Catalysis-chemistry

Tsai, Jung-Chin published the artcileSolid-liquid equilibrium measurements using DSC for three binary mixtures of 2-methylbenzoic acid + 3-methylbenzoic acid, 2-methoxybenzoic acid + 3-methylbenzoic acid, and N-phenylacetamide + benzamide, Quality Control of 118-90-1, the publication is Fluid Phase Equilibria (2022), 113443, database is CAplus.

This study reports the solid-liquid equilibrium (SLE) data for three binary mixtures of 2-methylbenzoic acid + 3-methylbenzoic acid, 2-methoxybenzoic acid + 3-methylbenzoic acid, and N-phenylacetamide + benzamide. These phase equilibrium data were measured using the Differential Scanning Calorimetry (DSC). The solidus and liquidus temperatures for each binary mixture at various compositions are presented. All three binary mixtures show the simple eutectic behavior. The eutectic temperatures and compositions for these binary mixtures were determined using the fractional transformation method. The fractional transformation is defined as the fraction of the mixture that is liquefied during the heating process using DSC. The fractional transformation data at the eutectic point, denoted as the eutectic fraction, were evaluated from the exptl. DSC results over various time intervals during the measurements. A triangular plot of the eutectic fractions against various compositions of a binary mixture effectively illustrated the eutectic point condition. The liquidus curves for each binary system were correlated using the Wilson and NRTL (Non-Random Two-Liquid) activity coefficient models. The optimally fitted model parameters for each binary mixture are presented in this study. Satisfactory correlation results are also demonstrated for all binary systems.

Fluid Phase Equilibria published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C9H6BrNO, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Alfie, Rachel J. published the artcileA kinetically controlled direct aldol addition of ¦Á-chloro thioesters via soft enolization, Category: catalysis-chemistry, the publication is Tetrahedron Letters (2017), 58(3), 185-189, database is CAplus.

¦Á-Chloro thioesters such as ClCH₂COSR (R = 2,4,6-i-Pr₃C₆H₂)(I) underwent diastereoselective aldol additions to aldehydes R¹CHO [R¹ = 2-naphthyl, Ph, t-Bu, cyclohexyl, i-Pr, PhCH₂CH₂, Me(CH₂)₆] in the presence of MgBr₂¡¤OEt₂ and i-Pr₂NEt in CH₂Cl₂ at -78¡ã to give the syn-aldol adducts II [R¹ = 2-naphthyl, Ph, t-Bu, cyclohexyl, i-Pr, PhCH₂CH₂, Me(CH₂)₆] as the major products in 40-80% yields and in 2:1-11:1 dr. Both enolizable and nonenolizable aldehydes underwent chemo- and stereoselective aldol addition under these conditions. At -78¡ã, the reactions are kinetically controlled, as shown by the lack of aldehyde exchange when p-tolualdehyde and an aldol adduct were submitted to the reaction conditions at -78¡ã. Aldol addition of I to (S)-i-PrCH(OTBDMS)CHO (TBDMS = tert-butyldimethylsilyl) at either -78¡ã or 24¡ã yielded III (R² = COSR) as a single diastereomer. The structure of III (R² = HOCH₂) was determined by X-ray crystallog.

Tetrahedron Letters published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Amin, Sk. Abdul published the artcileQuantitative activity-activity relationship (QAAR) driven design to develop hydroxamate derivatives of pentanoic acids as selective HDAC8 inhibitors: synthesis, biological evaluation and binding mode of interaction studies, COA of Formula: C8H7NO4, the publication is New Journal of Chemistry (2021), 45(37), 17149-17162, database is CAplus.

Histone deacetylase 8 (HDAC8) has been implicated as a potential drug target of many diseases including cancer. HDAC8 isoform selectivity over other class-I HDACs is a major concern nowadays. In this work, a series of pentanoic acid based hydroxamates with different substituted cap groups have been designed, synthesized, characterized, and screened against class-I HDACs. A quant. activity-activity relationship (QAAR) model was developed to design HDAC8 selective inhibitors. The designed compounds obtained through the mol. modeling study were synthesized, characterized, and their enzymic as well as cytotoxic activities were measured. Two compounds 2-(2-(2,4-Dichlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide and 2-(2-(4-Chlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide are found to be selective HDAC8 inhibitors over other class-I HDACs. These compounds possess better antiproliferative activities against some cancer cell lines. These observations are in agreement with the mol. docking studies for the binding mode of interactions. Further studies show that compounds 2-(2-(2,4-Dichlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide and 2-(2-(4-Chlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide induce significant cell growth arrest in the G2/M phase, indicating their anticancer potentials. In summary, our study confirms pentanoic acid based hydroxamate as selective HDAC8 inhibitors and two compounds 2-(2-(2,4-Dichlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide and 2-(2-(4-Chlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide may serve as lead mols. for further investigation.

New Journal of Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, COA of Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mott, Bryan T. published the artcileSynthesis and Antimalarial Efficacy of Two-Carbon-Linked, Artemisinin-Derived Trioxane Dimers in Combination with Known Antimalarial Drugs, Synthetic Route of 6084-58-8, the publication is Journal of Medicinal Chemistry (2013), 56(6), 2630-2641, database is CAplus and MEDLINE.

Malaria continues to be a difficult disease to eradicate largely because of the widespread populations it affects and the resistance that malaria parasites have developed against once very potent therapies. The natural product artemisinin has been a boon for antimalarial chemotherapy, as artemisinin combination therapy (ACT) has become the first line of chemotherapy. Because the threat of resistance is always on the horizon, it is imperative to continually identify new treatments, comprising both advanced analogs of all antimalarial drugs, especially artemisinin, and the exploration of novel combinations, ideally with distinct mechanisms of action. Here we report for the first time the synthesis of a series of two-carbon-linked artemisinin-derived dimers (I and oxime derivatives), their unique structural features, and demonstration of their antimalarial efficacy via single oral dose administration in two 60-day survival studies of Plasmodium berghei infected mice. Several of the new endoperoxide chem. entities consistently demonstrated excellent antimalarial efficacy, and combinations with two non-peroxide antimalarial drugs have been studied.

Journal of Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kibardina, L. K. published the artcilePyridoxal reactions with amines and aliphatic diamines, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Russian Journal of General Chemistry (2016), 86(3), 607-612, database is CAplus.

Interaction of pyridoxal with amines such as pyridin-2-amine, N-(2-aminoethyl)aniline, methyl[2-(methylamino)ethyl]amine, etc. led to the formation of compounds having imine, imidazolidine and pyrimidine moieties in their structure, e.g., I. Structure of the obtained compounds was proved by X-ray diffraction anal.

Russian Journal of General Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kibardina, L. K. published the artcileAzomethines Based on Pyridoxal-Derived Aromatic Aldehydes, Application In Synthesis of 140-28-3, the publication is Russian Journal of General Chemistry (2018), 88(1), 41-47, database is CAplus.

The reaction of pyridoxal with 2,4-dihydroxybenzaldehyde in a hydrochloric acid solution gave 1-(5-formyl-2,4-dihydroxyphenyl)-7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-5-ium chloride. Treatment of the latter with sodium hydride in ethanol afforded a free aldehyde, 2,4-dihydroxy-5-(7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-1-yl)benzaldehyde in 85% yield. A series of azomethines I [R = (CH₂)₃NMe, Ph, 4-H₂NC₆H₄, etc.] and imidazolidines II [R¹ = Me, Bn] was obtained by reacting the obtained aldehyde with various amines and diamines.

Russian Journal of General Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dorval, Celine published the artcileCobalt-Catalyzed C(sp²)-CN Bond Activation: Cross-Electrophile Coupling for Biaryl Formation and Mechanistic Insight, Application of 4,4′-Dimethyldiphenyl, the publication is ACS Catalysis (2020), 10(21), 12819-12827, database is CAplus.

Herein, we report a cross-electrophile coupling of benzonitrile derivatives and aryl halides with a simple cobalt-based catalytic system under mild conditions to form biaryl compounds Even though the cobalt catalyst is able to activate the C(sp²)-CN bond alone, the use of the AlMe₃ Lewis acid enhances the reactivity of benzonitriles and improves the cross-selectivity with barely any influence on the functional group compatibility. X-ray structure determination of an original low-valent cobalt species combined with catalytic and stoichiometric reactions reveals a catalytically active cobalt(I) species toward the aryl halide partner. On the other hand, exptl. insights, including cyclic voltammetry experiments, suggest the involvement of a cobalt complex of a lower oxidation state to activate the benzonitrile derivative Finally, d. functional theory calculations support the proposed mechanistic cycle involving two low-valent cobalt species of different oxidation states to perform the reaction.

ACS Catalysis published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Application of 4,4′-Dimethyldiphenyl.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Frumina, N. S. published the artcileUse of p-nitrodiphenylamine as a redox indicator for determining chromium in the presence of vanadium, Application In Synthesis of 1821-27-8, the publication is Zavodskaya Laboratoriya (1969), 35(11), 1297-9, database is CAplus.

Cr was titrated with (NH4)2Fe(SO4)2 in 3-4N H2SO4 and in the presence of V (Cr:V > 3:1) with 0.1% p-nitrophenylamine in 1:1 H2SO4 as a redox indicator. For the determination of V the optimum medium is 8-18N H2SO4. The method is suitable for the determination of Cr in alloy steels.

Zavodskaya Laboratoriya published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Application In Synthesis of 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fan, Bo published the artcileEnd-Capping Strategies for Triggering End-to-End Depolymerization of Polyglyoxylates, Name: 2,2-Diallylpent-4-en-1-amine, the publication is Macromolecules (Washington, DC, United States) (2016), 49(24), 9309-9319, database is CAplus.

Polymers that undergo end-to-end depolymerization in response to the cleavage of a stimuli-responsive end-cap are promising for diverse applications from drug delivery to responsive coatings and plastics. The end-cap is designed to respond to an appropriate stimulus for the application. In the current work, end-caps for triggering the depolymerization of poly(Et glyoxylate) (PEtG) were explored. First a phenylboronate, a disulfide, and an azobenzene were utilized to impart redox-responsive properties to PEtG. Then, methoxy-substituted trityl groups were used to provide sensitivity to mild acid. A multiresponsive platform was also introduced, allowing PEtG to respond to multiple stimuli, either simultaneously or independently. Incorporation of a cross-linkable trialkene end-cap enabled the preparation of networks that could subsequently be depolymerized Finally, high molar mass PEtG could be depolymerized by mech. stimulation independent of the end-cap. The versatility in end-capping strategies and potential depolymerization stimuli will not only expand PEtG’s utility for different applications, but will also be useful for other classes of end-to-end depolymerizable polymers.

Macromolecules (Washington, DC, United States) published new progress about 928836-00-4. 928836-00-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain, name is 2,2-Diallylpent-4-en-1-amine, and the molecular formula is C11H19N, Name: 2,2-Diallylpent-4-en-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

di Mauro, Chiara published the artcileEnhancing the Recyclability of a Vegetable Oil-Based Epoxy Thermoset through Initiator Influence, SDS of cas: 119-80-2, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(20), 7690-7700, database is CAplus.

Bisphenol A based epoxy thermosets involve both environmental and health risks. By reacting a vegetal oil-based epoxide with an aromatic diacid containing S-S bonds a thermoset is produced. Herein, reprocessable thermosets were synthesized, the recyclability being designed through a dual mechanism: that of disulfide metathesis and of transesterifications. To assess the feasibility of the reprocessing, a series of ten initiators were tested to probe their effect not only on the crosslinking reaction but also on the recyclability. This study introduces for the first time the key role of the initiator on the material performances and on their reprocessing. A very good reprocessability was obtained for thermosets prepared using as initiator the imidazole. Moreover, the thermosets exhibit complete chem. recyclability in 1N NaOH at 80¡ãC, after 3 days, without needing addnl. chems. The reprocessed materials have similar performances with the virgin ones, even after 10 cycles of reprocessing.

ACS Sustainable Chemistry & Engineering published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, SDS of cas: 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia