Tag: M.W=200-250

Berger, Michael published the artcileMetal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers, Synthetic Route of 163839-73-4, the publication is Chemical Science (2020), 11(23), 6053-6057, database is CAplus and MEDLINE.

Electrochem. decarboxylation of aryloxyacetic acids followed by fluorination provided easy access to fluoromethyl aryl ethers. This electrochem. fluorodecarboxylation offers a sustainable approach with elec. current as traceless oxidant. Using Et₃N¡¤5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis afforded various fluoromethoxyarenes in yields up to 85%.

Chemical Science published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Synthetic Route of 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Berger, Michael published the artcileMetal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Chemical Science (2020), 11(23), 6053-6057, database is CAplus and MEDLINE.

Electrochem. decarboxylation of aryloxyacetic acids followed by fluorination provided easy access to fluoromethyl aryl ethers. This electrochem. fluorodecarboxylation offers a sustainable approach with elec. current as traceless oxidant. Using Et₃N¡¤5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis afforded various fluoromethoxyarenes in yields up to 85%.

Chemical Science published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Jaeseung published the artcileSilanediol Inhibitors of Angiotensin-Converting Enzyme. Synthesis and Evaluation of Four Diastereomers of Phe[Si]Ala Dipeptide Analogues, Safety of Difluorodiphenylsilane, the publication is Journal of Organic Chemistry (2005), 70(15), 5781-5789, database is CAplus and MEDLINE.

Phe-Ala silanediol dipeptide mimics I as four diastereoisomers [(S,S)-, (S,R)-, (R,R)- and (R,S)-I] have been evaluated as inhibitors of angiotensin-converting enzyme (ACE) and compared to ketone-based inhibitors II reported by Almquist et al. One stereogenic center of the isomers was derived from the individual enantiomers of Me 3-hydroxy-2-methylpropionate, with separation of diastereomers after introduction of the second stereogenic center. The diastereomeric identities were established by x-ray crystallog. of an intermediate. Inhibition of ACE by (S,S)-I, (R,R)-I, (R,S)-I diastereomers (IC₅₀ = 3.8 – 207 nM) closely paralleled that of the corresponding diastereomeric ketones II (IC₅₀ = 1.0 – 46 nM). (S,R)-I, corresponding to the least inhibitory ketone (IC₅₀ = 3200 nM), exhibited an unexpected level of inhibition in the silanediol (IC₅₀ = 72 nM), suggesting an alternative mode of binding to the enzyme.

Journal of Organic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Safety of Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hill, Carl M. published the artcileThe synthesis, properties, and catalytic hydrogenation of several aryloxy substituted ketene monomers and dimers, Product Details of C12H16O3, the publication is Journal of the American Chemical Society (1953), 1084-6, database is CAplus.

p-Me₃CC₆H₄ONa treated with EtCHBrCO₂Et in MeOH gave p-Me₃CC₆H₄OCHEtCO₂Et which was hydrolyzed to the corresponding acid (I), 63%, m. 87-8.5¡ã (from petr. ether-C₆H₆) (all m.ps. reported are corrected). Similarly were obtained: p-Me₃CC₆H₄CHBuCO₂H, 69%, m. 89-90¡ã, and p-Me₃CC₆H₄CHAmCO₂H, 63%, m. 72-3¡ã. The ¦Á-aryloxy acids were converted with SOCl₂ to the corresponding acyl chlorides, p-Me₃CC₆H₄OCHRCOCl (II) (R, b.p./mm., % yield, n²⁰_D, and d₂₀ given): H (III), 130-2¡ã/5, 90, 1.5162, 1.1128, from p-tert-BuC₆H₄OCH₂CO₂H, m. 88-9¡ã; Me (IV), 143-5¡ã/26, 60, 1.5092, 1.0775, from p-Me₃CC₆H₄OCHMeCO₂H, m. 86-7¡ã; Et, 131-2¡ã/3, 94, 1.5055, 1.0651; Bu, 143-4¡ã/3, 95, 1.5018, 1.0641; and Am, 149-50¡ã/6, 97, 1.5003, 0.9984. To 0.5 g. II in 100 cc. dry Et₂O was added dry NH₃ and the crude precipitate filtered off and recrystallized from MeOH to give the amides p-Me₃CC₆H₄OCHRCONH₂ (R, m.p., and % yield given): H, 131-2¡ã, 86; Me, 116-17¡ã, 91; Et, 97-9¡ã, 87; Bu, 145-6¡ã, 71; and Am, 86-7¡ã, 76. III in 20 cc. dry C₆H₆ warmed with an equivalent amount PhNH₂ on the water bath gave p-Me₃CC₆H₄OCH₂CONHPh, m. 91-2¡ã. Similarly was prepared p-Me₃CC₆H₄OCHMeCONHPh, m. 83-4¡ã. The dehydrochlorination of III as previously described (cf. C.A. 45, 10128i) gave 37% p-tert-butylphenoxyketene dimer (V), m. 85-6¡ã, b₅ 180-3¡ã. IV gave similarly 55% p-tert-butylphenoxymethylketene dimer (VI), m. 78-9¡ã, b₆ 147-50¡ã. By the same procedure were prepared the following p-tert-butylphenoxyalkylketene monomers (alkyl, b.p./mm., % yield, n²⁰_D, and d₂₀ given): Et (VII), 175-6¡ã/12, 66, 1.5178, 1.0132; Bu (VIII), 169-71¡ã/10, 54, 1.5044, 1.0157; and Am (IX), 132-3¡ã/5, 73, 1.5056, 0.9771. Weighed samples of the ketenes (5-15 g.) in 25 cc. petr. ether were hydrogenated 4-6 hrs. over 2-4 g. Raney Ni at 1500-3500 lb./sq. in. pressure, the mixture filtered, the solvent distilled off, the residue distilled, and the glycol fraction washed with small portions 15% aqueous Na₂CO₃ and H₂O, dried with MgSO₄, and redistilled, giving 2 fractions, p-Me₃CC₆H₄OH, m. 94-5¡ã (from petr. ether-C₆H₆), and glycols corresponding to the ketene dimer. In the case of V, the p-Me₃C₆H₄ was not split off and the only product was 2,4-bis(p-tert-butylphenoxy)-1,3-butanediol dimer, m. 88-9¡ã ; bis(3,5-dinitrobenzoate), m. 140-1¡ã. VI gave by hydrogenation 50% CHMe.CH(OH).CHMe.CHOH, b₂₀ 83-4¡ã n²⁰_D 1.5328, d₂₀ 1.0570; bis(3,5-dinitrobenzoate), 40%, m. 126-7¡ã. The other ketenes were converted similarly to the corresponding CHR.CH(OH).CHR.CHOH (X) [R, % yield, b.p./mm., n²⁰_D, d₂₀, and, in parentheses, the % yield and m.p. of the bis(3,5-dinitrobenzoate), given]: Et, 65, 75-7¡ã/10, 1.4458, 0.9165 (37, 165-6¡ã); Bu, 40, 125-6¡ã/3, 1.4343, 0.9108 (35, 162-3¡ã); and Am, 35, 125-7¡ã/5, 1.4388, 0.8957 (50, 163-4¡ã). The 2 isomeric forms of the previously prepared (2,4-Cl₂C₆H₃OCR:C:O)₂ (XI), where R is Et, Pr, and Bu, gave by the same procedure the following pairs of isomeric X [R, % yield, b.p./mm., n²⁰_D (except where otherwise stated), d₂₀ values and in parentheses, the % yield and m.p. of the bis(p-nitrobenzoate) given]: Et, 55, 60-3¡ã/3, n²¹_D 1.5228, 1.0018 (48, 118-19¡ã), and 40% 2,4-Cl₂C₆H₃OH (XII), m. 42-3¡ã (3,5-dinitrobenzoate, m. 142-3¡ã), from liquid XI with R = Et; Et, 20, 59-61¡ã/3, 1.5362, 1.0784, MR_D 41.64 (54, 85-6¡ã), and 35% XII from solid XI with R = Et; Pr, 20, m. 21-3¡ã, 63-5¡ã/3, n²⁵_D 1.5362, 1.0757 (56, 88-90¡ã), and 65% XII from liquid XI with R = Pr; Pr, 67, 102-4¡ã/3, 1.5261, 1.0612, MR_D 49.76 (68, 114-15¡ã), and 28% XII from solid XI with R = Pr; Bu, 27, 62¡ã/4, 1.5183, 1.0688, MR_D) 56.73 (45, 115-16¡ã), and 45% XII from liquid XI with R = Bu; and Bu, 56, 65-8¡ã/2, 1.5299, 1.0378, MR_D 59.53 (61, 119-20¡ã), and 38% XII from solid XI with R = Bu.

Journal of the American Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Product Details of C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tamao, Kohei published the artcileElectronic and steric effects in pentacoordinate anionic diorganotrifluorosilicates: x-ray structures and carbon-13 NMR studies for evaluation of charge distribution in aryl groups on silicon, Quality Control of 312-40-3, the publication is Organometallics (1992), 11(1), 182-91, database is CAplus.

A series of diorganotrifluorosilicates, (4-XC₆H₄)MeSiF₃^– (I), (4-XC₆H₄)PhSiF₃^– (II), (Me_nC₆H_5-n)PhSiF₃^–, (2-MeC₆H₄)(4-MeC₆H₄)SiF₃^– (III), and (2,6-Me₂C₆H₃)(3,5-Me₂C₆H₃)SiF₃^– (IV) with the 18-crown-6 potassium countercation were prepared Mol. structures of II (X = CF₃, Me, MeO, Me₂N), III, and IV were determined by X-ray crystallog., confirming trigonal-bipyramidal structures. The dihedral angle between the substituted Ph group and the equatorial plane depends not on the electronic effect but on the steric effect. Variable-temperature ¹⁹F NMR studies on II provide the electronic effects on energy barriers for pseudorotation. In ¹³C NMR studies, all carbon chem. shifts were observed and assigned unambiguously: the Si ipso carbons of aromatic rings and the Me group were observed for the first time. Changes in chem. shifts ¦¤¦Ä(C) of anionic pentacoordinate silicates, I and II, vs. the corresponding neutral tetracoordinate silanes are +17 to +20 ppm for Si ipso (C1), +3 to +4 ppm for ortho (C2), -3 ppm for meta (C3), -4 to -7 ppm for para (C4), and +9 ppm for Me carbon. The charge distribution in the Ph groups in silicates is discussed in terms of the electron-donating nature by the SiRF₃^– group via the ¦Ð polarization effect. There are linear correlations of the chem. shifts of Si ipso C1 (para to X) in the para-substituted Ph groups and Si ipso C1′ in the parent Ph groups in II and (4-XC₆H₄)PhSiF₂ with the Hammett ¦Ò_p⁺, from which are estimated the relative electron densities on Si ipso carbons C1 and C1′.

Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C9H7NO2, Quality Control of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tamao, Kohei published the artcileAnion complexation by bidentate Lewis acidic hosts, ortho-bis(fluorosilyl)benzenes, SDS of cas: 312-40-3, the publication is Journal of Organometallic Chemistry (1996), 506(1-2), 85-91, database is CAplus.

Ortho-bis(fluorosilyl)benzenes (precursors for bis-siliconates: o-C₆H₄(SiPhF₂)₂ (1), o-C₆H₄(SiF₃)(SiPh₂F) (2), o-C₆H₄(SiPhF₂)(SiPh₂F) (3)) possess anion binding properties as bidentate Lewis acidic hosts in organic solvents. Compound 1 quant. binds a F^– ion from KF suspended in acetone or THF without support of 18-crown-6 to form the corresponding soluble bis-siliconate [o-C₆H₄(SiPhF₂)₂F]K (4). The binding constants of F^– by a series of fluorosilanes were measured by ¹H and ¹⁹F NMR spectroscopies. The affinity of fluorosilanes towards F^– increases in the order PhMeSiF₂ (7)<Ph₂SiF₂ (9)<3<1<2. The fluoride ion binding constant of 2 is estimated to be K > 1.1 ¡Á 10⁹ M^-1 at 193 K. These bidentate Lewis acids 1–3 are among the strongest organic hosts for a fluoride ion in organic solvents ever reported.

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C13H16O2, SDS of cas: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dunn, Simon C. published the artcileSynthesis and Reactions of Group 4 Imido Complexes Supported by Cyclooctatetraene Ligands, Recommanded Product: 2,4,6-Triisopropylbenzenethiol, the publication is Organometallics (2006), 25(7), 1755-1770, database is CAplus.

The reactions of the pseudo-two-coordinate Ti imido complexes [Ti(N^tBu)(COT)] (1) (COT = ¦Ç⁸-C₈H₈), [Ti(N^tBu)(COT”)] (2) (COT” = ¦Ç⁸-1,4-C₈H₆(SiMe₃)₂), and [Ti(NAr)(COT)] (3) (Ar = 2,6-ⁱPr₂C₆H₃) with a variety of organic substrates are reported. Reaction of 1 with CO₂, ^tBuNCO, or ArNCO and reaction of 3 with CO₂ or ^tBuNCO afforded the organic products ^tBuNCO, ^tBuNCN^tBu, ^tBuNCNAr, ArNCO, and ArNCN^tBu, resp., and a Ti oxo species. These reactions proceeded via an initial [2 + 2] cycloaddition to form an N,O-bound intermediate [Ti{N(R)C(O)R’}(COT)], which subsequently underwent a retrocycloaddn. to give an organic product and the Ti oxo species. In contrast, reaction of 3 with ArNCO gave the N,N-bound [2 + 2] cycloaddition product [Ti{N(Ar)C(O)N(Ar)}(COT)] (7). In general, the reactions of 1 and 3 with CS₂ and isothiocyanates also resulted in an initial [2 + 2] cycloaddition to form an N,S-bound intermediate [Ti{N(R)C(S)R’}(COT)], which also subsequently underwent a retrocycloaddn. to give an organic product and a metal sulfide species. However, the N,S-bound compound [Ti{N(Ar)C(S)S}(COT)] (10) was stable to retrocycloaddn. and was isolated. Proton transfer reactions occurred between pinacol and compounds 1–3 to form the bis(alkoxide) species [Ti{OC(Me)₂C(Me)₂O}(COT)] (11) (from 1 or 3) or [Ti{OC(Me)₂C(Me)₂O}(COT”)] (12) (from 2) and the corresponding free amine. The reactions between 1–3 and 2 equiv of the thiols ^tBuSH and HS-2,4,6-ⁱPr₃C₆H₂ all resulted in the oxidation of the thiol to the disulfides ^tBuS-S^tBu and (2,4,6-ⁱPr₃C₆H₂)S-S(2,4,6-ⁱPr₃C₆H₂). Treatment of 1 with ^tBuNC in the presence of 1,3,5,7-cyclooctatetraene led to formal nitrene group transfer and the formation of the Ti(II) species [Ti(COT)(¦Ç⁴-C₈H₈)] (13) and ^tBuNCN^tBu. The analogous reactions between 2 and 3 and ^tBuNC gave [Ti(N^tBu)(COT”)(CN^tBu)] (15) and [Ti(NAr)(COT)(CN^tBu)] (17), and similarly the reaction between 1 and pyridine gave [Ti(N^tBu)(COT)(py)] (19) (py = pyridine). Complex 19 was crystallog. characterized. DFT studies indicated that the interaction between pyridine and the Ti center in 19 and ^tBuNC and the Ti center in 17 was electrostatic in nature. [Ti(NR)(COT)(AlMe_3-xCl_x)] (R = ^tBu, x = 0 (20); R = Ar, x = 0 (21); R = ^tBu, x = 1 (22); R = Ar, x = 1 (23)) were formed through the reactions of 1 and 3 with AlMe₃ and AlMe₂Cl, and DFT studies indicated that they contained four-membered metallacyclic rings. Attempts to prepare monomeric Zr imido cyclooctatetraene complexes through the reactions of [Zr₂(¦Ì-NR)₂Cl₄(THF)_x] (R = ^tBu, x = 3; R = 2,6-Me₂C₆H₃(Ar’), x = 4) with K₂COT, Li₂COT”¡¤1.8(THF), or Li₂[COT^*] (COT^* = 1,4-C₈H₆(SiMe₂^tBu)₂) were unsuccessful. Only the crystallog. characterized dimeric species [Zr₂(¦Ì-NAr’)₂(COT”)₂] (24) was isolated.

Organometallics published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Recommanded Product: 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bai, Yajun published the artcilePolygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic ¦Á-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study, Synthetic Route of 16909-09-4, the publication is European Journal of Medicinal Chemistry (2019), 111650, database is CAplus and MEDLINE.

Inspired by the traditional Chinese herbal pair of Polygala tenuifolia-Acori Tatarinowii for treating epilepsy, 33 novel substituted cinnamic ¦Á-asaronol esters and analogs, I [R = 2-, 3-, 4-OMe, 2,3-(MeO)₂, 2,3,5-(MeO)₃, 2,3,4,5,6-(MeO)₅, 4-Br, 3-CF₃, etc.], II, III, and IV, were designed by Combination of Traditional Chinese Medicine Mol. Chem. (CTCMMC) strategy, synthesized and tested systematically not only for anticonvulsant activity in three mouse models but also for lactate dehydrogenase (LDH) inhibitory activity. Thus, compounds I [R = 3,4,5-(MeO)₃, 2,3,4,5-(MeO)₄, 2,3,4,6-(MeO)₄, 4-F] (V) displayed excellent and broad spectra of anticonvulsant activities with modest ability in preventing neuropathic pain, as well as low neurotoxicity. The protective indexes of these four compounds compared favorably with stiripentol, lacosamide, carbamazepine and valproic acid. 68-70 exhibited good LDH1 and LDH5 inhibitory activities with noncompetitive inhibition type, and were more potent than stiripentol. Compounds V exhibited good LDH1 and LDH5 inhibitory activities with noncompetitive inhibition type, and were more potent than stiripentol. Notably, I [R = 2,3,4,6-(MeO)₄], as a representative agent, was also shown as a moderately pos. allosteric modulator at human ¦Á1¦Â2¦Ã2 GABA_A receptors (EC₅₀ 46.3 ¡À 7.3 ¦ÌM). Thus, I [R = 3,4,5-(MeO)₃, 2,3,4,5-(MeO)₄, 2,3,4,6-(MeO)₄] were promising candidates for developing into anti-epileptic drugs, especially for treatment of refractory epilepsies such as Dravet syndrome.

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Synthetic Route of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Taghiof, Majid published the artcileOrganoaluminum and -gallium Thiolates. 1. Synthetic and X-ray Structural Studies, Synthetic Route of 22693-41-0, the publication is Organometallics (1995), 14(6), 2903-17, database is CAplus.

Organoaluminum and -Ga thiolates were prepared in high yield by the reaction of triorganoaluminum and -Ga derivatives with thiols. In this way, [Mes₂Al(¦Ì-SBz)]₂ (Mes = 2,4,6-Me₃C₆H₂; Bz = CH₂Ph) (1), [Me₂Al(¦Ì-SSiPh₃)]₂ (2), [Mes₂Al(¦Ì-SPh)]₂ (3), {Me₂Al[¦Ì-S(2-t-BuC₆H₄)]}₃ (4), {Me₂Al[¦Ì-S(2-Me₃Si)C₆H₄]}₃ (5), {Me₂Al[¦Ì-S(2-i-PrC₆H₄)]}₃ (6), {i-Bu₂Al[¦Ì-S(2,4,6-i-Pr₃C₆H₂)]}₃ (7), {Me₂Al[¦Ì-S(2,6-Me₂C₆H₃)]}₄ (8), and {Me₂Ga[¦Ì-S(2,6-Me₂C₆H₃)]}₄ (9) were prepared and crystallog. characterized. The dimethyl- and dimesitylaluminum thiolates 1–3 are dimeric with four-membered (AlS)₂ rings. The structure of 1 was determined in space group P2₁/n (Number 14): a 10.660(4), b 12.268(2), c 17.793(3) ?, ¦Â 106.94(2)¡ã, Z = 4, R = 6.7%, and R_w = 6.1%. The structures of 2 and 3 were determined in space group P1? (Number 2): a 9.077(2), b 13.847(3), c 16.724(4) ?, ¦Á 101.08(2), ¦Â 95.34(2), ¦Ã 103.38(2)¡ã, Z = 2 (dimers), R = 5.2%, and R_w = 5.1% for 2, and a 11.068(5), b 12.470(3), c 17.654(5) ?, ¦Á 90.97(2), ¦Â 107.77(3), ¦Ã 112.23(3)¡ã, Z = 4, R = 5.9%, and R_w = 4.8% for 3. The dialkylaluminum thiolates, 4–7, are trimeric in the solid state. The structure of 4 was determined in space group P2₁/c, a 9.324(7), b 18.632(5), c 23.959(9) ?, ¦Â 98.31(5)¡ã, Z = 4 (trimers), R = 7.6%, and R_w = 5.2%; 5 in space group P1?, a 10.149(4), b 14.427(5), c 15.159(4) ?, ¦Á 88.19(3), ¦Â 89.39(3), ¦Ã 88.57(3)¡ã, Z = 2 (trimers), R = 5.0%, and R_w = 5.0%; 6 in space group P1?, a 12.538(5), b 13.180(2), c 13.873(2) ?, ¦Á 74.38(1), ¦Â 64.18(2), ¦Ã 69.44(2)¡ã, Z = 2 (trimers), R = 5.2% and R_w = 4.4%; and 7 in space group P2₁/c, a 13.935(2), b 22.563(4), c 25.044(4) ?, ¦Â 101.44(1)¡ã, Z = 4 (trimers), R = 12.5%, and R_w = 14.2%. The S atoms in 7 are in a planar environment. Compounds 8 and 9 are tetrameric with eight-membered (MS)₄ (M = Al, Ga) ring systems. They are isomorphous, and their structures were determined in space group P1?. For 8 a 8.555(1), b 11.869(1), c 12.688(1) ?, ¦Á 96.546(8), ¦Â 106.34(1), ¦Ã 109.06(1)¡ã, Z = 2, R = 5.0%, and R_w = 5.2%, and for 9 a 8.525(2), b 11.805(3), c 12.714(4) ?, ¦Á 96.36(2), ¦Â 106.46(2), ¦Ã 108.90(2)¡ã, Z = 2, R = 6.1%, and R_w = 6.6%.

Organometallics published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C11H10O, Synthetic Route of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Musdal, Yaman published the artcileFDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1, Application In Synthesis of 38260-01-4, the publication is Chemico-Biological Interactions (2013), 205(1), 53-62, database is CAplus and MEDLINE.

Glutathione transferase P1-1 (GST P1-1) is often overexpressed in tumor cells and is regarded as a contributor to their drug resistance. Inhibitors of GST P1-1 are expected to counteract drug resistance and may therefore serve as adjuvants in the chemotherapy of cancer by increasing the efficacy of cytostatic drugs. Finding useful inhibitors among compounds used for other indications would be a shortcut to clin. applications and a search for GST P1-1 inhibitors among approved drugs and other compounds was therefore conducted. We tested 1040 FDA-approved compounds as inhibitors of the catalytic activity of purified human GST P1-1 in vitro. We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC₅₀ values in the low micromolar range. For comparison, these compounds were even more potent in the inhibition of human GST A3-3, an enzyme implicated in steroid hormone biosynthesis. In distinction from the other inhibitors, which showed conventional inhibition patterns, the competitive inhibitor ethacrynic acid elicited strong kinetic cooperativity in the glutathione saturation of GST P1-1. Apparently, ethacrynic acid serves as an allosteric inhibitor of the enzyme. In their own right, the compounds investigated are less potent than desired for adjuvants in cancer chemotherapy, but the structures of the most potent inhibitors could serve as leads for the synthesis of more efficient adjuvants.

Chemico-Biological Interactions published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia