Tag: M.W=100-150

Gao, Yang published the artcilePractical synthesis of 3-aryl anthranils via an electrophilic aromatic substitution strategy, Computed Properties of 118-90-1, the publication is Chemical Science (2022), 13(7), 2105-2114, database is CAplus and MEDLINE.

A practical route for the synthesis of valuable 3-aryl anthranils from readily available anthranils and simple arenes by using the classical electrophilic aromatic substitution (EAS) strategy was reported. This transformation goes through an electrophilic substitution and rearomatisation sequence by employing Tf₂O as an effective activator. A wide range of arenes were compatible in this transformation, delivering various structurally diversified 3-aryl anthranils in good yields and high regioselectivity. In addition, a variety of readily available feedstocks such as olefins, alkenyl triflates, silyl enolethers, carbonyl compounds, thiophenols and thiols could also participate in the reaction to achieve the C3 alkenylation, alkylation and thioetherification of anthranils. Of note, the synthesized 3-aryl anthranils proved to be a highly robust platform to access a series of biol. active compounds, drug derivatives and organic optoelectronic materials.

Chemical Science published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

He, Qiyuan published the artcilePalladium-Catalyzed Site-Selective [5 + 1] Annulation of Aromatic Amides with Alkenes: Acceleration of ¦Â-Hydride Elimination by Maleic Anhydride from Palladacycle, Name: 2-Methylbenzoic acid, the publication is ACS Catalysis (2022), 12(2), 1595-1600, database is CAplus.

The palladium-catalyzed reaction of 2-methylbenzamides with acrylic esters, leading to the production of isoquinolinones, is reported. The reaction occurs exclusively at the ortho Me C-H bond via a six-membered palladacycle and not at the ortho C-H bond via a five-membered palladacycle. A key to the success of the reaction is the use of maleic anhydride as a ligand. Computational analyses suggest that the coordination of the maleic anhydride ligand highly stabilizes the transition state for ¦Â-hydride elimination and accelerates the ¦Â-hydride elimination.

ACS Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Wenbo published the artcileRhodium(III)-Catalyzed Three-Component Cascade Annulation for Modular Assembly of N-Alkoxylated Isoindolin-1-Ones with Quaternary Carbon Center, Recommanded Product: 2-Methylbenzoic acid, the publication is Advanced Synthesis & Catalysis (2022), 364(15), 2589-2595, database is CAplus.

A cascade C-H activation, annulation and etherification of N-hydroxybenzamides with propargylamines provided a flexible route to N-alkoxylated 3-arylisoindolin-1-ones. Three new bonds (C-C, C-N, and C-O) were generated to afford a series of isoindolin-1-ones bearing a tetrasubstituted carbon in 49-82% yield. The utility of this method was showcased by gram-scale synthesis and synthetic transformations of the product to access structurally diverse isoindolinones.

Advanced Synthesis & Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Yanshuang published the artcileSynthesis and fungicidal activity of 4-alkyloxyiminohexanolactone derivatives, Name: O-Isobutylhydroxylamine hydrochloride, the publication is Nongyaoxue Xuebao (2009), 11(1), 55-58, database is CAplus.

The title compounds [i.e., 4-[(alkoxy)imino]hexanolactone derivatives] were obtained by a reaction of cyclohexanedione, formation of 2,5-oxepanedione and subsequent oximation and the product structures were confirmed by NMR and elemental anal., MS. A preliminary bioassay indicated that some compounds possess fungicidal activity against Phytophthora parasitica (Phytophthora nicotianae), Rhizoctonia solani, Botrytis cinerea, Sclerotinia sclerotiorum (Whetzelinia sclerotiorum), Puccinia asparagi.

Nongyaoxue Xuebao published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C14H31NO2, Name: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Yan-shuang published the artcileDesign, synthesis and fungicidal activity of 11-alkoxyimino-5,6-dihydro-dibenzo[b,e] azepine-6-one derivatives, HPLC of Formula: 6084-58-8, the publication is Pest Management Science (2013), 69(7), 814-826, database is CAplus and MEDLINE.

Background: Macrocyclic compounds with an oxime ether side chain are known to show good fungicidal activity. However, the long synthetic route makes the cost too high for them to be developed further as practical fungicides. Alternative compounds with good fungicidal activity and an easier synthesis than these macrolactams were sought, and a series of 11-alkoxyimino-5,6-dihydro-dibenzo[b,e]azepine-6-one derivatives (I; R = alkyl, etc.; X = H, Cl, Br, or I) were designed and bioassayed. Results: The structures were confirmed by ¹H NMR, ¹³C NMR and LC-MS. The bioassay showed that about half of the 11-alkoxyimino-5,6-dihydro-dibenzo[b,e]azepine-6-one derivatives displayed good fungicidal activity against Sclerotinia sclerotiorum, with EC₅₀ values <15 ¦Ìg mL^-1. 11-(N-Butyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one, 11-(4-nitrobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one, and 11-(2-chloro-6-fluorobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one displayed excellent fungicidal activity, with EC₅₀ values of <2.5 ¦Ìg mL^-1, much better than the com. fungicide chlorothalonil with an EC₅₀ value of 7.16 ¦Ìg mL^-1. In addition, about half of the 11-alkoxyimino-5,6-dihydro-dibenzo[b,e]azepine-6-one derivatives had good fungicidal activity against Botrytis cinerea, with EC₅₀ values of <10 ¦Ìg mL^-1. 11-(2-Fluorobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one, 11-(3-fluorobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one, and 11-(2-chloro-6-fluorobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one displayed excellent fungicidal activity, with EC₅₀ values of 3.73, 2.54 and 3.20 ¦Ìg mL^-1 resp., comparable with the com. fungicide procymidone with an EC₅₀ value of 2.45 ¦Ìg mL^-1. Their structure-activity relationship is discussed. ? 2013 Society of Chem. Industry.

Pest Management Science published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C13H18BClO3, HPLC of Formula: 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guo, Xin published the artcileEffect of traditional chinese medicine (TCM) and its fermentation using Lactobacillus plantarum on ceftriaxone sodium-induced dysbacteriotic diarrhea in mice, Application of (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Chinese Medicine (London, United Kingdom) (2022), 17(1), 20, database is CAplus and MEDLINE.

Buzhongyiqi decoction (BD), Sijunzi decoction (SD), and Shenlingbaizhu decoction (SHD) have been extensively used clin. for the treatment of diseases caused by spleen-Qi deficiency and microbial fermentation has historically been utilized in traditional Chinese medicine (TCM). This study aimed to investigate the mitigative effect of TCM and fermented TCM (FTCM) with Lactobacillus plantarum (LP) on antibiotic-associated diarrhea, and to select an optimal formula and then identify its compounds Dysbacteriosis in mice was induced by ceftriaxone sodium (CS). The mice were then treated with LP, BD, SD, SHD, fermented BD, fermented SD (FSD), and fermented SHD. Diarrhea indexes, the abundances of gut bacteria, intestinal morphometrics, and mRNA expressions of genes related to intestinal barrier function were assessed. Then, ultra-high-performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) were employed to identify and relatively quantify the compounds in the selected decoctions. CS significantly increased the fecal output weight, the total number of fecal output, and fecal water content, indicating the occurrence of diarrhea. Bacterial culture tests showed that the above symptoms were accompanied by the disruption of specific intestinal flora. TCM, LP, and FTCM alleviated the diarrhea index and recovered the intestinal microbiota. FTCM showed more advantageous than TCM or LP alone. The mRNA expressions of aquaporins (AQPs) and tight junctions (TJs) decreased by CS were enhanced by TCM, LP, and FTCM. In addition, through UHPLC-Q-TOF/MS, (S)-(-)-2-hydroxyisocaproic acid, L-methionine, 4-guanidinobutyric acid (4GBA), and phenyllactate (PLA) in SD and FSD were identified and relatively quantified. TCM, LP, and TCM fermented with LP alleviated CS-induced diarrhea symptoms, and improved the intestinal flora and barrier function. Four compounds including (S)-(-)-2-hydroxyisocaproic acid, L-methionine, 4GBA, and PLA in FSD, which were identified by UHPLC-Q-TOF/MS, might function in modulating intestinal flora and improving villi structure.

Chinese Medicine (London, United Kingdom) published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Application of (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Xiaofei published the artcileReinforced catalytic oxidation of polyoxometalate@charge transfer complex by on-site heating from photothermal conversion, Safety of 2-Methylbenzoic acid, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 446(Part_2), 137134, database is CAplus.

Near IR (NIR) absorption at low energy region has been demonstrated to devoted to photothermal conversion efficiently. This process provides a possibility for valuable extension in emerging photothermal catalysis following a specific approach of mol. composition To exploit novel photothermal materials in increasing the catalytic activity of comment catalysts, a typical yet unnoticed charge transfer (CT) complex of 3,3¡ä,5,5¡ä-tetramethylbenzidine (TMB_CT) is used here as an on-site heater. Through the electrostatic complexation of cationic CT complex bearing strong NIR absorption with series polyanionic clusters, composite catalysts are prepared These nano-assembled catalysts in size of 5-10 nm display integrated NIR photothermal effect and highly enhanced catalysis for the mild oxidation of toluene and its derivatives into corresponding alcs. with high conversion and selection. While NIR photothermal stability of TMB_CT is maintained, the catalytic activity of inorganic clusters is largely improved. The increments in conversion unattainable under external heating condition are realized and the extension to the mild oxidation of thioethers and olefins into sulfoxides and epoxides with acceptable catalytic recyclability and structural stability are demonstrated. All results from the detailed characterizations figure out the applicability of the NIR photothermal conversion to the catalytic reactions with similar catalytic centers.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Park, Hongsun published the artcileHornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions, SDS of cas: 63-68-3, the publication is Acta Neuropathologica Communications (2022), 10(1), 28, database is CAplus and MEDLINE.

Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder, characterized by the presence of eosinophilic inclusions (NIIs) within nuclei of central and peripheral nervous system cells. This study aims to identify the components of NIIs, which have been difficult to analyze directly due to their insolubility In order to establish a method to directly identify the components of NIIs, we first analyzed the huntingtin inclusion-rich fraction obtained from the brains of Huntington disease model mice. Although the sequence with expanded polyglutamine could not be identified by liquid-chromatog. mass spectrometry, amino acid anal. revealed that glutamine of the huntingtin inclusion-rich fraction increased significantly. This is compatible with the calculated amino acid content of the transgene product. Therefore, we applied this method to analyze the NIIs of diseased human brains, which may have proteins with compositionally biased regions, and identified a serine-rich protein called hornerin. Since the analyzed NII-rich fraction was also serine-rich, we suggested hornerin as a major component of the NIIs. A specific distribution of hornerin in NIID was also investigated by Matrix-assisted laser desorption/ionization imaging mass spectrometry and immunofluorescence. Finally, we confirmed a variant of hornerin by whole-exome sequencing and DNA sequencing. This study suggests that hornerin may be related to the pathol. process of this NIID, and the direct anal. of NIIs, especially by amino acid anal. using the NII-rich fractions, would contribute to a deeper understanding of the disease pathogenesis.

Acta Neuropathologica Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, SDS of cas: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Yangyang published the artcileLigand-Enabled C-H Olefination and Lactonization of Benzoic Acids and Phenylacetic Acids via Palladium Catalyst, Quality Control of 118-90-1, the publication is Organic Letters (2022), 24(3), 821-825, database is CAplus and MEDLINE.

A novel ligand propan-2-one O-(p-tolylcarbamoyl) oxime had been developed to promote C(sp²)-H olefination of benzoic acids and phenylacetic acids via a palladium catalyst. With the subsequent lactonization of the olefinated products through 1,4-addition, a highly monoselective cyclic lactone products of benzopyrones I [R¹ = 5-Me, 7-Cl, 5-F, etc.; R² = CO₂Me, CO₂Et, CO₂Bu, CO₂Bn, C(O)NHCH(CH₃)₂, P(O)(OEt)₂] and benzofuranones II [R³ = 5-Me, 6-MeO, 6-CF₃, etc.; R² = CO₂Me, CO₂Et, CO₂Bu, etc.] were obtained in moderate to excellent yields. The DFT calculation demonstrated that the novel ligand propan-2-one O-(p-tolylcarbamoyl) oxime could lubricate the C-H activation reaction to give cyclic lactone products elegantly.

Organic Letters published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C25H47NO8, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cai, Mingzhong published the artcileRecyclable palladium-catalyzed Suzuki coupling of aromatic triazine esters: A practical one-pot synthesis of aryl ketones from aromatic acids, Application of 2-Methylbenzoic acid, the publication is Synthetic Communications (2022), 52(7), 1079-1090, database is CAplus.

An efficient heterogeneous palladium-catalyzed Suzuki coupling of aromatic triazine esters I (Ar = 4-methylphenyl, naphthalen-1-yl, thiophen-2-yl, etc.) with arylboronic acids Ar¹B(OH)₂ (Ar¹ = Ph, 3,5-dichlorophenyl, furan-2-yl, etc.) has been developed. The reaction proceeds smoothly in toluene at 110¡ãC using 2 mol% of MCM-41-bound bidentate phosphine palladium complex [MCM-41-2P-Pd(OAc)₂] as catalyst and provides a novel and practical method for the synthesis of aryl ketones ArC(O)Ar¹ starting from readily available aromatic acids ArCOOH in a one-pot procedure with moderate to excellent yields. The MCM-41-2P-Pd(OAc)₂ catalyst can be reused at least seven times without any apparent decrease in its catalytic activity.

Synthetic Communications published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Application of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia