Tag: M.W=100-150

Dai, Chaoyang published the artcile2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors, Computed Properties of 6972-05-0, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(10), 3172-3176, database is CAplus and MEDLINE.

TNF-¦Á converting enzyme (TACE) inhibitors are promising agents to treat inflammatory disorders and cancer. We have investigated novel tartrate diamide TACE inhibitors where the tartrate core binds to zinc in a unique tridentate fashion. Incorporating (R)-2-(2-N-alkylaminothiazol-4-yl)pyrrolidines into the left hand side amide of the tartrate scaffold led to the discovery of potent and selective TACE inhibitors, some of which exhibited good rat oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Song, Li-Rui published the artcileMetal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)-C(Alkyl) bond cleavage for quinolone scaffold synthesis, HPLC of Formula: 118-90-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(60), 8340-8343, database is CAplus and MEDLINE.

An unexpected iodine(III)-mediated C(sp³)-C(sp²) bond cleavage of 3-(methylamino)-2-(2-substitutedbenzoyl)acrylates 2-R-3-R¹-4- R²-5-R³C₆HC(O)C(C(O)OEt)=CHNHR⁴ (R = H, Me, Ph, 2-(naphthalen-2-yl)ethyl, etc.; R¹ = H, Me, OMe, NO₂, etc.; R² = H, Me, Br, NO₂, etc.; R³ = H, Me; R⁴ = Et, Bn, Me, i-pr) for efficient synthesis of privileged scaffold 4-quinolones I was described. Notably, a wide range of alkyl groups (e.g. Me, tert-Bu or alkyl chain) can be conveniently cleaved in this system. The detailed mechanism studies revealed that the transformation proceeded through cascade ipso-cyclization and 1,2-carbonyl migration, and the smaller bond energy determined ortho C-C bond cleavage rather than C-H bond cleavage, via an enamine radical intermediate.

Chemical Communications (Cambridge, United Kingdom) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C12H15BBrFO2, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Bing published the artcileSelective Oxidative Cleavage of the C-C Bond in ¦Á,¦Â-Epoxy Ketone into Carbonyl Compounds, Name: 2-Methylbenzoic acid, the publication is ACS Omega (2022), 7(25), 21608-21614, database is CAplus and MEDLINE.

This method afforded aromatic carbonyl compounds under TBHP via selective oxidative cleavage of the C-C bond in ¦Á,¦Â-epoxy ketones. Aromatic acid came from the aroyl section, and aromatic aldehyde came from the other aromatic group. TBHP acted as a free radical initiator and oxidant. The reaction within the solvent went through a ring-opening addition, cleavage of the C-C bond in the ethylene oxide section, and oxidation, affording the target compounds in moderate to good yields. The HPLC yield of aromatic aldehyde was up to 91%. The HPLC yield of aromatic acid was up to 99%. The reaction under solvent-free conditions gave two kinds of aromatic acids coming from different moieties of ¦Á,¦Â-epoxy ketone via the further oxidation of aromatic aldehyde. The substituent effect was discussed, and the reaction mechanism was proposed. This method allowed the reaction to occur in a simple system metal-free.

ACS Omega published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Dan published the artcileSelective oxidation of alcohols to high value-added carbonyl compounds using air over Co-Co₃O₄@NC catalysts, HPLC of Formula: 118-90-1, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 134545, database is CAplus.

The sustainable catalytic transformation of alcs. to high value-added fine chems. is a significant and challenging research topic. Herein, a set of nitrogen-doped carbon encapsulated Co-based catalysts (Co-Co₃O₄@NC-T) were prepared by using low-cost dicyandiamide, glyoxal and cobalt nitrate as precursors. The obtained catalysts were utilized for the selective oxidation of alcs. to high value-added esters and carboxylic acids with air as the oxygen source and displayed wide applicability for the oxidation of both aromatic and aliphatic alcs. Based on the controlled experiments, the protective effect of N-doped carbon structure and the synergistic effect between Co core and Co₃O₄ species guaranteed the high reaction conversion and selectivity. Benefitting from heterogeneity and magnetism of the catalyst, it can be easily recycled and reused for long-term stability. Reasonable mechanisms of selective oxidation reaction were proposed through EPR anal. and controlled experiments The present work provides a facile strategy for potential large-scale preparation of heterogeneous catalyst for sustainable and green catalytic transformations.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C19H21N, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Yuying published the artcileComprehensive analysis of complete chloroplast genome and phylogenetic aspects of ten Ficus species, Name: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is BMC Plant Biology (2022), 22(1), 253, database is CAplus and MEDLINE.

The large genus Ficus comprises approx. 800 species, most of which possess high ornamental and ecol. values. However, its evolutionary history remains largely unknown. Plastome (chloroplast genome) anal. had become an essential tool for species identification and for unveiling evolutionary relationships between species, genus and other rank groups. In this work we present the plastomes of ten Ficus species. The complete chloroplast (CP) genomes of eleven Ficus specimens belonging to ten species were determined and analyzed. The full length of the Ficus plastome was nearly 160 kbp with a similar overall GC content, ranging from 35.88 to 36.02%. A total of 114 unique genes, distributed in 80 protein-coding genes, 30 tRNAs, and 4 rRNAs, were annotated in each of the Ficus CP genome. In addition, these CP genomes showed variation in their inverted repeat regions (IR). Tandem repeats and mononucleotide simple sequence repeat (SSR) are widely distributed across the Ficus CP genome. Comparative genome anal. showed low sequence variability. In addition, eight variable regions to be used as potential mol. markers were proposed for future Ficus species identification. According to the phylogenetic anal., these ten Ficus species were clustered together and further divided into three clades based on different subgenera. Simultaneously, it also showed the relatedness between Ficus and Morus. The chloroplast genome structure of 10 Ficus species was similar to that of other angiosperms, with a typical four-part structure. Chloroplast genome sizes vary slightly due to expansion and contraction of the IR region. And the variation of noncoding regions of the chloroplast genome is larger than that of coding regions. Phylogenetic anal. showed that these eleven sampled CP genomes were divided into three clades, clustered with species from subgenus Urostigma, Sycomorus, and Ficus, resp. These results support the Berg classification system, in which the subgenus Ficus was further decomposed into the subgenus Sycomorus. In general, the sequencing and anal. of Ficus plastomes, especially the ones of species with no or limited sequences available yet, contribute to the study of genetic diversity and species evolution of Ficus, while providing useful information for taxonomic and phylogenetic studies of Ficus.

BMC Plant Biology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Name: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Xiaopeng published the artcileNickel-catalyzed Thioester Transfer Reaction with sp²-Hybridized Electrophiles, Quality Control of 118-90-1, the publication is Journal of Organic Chemistry (2022), 87(15), 10003-10017, database is CAplus and MEDLINE.

Authors report a thioacylation transfer reaction based on nickel-catalyzed C-C bond cleavage of thioesters with sp²-hybridized electrophiles. Aryl bromides, iodides, and alkenyl triflates can participate in thioester transfer reaction of aryl thioesters, affording a wide range of structurally diverse new thioesters in yields of up to 98% under mild reaction conditions. With this protocol, it is possible to construct alkenyl thioesters from the corresponding ketones through the generation of alkenyl triflates.

Journal of Organic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C9H12O, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mayrand, Robert R. published the artcileUrea and ethylene glycol-facilitated transport systems in the human red cell membrane. Saturation, competition, and asymmetry, Name: 1,1-Dimethylthiourea, the publication is Journal of General Physiology (1983), 81(2), 221-37, database is CAplus and MEDLINE.

The equilibrium exchange of [¹⁴C]urea and ethylene glycol was measured using a new type of fast flow system. Approx. equal volumes of saline and air were mixed to form a segmented fluid stream into which ¹⁴C-loaded red cells are injected. The stream flows through 3 filter chambers which allow sampling of the ¹⁴C in the extracellular fluid at 3 time points. The chambers are designed so that they do not disrupt the segmented bubble pattern. The alternating air and saline segments prevent laminar dispersion in the flowing stream and ensure good mixing at the injection and sampling sites. The equilibrium exchange of both urea and ethylene glycol showed saturation kinetics. The maximum permeability (P₀) measured in the limit of zero solute concentration is 1.16 ¡Á 10^-3 cm/s for urea and 4.8 ¡Á 10^-4 cm/s for ethylene glycol (23¡ã). The apparent dissociation constant (K_m) was 218 mM for urea and 175 mM for ethylene glycol. The P₀ for thiourea is 2.3 ¡Á 10^-6 cm/s and the K_m is 19 mM. Urea and thiourea inhibit the transport of each other and the inhibition constant (K_i) is approx. equal to the K_m for both compounds Fifty-three other analogs of urea were screened for their inhibition of urea or thiourea transport. Several analogs [e.g., 1-(3,4-dichloro-phenyl)-2-thiorea] had a K_i in the range of 0.03 mM. The affinity of the inhibitor increased as it was made more hydrophobic. The urea analogs did not significantly inhibit the ethylene glycol or osmotic permeability. Glycerol inhibited ethylene glycol permeability with a K_i of 1200 mM.

Journal of General Physiology published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Name: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Feng, Yu-Xi published the artcileImplications of the fate of hydrogen sulfide derived from assimilation of thiocyanate in rice plants, Name: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Chemosphere (2022), 135500, database is CAplus and MEDLINE.

Thiocyanate (SCN-) is a sulfur-containing pollutant, which is frequently detected in irrigation water and has neg. effects on plant growth and crop yields. Uptake and assimilation of exogenous SCN- in rice plants was evident, in which two metabolic pathways, carbonyl sulfide (COS) and cyanate (CNO), are activated. Hydrogen sulfide (H2S) is an important concomitant derived from detoxification of exogenous SCN- in rice plants, which may cause coupling action on the endogenous source of H2S from sulfur metabolism Since H2S has dual regulatory effects, the fate of H2S derived from assimilation of SCN- in plants is critical for clarifying the inclusiveness of H2S in various physiol. activities. In fact, application of exogenous H2S not only pos. changed the root phenotype traits of SCN–treated seedlings, but also effectively mitigated the toxic effects of SCN- in rice seedlings by stimulating the process of the PSII repair cycle. In this study, it is tempting to analyze and clarify the flux of the concomitant production of H2S from assimilation of exogenous SCN- into the innate pool, which may function in signaling regulation and other physiol. processes in rice plants. This study would update our understanding of the fate of H2S derived from assimilation of SCN- in plants and provide new insights into the affirmative actions of H2S in direct proximity to SCN- exposure.

Chemosphere published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Name: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Peng, Ming published the artcileInsights into methionine S-methylation in diverse organisms, Safety of (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Nature Communications (2022), 13(1), 2947, database is CAplus and MEDLINE.

Abstract: Dimethylsulfoniopropionate (DMSP) is an important marine anti-stress compound, with key roles in global nutrient cycling, chemotaxis and, potentially, climate regulation. Recently, diverse marine Actinobacteria, ¦Á- and ¦Ã-proteobacteria were shown to initiate DMSP synthesis via the methionine (Met) S-methyltransferase enzyme (MmtN), generating S-methyl-Met (SMM). Here we characterize a roseobacterial MmtN, providing structural and mechanistic insights into this DMSP synthesis enzyme. We propose that MmtN uses the proximity and desolvation mechanism for Met S-methylation with two adjacent MmtN monomers comprising the Met binding site. We also identify diverse functional MmtN enzymes in potentially symbiotic archaeal Candidatus Woesearchaeota and Candidate Phyla Radiation (CPR) bacteria, and the animalcule Adineta steineri, not anticipated to produce SMM and/or DMSP. These diverse MmtN enzymes, alongside the larger plant MMT enzyme with an N-terminus homologous to MmtN, likely utilize the same proximity and desolvation mechanism. This study provides important insights into the catalytic mechanism of SMM and/or DMSP production, and proposes roles for these compounds in secondary metabolite production, and SMM cycling in diverse organisms and environments.

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Safety of (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Hyo Won published the artcileSequential Post-Polymerization Modification of Aldehyde Polymers to Ketone and Oxime Polymers, Recommanded Product: O-Isobutylhydroxylamine hydrochloride, the publication is Macromolecular Rapid Communications (2021), 42(22), 2100478, database is CAplus and MEDLINE.

A new sequential post-polymerization modification route has been developed for the synthesis of multifunctional polymers from a simple aldehyde polymer. In the first modification step, a template polymer derived from the radical polymerization of 4-vinylbenzaldehyde undergoes Rh-catalyzed hydroacylation with alkenes to furnish a group of ketone polymers. In the second modification step, Schiff base formation with alkoxy ammonium salts introduces a second group-an oxime functionality. Both the steps are highly efficient, introducing evenly distributed dual functionalities at the same position.

Macromolecular Rapid Communications published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Recommanded Product: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia