Tag: M.W=100-150

Xue, Weijian published the artcilePillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water, Formula: C3H12Cl2N2, the publication is Angewandte Chemie, International Edition (2020), 59(32), 13313-13319, database is CAplus and MEDLINE.

The authors report the synthesis, x-ray crystal structure, and mol. recognition properties of pillar[n]arene derivative P[6]AS, which the authors refer to as Pillar[6]MaxQ along with analogs P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo noncovalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.

Angewandte Chemie, International Edition published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C12H9N3O4, Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zeng, Xiang published the artcileAlterations of the gut microbiota and metabolomics in children with e-waste lead exposure, Safety of 2-Methylbenzoic acid, the publication is Journal of Hazardous Materials (2022), 128842, database is CAplus and MEDLINE.

A lead (Pb) exposure can alter the composition and metabolites of gut microbiota. However, few studies investigated this association in the children. A total of 551 children aged 3-7 years were recruited from Guiyu (the e-waste dismantling area) and Haojiang (the reference area). There were finally 70 subjects met the inclusive criteria. Blood and urinary Pb concentrations were detected by GFAAS and ICP-MS techniques. The microbiota and metabolites were measured in stool samples using 16 S rRNA MiSeq sequencing technol. and gas chromatog.-mass spectrometry (GC-MS), resp. Average Pb concentrations in the blood and urine of children were higher in Guiyu than in Haojiang. There were 58 kinds of differential genera and 19 types of discrepant metabolites between the two groups, and wide and significant correlations were found between them. Exposure to Pb caused the most significant differences in microbiota, metabolites, and phys. development parameters between the two groups in terms of microbiota, metabolites, and phys. development indicators. Sphingolipid metabolism and ion transport may also be altered by Pb exposure. Exposure to Pb is associated with significant alterations in the gut microbiota and metabolome in children. More research is needed to confirm the findings of this study.

Journal of Hazardous Materials published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C5H5NO3S, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zahra, Urage published the artcileNew acetylphenol-based acyl thioureas broaden the scope of drug candidates for urease inhibition: synthesis, in vitro screening and in silico analysis, HPLC of Formula: 118-90-1, the publication is International Journal of Biological Macromolecules (2022), 157-167, database is CAplus and MEDLINE.

In the present research, developed a new series of acetylphenol-based acyl thioureas I [R = t-Bu, 2-MeC₆H₄, 4-ClC₆H₄, etc.] that could potentially provide a new template for drug candidates to inhibit urease enzyme. Newly synthesized compounds I were evaluated for urease inhibitory strength using thiourea as a pos. control. In vitro inhibitory results revealed that all the tested compounds were significantly potent than the standard drug. The most active lead compound I [R =3-ClC₆H₄] competitively inhibited the enzyme and displayed an IC₅₀ value of 0.054 ¡À 0.002¦ÌM, a ?413-fold strong inhibitory potential than thiourea (IC₅₀ = 22.3 ¡À 0.031¦ÌM). Various insightful structure-activity relationships were developed showing the key structural requirements for potent inhibitory effects. Mol. docking anal. of compound I [R =3-ClC₆H₄] inside the active pocket of urease suggested several important interactions with amino acid residues such as ILE411, MET637, ARG439, GLN635, ALA636 and ALA440. Finally, pharmacokinetic properties suggested that the tested derivatives were safe to develop as low-mol.-weight drugs to treat ureolytic bacterial infections.

International Journal of Biological Macromolecules published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C9H12O, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gudun, Kristina A. published the artcileCobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides, Product Details of C8H8O2, the publication is Advanced Synthesis & Catalysis (2022), 364(3), 601-611, database is CAplus.

The com. available and bench-stable Co(acac)₂ ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h^-1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds

Advanced Synthesis & Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Product Details of C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bianchi, Alberto published the artcileUltrastructural studies of the effects of Allium sativum on phytopathogenic fungi in vitro, COA of Formula: C3H8N2S, the publication is Plant Disease (1997), 81(11), 1241-1246, database is CAplus and MEDLINE.

A study was made of the effects of garlic on the development of mycelium in the following phytopathogenic fungi: Fusarium solani (Mart.) Sacc., Rhizoctonia solani Kuhn, Pythium ultimum Trow var. ultimum, and Colletotrichum lindemuthianum (Sacc. and Magnus) Briosi and Cav. A suspension of micronized garlic powder, which has volatile organic compounds mainly consisting of linear chain aldehydes, allyl sulfides and disulfides, was used for the trials. Mycelial development of the fungi was strongly inhibited at the maximum concentration of the aqueous extract tested (100 mL/L); however only the growth of P. ultimum var. ultimum was entirely blocked. Transmission and SEM revealed cytomorphol. alterations of the hyphae treated with garlic. R. solani and C. lindemuthianum hyphae appeared especially collapsed, while those of F. solani were less damaged, although thinner than the control hyphae. A general increase in vacuolization was also observed, with consequent reduction in the cytoplasm of the treated fungal cells. R. solani also revealed a thickening of the cell wall, whereas C. lindemuthianum revealed a singular accumulation of osmiophil bodies immediately under the cell membrane.

Plant Disease published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, COA of Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guo, Ying published the artcilePalladium-Catalyzed Divergent Regioselective Homocoupling and Hydroxylation of 3-Arylbenzo[d]isoxazoles, Product Details of C3H4F2O2, the publication is Advanced Synthesis & Catalysis (2017), 359(3), 410-418, database is CAplus.

Palladium-catalyzed oxidative homocoupling and hydroxylation of 3-arylbenzo[d]isoxazoles was developed via direct C(sp²)-H bond activation using benzoisoxazoles as a new directing group. The protocols offered a divergent approach to functionalized, synthetically useful benzoisoxazoles in good yields. Critically, 1-iodo-4-methoxybenzene functioned as an oxidant to mediate the dehydrogenative homocoupling and minimize the cross-coupling. A dual-core dimeric palladacycle intermediate was confirmed by X-ray crystallog., and served as an active catalytic species in the catalytic cycles.

Advanced Synthesis & Catalysis published new progress about 155142-69-1. 155142-69-1 belongs to catalysis-chemistry, auxiliary class Difluoromethyl,Fluoride,Carboxylic acid,Aliphatic hydrocarbon chain, name is 3,3-Difluoropropanoic acid, and the molecular formula is C3H4F2O2, Product Details of C3H4F2O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hong, Chao published the artcileRh-Catalyzed Coupling of Acrylic/Benzoic Acids with ¦Á-Diazocarbonyl Compounds: An Alternative Route for ¦Á-Pyrones and Isocoumarins, Formula: C8H8O2, the publication is Organic Letters (2022), 24(3), 815-820, database is CAplus and MEDLINE.

A coupling of acrylic acids/benzoic acids with ¦Á-diazocarbonyl compounds had been realized by a combined catalytic system of rhodium catalyst and Zn(OAc)₂ additive. The presence of Zn(OAc)₂ obviously accelerates the C(sp²)-H activation and destructed the formation of carboxylic ester that was formed via a nucleophilic O-H insertion to metal carbenoid. The procedure featured mild reaction conditions and broad substrate scope, providing a straightforward approach to the synthesis of ¦Á-pyrones I [R¹ = Me, Ph, Bn, etc.; R² = H, Me, Ph; R¹R² = (CH₂)₄; R³ = Me, Et, allyl, t-Bu, R⁴ = Me, Et, Ph, etc.] and isocoumarins II [R = H, 8-Me, 8-Me-6-MeO, etc.] without the transformation of carboxylic acids to the corresponding amides.

Organic Letters published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Yi-fan published the artcileComparative transcriptome and metabolome analyses reveal the methanol dissimilation pathway of Pichia pastoris, Application of (S)-2-Amino-4-(methylthio)butanoic acid, the publication is BMC Genomics (2022), 23(1), 366, database is CAplus and MEDLINE.

Pichia pastoris (Komagataella phaffii) is a model organism widely used for the recombinant expression of eukaryotic proteins, and it can metabolize methanol as its sole carbon and energy source. Methanol is oxidized to formaldehyde by alc. oxidase (AOX). In the dissimilation pathway, formaldehyde is oxidized to CO2 by formaldehyde dehydrogenase (FLD), S-hydroxymethyl glutathione hydrolase (FGH) and formate dehydrogenase (FDH). The transcriptome and metabolome of P. pastoris were determined under methanol cultivation when its dissimilation pathway cut off. Firstly, ¦¤fld and ¦¤fgh were significantly different compared to the wild type (GS115), with a 60.98% and 23.66% reduction in biomass, resp. The differential metabolites between GS115 and ¦¤fld were mainly enriched in ABC transporters, amino acid biosynthesis, and protein digestion and absorption. Secondly, comparative transcriptome between knockout and wild type strains showed that oxidative phosphorylation, glycolysis and the TCA cycle were downregulated, while alc. metabolism, proteasomes, autophagy and peroxisomes were upregulated. Interestingly, the down-regulation of the oxidative phosphorylation pathway was pos. correlated with the gene order of dissimilation pathway knockdown. In addition, there were significant differences in amino acid metabolism and glutathione redox cycling that raised our concerns about formaldehyde sorption in cells. This is the first time that integrity of dissimilation pathway anal. based on transcriptomics and metabolomics was carried out in Pichia pastoris. The blockage of dissimilation pathway significantly down-regulates the level of oxidative phosphorylation and weakens the methanol assimilation pathway to the point where deficiencies in energy supply and carbon fixation result in inefficient biomass accumulation and genetic replication. In addition, transcriptional upregulation of the proteasome and autophagy may be a stress response to resolve formaldehyde-induced DNA-protein crosslinking.

BMC Genomics published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C22H18O2, Application of (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Long published the artcileOne-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by DEAD-Promoted Oxidative Ugi-Wittig Reaction Starting from Phosphonium Salt Precursors, COA of Formula: C8H8O2, the publication is Synlett (2022), 33(1), 66-69, database is CAplus.

A new one-pot synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2 H)-ones I (R¹ = H, Cl, Br; R² = TsCH₂, C₆H₅CH₂, CH₂CO₂OMe; R³ = Ph, 4-MeC₆H₄, etc.) by DEAD-promoted oxidative Ugi-Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts II?Br^– (R¹ = H, Cl, Br), isocyanides R²NC, and N-aryl-1,2,3,4-tetrahydroisoquinolines III produced 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2 H)-ones I in moderate to good overall yields in the presence of DEAD and Et₃N.

Synlett published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C13H11NO, COA of Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

He, Min published the artcile7,10-Dibromo-2,3-dicyanopyrazinophenanthrene Aggregates as a Photosensitizer for Nickel-Catalyzed Aryl Esterification, Quality Control of 118-90-1, the publication is Synlett (2022), 33(12), 1189-1193, database is CAplus.

Self-assembled aggregates of 7,10-dibromo-2,3-dicyanopyrazinophenanthrene which act as a new organophotocatalyst in combination with Ni catalyst for the C_aryl-O_acyl cross-coupling reactions of carboxylic acids with aryl halides are described. This visible-light-induced C_aryl-O_acyl bond-formation reaction proceeded smoothly to afford aryl esters with satisfactory to excellent yields.

Synlett published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia