Tag: M.W=200-250

Matassini, Camilla published the artcileOn the Virtue of Indium in Reduction Reactions. A Comparison of Reductions Mediated by Indium and Zinc: Is Indium Metal an Effective Catalyst for Zinc Induced Reductions?, HPLC of Formula: 4230-93-7, the publication is European Journal of Inorganic Chemistry (2020), 2020(11-12), 1106-1113, database is CAplus.

Indium(0)-mediated reductions have been reported for the transformation of several functional groups (imines, oximes, nitro groups, isoxazolidines, and conjugated alkenes, among others), prompted by the opportunity of performing the reactions in aqueous media and green conditions. We describe here the comparison of several reactions using indium or the less expensive zinc, carried out in order to evaluate the effective advantages brought about indium metal. We found some reactions for which use of In is mandatory and others where Zn worked equally well or even better. The reduction of hydroxylamines to the corresponding amines was the only reduction for which use of In provided much better results than Zn and was also possible to apply an efficient catalytic version with use of 2-5 mol-% In in the presence of stoichiometric Zn. Applicability of this catalytic reduction to “one-pot” model processes is also demonstrated.

European Journal of Inorganic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, HPLC of Formula: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Klingebiel, Uwe published the artcileCycloaddition reactions of aminofluorosilanes, SDS of cas: 312-40-3, the publication is Journal of Organometallic Chemistry (1978), 144(3), 381-8, database is CAplus.

[2+2] Cycloaddition reaction of RR¹FSiNHR² with BuLi gave 70-80% I (R = Me, Ph; R¹ = Me, MeEtCH, Ph; R² = Me₂CH, Me₃C, 2,4,6-Me₃C₆H₂) (5 compounds). RR¹FSiNHR² were prepared in 70-90% yields by treating RR¹SiF₂ with LiNHR².

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, SDS of cas: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Elumalai, Nagarajan published the artcileNanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a, Formula: C10H10O6, the publication is Angewandte Chemie, International Edition (2015), 54(16), 4758-4763, database is CAplus and MEDLINE.

Src homol. 2 (SH2) domains play a central role in signal transduction. Although many SH2 domains have been validated as drug targets, their structural similarity makes development of specific inhibitors difficult. The cancer-relevant transcription factors STAT5a and STAT5b are particularly challenging small-mol. targets because their SH2 domains are 93% identical on the amino acid level. Here the authors present the natural product-inspired development of the low-nanomolar inhibitor I, as the first small mol. which inhibits the STAT5b SH2 domain (K_i=44 nM) with more than 50-fold selectivity over STAT5a. The binding site of the core moiety of I was validated by functional anal. of point mutants. A prodrug of I was shown to inhibit STAT5b with high selectivity over STAT5a in tumor cells. I provides the first demonstration that naturally occurring SH2 domains with more than 90% sequence identity can be selectively targeted with small organic mols.

Angewandte Chemie, International Edition published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Formula: C10H10O6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Balavoine, Gilbert published the artcileThio glycosides as potential glycosyl donors in electrochemical glycosidation reactions. Part 1. Their preparation and reactivity toward simple alcohols, Related Products of catalysis-chemistry, the publication is Journal of Carbohydrate Chemistry (1995), 14(8), 1217-36, database is CAplus.

Constant potential electrolysis of several glycosyl donors such as substituted Ph 2,3,4,6-tetra-O-acetyl, benzoyl or benzyl-1-thio-β-D-gluco or galactopyranosides in dry acetonitrile in the presence of various primary, secondary or tertiary alcs. performed in an undivided cell, gave preferentially β-linked saccharides in moderate to good yields according to the nature of the protective groups on the sugar moiety. 2-Deoxy-2-phthalimido-1-thio-β-D-gluco derivatives gave the β-glucosides selectively in excellent yields. It was found, as expected, that substitution of the Ph group with methoxy or Me radicals facilitates the electrochem. glycosidation reaction by lowering the oxidation potentials of the corresponding thio glycosides.

Journal of Carbohydrate Chemistry published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Das, Sukant K. published the artcileTowards a stereoselective synthesis of α,α-disubstituted proline analogs, Synthetic Route of 4230-93-7, the publication is Tetrahedron Letters (2015), 56(37), 5172-5174, database is CAplus.

A mild organocatalytic protocol for the syntheses of α,α-disubstituted proline analogs has been developed. The 3-ketoproline scaffold was functionalized using various aromatic nitrostyrenes in the presence of a bifunctional organocatalyst. The resulting quaternary proline derivatives could easily be transformed into α-alkyl-β-hydroxyproline analogs. Furthermore, the methodol. could also be applied to the synthesis of 3-ketoproline functionalized peptides with high selectivity and good yields.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dekkers, Bart G. J. published the artcileRelevance of the drug-drug interactions between lidocaine and the pharmacokinetic enhancers ritonavir and cobicistat, Related Products of catalysis-chemistry, the publication is AIDS (London, United Kingdom) (2019), 33(6), 1100-1102, database is CAplus and MEDLINE.

Reporting on the serol. response to syphilis treatment with penicillin benzathine or doxycycline in patients with HIV following a manufacturing shortfall of penicillin benzathine. Discomfort of these injections can be reduced by replacing part of the solvent by a lidocaine (lignocaine) solution To enhance exposure to antiretroviral drugs, such as atazanavir, darunavir and elvitegravir, ritonavir and cobicistat are used as boosters in combined antiretroviral therapy. Ritonavir and cobicistat inhibit CYP3A4, resulting in an increased exposure (increased area under the curve) , increased maximum concentration (Cmax) and increased half-life 1/2 of antiretroviral drugs that are substrates of CYP3A4. Drug-drug interactions between ritonavir or cobicistat and lidocaine have been suggested to increase lidocaine exposure by more than three-fold complicating treatment with benzylpenicillin benzathine as this interaction may lead to higher plasma lidocaine levels and adverse effects, including neurol. and cardiac side effects.

AIDS (London, United Kingdom) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Renaud, Johanne published the artcileSelective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure-Activity Relationship of ERα-Selective Tetrahydroisoquinoline Ligands, Formula: C15H14O3, the publication is Journal of Medicinal Chemistry (2005), 48(2), 364-379, database is CAplus and MEDLINE.

The authors disclose herein the discovery of estrogen receptor α (ERα) selective estrogen receptor modulators (SERMs) of the tetrahydroisoquinoline series that incorporate novel conformationally restricted side chains as replacement of the aminoethoxy residue typical of SERMs. Mol. modeling studies used in conjunction with the x-ray crystal structure of the ERα ligand binding domain (LBD) with raloxifene (7) suggested a diazadecaline moiety as a viable mimic of the SERM side chain. On the basis of this knowledge, the piperidinylethoxy moiety of our lead compound I was replaced by a diazadecaline subunit, providing the novel tetrahydroisoquinoline II. In addition to exhibiting a binding affinity to ERα and antagonistic properties in the estrogen response element and MCF-7 assays similar to those of the parent compound I, ligand II showed a reduced agonist behavior in the MCF-7 assay in the absence of 17β-estradiol. These data point toward the fact that II may have a potential for breast cancer prevention/treatment in vivo, a feature which is particularly attractive in the quest for safe alternatives to hormone replacement therapy. In a pharmacokinetic experiment carried out in rats, II displayed an interesting profile, with a bioavailability of 49%. The authors also disclose the x-ray crystal structure of II in complex with ERα-LBD, which reveals the preferred configurations of II at the two chiral centers and the details of its interactions with the receptor. Finally, our structure-activity relationship studies show that other analogs bearing constrained side chains retain potency and antagonist activity and that a 3-OH substituted Ph D-ring increases the selectivity of a set of piperazinyl-containing ligands in favor of ERα over ERβ.

Journal of Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Formula: C15H14O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Narayan, Rishikesh published the artcileCatalytic enantioselective synthesis of functionalized tropanes reveals novel inhibitors of hedgehog signaling, Quality Control of 4230-93-7, the publication is Angewandte Chemie, International Edition (2013), 52(49), 12892-12896, database is CAplus and MEDLINE.

We have developed a very efficient Cu(I)- catalyzed highly diastereoselective and enantioselective [3+2] cycloaddition reaction of 1,3-fused cyclic azomethine ylides and nitroalkenes. For the first time, S-shaped azomethine ylides were successfully used in an enantioselective catalytic process. This novel method provides an unprecedented and general access to functionalized tropane scaffolds that embody quaternary and tertiary stereocenters in a stereoselective manner. It allows the generation of stereochem. complex products in a single step under mild reaction conditions, and is characterized by a broad scope and versatility. Furthermore, the investigation of a tropane-inspired compound collection in a process that monitored signaling through the hedgehog pathway revealed a novel class of hedgehog-signaling inhibitors.

Angewandte Chemie, International Edition published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Quality Control of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Barbero, Margherita published the artcileSynthetic and Mechanistic Aspects of Acid-Catalyzed Disproportionation of Dialkyl Diarylmethyl Ethers: A Combined Experimental and Theoretical Study, Safety of Bis(4-fluorophenyl)methane, the publication is European Journal of Organic Chemistry (2009), 4346-4351, S4346/1-S4346/33, database is CAplus.

The disproportionation reactions of various dialkyl diarylmethyl ethers were carried out in the presence of a catalytic amount (10 mol-%) of o-benzenedisulfonimide as a Broensted acid catalyst; the reaction conditions were mild, and the yields of the diarylmethane target products were good. The catalyst was easily recovered and purified, ready to be used in further reactions. The theor. study confirmed that the reaction proceeds in two steps: The formation of a carbocation from the protonated ether followed by hydride transfer. Although the hydride transfer is the rate-determining step, it is the stability of the carbocation that determines the reaction rate and therefore the yields. (© Wiley-VCH Verlag GmbH and Co. KGaA, 69451 Weinheim, Germany, 2009).

European Journal of Organic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Massacci, P. published the artcileBeneficiation of complex semi-oxidized lead-zinc ores, Related Products of catalysis-chemistry, the publication is Industria Mineraria (Rome) (1984), 5(5), 13-21, database is CAplus.

The process of beneficiation of complex oxidized Pb-Zn ores consisted in identifying the deposits, isolating the main Pb and Zn minerals, preparing samples of pure species to test the flotation processes, preparing ores of the oxidized minerals and verifying their degree of liberation, and testing the flotation process on the oxidized ores. Ores containing smithsonite  [14476-25-6] and cerussite  [14476-15-4] are conditioned with Na₂S for better sulfidization of the smithsonite surfaces. This is followed by dilution of the pulp before conditioning with dodecylamine acetate  [2016-56-0], so that the pH is as low as possible.

Industria Mineraria (Rome) published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia