Tag: M.W=200-250

Englich, Ulrich published the artcileSodium and Potassium Triisopropylbenzenethiolates: Influence on Solid-State Structure by Metal and Donor, Formula: C15H24S, the publication is Inorganic Chemistry (1998), 37(2), 283-293, database is CAplus.

The synthesis and characterization of a family of Na and K thiolates [MSTrip]_¡Þ (M = Na, K; HSTrip = 2,4,6-triisopropybenzenethiol, n = 1-¡Þ) is described. [Na(PMDTA)STrip]₂, 1 (PMDTA = N,N,N’,N”,N”-pentamethyldiethylenetriamine), [(NaSTrip)₂(Na(Et₂O)STrip)₄]¡¤0.5solvent, 2, [Na(TMEDA)STrip]_¡Þ, 3 (TMEDA = N,N,N’,N’-tetramethylethylenediamine), [Na(THF)STrip]_n, 4 (n = 6 or ¡Þ), [K(dibenzo-18-crown-6)(THF)STrip]¡¤THF, 5, [(KSTrip)₂(K(THF)STrip)₂(K(THF)₂STrip)₂], 6, [K(THF)STrip]_¡Þ, 7, [(K(THF)STrip)₂(K(TMEDA)STrip)₂(KSTrip)₂]¡¤THF, 8, and [K(PMDTA)STrip]_¡Þ, 9, were synthesized by treatment of HSTrip with NaH or KH along with the addition of various donors. The target mols. were characterized by IR, ¹H NMR, and depending on solubility, ¹³C NMR spectroscopy and m.p. Compounds 1–3 and 5–9 were also characterized by single-crystal x-ray crystallog. Anal. of structural data clearly indicates that the structural chem. of the target mols. can be influenced by donor choice, as exemplified by the large structural diversity observed in the target mols.: the use of a crown ether gave the monomeric species 5, whereas the use of a monodentate donor, such as THF, gave the ladder-type polymer 7 or the discrete hexameric compounds 2 and 6. Addition of the bidentate donor TMEDA to a solution of [NaSTrip]_¡Þ gave the 1-dimensional zigzag polymer 3, whereas use of the tridentate donor PMDTA gave the dimer 1. Changing from Na to K and use of the tridentate donor PMDTA yielded the 1-dimensional zigzag polymer 9, while employment of a mixture of mono- and bidentate donors (THF and TMEDA) resulted in the asym. coordinate hexamer 8. Crystal data with Mo K¦Á (¦Ë = 0.710 73 ?) at 150 K are as follows: 1, a 13.2300(1), b 10.6176(1), c 19.6262(3) ?, ¦Â 100.449(1)¡ã, V = 2711.19(5) ?³, Z = 4, monoclinic, space group P2₁/n, 6309 independent reflections, R1 (all data) = 0.1004; 2, a 14.4178(3), b 17.6498(4), c 26.2052(6) ?, ¦Á 89.847(1), ¦Â 77.475(1), ¦Ã 70.189(1)¡ã, V = 6106.3(2) ?³, Z = 2, triclinic, space group P1, 25,722 independent reflections, R1 (all data) = 0.1311; 3, a 9.2702(1), b 20.1017(2), c 25.9256(4) ?, V = 4831.15(10) ?³, Z = 8, orthorhombic, space group Pbca, 5032 independent reflections, R1 (all data) = 0.1125; 5, a 14.196(3), b 15.429(3), c 22.562(5) ?, ¦Á 101.92(2), ¦Â 97.31(3), ¦Ã 114.19(3)¡ã?, V = 4313(2) ?³, Z = 4, triclinic, space group P1, 6592 (I > 2¦Ò(I)) data, R = 0.074; 6, a 15.071(3), b 25.301(5) ?, c 17.866(4) ?, ¦Â 113.01(3)¡ã, V = 6270(3) ?³, Z = 2, monoclinic, space group P2₁/n, 2332 (I > 2¦Ò(I)) data, R = 0.103; 7, a 11.9079(2), b 14.7672(2), c 24.0448(1) ?, ¦Â 98.220(1)¡ã, Z = 4, monoclinic, space group P2₁/c, 9693 independent reflections, R1 (all data) = 0.1324; 8, a 18.324(4), b 14.323(3), c 26.300(5) ?, ¦Â 106.39(3)¡ã, Z = 2, monoclinic, space group P2₁/c, 4511 (I >3¦Ò(I)) data, R = 0.105; 9, a 10.4903(2), b 20.1551(5), c 26.4295(4) ?, Z = 8, orthorhombic.

Inorganic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Formula: C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Valadao, George Eduardo Sales published the artcileDepression of spodumene in pegmatite samples, Application of Dodecylamineacetate, the publication is Congresso Anual – Associacao Brasileira de Metais (1991), 46th(Vol. 2), 485-94, database is CAplus.

Conditions for depression of spodumene contained in Itinga-Aracuai (Brazil) pegmatitic bodies were studied using corn starch, dextrin, or Al(NO₃)₃ as the depressant. Dextrin exhibited no selective depressing action, whereas Al(NO₃)₃ could be used as a selective depressant. The concentrate obtained contained ?6.5% LiO₂ at recovery 91%. In the amine (Armac 12D)-corn starch system, the concentrate contained 5.87-6.74% LiO₂ at recovery 71.5-89.3%. NaOH pretreatment did not affect the results obtained with that system.

Congresso Anual – Associacao Brasileira de Metais published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C5H10O2S, Application of Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Zhiping published the artcileFeCl₂-catalyzed selective C-C bond formation by oxidative activation of a benzylic C-H bond, Safety of Bis(4-fluorophenyl)methane, the publication is Angewandte Chemie, International Edition (2007), 46(34), 6505-6507, database is CAplus and MEDLINE.

Readily available and non-toxic FeCl₂ effectively catalyzes C-C bond formation by oxidative activation of benzylic C-H bonds in the presence of tert-Bu peroxide as a stoichiometric oxidant. The mild reaction conditions, good yields, low catalyst cost, and easy operation are the major advantages of this cross-dehydrogenation coupling reaction. A series of substituted 1,3-dicarbonyl compounds, e.g., I, were generated using this method.

Angewandte Chemie, International Edition published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Capaccio, V. published the artcileOrganocatalytic Heterocyclization Driven by Dynamic Kinetic Resolution: Enantioselective Access to Multi-heteroatomic Cyclic Structures Mediated by Cinchona Alkaloid-based Catalysts, COA of Formula: C15H24S, the publication is Advanced Synthesis & Catalysis (2017), 359(16), 2874-2880, database is CAplus.

A new class of multi-heteroat. cyclic compounds containing N, S and O I (R = C₆H₅, 2-H₃CC₆H₄, c-hexyl, etc.) has been achieved in an enantioselective fashion via desymmetrization of 2-cyano-N-tosylbenzylidenimine with thiols and subsequent catalytic dynamic kinetic resolution (DKR). Both organo- and phase transfer catalysis based on cinchona alkaloids having two H-bonding coordination sites proved to be effective to furnish very good level of enantioselectivity (up to 95:5 er) in the heterocyclization of racemic N-Tosyl-protected N,S-acetals deriving from 2-formyl benzonitriles.

Advanced Synthesis & Catalysis published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, COA of Formula: C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Veerakanellore, Giri Babu published the artcileSolid-state photochemistry of cis-cinnamic acids: a competition between [2+2] addition and cis-trans isomerization, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is CrystEngComm (2016), 18(25), 4708-4712, database is CAplus.

With three examples, we have established that cis-cinnamic acids can dimerize via a diradical intermediate in the crystalline state provided that the intermol. distance is less than 4.2 ?. In the excited state of cis-isomers, C-C bond formation with an adjacent mol. competes with geometric isomerization.

CrystEngComm published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C13H10O2, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Smajlagic, Ivor published the artcileCharge-enhanced thiourea catalysts as hydrogen bond donors for Friedel-Crafts Alkylations, Synthetic Route of 4230-93-7, the publication is Tetrahedron (2019), 75(51), 130757, database is CAplus.

Charge-enhanced catalysis has emerged as a powerful alternative to the mainstream use of neutral catalysis. With this in mind, we report a catalytic Friedel-Crafts alkylation method catalyzed by a charged thiourea incorporating a cationic cyclopropenium moiety. Mechanistic studies, including d. functional theory computational calculations, variable time normalization anal., and ¹H NMR binding studies, collectively reveal this charge-enhanced reactivity proceeds by a dual hydrogen bond-mediated LUMO-lowering mode of substrate activation. Key to these findings is the observed steady-state concentration of the catalyst with in situ derived monomeric catalytic species predominating under the reaction conditions.

Tetrahedron published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C17H27BN2O4S, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bellini, Clement published the artcileBarium-Mediated Cross-Dehydrocoupling of Hydrosilanes with Amines: A Theoretical and Experimental Approach, Application In Synthesis of 140-28-3, the publication is Angewandte Chemie, International Edition (2015), 54(26), 7679-7683, database is CAplus and MEDLINE.

Alk.-earth (most prominently barium) complexes of the type [Ae{N(SiMe₃)₂}₂¡¤(THF)_x] and [{NN?}Ae{N(SiMe₃)₂}¡¤(THF)_x] are very active and productive precatalysts (TON = 396, TOF up to 3600 h^-1; Ca < Sr < Ba) for N-H/H-Si cross-dehydrocoupling, with excellent chemoselectivity in the reaction of (di)amines with (di)hydrosilanes. Exptl. and DFT investigations revealed that the reactions proceed by nucleophilic attack of a metal amide at the incoming silane and subsequent turnover-limiting hydrogen transfer to the metal center.

Angewandte Chemie, International Edition published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

O’Boyle, Niamh M. published the artcileSynthesis and Evaluation of Azetidinone Analogues of Combretastatin A-4 as Tubulin Targeting Agents, Synthetic Route of 1860-58-8, the publication is Journal of Medicinal Chemistry (2010), 53(24), 8569-8584, database is CAplus and MEDLINE.

The synthesis and antiproliferative activity of a new series of rigid analogs of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (¦Â-lactam) ring system in place of the usual ethylene bridge present in the natural combretastatin stilbene products. These novel compounds are also substituted at position 3 of the ¦Â-lactam ring with an aryl ring. A number of analogs showed potent nanomolar activity in human MCF-7 and MDA-MB-231 breast cancer cell lines, displayed in vitro inhibition of tubulin polymerization, and did not cause significant cytotoxicity in normal murine breast epithelial cells. 4-(4-Methoxyphenyl)-substituted compound, 4-(3-hydroxy-4-methoxyphenyl)-substituted compounds, and the 3-(4-aminophenyl)-substituted compounds displayed the most potent antiproliferative activity of the series. ¦Â-Lactam I in particular showed subnanomolar activity in MCF-7 breast cancer cells (IC₅₀ = 0.8 nM) together with significant in vitro inhibition of tubulin polymerization and has been selected for further biochem. assessment. These novel ¦Â-lactam compounds are identified as potentially useful scaffolds for the further development of antitumor agents that target tubulin.

Journal of Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Synthetic Route of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Carreiro, Elisabete Palma published the artcileArylid-OX and Arylid-BOX derived catalysts: applications in catalytic asymmetric cyclopropanation, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Tetrahedron: Asymmetry (2009), 20(11), 1272-1278, database is CAplus.

A novel family of chiral non-racemic monodentate oxazoline ligands known as Arylid-OXs I (R = Ph, t-Bu) was prepared in good overall yields. These ligands were screened in bench-mark Cu(I)-catalyzed cyclopropanations and gave ees as high as 58%. Both ¹H NMR and computational studies using I (R= Ph) indicated that the active catalyst was most likely to be the di-coordinated complex, Cu(I)-I (R= Ph)₂ (MeCN)₂. Two novel ortho-substituted Arylid-BOX ligands II (X = Cl, OMe) were also synthesized in very good yields. These ligands were tested in the same reaction as for I (R = Ph, t-Bu) and, although excellent yields could be obtained with II (R = OMe), which is assumed to be due to an electron-donating effect from the ortho-methoxy group, a best ee of only 56% was obtained with II (R = Cl). In fact, both the enantioselectivities and diastereoselectivities obtained with these ortho-substituted ligands were in line with those previously obtained with the para-substituted series.

Tetrahedron: Asymmetry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Molander, Gary A. published the artcileSynthesis and Application of Chiral Cyclopropane-Based Ligands in Palladium-Catalyzed Allylic Alkylation, Safety of 2,4,6-Triisopropylbenzenethiol, the publication is Journal of Organic Chemistry (2004), 69(23), 8062-8069, database is CAplus and MEDLINE.

A series of chiral, cyclopropane-based phosphorus/sulfur ligands have been synthesized and evaluated in the palladium-catalyzed allylic alkylation of 1,3-diphenylpropenyl acetate with di-Me malonate. Variation of the ligand substituents at phosphorus, sulfur, and the carbon backbone revealed [2-[(1R)-1-(methylthio)ethyl]cyclopropyl]diphenylphosphine (I) to have the optimal configuration for this reaction, giving the product in high yield and with good enantioselectivity (93%). A model for the observed enantioselectivity is discussed within the context of existing models, using X-ray crystallog. data, solution-phase NMR studies, and the absolute stereochem. of the products. Selected ligands were also evaluated in the palladium-catalyzed intermol. Heck reaction and the rhodium-catalyzed hydrogenation of a dehydroamino acid.

Journal of Organic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Safety of 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia