Tag: M.W=100-150

Podyunin, A. A. published the artcileSynthesis and evaluation of antiradiation activity of N-derivatives of guanidinoethanethiols in experiments with yeast cells of Saccharomyces cerevisiae, SDS of cas: 6972-05-0, the publication is Khimiko-Farmatsevticheskii Zhurnal (1990), 24(10), 44-6, database is CAplus.

The title compounds, R¹R²NC(R³HN)NHCH₂CHR⁴SH [I; R¹ = H, Me, Et, CH₂CO₂Na, hydroxy alkyl; R², R³, R⁴ = H, Me; or R²R³ = CH₂] were prepared from R¹R²N(R³NH)CS and BrCHR⁴CH₂NH₂.HBr in 1 step and isolated as trithiocarbonates in 16-46% yield. Compounds (I) were screened for toxicity and radioprotective activity. Derivatives (I; R¹ = Et; R² = R³ = R⁴ = H and R³ = Et; R² = R⁴ = H) showed radioprotective activity in yeast cells.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, SDS of cas: 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pei, Chunzhe published the artcileNi-Catalyzed Direct Carboxylation of Aryl C-H Bonds in Benzamides with CO₂, Name: 2-Methylbenzoic acid, the publication is Advanced Synthesis & Catalysis (2022), 364(3), 493-499, database is CAplus.

The direct carboxylation of inert aryl C-H bond catalyzed by abundant and cheap nickel is still facing challenge. Herein, authors report the Ni-catalyzed direct carboxylation of aryl C-H bonds in benzamides under 1 atm of CO₂ to afford various Me carboxylates or phthalimides, dealing with different post-processing. The reaction displays excellent functional group tolerance and affords moderate to high carboxylation yields under mild conditions. Detail mechanistic studies suggest that a Ni(0)-Ni(II)-Ni(I) catalytic cycle may be involved in this reaction.

Advanced Synthesis & Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dandu, Reddeppareddy published the artcileDesign and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases, Recommanded Product: O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(6), 1916-1921, database is CAplus and MEDLINE.

Fused dihydroindazolopyrrolocarbazole oximes have been identified as low nanomolar, potent dual TIE-2 and VEGF-R2 receptor tyrosine kinase inhibitors with excellent cellular potency. Development of the structure-activity relationships (SAR) led to identification of compounds I and II as potent, selective dual TIE-2/VEGF-R2 inhibitors with favorable pharmacokinetic properties. Compound I was orally active in tumor models with no observed toxicity.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Recommanded Product: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Tianhao published the artcileNickel-Catalyzed Decarbonylative Thioetherification of Carboxylic Acids with Thiols, Recommanded Product: 2-Methylbenzoic acid, the publication is Journal of Organic Chemistry (2022), 87(13), 8672-8684, database is CAplus and MEDLINE.

A nickel-catalyzed decarbonylative thioetherification of carboxylic acids RC(O)OH (R = naphthalen-2-yl, 1-benzofuran-2-yl, 1-benzothiophen-2-yl, etc.) with thiols R¹HS (R¹ = 4-methylphenyl, naphthalen-2-yl, 2-methylfuran-3-yl, etc.) was developed. Under the reaction conditions, benzoic acids, cinnamic acids, and benzyl carboxylic acids coupled with various thiols including both aromatic and aliphatic ones produce the corresponding thioethers RSR¹ in up to 99% yields. Moreover, this reaction was applicable to the modification of bioactive mols. such as 3-methylflavone-8-carboxylic acid, probenecid, and flufenamic acid, and the synthesis of acaricide chlorbenside. These results well demonstrated the potential synthetic value of this new reaction in organic synthesis.

Journal of Organic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H14O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Xiaochen published the artcileCombined Photoredox and Carbene Catalysis for the Synthesis of ¦Á-Amino Ketones from Carboxylic Acids, Application In Synthesis of 118-90-1, the publication is ACS Catalysis (2022), 12(4), 2522-2531, database is CAplus.

Herein, a mild, operationally simple method for direct acylation of ¦Á-amino C(sp³)-H bonds from carboxylic acids RC(O)OH (R = cyclopropyl, Ph, 2-chlorophenyl, etc.) via the merger of carbene and photoredox catalysis was reported. Specifically, cross-coupling reactions between a wide range of carboxylic acids, a class of feedstock chems., and readily available N-alkyl anilines R¹CH₂N(R²)R³ (R¹ = H; R² = Me; R¹R² = -(CH₂)₃-, -(CH₂OCH₂CH₂)-; R³ = Ph, 4-bromophenyl, pyridin-2-yl, etc.) and 1-phenyl-2,3-dihydro-1H-indole by means of single-electron N-heterocyclic carbene catalysis combined with photocatalysis provided access to structurally diverse ¦Á-amino ketones RC(O)CH(R¹)N(R²)R³ and (1-phenylindolin-2-yl)(p-tolyl)methanone. The method features a broad substrate scope and is compatible with a wide array of functional groups. To demonstrate the potential applications of the method, one of the ¦Á-amino ketone products was subjected to further transformations.

ACS Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C13H10O2, Application In Synthesis of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Guanghui published the artcileStudy on process for producing ¦Á-trifluoromethyl ethylamine, COA of Formula: C3H6F3N, the publication is Guangdong Huagong (2012), 39(1), 194-195, database is CAplus.

¦Á-Trifluoromethyl ethylamine was prepared under pressure by using L-alanine and sulfur tetrafluoride as raw materials for one step fluorination reaction. The optimal operating conditions for the process were investigated exptl. These conditions obtained are as follows: 100 g of L-alanine as raw material and molar ratio of sulfur tetrafluoride to L-alanine at 1: 2, the reaction at temperature of 55¡ãC and pressure of 18 ? 19 kgf/cm² for 12 h. The yield of the product is above 55% and the m.p. of the hydrochloride of the product is above 218.5¡ãC.

Guangdong Huagong published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C25H21N3O4, COA of Formula: C3H6F3N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ding, Xiumin published the artcileBottom-up synthetic biology approach for improving the efficiency of menaquinone-7 synthesis in Bacillus subtilis, Product Details of C5H11NO2S, the publication is Microbial Cell Factories (2022), 21(1), 101, database is CAplus and MEDLINE.

Menaquinone-7 (MK-7), which is associated with complex and tightly regulated pathways and redox imbalances, is produced at low titers in Bacillus subtilis. Synthetic biol. provides a rational engineering principle for the transcriptional optimization of key enzymes and the artificial creation of cofactor regeneration systems without regulatory interference. This holds great promise for alleviating pathway bottlenecks and improving the efficiency of carbon and energy utilization. We used a bottom-up synthetic biol. approach for the synthetic redesign of central carbon and to improve the adaptability between material and energy metabolism in MK-7 synthesis pathways. First, the rate-limiting enzymes, 1-deoxyxylulose-5-phosphate synthase (DXS), isopentenyl-diphosphate delta-isomerase (Fni), 1-deoxyxylulose-5-phosphate reductase (DXR), isochorismate synthase (MenF), and 3-deoxy-7-phosphoheptulonate synthase (AroA) in the MK-7 pathway were sequentially overexpressed. Promoter engineering and fusion tags were used to overexpress the key enzyme MenA, and the titer of MK-7 was 39.01 mg/L. Finally, after stoichiometric calculation and optimization of the cofactor regeneration pathway, we constructed two NADPH regeneration systems, enhanced the endogenous cofactor regeneration pathway, and introduced a heterologous NADH kinase (Pos5P) to increase the availability of NADPH for MK-7 biosynthesis. The strain expressing pos5P was more efficient in converting NADH to NADPH and had excellent MK-7 synthesis ability. Following three Design-Build-Test-Learn cycles, the titer of MK-7 after flask fermentation reached 53.07 mg/L, which was 4.52 times that of B. subtilis 168. Addnl., the artificially constructed cofactor regeneration system reduced the amount of NADH-dependent byproduct lactate in the fermentation broth by 9.15%. This resulted in decreased energy loss and improved carbon conversion. In summary, a “high-efficiency, low-carbon, cofactor-recycling” MK-7 synthetic strain was constructed, and the strategy used in this study can be generally applied for constructing high-efficiency synthesis platforms for other terpenoids, laying the foundation for the large-scale production of high-value MK-7 as well as terpenoids.

Microbial Cell Factories published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Product Details of C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zheng, Wei-Xiang published the artcileSynthesis of Aryl Ketones from Carboxylic Acids and Arylboronic Acids Using 2-Chloroimidazolium Chloride as a Coupling Reagent, Recommanded Product: 2-Methylbenzoic acid, the publication is Synthesis, database is CAplus.

Carboxylic acids are an abundant and structurally diverse class of com. available materials, which are commonly used as stable reagents in organic synthesis. The Suzuki-Miyaura coupling reaction directly using carboxylic acid as a substrate has been rarely reported. Here, authors report an efficient coupling reaction of carboxylic acids with arylboronic acids in toluene in the presence of IPrCl-Cl, Pd(OAc)₂, PPh₃, and K₃PO₄¡¤7H₂O at 90 ¡ãC to give the corresponding aryl ketones.

Synthesis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C7H6O3, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Jianguang published the artcileCorrelation between intestinal flora disruption and protein-energy wasting in patients with end-stage renal disease, COA of Formula: C5H11NO2S, the publication is BMC Nephrology (2022), 23(1), 130, database is CAplus and MEDLINE.

Different dialysis treatments may affect the composition and structure of the intestinal flora of dialysis-treated chronic kidney disease (CKD) patients. This study aimed to analyze the correlations between the different flora and the nutritional indexes and further explore the potential metabolic pathways in patients with CKD in end-stage renal disease (ESRD). Altogether, 102 patients with ESRD were recruited and categorized into the hemodialysis (HD) group (N = 49) and the peritoneal dialysis (PD) group (N = 53). Their biochem. indexes, anthropometric indicators, and inflammatory markers were determined The total genomic DNA was extracted for 16S ribosomal DNA sequencing. Furthermore, bioinformatics anal. was employed for functional anal. Anthropometric indicators, including handgrip strength, mid-upper arm circumference, mid-upper arm muscle circumference, and body mass index, in the HD and PD groups showed a pos. correlation with butyric acid-producing bacteria (Rosella and Phascolarctobacterium) and a neg. correlation with conditional pathogens (Escherichia spp.). Meanwhile, the inflammatory markers, including high-sensitivity C-reactive protein and interleukin-6, were significantly higher in the PD-protein-energy wasting (PEW) group than in the PD-non-protein-energy wasting (NPEW) group; although they showed an increasing trend in the HD-PEW group, no significant difference was noted. Rosella was considerably scarce in the HD-PEW group than in the HD-NPEW group, whereas Escherichia was substantially more abundant in the PD-PEW group than in the PD-NPEW group. Compared with the HD group, the essential amino acid synthesis pathway, amino acid metabolism-related enzyme pathways, and aminoacyl-tRNA biosynthesis pathways were weakened in the PD group. Most carbohydrate metabolic pathways were weakened, although the tricarboxylic acid cycle was slightly enhanced. Concurrently, the fatty acid metabolism was enhanced, whereas fatty acid synthesis was weakened; the metabolic pathways of B vitamins were also weakened. These potential metabolic pathways of the various compounds released by intestinal flora showed a significant correlation with blood biochem. indexes, anthropometric indicators, and inflammatory markers. In patients with ESRD, different dialysis treatments affected the abundance of butyric acid-producing bacteria (Rosella and Phascolarctobacterium) and conditional pathogens (Escherichia spp.). Butyric acid-producing bacteria showed a pos. correlation with PEW and showed a neg. correlation with Escherichia. Improving the intestinal diversity and increasing the amount of butyric acid-producing bacteria, such as Blautella, Faecococcus, and Phascolarctobacterium, are potential therapeutic approaches to enhance protein-energy consumption in patients with ESRD.

BMC Nephrology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yin, Shenxiang published the artcileAcceptorless dehydrogenation of primary alcohols to carboxylic acids by self-supported NHC-Ru single-site catalysts, Recommanded Product: 2-Methylbenzoic acid, the publication is Journal of Catalysis (2022), 165-172, database is CAplus.

The acceptorless dehydrogenation of diverse aromatic and aliphatic primary alcs. to corresponding carboxylic acids was accomplished by self-supported NHC-Ru single-site catalysts under mild reaction conditions. Besides broad substrates with excellent activity, selectivity and good tolerance to sensitive functional groups, the solid single-site catalyst could be recovered and reused for more than 20 runs without deactivation. Remarkably, up to 1.8 x 10⁴ turnover numbers could be achieved by this newly developed sustainable protocol in gram scale at low catalyst loading, highlighting its potential in industry.

Journal of Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia