly enantioselective process mediated by an organic base.

Organic Chemistry Frontiers published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, HPLC of Formula: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia